JP2001190558A - Device for applying organism tissue adhesive - Google Patents

Device for applying organism tissue adhesive

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Publication number
JP2001190558A
JP2001190558A JP2000320375A JP2000320375A JP2001190558A JP 2001190558 A JP2001190558 A JP 2001190558A JP 2000320375 A JP2000320375 A JP 2000320375A JP 2000320375 A JP2000320375 A JP 2000320375A JP 2001190558 A JP2001190558 A JP 2001190558A
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JP
Japan
Prior art keywords
chemical
tissue adhesive
inlet
color
solution
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2000320375A
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Japanese (ja)
Inventor
Masao Ikeda
Yukihiko Sakaguchi
幸彦 坂口
昌夫 池田
Original Assignee
Sumitomo Bakelite Co Ltd
住友ベークライト株式会社
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Publication date
Priority to JP30633099 priority Critical
Priority to JP11-306330 priority
Application filed by Sumitomo Bakelite Co Ltd, 住友ベークライト株式会社 filed Critical Sumitomo Bakelite Co Ltd
Priority to JP2000320375A priority patent/JP2001190558A/en
Publication of JP2001190558A publication Critical patent/JP2001190558A/en
Application status is Pending legal-status Critical

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Abstract

PROBLEM TO BE SOLVED: To provide a device for application allowing instinctive and easy operation for connecting syringes filled with the same liquid medecine, respectively, in the same liquid medecine inlet as the initial time of use when the syringes filled with a plurality of liquid medecines in repetitive use of the device for applying organism tissue adhesive are connected again. SOLUTION: A liquid medecine inlet on a rear side of the device for applying organism tissue adhesive or its vicinity is colored in accordance with different colors of plungers of syringes filled with a plurality of liquid medecines after preparing them.

Description

【発明の詳細な説明】 DETAILED DESCRIPTION OF THE INVENTION

【0001】 [0001]

【発明の属する技術分野】本発明は、主に複数成分系製剤として適用される組織接着剤の塗布用具に関するものであり、特に肝臓や肺の切除断端や消化管の縫合部の止血閉鎖などに好適な、生体の患部に噴霧して塗布するための用具に関する。 The present invention relates generally relates to applicator of tissue adhesive which is mainly applied as multiple-component formulations, such as in particular hemostatic closure of the stapling portion of the surgical margins and digestive tract of the liver and lungs a suitable, governing equipment for coating by spraying the affected area of ​​a living body.

【0002】 [0002]

【従来の技術】繊維素原(フィブリノゲン)は、いわゆる血液凝固カスケードの最終段階に存在する非常に重要な役割を担う凝固因子である。 BACKGROUND ART fibrinogen (fibrinogen) is a coagulation factor plays a very important role present in the final stage of the so-called blood clotting cascade. フィブリノゲンは、例えば損傷後の血液凝固系の活性化において、トロンビンにより、その可溶性形態から止血及び創傷治療に重要な寄与をする不溶性のフィブリンに変換される。 Fibrinogen, for example in the activation of blood coagulation system after injury, by thrombin, is converted to insoluble fibrin which plays an important contribution to hemostasis and wound healing from its soluble form. この血液凝固の最終相の原理を利用した組織接着剤が開発され、外科手術において肝臓または脾臓のような軟部器官の縫合代用の接着剤として、または縫合補助剤として使用されている。 The tissue adhesive the principles of the final phase utilizing the blood coagulation it has been developed, as an adhesive for the suture substitute soft organs such as the liver or spleen in surgery, or have been used as sutures adjuvant. 同時に、幅広い臨床の現場で応用されている。 At the same time, it has been applied in a wide range of clinical settings.
近年、2本のシリンジ体に収納されたフィブリノゲン溶液およびトロンビン溶液を同時に射出し、無菌ガスを利用して、射出させた2液を霧状に噴霧して混合するスプレー塗布法が普及し始めている。 Recently, two syringes body housed fibrinogen solution and thrombin solution was injected at the same time, by using the sterilized gas, a spray coating method for mixing by spraying a 2 solution was injected into mist has begun to spread . このような器具の好適な例は、例えばWO94−7420号に記載されている。 Suitable examples of such devices are described, for example, No. WO94-7420.

