JP2011056019A - Biological tissue adhesive applicator - Google Patents
Biological tissue adhesive applicator Download PDFInfo
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本発明は、生体組織接着剤塗布用具に関するものである。 The present invention relates to a biological tissue adhesive application tool.
繊維素原（フィブリノゲン）は、いわゆる血液凝固カスケードの最終段階に存在する非常に重要な役割を担う凝固因子である。フィブリノゲンは、例えば損傷後の血液凝固系の活性化において、トロンビンによりその可溶性形態から止血及び創傷治療に重要な役目となる不溶性のフィブリンに変換される。この血液凝固の最終相の原理を利用した組織接着剤が開発され、外科手術において肝臓または脾臓のような軟部器官の縫合代用の接着材として、または縫合補助剤として使用され、幅広く臨床の現場で応用されている。
近年、２本のシリンジ体に収納されたフィブリノゲン溶液およびトロンビン溶液を、無菌ガスを利用して同時に噴霧して混合して塗布する、所謂二液混合スプレー塗布法が普及し始めている（例えば、特許文献１参照）。
Fibrinogen is a coagulation factor that plays a very important role in the final stage of the so-called blood coagulation cascade. Fibrinogen is converted by thrombin from its soluble form to insoluble fibrin, which plays an important role in hemostasis and wound treatment, for example in the activation of the blood clotting system after injury. A tissue adhesive using the principle of the final phase of blood coagulation has been developed and used in surgical operations as an adhesive for suture replacement of soft organs such as the liver or spleen or as a suturing aid. Applied.
In recent years, a so-called two-component mixed spray coating method in which a fibrinogen solution and a thrombin solution housed in two syringe bodies are simultaneously sprayed, mixed and applied using aseptic gas has begun to spread (for example, patents) Reference 1).
しかしながら本法を用いた不具合として先端部での詰まりという現象がしばしば見られ、これは特に断続的に使用する際に多く発生していた。断続的使用とは、薬液噴霧を一時中断し、処置を行った後に再度薬液噴霧を行うもので、中断時間は数分から数十分間の範囲である。この中断時に、噴霧されたフィブリノゲン溶液及びトロンビン溶液の霧状の微粒子が術野より跳ね返ってノズルチップ先端に付着し、その際、２溶液が互いに接触することにより薬液抽出口や薬液流通管内の先端部において凝固が進み、詰まりが発生するものと考えられている。
また中断している間は、術野における空気の巻き上げ防止や無菌ガス流出音をなくすため、無菌ガスを一時停止させる操作がなされる。その間、薬液流通管内に残った薬液が薬液流通管内やシリンジ内の残圧によりわずかに吐出してノズル先端に付着し、先端部の詰まりの原因となることがあると考えられており、この場合も結果として噴霧を再開することが出来ず、スプレーヘッド本体の交換が必要になるという問題があった。
However, as a problem using this method, a phenomenon of clogging at the tip portion is often observed, and this phenomenon occurs frequently especially when used intermittently. Intermittent use is a method in which chemical spraying is temporarily suspended, treatment is performed, and then chemical spraying is performed again. The interruption time is in the range of several minutes to several tens of minutes. At the time of this interruption, the atomized fine particles of the fibrinogen solution and the thrombin solution splashed from the operative field and adhered to the tip of the nozzle tip. At that time, the two solutions contacted each other, thereby leading the tip in the drug solution extraction port or the drug solution distribution pipe. It is thought that solidification proceeds at the part and clogging occurs.
During the interruption, an operation for temporarily stopping the sterilized gas is performed in order to prevent air from being rolled up in the operative field and to eliminate the sterilized gas outflow sound. In the meantime, it is thought that the chemical solution remaining in the chemical solution distribution pipe is slightly discharged by the residual pressure in the chemical solution distribution pipe or syringe and adheres to the nozzle tip, which may cause clogging of the tip part. However, as a result, there is a problem that spraying cannot be resumed and the spray head body needs to be replaced.
