JP2003126268A - Biological tissue adhesive applicator - Google Patents

Biological tissue adhesive applicator

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Publication number
JP2003126268A
JP2003126268A JP2001323890A JP2001323890A JP2003126268A JP 2003126268 A JP2003126268 A JP 2003126268A JP 2001323890 A JP2001323890 A JP 2001323890A JP 2001323890 A JP2001323890 A JP 2001323890A JP 2003126268 A JP2003126268 A JP 2003126268A
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Prior art keywords
chemical
nozzle
biological tissue
spray
tissue adhesive
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JP2001323890A
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Japanese (ja)
Inventor
Masao Ikeda
Yukihiko Sakaguchi
幸彦 坂口
昌夫 池田
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Sumitomo Bakelite Co Ltd
住友ベークライト株式会社
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Application filed by Sumitomo Bakelite Co Ltd, 住友ベークライト株式会社 filed Critical Sumitomo Bakelite Co Ltd
Priority to JP2001323890A priority Critical patent/JP2003126268A/en
Publication of JP2003126268A publication Critical patent/JP2003126268A/en
Application status is Pending legal-status Critical

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Abstract

PROBLEM TO BE SOLVED: To provide an applicator providing a strong adhesion for a biological tissue adhesive and reducing wasteful application to parts other than an affected region by sufficiently mixing sprays of an equal or different quantities of two or more biological tissue adhesives using a turning flow. SOLUTION: The biological tissue adhesive applicator is intended to spray a liquid medicine composed of a plurality of components, and has a means to generate the turning flow of a sterile gas, including all liquid medicine spray nozzles.

Description

【発明の詳細な説明】 【0001】 【発明の属する技術分野】本発明は、主に複数成分系製剤として適用される組織接着剤の塗布用具に関するものであり、特に肝臓や肺の切除断端や消化管の縫合部の止血閉鎖などに好適な、生体の患部に噴霧して塗布するための生体組織接着剤塗布用具に関する。 BACKGROUND OF THE INVENTION [0001] [Technical Field of the Invention The present invention relates primarily to application tool of tissue adhesive which is applied as a multi-component-based formulation, in particular liver and margins of the lung and gastrointestinal stapling portion hemostatic closure such as a suitable of, relating to a biological tissue adhesive applicator for applying by spraying onto the affected area of ​​a living body. 【0002】 【従来の技術】繊維素原(フィブリノゲン)は、いわゆる血液凝固カスケードの最終段階に存在する非常に重要な役割を担う凝固因子である。 [0002] fibrinogen (fibrinogen) is a coagulation factor plays a very important role present in the final stage of the so-called blood clotting cascade. フィブリノゲンは、例えば損傷後の血液凝固系の活性化において、トロンビンにより、その可溶性形態から止血及び創傷治療に重要な寄与をする不溶性のフィブリンに変換される。 Fibrinogen, for example in the activation of blood coagulation system after injury, by thrombin, is converted to insoluble fibrin which plays an important contribution to hemostasis and wound healing from its soluble form. この血液凝固の最終相の原理を利用した組織接着剤が開発され、外科手術において肝臓または脾臓のような軟部器官の縫合代用の接着剤として、または縫合補助剤として使用されている。 The tissue adhesive the principles of the final phase utilizing the blood coagulation it has been developed, as an adhesive for the suture substitute soft organs such as the liver or spleen in surgery, or have been used as sutures adjuvant. 同時に、幅広い臨床の現場で応用されている。 At the same time, it has been applied in a wide range of clinical settings.
