JP2007252880A - Biological tissue adhesive applicator - Google Patents
Biological tissue adhesive applicator Download PDFInfo
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- JP2007252880A JP2007252880A JP2006134737A JP2006134737A JP2007252880A JP 2007252880 A JP2007252880 A JP 2007252880A JP 2006134737 A JP2006134737 A JP 2006134737A JP 2006134737 A JP2006134737 A JP 2006134737A JP 2007252880 A JP2007252880 A JP 2007252880A
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本発明は、主に複数成分系製剤として適用される組織接着剤の塗布用具に関するものであり、特に肝臓や肺の切除断端や消化管の縫合部の止血閉鎖などに好適な、生体の患部に噴霧して塗布するための用具に関する。 The present invention relates to a tissue adhesive applicator mainly applied as a multi-component preparation, and is particularly suitable for the affected part of a living body, which is suitable for, for example, resection stumps of the liver and lungs and hemostasis closure of digestive tract sutures. It is related with the tool for spraying and apply | coating.
繊維素原（フィブリノゲン）は、いわゆる血液凝固カスケードの最終段階に存在する非常に重要な役割を担う凝固因子である。フィブリノゲンは、例えば損傷後の血液凝固系の活性化において、トロンビンにより、その可溶性形態から止血及び創傷治療に重要な寄与をする不溶性のフィブリンに変換される。この血液凝固の最終相の原理を利用した組織接着剤が開発され、外科手術において肝臓または脾臓のような軟部器官の縫合代用の接着剤として、または縫合補助剤として使用されている。同時に、幅広い臨床の現場で応用されている。近年、２本のシリンジ体に収納されたフィブリノゲン溶液およびトロンビン溶液を同時に射出し、無菌ガスを利用して、射出させた２液を噴霧して混合するスプレー塗布法が普及し始めている（例えば特許文献１）。 Fibrinogen is a coagulation factor that plays a very important role in the final stage of the so-called blood coagulation cascade. Fibrinogen is converted by thrombin from its soluble form to insoluble fibrin, which makes an important contribution to hemostasis and wound treatment, for example in the activation of the blood clotting system after injury. A tissue adhesive utilizing the principle of the final phase of blood coagulation has been developed and used as an adhesive for suturing a soft organ such as the liver or spleen or as a suture aid in surgery. At the same time, it is applied in a wide range of clinical settings. In recent years, a spray coating method in which a fibrinogen solution and a thrombin solution housed in two syringe bodies are simultaneously injected, and the injected two liquids are sprayed and mixed using aseptic gas has begun to spread (for example, patents) Reference 1).
しかしながら本器具を用いた不具合として先端部での詰まりという現象がしばしば発生しており、これは特に断続して使用する際に多く発生していた。また、断続使用とは、薬液噴霧を一時中断し、手技を行った後再度、薬液噴霧を行うもので、中断時間は数分から数十分の範囲である。そのため、噴霧中にフィブリノゲン溶液とトロンビン溶液の霧状の微粒子が術野より反射し、ノズルチップ先端に付着、その際、異なる溶液と接触することにより薬液注出口や薬液流通管内の先端部において凝固が進み、結果として詰まりが発生するものと考えられている。
また、中断している間は、術野における空気の巻き上げ防止や、無菌ガス流出音をなくすため、無菌ガスを一時停止させる操作がなされる。そのため、薬液流通管内の残圧により、わずかに吐出された薬液が噴霧されずにノズル先端に付着し、それが先端部の詰まりの原因となり、また、ノズル部分の交換が必要になるという問題があった。
However, the phenomenon of clogging at the tip often occurs as a defect using this device, and this phenomenon occurs frequently especially when used intermittently. In addition, the intermittent use is for temporarily stopping the spraying of the chemical solution, performing the procedure again after performing the procedure, and the interruption time is in the range of several minutes to several tens of minutes. Therefore, the atomized fine particles of fibrinogen solution and thrombin solution are reflected from the operative field during spraying and adhere to the tip of the nozzle tip. As a result, clogging is considered to occur.