本発明は、従来のこのような問題点を解決することを目的とするもので、断続的使用時において、薬液を無駄にすることがなく、且つ詰まりを発生させない生体組織接着剤塗布用具を提供するものである。 The present invention is intended to solve the conventional problems as described above, and provides a biological tissue adhesive applicator that does not waste chemicals and does not cause clogging during intermittent use. To do.
即ち本発明は、
二種類の薬液を混合噴霧する生体組織接着剤塗布用具であって、
内部に無菌ガス流通室（１３）が形成され向かい合った平面が略三角形状のスプレーヘッド本体（１）と、
前記スプレーヘッド本体（１）の一方の平面に備えられ無菌ガス（１２）を前記無菌ガス流通室（１３）に注入可能な無菌ガス注入口（３）と、
前記スプレーヘッド本体（１）の後端部側に付設された２つの薬液注入口（２）と、
前記スプレーヘッド本体（１）の先端部側に付設された２つの薬液吐出ノズル（４）と、
前記各々の薬液吐出ノズル（４）に対して同軸且つ外周に略環状に配置され前記無菌ガス流通室（１３）と連通し無菌ガスを噴出する２つの無菌ガス噴出口（５）と、
を備え、
更に、前記無菌ガス流通室（１３）内において、前記２つの薬液注入口（２）と前記２つの薬液吐出ノズル（４）とを連結する２つの薬液流通管（６）と、前記２つの薬液流通管（６）を各々被装する少なくとも一つの被装管（７）とが備えられていると共に、前記薬液流通管（６）と前記被装管（７）との被装面の長軸方向に前記無菌ガス流通室（１３）と前記薬液流通管（６）内腔とを連通する少なくとも一つの無菌ガス流通溝（８）を有していることを特徴とする生体組織接着剤塗布用具である。
That is, the present invention
A biological tissue adhesive applicator for mixing and spraying two types of chemicals,
A spray head body (1) in which a sterile gas circulation chamber (13) is formed and the opposing planes are substantially triangular;
A sterile gas inlet (3) provided on one plane of the spray head body (1) and capable of injecting a sterile gas (12) into the sterile gas flow chamber (13);
Two chemical liquid inlets (2) attached to the rear end side of the spray head body (1);
Two chemical liquid discharge nozzles (4) attached to the tip side of the spray head body (1);
Two aseptic gas jets (5) which are arranged coaxially with respect to each of the chemical solution discharge nozzles (4) and arranged in a substantially annular shape on the outer periphery thereof and which communicate with the aseptic gas circulation chamber (13) and eject aseptic gas;
With
Furthermore, in the aseptic gas circulation chamber (13), two chemical liquid flow pipes (6) connecting the two chemical liquid injection ports (2) and the two chemical liquid discharge nozzles (4), and the two chemical liquids And at least one covered pipe (7) for covering each of the flow pipes (6), and the major axis of the mounting surface of the chemical liquid flow pipe (6) and the covered pipe (7) A biological tissue adhesive applicator characterized by having at least one sterile gas flow groove (8) communicating with the sterilized gas flow chamber (13) and the lumen of the chemical solution flow pipe (6) in a direction. It is.
以上に述べた如く、本発明による生体組織接着剤塗布用具は、断続的使用時において、薬液を無駄にすることなく、且つ詰まりを発生させない生体組織接着剤塗布用具を提供することができる。 As described above, the biological tissue adhesive application tool according to the present invention can provide a biological tissue adhesive application tool that does not waste chemicals and does not cause clogging during intermittent use.
以下、図面をもとに本発明について詳細に説明する。図１は本発明の一実施例となる生体組織接着剤塗布用具の構造を示す平面断面図である。 Hereinafter, the present invention will be described in detail with reference to the drawings. FIG. 1 is a plan sectional view showing a structure of a biological tissue adhesive applicator according to an embodiment of the present invention.