一般にはシリンジに別々に収納されたフィブリノゲン溶液およびトロンビン溶液を別々、または同時に適用部位へ滴下する方法が取られていたが閉鎖効果が不十分であるため、簡易により高い閉鎖効果を得る方法として、1 Because it is generally insufficient but closed effective method has been taken of dropping the fibrinogen solution and thrombin solution are housed separately in a syringe separately or simultaneously to the application site, as a method of obtaining a high closing effect by the simple, 1
流体ノズルによるスプレー法が考案され実用化されているが、十分な閉鎖効果を得るまでには至っていない上、 While spraying by the fluid nozzle is devised practical, on non yet to obtaining a satisfactory closure effect,
詰まりの問題などもあり実用性に劣っていた。 It was inferior to there is also such a problem practicality of clogging. 【0003】これを改善する方法として、近年は2本のシリンジに収納されたフィブリノゲン溶液およびトロンビン溶液を同時に射出し、無菌ガスを利用して、射出させた2液を霧状に噴霧して混合するスプレー塗布法が普及し始めている。 As a method to improve this, in recent years were injection two housed in the syringe fibrinogen solution and thrombin solution simultaneously by using sterile gas, mixed by spraying 2 solution was injected into mist spray coating method that is beginning to spread. このような器具の好適な例は、例えばWO/947420号に開示されている。 Suitable examples of such devices are disclosed, for example, WO / No. 947,420. しかしながら、このような複数の2流体平行型ノズルの並列による混合スプレーには、各々の噴霧角度と位置関係により互いに重複する塗布面積以外の混合効率が悪く薬液の無駄も多いため、大血管の処置や、肺のエアーリークの処置などの強い接着・閉鎖効果が求められる症例では、組織接着剤が十分な効果を発揮するまでにはなお克服するべき問題が存在した。 However, the mixing spray by the parallel of such a plurality of two-fluid parallel type nozzle, for mixing efficiency than coating area that overlap one another by positional relationship with each of the spray angle is greater poor waste of liquid medicine, the treatment of great vessels and, strong adhesion and closing effect of such treatment of pulmonary air leak in cases sought, there were problems to tissue adhesives still overcome before a satisfactory effort. 【0004】一方、組織接着剤の効果を増強する方法としてフィブリノゲン溶液とトロンビン溶液との混合比を変更し、フィブリノゲン濃度を高めることが有効であることが実験的には確認されている。 On the other hand, by changing the mixing ratio of the fibrinogen solution and the thrombin solution as a way to enhance the effect of tissue adhesive, it is effective to increase the fibrinogen concentration is confirmed experimentally. これらの組織接着剤に適用する装置、すなわちフィブリノゲン溶液とトロンビン溶液とを異なる容量で同時に注入するための装置が特開昭61−293443号公報、WO97−3363 Device applied to these tissue adhesive, i.e. apparatus Sho 61-293443 discloses to inject simultaneously at different volumes and fibrinogen solution and thrombin solution, WO97-3363
3号公報、及び特開2000−262525号公報等に開示されている。 3 JP, and disclosed in Japanese 2000-262525 Patent Publication. しかしながら塗布用具に関しては通常の2本の薬液噴霧ノズルを持つ同じ容量の2成分薬液を塗布するためのものが用いられており、吐出バランスが不均一となるため十分な混合状態が得られない問題があった。 However the coating and is used for the purpose of applying the two component chemical same volume with normal two chemical spray nozzles with respect to equipment, problems discharge balance is not sufficient mixed state is obtained to become uneven was there. すなわち2成分の薬液の容量が著しく異なる場合、個々の薬液の吐出速度が大きく異なるため同時に2 That is, when the capacity of the two components of the chemical solution is significantly different, simultaneously since the discharge rate of each chemical solution differs greatly 2
液をミスト化するのが難しく、前記塗布法以上の不十分な混合状態となってしまい、特に接着剤の硬化時間が延長してしまうことがあった。 Liquid difficult to mist and becomes insufficient mixing conditions described above the coating method, in particular the curing time of the adhesive was sometimes become extended. 【0005】この問題を解決するべく手段として、特開2001−57979号公報に開示されているような異なる容量の2液以上の薬液の吐出速度をより均一にすることにより薬液を無菌ガスの噴出により霧化して十分に混合させるノズルなどが示されている。 [0005] As a means to solve this problem, jetting a chemical sterilized gas by a more uniform discharge rate of 2 liquid or chemical solution with different capacities, such as disclosed in JP-A-2001-57979 such nozzles to mix thoroughly atomized is indicated by. しかしながら、 However,