【0003】しかしながら本器具を用いた不具合として、1回の処置でシリンジ体に準備した薬液のみでは間に合わない場合に再度シリンジ体に薬液を充填して本器具に再装着する際などの繰り返し使用の場でしばしば発生していた。 [0003] However, this instrument as a bug that was used, repeated use, such as when re-installed in this instrument is filled with a chemical solution again into the syringe body if it does not meet the deadline is only the chemical solution was prepared in the syringe body in a single treatment often it had occurred in the field. すなわち誤ってシリンジ体を初回に接続した配置と逆に装着してしまい薬液注入口においてフィブリノゲン溶液とトロンビン溶液が接触して凝固してしまうというものである。 That is that would solidify in contact fibrinogen solution and thrombin solution in chemical inlet will be attached to the arrangement opposite of connecting the syringe body first incorrectly. これを克服するべくスプレー本体の各薬液注入口根元部に識別のための文字等を施してあるものがあるがスプレー本体の金型への刻印にて成形されているためスプレー本体と同色をなし、識別が容易でなく一見気が付かずに使用される危険性があった。 No spray body and the same color for each chemical inlet root portion of the spray body are those are subjected to character or the like for identification has been molded by stamping to mold spray body so as to overcome this , there was a risk of being used without noticing seemingly not easy to identify.

【0004】 [0004]

【発明が解決しようとする課題】本発明は、従来のこのような問題点を解決することを目的とするもので、異なる2成分以上の薬液を注入する各薬液注入口を視覚的に識別できるようにすることにより、各成分を充填したシリンジを所定位置へ容易に接続することが可能な塗布用具を提供するものである。 The present invention 0005] is intended for the purpose of solving such a conventional problem, can be visually identify each chemical inlet for injecting two or more different components of the chemical by way, there is provided a capable applicator be easily connected to a syringe filled with the ingredients to a predetermined position.

【0005】 [0005]

【課題を解決するための手段】即ち本発明は、 1)2成分以上の薬液を塗布するための用具であって、 SUMMARY OF THE INVENTION The present invention provides 1) a tool for applying two or more components of the chemical solution,
後端部に設けられた複数の薬液注入口が互いに視覚的に識別できることを特徴とする生体組織接着剤塗布用具、 2)2成分以上の薬液を塗布するための用具は、無菌ガス注入口と複数の薬液注入口及び先端面に複数の薬液吐出ノズルが設けられ、さらに無菌ガス噴出口が各薬液吐出ノズルに対して同軸かつ外側略環状に配置されている(1)記載の生体組織接着剤塗布用具、 Biological tissue adhesive applicator, wherein a plurality of liquid injection port provided in the rear end portion can be visually distinguished from each other, 2) tools for applying two or more components of the chemical solution comprises a sterile gas inlet a plurality of solution discharge nozzle in a plurality of chemical inlet and the distal end surface is provided, further sterile gas ejection ports are arranged coaxially and outwardly substantially annular for each solution discharge nozzle (1), wherein the biological tissue adhesives application tool,

【0006】3)視覚的に識別できる方法が異なる配色である(1)又は(2)記載の生体組織接着剤塗布用具、 4)異なる配色において、薬液注入口またはその近傍の配色とそのシリンジの色がほぼ同色である(3)記載の生体組織接着剤塗布用具、 5)異なる配色において、薬液注入口と先端面の薬液吐出ノズルを連通させる薬液チューブの配色と、その薬液注入口に接続するシリンジ色がそれぞれほぼ同色であり、さらに各薬液チューブが塗布用具の外側から視覚的に識別できる請求項3記載の生体組織接着剤塗布用具 である。 [0006] 3) a visually method can identify different colors (1) or (2) a biological tissue adhesive applicator according, 4) in different colors, the chemical inlet or near the color scheme of the syringe color is almost the same color (3), wherein the biological tissue adhesive applicator, 5) in different colors, and color of the chemical liquid tube communicating the solution discharge nozzle of the liquid medicine inlet and the distal end surface, connected to the chemical inlet is substantially the same color syringe color respectively, a further visually identifiable claim 3 biological tissue adhesive applicator according from the outside of the liquid chemical tube applicator.

