JP2000354797A - Utensil for applicating adhesive to living tissue - Google Patents

Abstract

PROBLEM TO BE SOLVED: To adjust a spray diameter to fit to the size of a wound and to hardly choke a nozzle with liquid chemicals by providing a spray head which surrounds all liquid chemical discharge nozzles and a sterilized gas jetting port for mixing the liquid chemicals and is provided with an almost circularly arranged sterilized gas jetting port for adjusting the spray diameter. SOLUTION: The adhesive application utensil is provided with a plurality of injecting ports 7 and a sterilized gas injecting port 9 in the rear end side of a spray main body 1 and possesses a spray head 2 in the tip end side. The tip end of the spray head 2 is provided with a plurality of liquid chemical discharge nozzles 3, a sterilized gas jetting port 4 for mixing the liquid chemical which is arranged coaxially with each liquid chemical discharge nozzle 3 and circularly at the outside thereof, and a sterilized gas jetting port 5 for adjusting the spray diameter which surrounds all liquid chemical discharge nozzles 3 and the sterilized gas jetting port 4 for mixing the liquid chemical and is arranged almost on the outer circumference of the spray head 2. Further, a control cover 6 for controlling the flow rate of the sterilized gas jetted from the sterilized gas jetting port 5 for adjusting the spray diameter is installed. As a result, the spray diameter is adjusted to fit the size of the wound.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a device for applying a tissue adhesive which is mainly applied as a multi-component preparation, and more particularly to a hemostatic closure of a cut edge of a liver or a lung or a suture of a digestive tract. The present invention relates to a tool suitable for spraying and applying to an affected part of a living body.

[0002]

BACKGROUND OF THE INVENTION Fibrinogen is a coagulation factor that plays a very important role in the final stages of the so-called blood clotting cascade. Fibrinogen is converted by thrombin from its soluble form to insoluble fibrin, which makes a significant contribution to hemostasis and wound healing, for example, in the activation of the blood coagulation system after injury. Tissue adhesives utilizing the principle of the final phase of blood coagulation have been developed and used in surgical operations as adhesives for suture replacement of soft organs such as liver or spleen or as suture aids. At the same time, it is applied in a wide range of clinical settings.
2. Description of the Related Art In recent years, a spray coating method in which a fibrinogen solution and a thrombin solution stored in two syringes are simultaneously ejected, and the two ejected solutions are atomized and mixed by using aseptic gas has begun to spread. .

A disclosed example of such a device is disclosed in, for example, WO9.
It is described in JP-A-4-07420. In the spray application method using the tool described here, in order to adjust the spray diameter according to the size of the wound of the affected part to perform the application more efficiently because the spray diffusion angle is always constant For example, measures such as adjusting the distance between the nozzle and the wound were taken. However, when the wound is as small as about 1 cm, if the spray diameter is too close to reduce the spray diameter, the central adhesive is blown off by the gas flow, so that the spray diameter cannot be adjusted to a very small spray diameter.

Japanese Patent Application Laid-Open Nos. Hei 6-205831 and Hei 8-19619 disclose an application tube in which a cylindrical hood for regulating the spray diameter is provided at the tip end of a main body. However, since the adhesive adheres and accumulates inside the cylindrical hood, not only is the chemical liquid wasted very much, but also there is a risk of clogging during intermittent use. Japanese Patent Application Laid-Open No. 7-255729 describes an application tool as a prior art for adjusting the spray diameter by using a sterile gas. However, the plurality of chemical liquid discharge paths are not only separated by the aseptic gas flow but are adjacent to each other, and since they do not protrude in a nozzle shape, there is also a great risk that the chemical liquids come into contact with each other and cause clogging. .

[0005]

SUMMARY OF THE INVENTION An object of the present invention is to solve the above-mentioned conventional problems, in which the spray diameter can be adjusted according to the size of the wound and the liquid medicine is clogged. An object of the present invention is to provide a living tissue adhesive application tool which is difficult to apply.