In addition, during the interruption, an operation of temporarily stopping the sterilized gas is performed in order to prevent the air from being rolled up in the operative field and to eliminate the sterilized gas outflow sound. Therefore, due to the residual pressure in the chemical solution distribution pipe, the slightly discharged chemical solution is not sprayed and adheres to the tip of the nozzle, which causes clogging of the tip portion, and also requires replacement of the nozzle portion. there were.
本発明は、上記事情に鑑みてなされたものであり、断続使用においても先端部分の薬液詰まりのない生体組織接着剤塗布用具を提供することを課題とする。 This invention is made | formed in view of the said situation, and makes it a subject to provide the biological tissue adhesive application tool without the chemical | medical solution clogging of a front-end | tip part also in intermittent use.
本発明による生体組織接着剤塗布用具は、内部に空間を有する本体と、前記本体内部にガスを満たすためのガス注入口と、前記本体の後端に複数の薬液注入口と、前記本体の先端に薬液注出口と、前記薬液注出口近傍に設けられ、前記薬液注出口から吐出した薬液を霧状噴霧混合して接着剤を生成するガス噴出口とを備え、前記本体内部には、前記薬液注入口と前記薬液注出口と連通した薬液流通管が設けられるとともに、前記薬液流通管には、管壁面を貫通する連通部が設けられたことを特徴とする。 A biological tissue adhesive applicator according to the present invention includes a main body having a space therein, a gas injection port for filling a gas inside the main body, a plurality of chemical liquid injection ports at a rear end of the main body, and a tip of the main body And a gas spout provided in the vicinity of the chemical liquid outlet for generating an adhesive by spraying and mixing the chemical liquid discharged from the chemical liquid outlet, and the inside of the main body includes the chemical liquid A chemical fluid circulation pipe communicating with the inlet and the chemical fluid outlet is provided, and the chemical fluid circulation pipe is provided with a communication portion penetrating the pipe wall surface.
この生体組織接着剤塗布用具においては、薬液流通管に管壁面を貫通する連通部が設けられている。これにより、薬液注入を停止したとき、この連通部よりガスが進入し、進入した部分より先端側に滞留している薬液を確実に外部に吐出できるので断続的な使用においても、ノズル先端部が詰まることを防止できる生体組織接着剤塗布用具が実現される。 In this biological tissue adhesive applicator, a communication portion that penetrates the tube wall surface is provided in the chemical solution circulation tube. As a result, when the chemical injection is stopped, the gas enters from this communication part, and the chemical liquid staying at the tip side from the entered part can be surely discharged to the outside. A biological tissue adhesive applicator that can prevent clogging is realized.
また、前記薬液流通管は、軟質チューブで形成されていてもよい。こうすることにより、薬液が流動しているときは、内圧により軟質チューブに形成された連通部が閉塞され、連通部より薬液が本体内部に漏れ出すことを防ぐ生体組織接着剤塗布用具とすることができる。 Moreover, the said chemical | medical solution distribution pipe may be formed with the soft tube. By doing this, when the drug solution is flowing, the communicating part formed in the soft tube is blocked by the internal pressure, and the biological tissue adhesive application tool is prevented from leaking into the main body from the communicating part. Can do.
本発明によれば、断続使用においても先端部分の薬液詰まりのない生体組織接着剤塗布用具を提供することができる。 ADVANTAGE OF THE INVENTION According to this invention, the biological tissue adhesive application tool without the chemical | medical solution clogging of a front-end | tip part also in intermittent use can be provided.
以下、本発明の実施形態について図面を用いて説明する。なお、すべての図面において、共通する構成要素には同一符号を付し、以下の説明においては詳細な説明を適宜省略する。 Hereinafter, embodiments of the present invention will be described with reference to the drawings. In all the drawings, common constituent elements are denoted by the same reference numerals, and detailed description will be appropriately omitted in the following description.