【0007】 [0007]

【発明の実施の形態】以下、図面をもとに本発明について詳細に説明する。 DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described in detail based on the drawings. 図1は本発明の一実施例となる生体組織接着剤塗布用具にホルダーにて一体に固定された2 Figure 1 is integrally fixed to an embodiment become biological tissue adhesive applicator of the present invention at the holder 2
本のシリンジを接続した状態を示す図で、(a)はこれらを上から見た上面図、(b)は(a)の側面図である。 In view showing a state in which the present syringe has been connected, (a) shows the top view them from above, a side view of (b) is (a). 図2の(a)、(b)は本発明の他の実施例となる生体組織接着剤塗布用具のスプレーヘッドを上方向から見た2種類の上面図である。 In Figure 2 (a), (b) is a two top view from above the spray head to become a biological tissue adhesive applicator another embodiment of the present invention.

【0008】本発明による生体組織接着剤塗布用具は、 [0008] The living tissue adhesive application tool according to the present invention,
図1に示すように、スプレーヘッド(1)の後端側に2 As shown in FIG. 1, 2 at the rear end of the spray head (1)
本の薬液注入口(4)、(5)と無菌ガス注入口(8) This chemical liquid inlet (4), (5) and sterilized gas inlet (8)
が設けられ、先端には複数の薬液吐出ノズル(2)と、 Is provided with a plurality of solution discharge nozzle (2) at the tip,
各薬液吐出ノズル(2)に同軸でかつ外側に略環状に配置された薬液を霧状にして混合するための無菌ガス噴出口(3)が備えられている。 Each solution discharge nozzle (2) coaxially at and outside the arranged substantially annular chemical liquid atomized in to a sterile gas ports for mixing (3) is provided. スプレーヘッド(1)内は薬液の流路と無菌ガスの流路とに分かれ例えば薬液注入口(4)、(5)と薬液吐出ノズル(2)を薬液チューブ(6)、(7)で連結することによりそれぞれの流路を分割することができるが、スプレーヘッド(1)の成形品そのものに分割された流路を予め施しても何ら構わない。 Spray head (1) in the flow path and a flow path of the sterilized gas and the divided example chemical inlet of the chemical (4), (5) and the solution discharge nozzle (2) a drug solution tube (6), linked by (7) may no be can be dividing each flow path, previously subjected to a flow path which is divided into moldings itself of the spray head (1) by. また、無菌ガス注入口(8)の端末には予め無菌フィルター(9)を設置しておくことも望ましい実施例の一つである。 Further, the terminal of the sterilized gas inlet (8) which is also one of the preferred embodiments that you set up the previously sterile filter (9).

【0009】後端側に設けられた2本の薬液注入口(4)、(5)はお互いに異なる色調をなし、その製造方法は射出成形における2色成形により2色配色に成形されることがコスト的安価となり望ましいが、他の実施例を示すように図2(a)ではスプレーヘッド(1)全体を2本の薬液注入口(4)と(5)を2分する中心線にて2分割した成形品とし、個々の成形色を違える方法を示し、また図2(b)では2本の薬液注入口(4)、 [0009] Two chemical inlet provided at the rear side (4), (5) forms a color tone different from each other, that the manufacturing method is formed into two-color scheme by two-color molding in the injection molding Although but preferably will cost inexpensive, 2 as shown another embodiment (a) in the spray head (1) across the two chemical inlet (4) and (5) at a center line bisecting a bisected molded article shows how made different individual molding colors, also FIG. 2 (b), the two chemical inlet (4),
(5)を個々に色分けした成形を行いスプレーヘッド(1)に設置する方法を示している。 (5) shows a method of installing a spray head (1) performs a molding which is colored individually. 更に図2(c)では、スプレーヘッド(1)全体を透明な成形品とし、薬液注入口(4)、(5)に接続される薬液チューブ(6)、(7)に配色を施して識別できる方法を示している。 In addition FIG. 2 (c), the spray head (1) The whole is a transparent molded article, chemical inlet (4), chemical liquid tube connected to the (5) (6), identified by applying the color scheme to (7) It shows how you can. ここまでは薬液注入口(4)、(5)または薬液チューブ(6)、(7)を成形時に色付けする方法を述べたが、印刷やシールにて色付けしても何ら構わない。 Chemical inlet is far (4), (5) or chemical tube (6), (7) a has been described a method of coloring in molding, may no be colored by printing or seal.