基本的に2流体平行型ノズルを複数個配置した構造であるため、この方式のノズルが根本的に持つ各成分の霧の混合効率の悪さ、すなわち各薬液噴霧ノズルの噴霧の塗布重複部分以外の混合効率が悪く、言い換えれば無駄に薬液を適用部以外へ塗布しているという問題が存在した。 For basically the structure by arranging a plurality of two-fluid parallel type nozzle, the nozzle of this method is poor mixing efficiency mist of the components with fundamentally, i.e. other than the spray coating overlap each chemical spray nozzles mixing efficiency is poor, a problem is wastefully applied chemicals to the non-applied portion in other words there was. 【0006】 【発明が解決しようとする課題】本発明は、従来のこのような問題点を解決することを目的とするもので、等量、もしくは異なる容量の2液以上の薬液の噴霧を旋回流を利用して十分に混合させることにより、高強度の組織接着剤を塗布可能であり、加えて適用部以外への無駄な塗布の底減が可能な用具を提供するものである。 [0006] The present invention invention is to solve the above is to solve the above problems is an object of the present invention, an equal amount, or spraying of two solutions or more chemical different capacities pivot by mixing well using a flow, high strength is a tissue adhesive can be applied in, there is provided a addition wasteful bottom down capable tool application to the non-application portion. 【0007】 【課題を解決するための手段】即ち本発明は、(1)複数成分の薬液を噴霧するための塗布用具において、薬液噴霧ノズルを包含する無菌ガスの旋回流を発生させる手段を設けたことを特徴とする生体組織接着剤塗布用具、 [0007] Means for Solving the Problems] The present invention provides (1) the application tool for spraying a chemical multi-component, provided with means for generating a swirling flow encompassing sterilized gas the chemical spray nozzle biological tissue adhesive applicator, characterized in that the,
(2)旋回流を発生させる手段が、薬液噴霧ノズルを包含する円周上に設けられた複数の無菌ガス流通路よりなり、無菌ガス噴出口直前までの無菌ガス流通路が、噴霧方向の軸に対し、全て同じ方向に傾けられたほぼらせん形状よりなる(1)記載の生体組織接着剤塗布用具、 (2) means for generating a swirling flow is comprised of a plurality of sterilized gas flow passage provided on the circumference encompassing a chemical spray nozzle, sterilized gas flow path immediately before sterile gas ejection port, the spray direction axis contrast, all made of substantially helical shape inclined in the same direction (1), wherein the biological tissue adhesive applicator,
(3)塗布用具には後端に複数の薬液注入口、中央付近に無菌ガス注入口、更に先端には薬液注入口と薬液流通路を介して連通する複数の薬液噴霧ノズルが設けられている(1)又は(2)記載の生体組織接着剤塗布用具、 (3) a plurality of chemical inlet at the rear end to the applicator, the sterile gas inlet, a plurality of chemical spray nozzles further communicating through a chemical inlet and a chemical solution flow path at the tip is provided in the vicinity of the center (1) or (2) above, wherein the biological tissue adhesive applicator,
(4)各薬液噴霧ノズルが、薬液吐出口と該薬液吐出口に対してほぼ同軸且つ外側にほぼ環状に配置された無菌ガス噴出口からなる2流体平行型ノズルである(3)記載の生体組織接着剤塗布用具、(5)各薬液噴霧ノズルが微細孔よりなる1流体ノズルである(3)記載の生体組織接着剤塗布用具である。 (4) Each chemical spray nozzle is a two fluid parallel type nozzle consisting substantially coaxially and sterilized gas ejecting ports arranged in a generally annular outwardly relative solution discharge port and the drug solution discharge port (3), wherein the biological tissue glue applicator, a (5) each drug solution spray nozzle is 1-fluid nozzle made of micropores (3) biological tissue adhesive applicator according. 【0008】 【発明の実施の形態】以下、図面をもとに本発明について詳細に説明する。 DETAILED DESCRIPTION OF THE INVENTION Hereinafter, the present invention is explained in detail based on the drawings. 図1は本発明の一実施例の外観を示す図で、図2はノズルの一実施例の拡大図で、(a)は分解図及び(b)は組立後の図である。 Figure 1 is a view showing an external appearance of an embodiment of the present invention, FIG. 2 is an enlarged view of one embodiment of a nozzle, (a) shows the exploded view and (b) is a view after assembly. 図3は噴霧時のスプレーヘッド(1)の断面図で、同じく図4は噴霧時のノズル(2)の断面拡大図である。 Figure 3 is a cross-sectional view of the spray head (1) at the time of spraying, also FIG. 4 is an enlarged sectional view of the nozzle (2) at the time of spraying. (a)は本発明による噴霧状態の一実施例で、(b)は従来の噴霧の状態を示したものである。 (A) in one embodiment of the spray state of the present invention, there is shown a (b) the state of the conventional spray. また、図5(a)〜(d)は本発明の旋回流発生装置の実施例の一部を示した図であり、 Further, FIG. 5 (a) ~ (d) is a diagram showing some examples of the swirling flow generator of the present invention,
図6は本発明に適用可能な薬液噴霧ノズルの構造の一実施例を示したもので、(a)は無菌ガスを用いて噴霧とする2流体平行型ノズル、(b)は無菌ガスを使用せずに薬液の加圧のみで噴霧を行う1流体ノズルの一実施例を示したものである。 6 shows one example of applicable chemical spray nozzle structure in the present invention, using (a) the two-fluid parallel type nozzle to spray using sterile gas, (b) is sterilized gas It illustrates an embodiment of a 1-fluid nozzle that performs spray only under pressure of the drug solution without. 【0009】図1は本発明の一実施例で、前述のようにフィブリノゲン溶液及びトロンビン溶液を別々に充填したシリンジ(6)をホルダー1(7),ホルダー2 [0009] Figure 1 is one embodiment of the present invention, the holder 1 (7) of a syringe (6) that the fibrinogen solution and thrombin solution were charged separately as described above, the holder 2