本実施形態に係る生体組織接着剤塗布用具は、図１に示すように、内部に空間を有する本体（１）と、本体（１）の後端に複数の薬液注入口（２）と、本体内部にガスを満たすためのガス注入口（３）と、本体（１）の先端には薬液注出口（４）と、薬液注出口（４）近傍に設けられ、薬液を霧状噴霧混合するためのガス噴出口（５）とを備え、本体内部には、薬液注入口（２）と薬液注出口（４）と連通した薬液流通管（６）が設けられるとともに、薬液流通管（６）には、管壁面を貫通する連通部（７）が設けらている。以下、本体をスプレーヘッドという。 As shown in FIG. 1, the biological tissue adhesive applicator according to the present embodiment includes a main body (1) having a space inside, a plurality of chemical liquid injection ports (2) at the rear end of the main body (1), and a main body. A gas inlet (3) for filling the gas inside, a chemical liquid outlet (4) at the tip of the main body (1), and a chemical liquid outlet (4) are provided in the vicinity of the chemical liquid outlet for mixing the mist with spray And a chemical solution distribution pipe (6) communicating with the chemical solution injection port (2) and the chemical solution injection port (4) are provided inside the main body, and the chemical solution distribution pipe (6) is provided with the chemical solution injection port (5). Is provided with a communicating portion (7) penetrating the pipe wall surface. Hereinafter, the main body is referred to as a spray head.
次にフィブリノゲン溶液とトロンビン溶液による生体組織接着剤の塗布操作についての具体例を図１および図４を用いて述べる。まずフィブリノゲン溶液を充填したシリンジ（１０）とトロンビン溶液を充填したシリンジ（１０）の先端をスプレーヘッド（１）の後端の薬液注入口（２）にそれぞれ接続する。次にガス注入口（３）に無菌フィルター（９）を介してガス供給源を接続し、適度なエアー流量を保つ。そして一般的には止血するべく患部へスプレーヘッド（１）を向けシリンジ（１０）を加圧することにより薬液注出口（４）よりフィブリンノゲン溶液とトロンビン溶液の薬液（１１）がガス噴出口（５）より噴出されたガス（１２）により混合され患部に噴霧され止血がなされることとなる。そしてシリンジ（１０）の加圧を止めた瞬間にガスが連通部（７）より薬液流通管（６）に進入し、連通部（７）から薬液注出口（４）までの薬液流通管（６）内の薬液を排出するフラッシュ操作がなされる。従って薬液注出口（４）先端内の微粒子反射による凝固気味の薬液が排出されるため、詰まりを発生させることなく再使用が可能となる。 Next, a specific example of the operation of applying the biological tissue adhesive using a fibrinogen solution and a thrombin solution will be described with reference to FIGS. First, the tip of the syringe (10) filled with the fibrinogen solution and the tip of the syringe (10) filled with the thrombin solution are respectively connected to the chemical solution inlet (2) at the rear end of the spray head (1). Next, a gas supply source is connected to the gas injection port (3) through a sterile filter (9) to maintain an appropriate air flow rate. In general, the spray head (1) is directed to the affected area to stop hemostasis, and the syringe (10) is pressurized so that the medicinal solution (11) of the fibrinogen solution and the thrombin solution is discharged from the gas spout ( 5) The gas (12) ejected from 5) is mixed and sprayed on the affected area to stop hemostasis. At the moment when the pressurization of the syringe (10) is stopped, the gas enters the chemical liquid distribution pipe (6) from the communication part (7), and the chemical liquid distribution pipe (6) from the communication part (7) to the chemical liquid outlet (4) ) The flush operation to discharge the chemical solution is performed. Accordingly, since the chemical liquid with a coagulation flavor due to the reflection of fine particles in the tip of the chemical liquid outlet (4) is discharged, it can be reused without causing clogging.