【0010】次に配色について述べると、一般に市販されている生体組織接着剤の2成分薬液の調製用に使用されているシリンジ体はプランジャー色や目盛印刷色を色違にしており、フィブリノゲン溶液用には青色、トロンビン溶液用には赤色となっている。 [0010] Next the described color, syringe body which are generally used for the preparation of 2-component chemical biological tissue adhesive commercially available is of a plunger color and scale printing colors Iro違, fibrinogen solution the use blue, the thrombin solution has a red color. 従って薬液注入口(4)、(5)またはその近傍の配色も青色と赤色に配色されていることが望ましい。 Thus chemical inlet (4), it is desirable that the color scheme (5) or to the blue and red color in the vicinity thereof. 全ての構成部品の材質および配色のための顔料については特に限定されるものではないが、少なくとも薬液と接触する薬液注入口(4)、(5)、薬液チューブ(6)、(7)、薬液吐出ノズル(2)、の材質は医療用プラスチック材料であり、かつ薬液に影響をおよぼさないものであることが求められる。 There is no particular limitation on the pigment for the material and color of all components, chemical inlet in contact with at least the drug solution (4), (5), chemical tube (6), (7), chemical discharge nozzle (2), the material is a medical grade plastic material, and is required to be one which does not affect the chemical. また、本発明の塗布用具の製作は複数の成形品を接着するか、又は溶着等により組み立てられる。 Also, manufacture of the applicator device of the present invention is assembled by either bonding a plurality of molded articles, or welding.

【0011】次にフィブリノゲン溶液とトロンビン溶液による生体組織接着剤の塗布操作についての具体例を述べる。 [0011] described below an example of coating operation of the biological tissue adhesive according fibrinogen solution and thrombin solution. まずフィブリノゲン溶液を充填したシリンジ(9)とトロンビン溶液を充填したシリンジ(10)をホルダー(12)、(13)に装着し、シリンジ(1 First fibrinogen solution was charged with thrombin solution and syringe (9) filled with a syringe (10) holder (12), mounted on the (13), the syringe (1
0)、(11)の先端をスプレーヘッド(1)後端の薬液注入口(4)、(5)に接続する。 0), (distal spray head (1) the rear end of the chemical inlet 11) (4), connected to (5). このとき、シリンジ(9)と同じ配色に対応する薬液注入口(4)を、さらに同様に(10)と(5)というように配色が同じ位置になるように接続する。 In this case, chemical inlet corresponding to the same color as the syringe (9) (4), further color schemes and so likewise (10) and (5) connected to be the same position. 次に無菌ガス注入口(8)の無菌フィルター(9)にエアー源を接続し、適度なエアー流量を保つ。 Next, the air source is connected to the sterile filter (9) of sterile gas inlet (8), keeping the proper air flow. そして一般的には止血するべく患部へスプレーヘッド(1)を向けホルダー(12)を加圧することにより薬液吐出ノズル(2)よりフィブリンノゲン溶液とトロンビン溶液が無菌ガス噴出口(3)より噴出された無菌ガスにより混合され患部に噴霧され止血がなされることとなる。 The ejected from generally solution discharge nozzle (2) from fibrin Bruno Gen solution and thrombin solution is sterile gas ejection port by pressurizing holder (12) toward the spray head to the affected area (1) in order to Hemostasis (3) sprayed which the affected part is mixed by, sterile gas is so that the hemostasis is performed. そして一度充填した容量の薬液を使い切り、さらに使用を追加する場合には改めてシリンジ(10)、(11)への薬液充填を行い、手早くスプレーヘッド(1)の薬液注入口(4)、(5)とシリンジ(10)、(11)の配色の対応を合わせて接続し再操作する。 The use-up a chemical capacity filled once again syringe when to add additional use (10), the drug solution filling into (11), quickly spray chemical inlet of the head (1) (4), (5 ) and the syringe (10), re-operating connecting corresponding combined with the color scheme (11).