(8)にセットし、ホルダー2(8)を押すことで同時にノズル(2)より噴霧される。 (8) to set, it is sprayed from the nozzle (2) at the same time by pressing the holder 2 (8). ノズル(2)は薬液を霧状にする目的の薬液噴霧ノズル(9)と、薬液噴霧ノズル(9)で生成した霧を包み込み混合させるための旋回流をつくる旋回流発生装置から構成される。 A nozzle (2) is chemical spray nozzles (9) of the purpose of the drug solution into mist, and a swirling flow generating device to create a swirling flow for mixing enveloping mist generated in chemical spray nozzle (9). 【0010】更に詳細には図3に示すように、薬液噴霧ノズル(9)は薬液吐出口(10)と薬液吐出口(1 [0010] As more particularly shown in FIG. 3, the chemical solution spraying nozzle (9) is chemical liquid discharging ports (10) and the chemical liquid discharging ports (1
0)周りにほぼ環状に配置された無菌ガス噴出口(1 0) sterile gas ejection ports arranged substantially annularly about (1
1)から成る2つの2流体平行型ノズルを有した形態のスプレーであり、各薬液と無菌ガスの流通路の関係は図3に示すように完全に独立しており、無菌ガスは無菌ガス注入口(4)からスプレーヘッド(1)内を通り、各無菌ガス噴出口(11)より外部へと噴出する。 In the form of a spray having a two two-fluid parallel type nozzle consisting of 1), the relationship of the flow paths of the liquid medicine and aseptic gas are completely independent as shown in FIG. 3, a sterile gas is sterilized gas Note inlet (4) through the spray head (1) in the, ejected to the outside from the sterile gas ejection ports (11). 無菌ガス噴出口(11)は完全な環状である必要はなく、薬液吐出口(10)をほぼ同軸に固定しておくためのリブ等によって区切られていても問題はないが、無菌ガス噴出口(11)の開口面積の合計よりも同一環状内のリブの面積の合計のほうが大きい場合は噴霧の粒子が粗くなることが懸念され好ましくなく、無菌ガス噴出口(11) Sterile gas port (11) need not be a complete ring, there is no problem even if separated by ribs or the like used for fixing solution discharge port (10) generally coaxially, sterile gas ports (11) is not preferable is concern that the spray of particles becomes rough when larger towards the total area of ​​the rib in the same annular than the total opening area of ​​the sterile gas ejection port (11)
の開口面積の合計のほうが大きいことが好ましい。 It is preferred that the larger total opening area of. 更に好ましくは、無菌ガス噴出口の合計面積:リブ合計面積=2:1以上である。 More preferably, the total area of ​​the sterile gas ejection ports: rib total area = 2: 1 or greater. また、このリブは等間隔で整然と配置されることが好ましい。 Further, it is preferred that the ribs are arranged orderly at equal intervals. 【0011】一方、各薬液は各々の薬液注入口(3)より注入され、薬液流通路(13)内を通り薬液吐出口(10)より外部へと吐出されるものである。 Meanwhile, each drug solution is injected from each of the chemical inlet (3), are intended to be discharged to the outside from the liquid medicine passage (13) in the street drug solution discharge port (10). 図2に示す本実施例の旋回流発生装置は、全ての薬液噴霧ノズル(9)を包含するほぼ環状線上にほぼ等間隔で配置した複数の旋回流生成ノズル(12)の集合体で、噴霧軸にほぼ軸対象に噴霧軸に対して角度を設けたほぼらせん形状を呈する無菌ガス流通路(14)の集合より成る。 Swirling flow generator of the present embodiment shown in FIG. 2 is a set of a plurality of whirling flow generation nozzle disposed at substantially equal intervals on the substantially annular line encompasses all of the chemical solution spraying nozzle (9) (12), spraying consisting set of substantially sterilized gas flow passage substantially exhibiting a helical shape having a angle to the spray axis in the axial object (14) to the shaft. この旋回流生成ノズル(12)より噴出した無菌ガスは噴霧軸方向に対して回転方向成分を持ちつつ前進する円筒状の回転する流れ、所謂旋回流を生成するため、これに内包される各薬液噴霧ノズル(9)により作られる霧は互いによく混合され、塗布されることになる。 Flow The sterile gas ejected from the swirling flow generating nozzle (12) is a rotating cylindrical advancing while maintaining the rotation direction component with respect to the spray axis to produce a so-called swirling flow, the liquid chemical to be encapsulated in this fog produced by the spray nozzle (9) are mixed well with each other, it will be applied. 【0012】より詳細には、図2(a)に示すようにノズル(2)を形成する円筒状の部品の外周にほぼらせん形状の溝が配置されており、図2(b)に示すようにスプレーヘッド(1)に嵌合することによりほぼらせん形状の無菌ガス流通路(14)を形成する。 [0012] More particularly, there is disposed a groove of substantially helical shape on the outer periphery of a cylindrical part forming the nozzle (2) as shown in FIG. 2 (a), as shown in FIG. 2 (b) forming a substantially sterilized gas flow path helically shaped (14) by fitting the spray head (1) to. この無菌ガス流通路(14)の形や大きさなどは無菌ガスの種類や使用時のガス圧、流量などを考慮し、適切な寸法形状とすることが望ましいものであり、図5(a)〜(d)に正面図の例を示すように様々な寸法・形状が考えられる。 Shapes and sizes such as sterile gas kind and time of the gas pressure of the sterile gas flow path (14), including the consideration of flow rate, is intended it is desirable that the appropriate dimensions, FIGS. 5 (a) various sizes and shapes is considered as an example of a front view ~ (d).