スプレーヘッド１内部には、薬液流通管（６）が設けられている。薬液注入口（２）と薬液注出口（４）（薬液吐出ノズル）を結ぶ薬液流通管（６）は、チューブ状が用いられる。薬液流通管（６）を構成する材料としては、例えば、ポリ塩化ビニル樹脂、ポリウレタン樹脂、シリコーン樹脂、などの軟質チューブから選ぶことが好ましい。軟質チューブを使うことにより、薬液流通管（６）を、薬液が流通しているとき、流通管内を外側に押し広げるが力が働き、薬液流通路（６）に設けられた連通部（７）が、その圧力により閉塞し、薬液がスプレーヘッド（１）内部に漏れ出すことを防ぐことができるのでより好ましい。 Inside the spray head 1, a chemical solution distribution pipe (6) is provided. The chemical solution flow pipe (6) connecting the chemical solution inlet (2) and the chemical solution outlet (4) (chemical solution discharge nozzle) has a tubular shape. The material constituting the chemical solution distribution pipe (6) is preferably selected from soft tubes such as polyvinyl chloride resin, polyurethane resin, and silicone resin. By using a soft tube, when the chemical solution is flowing through the chemical solution distribution pipe (6), the force works to push the inside of the distribution tube outward, but the communication portion (7) provided in the chemical solution flow passage (6). However, it is more preferable because it can be blocked by the pressure and the chemical liquid can be prevented from leaking into the spray head (1).
スプレーヘッド（１）の先端部は、図１（ｃ）の拡大断面図に示すように、本実施形態では、２本のガス噴出口（５）が、薬液注出口（４）を包むように、同心円状に形成されている。薬液注出口（４）が３本以上となったときの薬液注出口の配列として、同心円上の等角位置に配置することが好ましい。 As shown in the enlarged cross-sectional view of FIG. 1 (c), the tip of the spray head (1) is, in this embodiment, the two gas outlets (5) wrapping the chemical injection port (4), It is formed concentrically. As an arrangement of the chemical liquid outlets when there are three or more chemical liquid outlets (4), it is preferable to arrange them at equiangular positions on concentric circles.
薬液の流通が止まると、薬液流通路（６）を押し広げる力が弱まり、それまで、閉塞していた連通部（７）に開口部ができる。この開口部から、ガスが流入する。流入したガスは、薬液流通路（６）の基端側へ移動しようとしても、薬液注入口（２）は、シリンジ（１０）で塞がれているため流れず、開口部がある薬液注出口（４）に向かってガスが流入することになる。その結果、連通部（７）より先端側に滞留していた、薬液を外部に吐出することになり先端側の薬液での詰まりを防止することが可能となる。 When the distribution of the chemical liquid stops, the force that pushes the chemical liquid flow path (6) weakens, and an opening is formed in the communication section (7) that has been blocked until then. Gas flows from this opening. Even if the inflowing gas tries to move to the proximal end side of the chemical liquid flow path (6), the chemical liquid injection port (2) does not flow because it is blocked by the syringe (10), and the chemical liquid outlet has an opening. Gas will flow toward (4). As a result, the chemical solution staying on the tip side from the communication portion (7) is discharged to the outside, and clogging with the chemical solution on the tip side can be prevented.
また、薬液流通路（６）は、スプレーヘッド（１）の成型品そのものにガス流通管と区分けされた薬液流通管（６）を成形等により予め施しても構わない。また、ガス注入口（３）の端末には予め無菌フィルター（９）を設置しておくことで二次感染を防止できる点でより好ましい。 In addition, the chemical flow passage (6) may be preliminarily formed by molding or the like on the molded product itself of the spray head (1) by molding or the like. Moreover, it is more preferable at the point which can prevent a secondary infection by installing the sterilization filter (9) previously in the terminal of a gas inlet (3).