[0006]

That is, the present invention provides at least two chemical liquid discharge nozzles, and a sterile gas injection port for chemical liquid mixing, which is disposed at least at the outlet with respect to each of the chemical liquid discharge nozzles in a coaxial and substantially annular shape. Further comprising a spray head provided with a sterile gas outlet for adjusting the diameter of the spray, which is arranged in a substantially annular shape around all the chemical liquid discharge nozzles and the sterile gas jet for mixing the chemical liquid. It is an agent application tool, and furthermore, a chemical liquid discharge nozzle protrudes from 0.1 to 5 mm from the tip surface of the spray head, or a movable adjustment cover for changing a spray angle adjusting sterile gas ejection angle is attached to the tip of the spray head. It is a living tissue adhesive application tool.

[0007]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail with reference to the drawings. FIG. 1 is a view showing the structure of a living tissue adhesive application tool according to one embodiment of the present invention. FIG. 1 (a) is a view from the tip side of the tool, FIG. 1 (b) is a view of the tool from above, and FIG. (C) is the figure which looked at the tool from the side. FIG. 2 is a view showing a detailed structure of a spray nozzle of the living tissue adhesive applying tool of the present invention, and FIG. 3 is a diagram showing a tip shape of a spray nozzle of the living tissue adhesive applying tool according to another embodiment of the present invention. FIG.

[0008] The living tissue adhesive application tool according to the present invention comprises:
As shown in FIG. 1, a plurality of chemical liquid inlets (7) and a sterile gas inlet (9) are provided on the rear end side of the spray main body (1).
A spray head (2) is provided on the distal end side. At the tip of the spray head (2), a plurality of chemical solution discharge nozzles (3)
And a chemical liquid mixing aseptic gas jet (4) coaxially arranged with each of the chemical liquid discharge nozzles (3) and arranged substantially annularly on the outside, and all the chemical liquid discharge nozzles (3) and the sterile gas jet for chemical liquid mixing ( A sterilizing gas outlet (5) for adjusting the spray diameter, which is disposed substantially on the outer periphery of the spray head (2) surrounding the spray head (4), is provided, and the aseptic gas ejected from the sterile gas outlet (5) for adjusting the spray diameter is further provided. An adjustment cover (6) for adjusting the gas flow rate is mounted. The interior of the spray main body (1) is divided into a channel for a chemical solution and a channel for a sterile gas. For example, each channel is connected by connecting a chemical solution inlet (7) and a chemical solution discharge nozzle (3) with a chemical solution tube (8). It can be divided, but it does not matter if a divided flow path is previously applied to the molded product of the spray body (1). It is also a desirable embodiment to install a sterile filter in advance at the terminal of the sterile gas inlet (9).

Next, the spray head (2) will be described in detail with reference to FIG. It is preferable that the plurality of chemical liquid ejection nozzles (3) protrude from the tip surface of the spray head (2) within a range of 5 mm or less. This is because the nozzle must be protruded in order to prevent non-uniform spraying due to clogging of the sterile gas jet for chemical liquid mixing (4) caused by dripping from the chemical liquid discharge nozzle (3) during intermittent use. Conversely, if the tip of the nozzle is too far away from the aseptic gas jet for chemical liquid mixing (4), it becomes difficult not only to form a fine mist but also to consume an unnecessarily large amount of aseptic gas. The protrusion length is in the range of 1-3 mm. Further, in this embodiment, the case where the chemical liquid mixing aseptic gas outlet (4) is located at the tip end surface of the spray head (2) is described. Further, it is one of the desirable embodiments to protrude the chemical solution discharge nozzle (3) coaxially with the center.

A plurality of aseptic gas jets for mixing a chemical solution (4) are provided coaxially around the outer periphery of a chemical solution discharge nozzle (3) in an annular shape having a uniform width in the circumferential direction, so that a uniform spray can be obtained. It is important to perform the process, and it is preferable to provide about 2 to 4 supports in order to prevent the nozzle from being eccentric. On the outer circumference of the tip end surface of the spray head (2), there is provided an aseptic gas outlet (5) for adjusting the spray diameter having a uniform width also in the circumferential direction. Further, the spray head (2) is provided with an adjusting cover (6) for changing the area of any of the flow paths communicating the aseptic gas outlet (5) for adjusting the spray diameter and the inside of the spray body (1), for example, by screw fitting. It is attached by a combination. The shapes of the spray diameter adjusting aseptic gas jet port (5) and the adjusting cover (6) are not particularly limited as long as the purpose is achieved, and as shown in FIG. A small hole may be provided in an annular shape, and the adjusting cover (6) may be inscribed in the tip end surface of the spray head (2) and rotated so as to open and close the flow passage alternately. The materials of all the components are not particularly limited, but at least the chemical liquid inlet (7), the chemical liquid tube (8), and the chemical liquid discharge nozzle (3) that are in contact with the chemical liquid are medical materials, and It is required that it does not affect the chemical solution. Also,
Production of the coating tool of the present invention is to bond a plurality of molded products,
Alternatively, it is assembled by welding or the like.