らせん形状の角度も同様に無菌ガスの種類や使用時のガス圧,流量、また噴霧する薬液の種類や吐出量などにより最適な旋回流を生成する形状とすることが望ましい。 Angle likewise sterile gas kind and when the gas pressure of the spiral shape, flow rate, also it is desirable that a shape generating an optimum swirl flow by the type and the discharge amount of the spray to chemicals. 【0013】本分野のスプレーはディスポーザブルであり、コスト面から簡易な構造が求められるものであるため、図2または図5に示すような構造が好ましいと考えるが、これ以外の構造でも全ての薬液噴霧ノズルを包含する旋回流を生成可能であればなんら問題はなく、例えば無菌ガス噴出口自体が回転する構造や、ファン等にて旋回流を発生させる構造でも構わない。 [0013] Spray of the art are disposable, for those that simple structure is obtained from the cost, but considered a structure as shown in FIG. 2 or FIG. 5 is preferred, other structures all chemical in the if the spray nozzle can generate encompasses swirling flow any problem is not, for example, the structure and the sterilized gas jet port itself is rotated, it may be a structure that generates a swirling flow in the fan or the like. 【0014】しかしながら、本発明は医療用途であるので、使用する部品の原材料は医療用に安全性の確認されたものであることが求められる。 [0014] However, since the present invention is a medical application, part of the raw materials to be used is determined in which confirmed the safety medical. 特に限定されるものではないが、ディスポーザブルということを考慮すれば、 Although not particularly limited, considering the fact that disposable,
ABSやポリプロピレン、ポリエチレン等の医療用グレードの樹脂であることが好ましく、加工、成形性、組立性等を考慮し適切なものを選定すればよい。 Preferably ABS or polypropylene, a resin of a medical grade polyethylene, processability, moldability, considering the assembly and the like may be selected as appropriate. 【0015】以下、旋回流生成ノズル(12)の効果を説明する。 [0015] Hereinafter will be described the effect of swirling flow generating nozzle (12). 一般に旋回流と呼ばれる所謂渦巻き流は、これに包含された物質を渦の中心軸の方向へと誘導する性質が知られており、複数のガスまたは霧をこの旋回流へと投入すれば互いに旋回流の中心軸方向に集まりつつ混合されることとなる。 Generally a so-called vortex called swirling flow is this property of inducing is known to encompass been direction of the central axis of the material vortex, swirl together when turned a plurality of gas or mist into the swirling flow so that the mixed while gathered in the central axis direction of the flow. この旋回流による噴霧の状態を図4(a)に示す。 The state of the spray by the swirl flow shown in Figure 4 (a). 旋回流生成ノズル(12)による旋回流は、薬液噴霧ノズル(9)を包含しているため霧の無駄な拡散を防ぎ、且つ渦を巻いているため旋回流の中心軸へ向けて霧を混合させると共に集中させるよう効果的に働き、結果として薬液の塗布部位以外への無駄な噴霧・塗布をなくすことが出来、本発明のノズル(2)では極めて効率的に混合され、塗布面積も小さく押えることが出来るため効率がよい。 Swirling flow by the swirling flow generating nozzle (12) is to prevent unnecessary diffusion fog for encompasses a chemical spray nozzles (9), and mixing the mist toward the central axis of the swirling flow since the swirling work effectively so as to concentrate together to, as a result it is possible to eliminate wasteful spray-application to the other application site of the chemical liquid is mixed nozzle (2) in very efficiently present invention, suppress coating area is small it is efficient because it is. 【0016】これに対し、従来のスプレーでは図4 [0016] On the other hand, in the conventional spray Figure 4