本発明の一実施例となる生体組織接着剤塗布用具は、図１及び図２に示すように、内部に無菌ガス流通室（１３）が形成され向かい合った平面が略三角形状のスプレーヘッド本体（１）と、スプレーヘッド本体（１）の一方の平面に備えられ無菌ガス（１２）を上記無菌ガス流通室（１３）に注入可能な無菌ガス注入口（３）と、スプレーヘッド本体（１）の後端部側に付設された２つの薬液注入口（２）と、スプレーヘッド本体（１）先端部側に付設された2つの薬液吐出ノズル（４）と、各々の薬液吐出ノズル（４）に対して同軸且つ外周に略環状に配置され無菌ガス流通室（１３）と連通し無菌ガス（１２）を噴出する無菌ガス噴出口（５）とが備えられている。また、無菌ガス注入口（３）の基端部には予め無菌フィルター（９）を設置しておくことも望ましい。 As shown in FIGS. 1 and 2, the biological tissue adhesive application tool according to one embodiment of the present invention has a spray head main body (as shown in FIGS. 1), a sterile gas inlet (3) provided on one plane of the spray head body (1) and capable of injecting a sterile gas (12) into the sterile gas circulation chamber (13), and a spray head body (1) Two chemical liquid injection ports (2) provided on the rear end side, two chemical liquid discharge nozzles (4) provided on the tip side of the spray head body (1), and each chemical liquid discharge nozzle (4) And an aseptic gas outlet (5) which is arranged in a substantially annular shape on the outer periphery of the same and communicates with the aseptic gas circulation chamber (13) to eject aseptic gas (12). It is also desirable to install a sterile filter (9) in advance at the proximal end of the sterile gas inlet (3).
更に、本発明の一実施例となる生体組織接着剤塗布用具は、図３に示すように、無菌ガス流通室（１３）内において、２つの薬液注入口（２）と２つの薬液吐出ノズル（４）とを連結する２つの薬液流通管（６）と、上記２つの薬液流通管（６）を各々被装する少なくとも一つの被装管（７）とが備えられていると共に、前記薬液流通管（６）と前記被装管（７）との被装面の長軸方向に前記無菌ガス流通室（１３）と前記薬液流通管（６）内腔とを連通する少なくとも一つの無菌ガス流通溝（８）を有している。 Furthermore, as shown in FIG. 3, the biological tissue adhesive application tool according to an embodiment of the present invention has two chemical liquid injection ports (2) and two chemical liquid discharge nozzles (in the sterile gas flow chamber (13)). 4) and two chemical liquid distribution pipes (6) for connecting the two chemical liquid distribution pipes (6) and at least one loaded pipe (7) for respectively covering the two chemical liquid distribution pipes (6). At least one sterile gas flow that communicates the sterile gas flow chamber (13) and the chemical solution flow tube (6) lumen in the major axis direction of the mounting surface of the tube (6) and the mounted tube (7). Has a groove (8).
無菌ガス流通溝（８）は薬液流通管（６）と無菌ガス流通室（１３）とを連通しているが、内径が小さく且つある程度の長さを有しているため、薬液（１１）の粘性による流通抵抗により、薬液流通管（６）を薬液（１１）が流通している間も容易には無菌ガス流通溝（８）内に流入することはない。この無菌ガス流通溝（８）の内径と長さによって決まる薬液（１１）の流通抵抗値を薬液流通抵抗値（Ａ）とする。
無菌ガス流通溝（８）の内径は０．１ｍｍ以下が好ましい。全長は３ｍｍ以上が好ましく、更に好ましくは5mm以上である。これにより、想定外の圧力が薬液（１１）に加わった場合でも、容易には無菌ガス流通溝（８）内に薬液（１１）が流れず、無菌ガス流通室（１３）へと漏出することを防ぐことができる。
The sterile gas flow groove (8) communicates the chemical solution flow pipe (6) and the sterile gas flow chamber (13). However, since the inner diameter is small and has a certain length, the chemical solution (11) Due to the flow resistance due to viscosity, the chemical liquid flow pipe (6) does not easily flow into the sterile gas flow groove (8) while the chemical liquid (11) is flowing. The flow resistance value of the chemical solution (11) determined by the inner diameter and length of the aseptic gas flow groove (8) is defined as a chemical solution flow resistance value (A).