薬液注入口（２）と薬液注出口（４）との間に設けられている薬液流通路（６）には連通部（７）（小孔）が形成されている（図２）。連通部（７）は、薬液流通管（６）内にある連通部（７）より前側の薬液をガスにより排出するためのものである。連通部設置の条件はガスが薬液流通管（６）に進入できることは当然であるが、ガス停止時に薬液をシリンジで加圧した際に連通部（７）より漏出しないこと、更にシリンジ非加圧時にガスの送気圧力でシリンジのプランジャー戻りが無いように設計されることが望ましく、口径は外径０．１ｍｍ以下で図２に示すように薬液注出口（４）を前側とした場合（薬液の流れ方向）に斜め後ろ向きに設置されることが望ましい。 A communicating part (7) (small hole) is formed in the chemical liquid flow passage (6) provided between the chemical liquid inlet (2) and the chemical liquid outlet (4) (FIG. 2). The communication part (7) is for discharging the chemical liquid in front of the communication part (7) in the chemical liquid flow pipe (6) with gas. It is natural that the gas can enter the chemical solution distribution pipe (6) as the condition for installing the communication portion, but when the chemical solution is pressurized with the syringe when the gas is stopped, it does not leak from the communication portion (7), and the syringe is not pressurized. It is sometimes desirable to design the syringe so that there is no return of the plunger of the syringe due to the gas supply pressure, the diameter is 0.1 mm or less, and the chemical solution outlet (4) is the front side as shown in FIG. It is desirable to install it diagonally backwards in the direction of chemical flow.
薬液流通路（６）の、内壁の連通口は、外壁の連通口よりも先端側に形成されていることが好ましい。これにより、薬液が流動している方向に連通部（７）が形成されるため、より広い範囲で、連通部（７）に内部から圧力を掛けることが可能となり、より確実に、連通部（７）を閉塞させておくことが可能となる。 It is preferable that the communication port on the inner wall of the chemical liquid flow passage (6) is formed on the tip side of the communication port on the outer wall. As a result, the communication part (7) is formed in the direction in which the chemical liquid flows, so that it is possible to apply pressure to the communication part (7) from the inside in a wider range, and the communication part ( 7) can be closed.
また、図３に示すように、連通部（７）の形状として、小孔の代わりにスリット（８）を設置することも可能であり、スリットの長さは薬液流通管（６）を形成する軟質チューブの弾性率を鑑み適宜設定される。スリットの場合も、薬液が流動しているときは、薬液が薬液流通路（６）を外に押し広げようとする力が働き、一方、スプレーヘッド（１）内部に充満しているガスは、薬液流通路（６）を押しつぶそうとする圧力が働いている。薬液が流動しているとき、内圧と外圧のバランスが取れた状態でスリット（８）は、スリット面が密着した状態となっており、薬液のスプレーヘッド（１）内部へも漏れを防いでいる。薬液の流通が止まると、スプレーヘッド（１）内の圧力が高まり、薬液流通路（６）を押しつぶそうとして、スリット（８）面が薬液流通路（６）内部に押され、スリット（８）が開口し、薬液流通路（６）内に、ガスが流入する。
流入したガスが、薬液流通路（６）の基端側へ移動しようとしても、薬液注入口（２）は、シリンジ（１０）で塞がれているため流れず、開口部がある薬液注出口（４）に向かってガスが流入することになる。その結果、スリット（８）より先端側に滞留していた、薬液を外部に吐出することになり先端側の薬液での詰まりを防止することが可能となる。
Moreover, as shown in FIG. 3, it is also possible to install a slit (8) instead of a small hole as the shape of the communication part (7), and the length of the slit forms the chemical solution distribution pipe (6). It is set as appropriate in view of the elastic modulus of the soft tube. Also in the case of the slit, when the chemical liquid is flowing, a force is exerted to push the chemical liquid flow path (6) outward and the gas filling the spray head (1) is A pressure is exerted to crush the chemical flow passage (6). When the chemical liquid is flowing, the slit (8) is in a state where the internal pressure and the external pressure are balanced, and the slit surface is in close contact, and the chemical liquid spray head (1) is prevented from leaking. . When the flow of the chemical liquid stops, the pressure in the spray head (1) increases, and the surface of the slit (8) is pushed into the chemical liquid flow path (6) to crush the chemical liquid flow path (6), and the slit (8 ) Is opened, and gas flows into the chemical flow passage (6).