(b)に示すように霧は薬液噴霧ノズル(9)から離れるにしたがい拡散することとなり、中央付近の各薬液の霧の重なる部位以外は各薬液の混合率が極めて低く各薬液が混合されることはないため接着閉鎖効果を得られず全くの無駄となっている。 Fog As shown in (b) becomes to diffuse as the distance from the chemical solution spraying nozzle (9), other than the region that overlaps the fog of each chemical in the vicinity of the center are mixing ratio of each liquid chemical is mixed very low each drug solution has become a completely not be obtained an adhesive closure effect because it is not waste it. また、本実施例の旋回流発生装置では、全ての旋回流生成ノズル(12)をほぼ環状に覆うフード(15)を設けている。 Further, in the swirling flow generator of the present embodiment is provided with a hood (15) covering all of the swirling flow generating nozzle (12) in substantially annular. これにより旋回流の乱れと広がりを整えて霧の混合効率を向上させるものであり、より塗布面積を小さくしたい場合などに設置することが望ましい。 Thus established a disturbance and spread of the swirling flow is intended to improve the mixing efficiency of the fog, it is desirable to install when you wish to reduce the more coating area. フード(15)の突出寸法は目的とする塗布面積により最適な寸法とすることが重要であるが、極端に長い場合には薬液のフード(15)内面への付着など、塗布の効率上好ましくない状況が生じることが懸念されることとなるため、薬液噴霧ノズル(9)との位置関係を考慮することが必要であり、以下に説明する薬液噴霧ノズルのタイプ別によって適切な寸法を検討することが望ましい。 While projecting dimension of the hood (15) It is important that the optimum size by coating an area of ​​interest, such as when an extremely long attachment to chemical hood (15) inner surface, the efficiency undesirable coating since the situation occurs is to be feared, it is necessary to consider the positional relationship between the chemical spray nozzles (9), to investigate the appropriate dimensions by another type of chemical spray nozzles as described below It is desirable 【0017】旋回流発生装置により従来よりも霧が無駄なく効率的に混合され得るので、薬液の霧化には図6 [0017] Since mist than conventional by the swirling flow generator can be mixed without waste efficiently, the atomized chemical liquid 6
(a)に例を示す2流体平行型ノズルを用いなくとも、 Without using a two-fluid parallel type nozzle showing an example (a), the
図6(b)に示すような微細孔(16)より加圧した薬液を噴出させ霧にする一般的な加圧式の1流体ノズルを利用した薬液噴霧ノズルであっても問題はなく、また2 Figure 6 A drug solution spray nozzle which utilizes a fluid nozzle common pressurized to mist is ejected from the pressurized chemical liquid fine holes (16) as shown in (b) is also not a problem, also 2
流体直行型ノズル等のその他の如何なる噴霧装置の原理を用いてもよい。 The principle of any other spray device such as a fluid straight type nozzle may be used. しかし、より簡易且つ確実に高強度の接着閉鎖効果を望むのであれば、比較的低圧領域にて霧の粒子が細かく良好な霧を得られる図6(a)のタイプの薬液噴霧ノズルを選択することが好ましい。 However, if desired the adhesive closure effect of more easily and reliably high strength, selects the type of chemical spray nozzles 6 fog particles at a relatively low pressure region to obtain a fine good fog (a) it is preferable. また、非等量の薬液噴霧を行う例であれば、3つや4つの複数の薬液吐出口や、数だけでなく薬液吐出口の開口面積を適切に配分した非等量に特化した薬液噴霧ノズルを用いると、更に高強度の接着閉鎖効果を得ることができ、効果的でより好ましい。 Further, in the example of performing unequal amounts of the chemical spray, three or four multiple chemical liquid discharging ports or chemical spray specializing in unequal amounts were appropriately distributed the opening area of ​​the chemical liquid discharging ports not only the number with nozzles, it is possible to further obtain the adhesive closure effect of high intensity, efficient and more preferable. 【0018】 【発明の効果】以上に述べた如く、本生体組織接着剤塗布用具を用いれば、全ての薬液噴霧ノズルを包含する無菌ガスの旋回流により各薬液の混合効率を高めることが出来、噴霧部位以外への無駄な塗布を削減出来るため、 [0018] As described above, according to the present invention, the use of the present biological tissue adhesive applicator, it is possible to improve the mixing efficiency of the drug solution by swirling flow of sterile gas encompasses all of the chemical solution spraying nozzle, because it can reduce unnecessary application to the non-spray site,
高い接着閉鎖効果を得る組織接着剤の塗布用具として極めて有用である。 It is extremely useful as a coating tool tissue adhesive to obtain high adhesive closure effect.