The inner diameter of the sterile gas flow groove (8) is preferably 0.1 mm or less. The total length is preferably 3 mm or more, more preferably 5 mm or more. Thereby, even when an unexpected pressure is applied to the chemical liquid (11), the chemical liquid (11) does not easily flow into the sterile gas flow groove (8) and leaks to the sterile gas flow chamber (13). Can be prevented.
無菌ガス流通溝（８）は上記のような寸法を有していても気体であり流通抵抗が低く且つ圧力作用力（Ｂ）をもつ無菌ガス（１２）の場合は、容易に通過させることができる。一方、薬液流通管（６）内に薬液（１１）を注入している間は薬液（１１）の注入圧、即ち薬液流通管（６）内における薬液流通時の薬液の圧力作用力（Ｃ）が無菌ガス流通溝（８）内に作用し、無菌ガス（１２）を無菌ガス流通溝（８）内に容易には通過させないため、薬液流通管（６）へと無菌ガス（１２）が過剰に流入することはない。即ち、無菌ガス流通溝（８）内径と長さによって生じる無菌ガス流通溝（８）内腔の薬液流通抵抗値（Ａ）と、スプレーヘッド本体（１）の内部に発生する無菌ガスによる圧力作用力（Ｂ）との加算値（Ａ）＋（Ｂ）が、薬液流通管内における薬液流通時の薬液の圧力作用力（Ｃ）よりも小さくなる構成（（Ａ）＋（Ｂ）＜（Ｃ））の状態であり、これにより薬液流通管（６）と無菌ガス流通室（１３）を連通する無菌ガス流通溝（８）があっても無菌ガス流通溝（８）から無菌ガス流通室（１３）へと薬液（１１）が流れ出ることなく噴霧できるものである。
他方、一度薬液（１１）の注入を止めれば、薬液流通管（６）内における薬液流通時の薬液の圧力作用力（Ｃ）が弱まり、薬液流通管（６）内に満たされた薬液（１１）の粘性のみによる流れの抵抗値だけになるため、薬液流通管（６）へと無菌ガス（１２）が流入し、無菌ガス（１２）の圧力により薬液流通管（６）内の薬液（１１）を薬液吐出ノズル（４）から排出することができる。
The aseptic gas circulation groove (8) can be easily passed in the case of the aseptic gas (12) having gas pressure, low flow resistance and pressure acting force (B) even if it has the above dimensions. it can. On the other hand, while the chemical liquid (11) is being injected into the chemical liquid distribution pipe (6), the injection pressure of the chemical liquid (11), that is, the pressure acting force (C) of the chemical liquid during the chemical liquid distribution in the chemical liquid distribution pipe (6). Acts in the sterile gas flow groove (8) and does not easily pass the sterile gas (12) into the sterile gas flow groove (8), so that the sterile gas (12) is excessive to the chemical liquid flow pipe (6). Will not flow into. That is, the chemical solution flow resistance value (A) in the lumen of the sterile gas flow groove (8) generated by the inner diameter and length of the sterile gas flow groove (8), and the pressure action by the sterile gas generated inside the spray head body (1) Structure (A) + (B) <(C) where the addition value (A) + (B) with the force (B) is smaller than the pressure acting force (C) of the chemical solution when the chemical solution flows in the chemical solution distribution pipe Thus, even if there is a sterile gas flow groove (8) communicating the chemical solution flow pipe (6) and the sterile gas flow chamber (13), the sterile gas flow groove (8) to the sterile gas flow chamber (13) The chemical liquid (11) can be sprayed without flowing out.
On the other hand, once the injection of the chemical liquid (11) is stopped, the pressure acting force (C) of the chemical liquid during the chemical liquid circulation in the chemical liquid circulation pipe (6) is weakened, and the chemical liquid (11) filled in the chemical liquid circulation pipe (6) ), The aseptic gas (12) flows into the chemical liquid distribution pipe (6), and the chemical liquid (11) in the chemical liquid distribution pipe (6) is caused by the pressure of the sterile gas (12). ) Can be discharged from the chemical solution discharge nozzle (4).