【0012】 [0012]

【発明の効果】以上に述べた如く、本発明による生体組織接着剤塗布用具はシリンジの配色に合わせて薬液注入口またはその近傍を配色してあるため、スプレーヘッド(1)の追加使用におけるシリンジの再接続が視覚的に手早くでき、誤ったシリンジ接続による詰まりの発生を防止できる組織接着剤の塗布用具として有用である。 As mentioned above, according to the present invention, since the biological tissue adhesive applicator according to the present invention are to color the chemical inlet or near to suit the color scheme of the syringe, the syringe in the additional use of the spray head (1) reconnection to visually quickly, and is useful as a coating tool tissue adhesive which can prevent the occurrence of clogging due to incorrect syringe connection.

【図面の簡単な説明】 BRIEF DESCRIPTION OF THE DRAWINGS

【図1】本発明の一実施例となる生体組織接着剤塗布用具にホルダーにて一体化した2本のシリンジを接続した状態を示す図で、(a)はこれらを上から見た上面図、 [1] a view showing a state of connecting the two syringes integrated with one embodiment become biological tissue adhesive applicator in the holder of the present invention, (a) is a top view them from above ,
(b)は側面図である。 (B) is a side view.

【図2】本発明の他の実施例となる生体組織接着剤塗布用具のスプレーヘッドを上から見た3種類の上面図である。 2 is a three top view of the spray head seen from above of another embodiment become biological tissue adhesive applicator of the present invention.

【符号の説明】 DESCRIPTION OF SYMBOLS

1 スプレーヘッド 2 薬液吐出ノズル 3 無菌ガス噴出口 4、5 薬液注入口 6、7 薬液チューブ 8 無菌ガス注入口 9 無菌フィルター 10、11 シリンジ 12、13 ホルダー 1 spray head 2 solution discharge nozzle 3 sterile gas ejection ports 4, 5 chemical inlet 6,7 liquid medicine tube 8 sterilized gas inlet 9 sterile filter 10, 11 syringes 12, 13 Holder

Claims (5)

    【特許請求の範囲】 [The claims]
  1. 【請求項1】 2成分以上の薬液を塗布するための用具であって、後端部に設けられた複数の薬液注入口が互いに視覚的に識別できることを特徴とする生体組織接着剤塗布用具。 1. A tool for applying two or more components of the chemical solution, the biological tissue adhesive applicator, wherein a plurality of liquid injection port provided in the rear end portion can be visually distinguished from each other.
  2. 【請求項2】 2成分以上の薬液を塗布するための用具は、互いに薬液チューブにて連通された複数の薬液注入口及び先端面の薬液吐出ノズルと、無菌ガス注入口が設けられ、さらに無菌ガス噴出口が各薬液吐出ノズルに対して同軸かつ外側略環状に配置されている請求項1記載の生体組織接着剤塗布用具。 2. A tool for applying two or more components of the chemical solution comprises a chemical dispensing nozzle of the plurality of chemical inlet which communicates and the distal end surface at one another chemical tube, sterilized gas inlet is provided, further sterile gas ejection port claim 1 biological tissue adhesive applicator according disposed coaxially and outwardly substantially annular for each solution discharge nozzle.
  3. 【請求項3】 視覚的に識別できる方法が異なる配色である請求項1又は2記載の生体組織接着剤塗布用具。 3. A visually claim 1 or 2 biological tissue adhesive applicator according methods are different colors can be identified.
  4. 【請求項4】 異なる配色において、薬液注入口またはその近傍の配色とそのシリンジの色がほぼ同色である請求項3記載の生体組織接着剤塗布用具。 4. A different color, chemical inlet or coloring living tissue adhesive applicator of claim 3, wherein the color of the syringe is substantially the same color in the vicinity thereof.
  5. 【請求項5】 異なる配色において、薬液注入口と先端面の薬液吐出ノズルを連通させる薬液チューブの配色と、その薬液注入口に接続するシリンジ色がそれぞれほぼ同色であり、さらに各薬液チューブが塗布用具の外側から視覚的に識別できる請求項3記載の生体組織接着剤塗布用具。 5. A different color, and color of the chemical liquid tube communicating the solution discharge nozzle of the liquid medicine inlet and the distal end surface is substantially the same color syringe colors respectively to be connected to the chemical inlet, further the chemical tubes coated visually discernable claim 3 biological tissue adhesive applicator according from the outside of the tool.
JP2000320375A 1999-10-28 2000-10-20 Device for applying organism tissue adhesive Pending JP2001190558A (en)