Next, the method of use will be described. First, a plurality of syringes previously filled with the biological tissue adhesive are connected to the drug solution inlet (7). At this time, if a syringe holder or the like for fixing a plurality of syringes and simultaneously injecting a chemical solution is attached to a barrel and a plunger of the syringe, the spraying operation becomes easy. Next, an air source is connected to the sterile gas inlet (9) via a sterile filter, and an appropriate air flow rate is maintained. In general, the spray head (2) is directed to the affected part to stop the bleeding, and the syringe is pressurized, so that two or more liquids discharged from the liquid discharge nozzle (3) are mixed with a sterile gas jet for mixing the liquid (4). The germ-free gas is mixed and sprayed onto the affected part to stop the bleeding. Here, if the biological tissue adhesive application tool of the present invention is used, the spray diameter of the biological tissue adhesive can be adjusted according to the size of the wound.
By retracting the adjusting cover (6) as shown in (a), the mixed and sprayed adhesive is wrapped from the outer periphery with the aseptic gas ejected from the aseptic gas outlet (5) for adjusting the spray diameter to narrow the spray diameter. Can be. Conversely, when the wound is large, the spray cover is advanced as shown in FIG. 2 (b) to reduce the flow of sterile gas from the sterile gas outlet (5) for spray diameter adjustment, thereby affecting the spray diameter. Spray can be performed without spreading.

[0012]

As described above, the living tissue adhesive application tool according to the present invention has a uniform adhesive spraying function because a plurality of chemical solution discharge nozzles are projected from the tip of the spray head by 5 mm or less. Even if an intermittent use method such as stopping the supply of sterile gas is performed, clogging does not occur, and an adjustment cover is provided on almost the outer circumference of the spray head including all the chemical solution discharge nozzles and the sterile gas jet port for mixing the chemical solution. As a sterile gas outlet for adjusting the spray diameter, which can adjust the flow rate of the sterile gas, the spray diameter of the biological tissue adhesive can be adjusted according to the size of the wound, making it efficient and safe It is useful as a biological tissue adhesive application tool having a high degree of adhesion.

[Brief description of the drawings]

FIG. 1A is a front view, FIG. 1B is a top view, and FIG. 1C shows a structure of a living tissue adhesive application device according to an embodiment of the present invention.
It is a side view.

FIGS. 2A and 2B are views showing a mechanism of a spray head of a living tissue adhesive applying device according to an embodiment of the present invention, wherein FIG. 2A shows a narrow spray diameter and FIG. FIG.

FIG. 3 is a front view showing a spray head of another embodiment of the living tissue adhesive application tool according to one embodiment of the present invention.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Spray main body 2 Spray nozzle 3 Chemical liquid discharge nozzle 4 Aseptic gas jet for chemical liquid mixing 5 Aseptic gas jet for spray diameter adjustment 6 Adjustment cover 7 Chemical liquid inlet 8 Chemical liquid tube 9 Aseptic gas inlet

Claims (3)

[Claims] At least two chemical liquid discharge nozzles, a chemical liquid mixing aseptic gas injection port arranged at least at the outlet, coaxially and substantially in an annular shape with respect to each of the chemical liquid discharge nozzles, and all of the chemical liquid discharge nozzles A biological tissue adhesive applying tool, comprising: a spray head provided with a sterile gas jet for adjusting a spray diameter, which is disposed in a substantially annular shape and surrounds a sterile gas jet for chemical liquid mixing. 2. The living tissue adhesive application tool according to claim 1, wherein the chemical solution discharge nozzle protrudes from the spray head tip surface by 0.1 to 5 mm. 3. The living tissue adhesive application tool according to claim 1, wherein a movable adjustment cover for changing a spray angle of the sterilizing gas for spray diameter adjustment is attached to a tip of the spray head.