無菌ガス流通溝（８）の配置は、薬液流通管（６）の薬液注入口（２）と薬液吐出ノズル（４）との中間位置よりも薬液吐出ノズル（４）側であることが望ましい。これは薬液流通管（６）内に満たされた薬液（１１）の粘性による流れの抵抗があるため、抵抗の軽い方向に無菌ガス（１２）の圧力によって薬液（１１）が動くので、薬液（１１）を排出したい薬液吐出ノズル（４）側の流路抵抗を低くする必要があるからである。
即ち薬液流通管（６）の中間位置より薬液吐出ノズル（４）側に無菌ガス流通溝（８）を配置することが望ましい。実際には薬液注入口（２）にはシリンジ（１０）が接続されているため、シリンジ（１０）のプランジャーの摺動抵抗があるので、無菌ガス流通溝（８）は薬液流通管（６）のどこに配置しても問題なく薬液吐出ノズル（４）側の薬液（１１）が排出されるが、薬液（１１）は高価であるため、不要に多量の薬液（１１）を排出し無駄にすることは避けたほうが好ましいことからも、無菌ガス流通溝（８）は薬液吐出ノズル（４）側に配置することが望ましい。
The disposition of the sterile gas flow groove (8) is preferably on the side of the chemical liquid discharge nozzle (4) with respect to the intermediate position between the chemical liquid inlet (2) and the chemical liquid discharge nozzle (4) of the chemical liquid flow pipe (6). This is because the chemical solution (11) is moved by the pressure of the sterilized gas (12) in the direction of light resistance because there is a flow resistance due to the viscosity of the chemical solution (11) filled in the chemical solution circulation pipe (6). This is because it is necessary to reduce the flow path resistance on the side of the chemical liquid discharge nozzle (4) to be discharged.
That is, it is desirable to arrange the sterile gas flow groove (8) on the side of the chemical liquid discharge nozzle (4) from the middle position of the chemical liquid flow pipe (6). Actually, since the syringe (10) is connected to the chemical liquid injection port (2), there is sliding resistance of the plunger of the syringe (10), so that the sterile gas flow groove (8) is connected to the chemical liquid flow pipe (6 ), The chemical solution (11) on the chemical solution discharge nozzle (4) side is discharged without any problem. However, since the chemical solution (11) is expensive, a large amount of the chemical solution (11) is discharged unnecessarily. Since it is preferable to avoid this, it is desirable that the sterile gas flow groove (8) is disposed on the side of the chemical solution discharge nozzle (4).
無菌ガス流通溝（８）の長さはスプレーヘッド本体（１）内および無菌ガス流通室（１３）内での配置を意味し、無菌ガス注入口（３）に近い配置であることが好ましい。無菌ガス流通室（１３）内での無菌ガス（１２）の流速は、一般的に、無菌ガス注入口（３）付近では遅く、無菌ガス噴出口（５）で早くなる分布を示す。流速が早い位置では無菌ガス（１２）の圧力は下がり、逆に流速が遅い位置では無菌ガス（１２）の圧力は高くなるため、より高い圧力の無菌ガス（１２）にて薬液（１１）を排出するためには、無菌ガス流通溝（８）の無菌ガス流通室（１３）側の配置は無菌ガス注入口（３）に近いほうが好ましい。無菌ガス流通溝（８）が長くなると製造技術的な問題、即ち製造コストが高くなるという問題も出てくる。薬液（１１）の粘性と薬液流通管（６）の内径および薬液流通管（６）と無菌ガス流通溝（８）との配置、無菌ガス（１２）の圧力等の関係を考慮することが必要である。 The length of the sterile gas flow groove (8) means the arrangement in the spray head main body (1) and the sterile gas flow chamber (13), and is preferably arranged close to the sterile gas injection port (3). The flow rate of the sterilized gas (12) in the sterilized gas circulation chamber (13) generally shows a distribution that is slow in the vicinity of the sterilized gas injection port (3) and fast in the sterilized gas injection port (5). At a position where the flow rate is fast, the pressure of the sterilized gas (12) decreases, and at a position where the flow rate is slow, the pressure of the sterilized gas (12) becomes high. In order to discharge, it is preferable that the arrangement of the sterile gas flow groove (8) on the sterile gas flow chamber (13) side is closer to the sterile gas inlet (3). When the aseptic gas flow groove (8) becomes long, a problem in manufacturing technology, that is, a problem in that the manufacturing cost increases. It is necessary to consider the relationship between the viscosity of the chemical liquid (11), the inner diameter of the chemical liquid distribution pipe (6), the arrangement of the chemical liquid distribution pipe (6) and the sterile gas flow groove (8), the pressure of the sterile gas (12), etc. It is.