Even if the inflowing gas tries to move to the proximal end side of the chemical flow passage (6), the chemical injection port (2) does not flow because it is blocked by the syringe (10), and the chemical injection port has an opening. Gas will flow toward (4). As a result, the chemical solution staying on the tip side from the slit (8) is discharged to the outside, and clogging with the chemical solution on the tip side can be prevented.
また、他の実施例として薬液流通管（６）に、薬液流通管（６）内方向のみに開口する一方弁（１５）を設置してもよい。これは、軟質チューブに用いてもよいが、スプレーヘッド（１）の成型品に成形して設けられた流路に設ける場合、薬液流通管（６）とガス流路を区分けする隔壁に薬液流通管（６）内方向のみに開口する一方弁（１５）を設置することがより好ましい（図５）。 Moreover, you may install the one-way valve (15) opened only to a chemical | medical solution distribution pipe (6) inward in a chemical | medical solution distribution pipe (6) as another Example. This may be used for a soft tube, but when it is provided in a flow path formed by molding the spray head (1), the chemical liquid is distributed in the partition that separates the chemical flow pipe (6) and the gas flow path. It is more preferable to install a one-way valve (15) that opens only in the pipe (6) (FIG. 5).
全ての構成部品の材質は特に限定されるものではないが、少なくとも薬液と接触する薬液注入口（２）、薬液注出口（４）、薬液流通管（６）の材質は医療用プラスチック材料であり、かつ薬液に影響をおよぼさないものであることが求められる。また、本発明の塗布用具の製作は複数の成型品を接着するか又は溶着等により組み立てられる。 The material of all the components is not particularly limited, but at least the material of the chemical solution inlet (2), the chemical solution outlet (4) and the chemical solution distribution pipe (6) that come into contact with the chemical solution is a medical plastic material. In addition, it is required to have no effect on the chemical solution. The application tool of the present invention can be assembled by bonding a plurality of molded products or welding.
１ スプレーヘッド（本体）
２ 薬液注入口
３ ガス注入口
４ 薬液注出口
５ ガス噴出口
６ 薬液流通管
７ 連通部
８ スリット
９ 無菌フィルター
１０シリンジ
１１薬液
１２ガス
１５一方弁
1 Spray head (main unit)
2
Claims (6)
前記本体内部にガスを満たすためのガス注入口と、
前記本体の後端に複数の薬液注入口と、
前記本体の先端に薬液注出口と、
前記薬液注出口近傍に設けられ、前記薬液注出口から吐出した薬液を霧状噴霧混合して接着剤を生成するガス噴出口とを備え、
前記本体内部には、前記薬液注入口と前記薬液注出口とを連通した薬液流通管が、設けられるとともに、前記薬液流通管には、管壁面を貫通する連通部が設けられたことを特徴とする生体組織接着剤塗布用具。 A body having a space inside;
A gas inlet for filling the gas inside the body;
A plurality of chemical injection ports at the rear end of the main body;
A chemical solution outlet at the tip of the main body,
A gas outlet that is provided near the chemical liquid outlet, and generates an adhesive by atomizing and mixing the chemical liquid discharged from the chemical liquid outlet;
In the main body, there is provided a chemical fluid circulation pipe that communicates the chemical fluid inlet and the chemical fluid outlet, and the chemical fluid circulation pipe is provided with a communication portion that penetrates the tube wall surface. A living tissue adhesive applicator.
2. The living body according to claim 1, wherein the chemical liquid circulation pipe is provided with a one-way valve that allows flow from the inside of the main body into the chemical liquid circulation pipe and regulates flow from the inside of the chemical liquid circulation pipe to the inside of the main body. Tissue adhesive applicator.