【図面の簡単な説明】 【図1】本発明の一実施例となる生体組織接着剤塗布用具の外観の一例を示す図である。 Is a diagram showing an example of an external view of an embodiment become biological tissue adhesive applicator BRIEF DESCRIPTION OF THE DRAWINGS [Figure 1] present invention. 【図2】本発明の一実施例となる生体組織接着剤塗布用具のノズルの拡大図で、(a)は分解図、(b)は組立後の透過図である。 [2] an enlarged view of a nozzle of a biological tissue adhesive applicator which is an embodiment of the present invention, (a) an exploded view, the (b) is a transparent view after assembly. 【図3】本発明の一実施例となる生体組織接着剤塗布用具の噴霧時の内部構造の一例を示す平面断面図である。 3 is a plan sectional view showing an example of the internal structure at the time of spraying of the one embodiment the biological tissue adhesive applicator of the present invention. 【図4】本発明の一実施例となる生体組織接着剤塗布用具の噴霧時のノズルの断面拡大図であり、(a)は本発明による噴霧状態の一例で、(b)は従来の噴霧の一例を示したものである。 [Figure 4] is a cross-sectional enlarged view of the nozzle at the time of spraying of an embodiment become biological tissue adhesive applicator of the present invention, (a) is an example of the spray state of the present invention, (b) is a conventional spray It illustrates an example of. 【図5】本発明の一実施例となる生体組織接着剤塗布用具の旋回流発生装置の例を示した図である。 5 is a diagram showing an example of the swirling flow generator of the embodiment the biological tissue adhesive applicator of the present invention. 【図6】本発明の一実施例となる生体組織接着剤塗布用具の薬液噴霧ノズルの構造の一例を示したもので、 [6] shows an example of the structure of the chemical liquid spray nozzle of one embodiment become biological tissue adhesive applicator of the present invention,
(a)は無菌ガスを用いて噴霧とする2流体平行型ノズルの一例、(b)は無菌ガスを使用せずに薬液の加圧のみで噴霧を行う1流体ノズルの一例を示した図である。 (A) is an example of a two-fluid parallel type nozzle to spray using sterile gas, (b) is a view showing an example of a fluid nozzle that performs spray only under pressure of the chemical solution without using sterile gas is there. 【符号の説明】 1 スプレーヘッド2 ノズル3 薬液注入口4 無菌ガス注入口5 無菌フィルター6 シリンジ7 ホルダー1 8 ホルダー2 9 薬液噴霧ノズル10 薬液吐出口11 無菌ガス噴出口12 旋回流生成ノズル13 薬液流通路14 無菌ガス流通路15 フード16 微細孔 [EXPLANATION OF SYMBOLS] 1 spray head 2 nozzle 3 chemical inlet 4 sterilized gas inlet 5 sterile filter 6 syringe 7 holder 1 8 Holder 2 9 chemical spray nozzle 10 chemical liquid discharging ports 11 sterile gas ejection ports 12 swirl flow generating nozzle 13 chemical flow passage 14 sterilized gas flow path 15 hood 16 micropores

───────────────────────────────────────────────────── フロントページの続き Fターム(参考) 4C060 MM24 MM26 4C167 AA67 BB02 BB21 BB70 CC06 CC20 CC21 CC23 CC24 4F033 QA01 QB03X QB17 QD02 QD09 QD18 QD25 QE19 QF17X ────────────────────────────────────────────────── ─── front page of continued F-term (reference) 4C060 MM24 MM26 4C167 AA67 BB02 BB21 BB70 CC06 CC20 CC21 CC23 CC24 4F033 QA01 QB03X QB17 QD02 QD09 QD18 QD25 QE19 QF17X

Claims (1)

  1. 【特許請求の範囲】 【請求項1】 複数成分の薬液を噴霧するための塗布用具において、薬液噴霧ノズルを包含する無菌ガスの旋回流を発生させる手段を設けたことを特徴とする生体組織接着剤塗布用具。 11. Claims 1. A multi-component applicator for spraying a chemical, biological tissue adhesive, characterized in that a means for generating a swirling flow encompassing sterilized gas the chemical spray nozzle application tool. 【請求項2】 旋回流を発生させる手段が、薬液噴霧ノズルを包含する円周上に設けられた複数の無菌ガス流通路よりなり、無菌ガス噴出口直前までの無菌ガス流通路が、噴霧方向の軸に対し、全て同じ方向に傾けられたほぼらせん形状よりなる請求項1記載の生体組織接着剤塗布用具。 2. A means for generating a swirling flow is comprised of a plurality of sterilized gas flow passage provided on the circumference encompassing a chemical spray nozzle, sterilized gas flow path immediately before sterile gas ejection port, the spray direction to the axis, all made of substantially helical shape inclined in the same direction claim 1 biological tissue adhesive applicator according. 【請求項3】 塗布用具には後端に複数の薬液注入口、 3. A plurality of liquid injection port in the rear end to the application tool,