無菌ガス流通溝（８）は、小径のチューブを薬液チューブに接着や溶着にて接続しても良いし、例えば無菌ガス流通溝（８）に相当する分岐路を有する射出成形品等を薬液流通管（６）の間に挟んで接続してもよいが、本発明の一実施例となる図２では、より簡易で安価な手段として薬液流通管（１３）と被装管（７）の嵌合接続による被装面に無菌ガス流通溝（８）を形成する方法を示している。即ち、被装面となる面に予め凹凸を設けておくことにより、嵌合後、被装面に無菌ガス流通溝（８）を形成するものである。
図２では薬液流通管（１３）の外周に無菌ガス流通溝（８）を設けた実施例を示しているがこれに限定するものではなく、薬液流通管（１３）を覆う被装管（７）の内面に無菌ガス流通溝（８）を設ける、または薬液流通管（１３）の外周と被装管（７）の内面の両方に無菌ガス流通溝（８）を設けてもよい。加えて無菌ガス流通溝（８）は長手軸方向に直線的に延びることに限定するものではなく、例えば螺旋状や波状等であってもよい。
更に無菌ガス流通溝（８）の数は特に規定するものではなく、複数設けることにより薬液除去の効率を上げる効果が期待できるため好ましいが、製造コストとのバランスを考慮することが望ましい。図２（ｂ）にて無菌ガス流通溝（８）が２本である例を示しているが、この構造は被装面の凹凸の数を変えることによって無菌ガス流通溝（８）の数を変えることが可能な簡易で安価な構造であり、無菌ガス流通溝（８）の数を任意に設定できる構造である。
The aseptic gas distribution groove (8) may connect a small-diameter tube to the chemical liquid tube by bonding or welding. For example, an injection molded product having a branch path corresponding to the sterile gas distribution groove (8) may be used as a chemical liquid distribution. In FIG. 2, which is an embodiment of the present invention, the chemical liquid flow pipe (13) and the covered pipe (7) are fitted as a simpler and cheaper means. The method of forming the aseptic gas flow groove (8) on the surface to be mounted by joint connection is shown. That is, by providing unevenness on the surface to be mounted in advance, the aseptic gas flow groove (8) is formed on the mounted surface after fitting.
Although FIG. 2 shows an embodiment in which the sterile gas flow groove (8) is provided on the outer periphery of the chemical liquid flow pipe (13), the present invention is not limited to this. ) May be provided with an aseptic gas circulation groove (8), or an aseptic gas circulation groove (8) may be provided on both the outer periphery of the chemical solution circulation pipe (13) and the inner surface of the covered pipe (7). In addition, the sterile gas flow groove (8) is not limited to linearly extending in the longitudinal axis direction, and may be, for example, a spiral shape or a wave shape.
Further, the number of aseptic gas flow grooves (8) is not particularly limited, and it is preferable to provide a plurality of aseptic gas flow grooves (8) because an effect of increasing the efficiency of removing the chemical solution can be expected. FIG. 2 (b) shows an example in which there are two aseptic gas circulation grooves (8), but this structure changes the number of aseptic gas circulation grooves (8) by changing the number of irregularities on the surface to be mounted. It is a simple and inexpensive structure that can be changed, and the number of aseptic gas flow grooves (8) can be arbitrarily set.