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| Application Number | Priority Date | Filing Date | Title |
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| JP2006134737A JP4360377B2 (en) | 2006-02-22 | 2006-05-15 | Biological tissue adhesive applicator |
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| Application Number | Priority Date | Filing Date | Title |
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| JP2006045056 | 2006-02-22 | ||
| JP2006134737A JP4360377B2 (en) | 2006-02-22 | 2006-05-15 | Biological tissue adhesive applicator |
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| Publication Number | Publication Date |
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| JP2007252880A true JP2007252880A (en) | 2007-10-04 |
| JP4360377B2 JP4360377B2 (en) | 2009-11-11 |
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| JP2006134737A Active JP4360377B2 (en) | 2006-02-22 | 2006-05-15 | Biological tissue adhesive applicator |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009131590A (en) * | 2007-11-08 | 2009-06-18 | Terumo Corp | Applicator |
| JP2009213786A (en) * | 2008-03-12 | 2009-09-24 | Terumo Corp | Applicator |
| JP2010075412A (en) * | 2008-09-25 | 2010-04-08 | Terumo Corp | Applicator |
| JP2010075286A (en) * | 2008-09-24 | 2010-04-08 | Terumo Corp | Applicator |
| JP2011056019A (en) * | 2009-09-09 | 2011-03-24 | Sumitomo Bakelite Co Ltd | Biological tissue adhesive applicator |
| WO2012063464A1 (en) | 2010-11-10 | 2012-05-18 | 住友ベークライト株式会社 | Tool for applying biological tissue adhesive |
| JP2013523335A (en) * | 2010-04-05 | 2013-06-17 | ネオメンド、インク． | Delivery system, device and method for hydrogel compositions with self-cleaning to prevent clogging |
| KR101851977B1 (en) | 2014-11-21 | 2018-04-25 | 단국대학교 천안캠퍼스 산학협력단 | A gene amplifying Tube having a plurality of separated injection chamber |
-
2006
- 2006-05-15 JP JP2006134737A patent/JP4360377B2/en active Active
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009131590A (en) * | 2007-11-08 | 2009-06-18 | Terumo Corp | Applicator |
| JP2009213786A (en) * | 2008-03-12 | 2009-09-24 | Terumo Corp | Applicator |
| JP2010075286A (en) * | 2008-09-24 | 2010-04-08 | Terumo Corp | Applicator |
| JP2010075412A (en) * | 2008-09-25 | 2010-04-08 | Terumo Corp | Applicator |
| JP2011056019A (en) * | 2009-09-09 | 2011-03-24 | Sumitomo Bakelite Co Ltd | Biological tissue adhesive applicator |
| JP2013523335A (en) * | 2010-04-05 | 2013-06-17 | ネオメンド、インク． | Delivery system, device and method for hydrogel compositions with self-cleaning to prevent clogging |
| WO2012063464A1 (en) | 2010-11-10 | 2012-05-18 | 住友ベークライト株式会社 | Tool for applying biological tissue adhesive |
| JP2012100851A (en) * | 2010-11-10 | 2012-05-31 | Sumitomo Bakelite Co Ltd | Biological tissue adhesive applicator |
| CN103237509A (en) * | 2010-11-10 | 2013-08-07 | 住友电木株式会社 | Tool for applying biological tissue adhesive |
| CN107051764A (en) * | 2010-11-10 | 2017-08-18 | 住友电木株式会社 | Bio-tissue adhesive applicator |
| CN107051764B (en) * | 2010-11-10 | 2020-05-08 | 住友电木株式会社 | Applicator for biological tissue adhesive |
| KR101851977B1 (en) | 2014-11-21 | 2018-04-25 | 단국대학교 천안캠퍼스 산학협력단 | A gene amplifying Tube having a plurality of separated injection chamber |
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| JP4360377B2 (en) | 2009-11-11 |
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