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JP30633099 1999-10-28
JP11-306330 1999-10-28
JP2000320375A JP2001190558A (en) 1999-10-28 2000-10-20 Device for applying organism tissue adhesive

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7658305B2 (en) 2006-10-25 2010-02-09 Ethicon Endo-Surgery, Inc. Adhesive applier with articulating tip
US7749235B2 (en) 2006-10-20 2010-07-06 Ethicon Endo-Surgery, Inc. Stomach invagination method and apparatus
US7833216B2 (en) 2006-11-08 2010-11-16 Ethicon Endo-Surgery, Inc. Fluid plunger adhesive dispenser
US7892250B2 (en) 2006-11-01 2011-02-22 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive on inflatable device for gastric restriction
US7914511B2 (en) 2006-10-18 2011-03-29 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive as bulking agent
WO2012063464A1 (en) * 2010-11-10 2012-05-18 住友ベークライト株式会社 Tool for applying biological tissue adhesive
US8603138B2 (en) 2006-10-04 2013-12-10 Ethicon Endo-Surgery, Inc. Use of an adhesive to treat intraluminal bleeding
US8608642B2 (en) 2010-02-25 2013-12-17 Ethicon Endo-Surgery, Inc. Methods and devices for treating morbid obesity using hydrogel
US8876844B2 (en) 2006-11-01 2014-11-04 Ethicon Endo-Surgery, Inc. Anastomosis reinforcement using biosurgical adhesive and device

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8603138B2 (en) 2006-10-04 2013-12-10 Ethicon Endo-Surgery, Inc. Use of an adhesive to treat intraluminal bleeding
US7914511B2 (en) 2006-10-18 2011-03-29 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive as bulking agent
US7749235B2 (en) 2006-10-20 2010-07-06 Ethicon Endo-Surgery, Inc. Stomach invagination method and apparatus
US7658305B2 (en) 2006-10-25 2010-02-09 Ethicon Endo-Surgery, Inc. Adhesive applier with articulating tip
US7892250B2 (en) 2006-11-01 2011-02-22 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive on inflatable device for gastric restriction
US8876844B2 (en) 2006-11-01 2014-11-04 Ethicon Endo-Surgery, Inc. Anastomosis reinforcement using biosurgical adhesive and device
US7833216B2 (en) 2006-11-08 2010-11-16 Ethicon Endo-Surgery, Inc. Fluid plunger adhesive dispenser
US8608642B2 (en) 2010-02-25 2013-12-17 Ethicon Endo-Surgery, Inc. Methods and devices for treating morbid obesity using hydrogel
WO2012063464A1 (en) * 2010-11-10 2012-05-18 住友ベークライト株式会社 Tool for applying biological tissue adhesive
JP2012100851A (en) * 2010-11-10 2012-05-31 Chemo-Sero-Therapeutic Research Inst Biological tissue adhesive applicator
CN103237509A (en) * 2010-11-10 2013-08-07 住友电木株式会社 Tool for applying biological tissue adhesive
CN107051764A (en) * 2010-11-10 2017-08-18 住友电木株式会社 Adhesive applicator for biological tissue

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