    中央付近に無菌ガス注入口、更に先端には薬液注入口と薬液流通路を介して連通する複数の薬液噴霧ノズルが設けられている請求項1又は2記載の生体組織接着剤塗布用具。 Sterilized gas inlet in the vicinity of the center, further a plurality of chemical spray nozzles claim 1 or 2 biological tissue adhesive applicator according is provided which communicates through a chemical inlet and a chemical solution flow path to the tip. 【請求項4】 各薬液噴霧ノズルが、薬液吐出口と該薬液吐出口に対してほぼ同軸且つ外側にほぼ環状に配置された無菌ガス噴出口からなる2流体平行型ノズルである請求項3記載の生体組織接着剤塗布用具。 Wherein each chemical spray nozzles, substantially coaxially and claim 3, wherein the outer side is a two-fluid parallel type nozzle consisting arranged sterile gas port substantially annular respect solution discharge port and the drug solution discharge port adhesive application tool of living tissue. 【請求項5】 各薬液噴霧ノズルが微細孔よりなる1流体ノズルである請求項3記載の生体組織接着剤塗布用具。 5. The biological tissue adhesive applicator according to claim 3, wherein the first fluid nozzle to the chemical solution spraying nozzle is made of micropores.
JP2001323890A 2001-10-22 2001-10-22 Biological tissue adhesive applicator Pending JP2003126268A (en)

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006122854A (en) * 2004-10-29 2006-05-18 Yoshino Kogyosho Co Ltd Two-liquid mixing type spray
US7658305B2 (en) 2006-10-25 2010-02-09 Ethicon Endo-Surgery, Inc. Adhesive applier with articulating tip
US7749235B2 (en) 2006-10-20 2010-07-06 Ethicon Endo-Surgery, Inc. Stomach invagination method and apparatus
US7833216B2 (en) 2006-11-08 2010-11-16 Ethicon Endo-Surgery, Inc. Fluid plunger adhesive dispenser
US7892250B2 (en) 2006-11-01 2011-02-22 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive on inflatable device for gastric restriction
US7914511B2 (en) 2006-10-18 2011-03-29 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive as bulking agent
US8603138B2 (en) 2006-10-04 2013-12-10 Ethicon Endo-Surgery, Inc. Use of an adhesive to treat intraluminal bleeding
US8608642B2 (en) 2010-02-25 2013-12-17 Ethicon Endo-Surgery, Inc. Methods and devices for treating morbid obesity using hydrogel
US8876844B2 (en) 2006-11-01 2014-11-04 Ethicon Endo-Surgery, Inc. Anastomosis reinforcement using biosurgical adhesive and device
JP2018065097A (en) * 2016-10-20 2018-04-26 株式会社アトマックス A plurality of fluids mixture nozzle and mixture nozzle spray method for a plurality of fluids

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006122854A (en) * 2004-10-29 2006-05-18 Yoshino Kogyosho Co Ltd Two-liquid mixing type spray
JP4722455B2 (en) * 2004-10-29 2011-07-13 株式会社吉野工業所 Mixtures of two liquids sprayer
US8603138B2 (en) 2006-10-04 2013-12-10 Ethicon Endo-Surgery, Inc. Use of an adhesive to treat intraluminal bleeding
US7914511B2 (en) 2006-10-18 2011-03-29 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive as bulking agent
US7749235B2 (en) 2006-10-20 2010-07-06 Ethicon Endo-Surgery, Inc. Stomach invagination method and apparatus
US7658305B2 (en) 2006-10-25 2010-02-09 Ethicon Endo-Surgery, Inc. Adhesive applier with articulating tip
US8876844B2 (en) 2006-11-01 2014-11-04 Ethicon Endo-Surgery, Inc. Anastomosis reinforcement using biosurgical adhesive and device
US7892250B2 (en) 2006-11-01 2011-02-22 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive on inflatable device for gastric restriction
US7833216B2 (en) 2006-11-08 2010-11-16 Ethicon Endo-Surgery, Inc. Fluid plunger adhesive dispenser
US8608642B2 (en) 2010-02-25 2013-12-17 Ethicon Endo-Surgery, Inc. Methods and devices for treating morbid obesity using hydrogel
JP2018065097A (en) * 2016-10-20 2018-04-26 株式会社アトマックス A plurality of fluids mixture nozzle and mixture nozzle spray method for a plurality of fluids

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