全ての構成部品の材質は特に限定されるものではないが、少なくとも薬液（１１）と接触する薬液注入口（２）、薬液吐出ノズル（４）、薬液流通管（６）、無菌ガス流通溝（８）の材質は医療用プラスチック材料であり、且つ薬液（１１）に影響を及ぼさないプラスチック材料を用いることができる。 Although the material of all the components is not particularly limited, at least the chemical liquid inlet (2) that contacts the chemical liquid (11), the chemical liquid discharge nozzle (4), the chemical liquid flow pipe (6), the sterile gas flow groove ( The material of 8) is a medical plastic material, and a plastic material that does not affect the chemical solution (11) can be used.
次に、図１を用いて、本発明の生体組織接着剤塗布用具の具体的な使用方法を、フィブリノゲン溶液トロンビン溶液からなる薬液（１１）を用いた場合を想定して述べる。
先ずフィブリノゲン溶液を充填したシリンジ（１０）とトロンビン溶液を充填したシリンジ（１０）の先端を、スプレーヘッド本体（１）の後端部側に付設された薬液注入口（２）に各々差し込む。次に無菌ガス注入口（３）に無菌フィルター（９）を介して無菌ガス供給源を接続し、適度な流量と圧力に設定し保持する。そして一般的には止血すべき患部へスプレーヘッド本体（１）の先端を向け、シリンジ（１０）のプランジャーを押して加圧することにより、薬液流通管（６）を介して薬液吐出ノズル（４）からフィブリノゲン溶液とトロンビン溶液とが吐出され、同時に無菌ガス噴出口（５）より噴出された無菌ガス（１２）によりせん断され霧状に混合されたフィブリノゲン溶液とトロンビン溶液が患部に塗布され凝固し止血がなされることとなる。そしてシリンジ（１０）の加圧を止めた瞬間に無菌ガス（１２）が無菌ガス流通溝（８）を介して薬液流通管（６）に流入し、薬液流通管（６）の無菌ガス流通溝（８）が配置された位置から薬液吐出ノズル（４）の中のフィブリノゲン溶液およびトロンビン溶液が排出される。このように、薬液吐出ノズル（４）内のフィブリノゲン溶液が排出されるため、薬液吐出ノズル（４）内でフィブリノゲン溶液が凝固し詰まりを発生させることがなく、塗布休止後の再使用が可能となる。
尚、詰まりは比較的粘度の高いフィブリノゲン溶液が吐出される側の薬液吐出ノズル（４）で生じる場合が大半であり、トロンビン溶液側の薬液流通管（６）に無菌ガス流通溝（８）は必ずしも必要ではなく、フィブリノゲン溶液が流通する薬液流通管（６）を限定可能であれば、最低限フィブリノゲン溶液が流通する薬液流通管（６）にのみ無菌ガス流通溝（８）設ければよい。
Next, with reference to FIG. 1, a specific method of using the biological tissue adhesive application tool of the present invention will be described assuming a case where a chemical solution (11) made of a fibrinogen solution thrombin solution is used.
First, the tips of the syringe (10) filled with the fibrinogen solution and the syringe (10) filled with the thrombin solution are respectively inserted into the chemical solution inlet (2) provided on the rear end side of the spray head body (1). Next, a sterile gas supply source is connected to the sterile gas inlet (3) via a sterile filter (9), and the flow rate and pressure are set to an appropriate level and held. In general, the tip of the spray head main body (1) is directed to the affected area to be hemostatic, and the plunger of the syringe (10) is pressed to pressurize, thereby the chemical liquid discharge nozzle (4) through the chemical liquid distribution pipe (6). The fibrinogen solution and the thrombin solution are discharged from the same, and simultaneously, the fibrinogen solution and the thrombin solution, which are sheared and mixed in the mist form by the sterile gas (12) ejected from the sterile gas outlet (5), are applied to the affected area and coagulated to stop hemostasis. Will be made. At the moment when the pressurization of the syringe (10) is stopped, the sterilized gas (12) flows into the chemical liquid flow pipe (6) through the sterile gas flow groove (8), and the sterile gas flow groove of the chemical liquid flow pipe (6). The fibrinogen solution and the thrombin solution in the chemical solution discharge nozzle (4) are discharged from the position where (8) is arranged. Thus, since the fibrinogen solution in the chemical solution discharge nozzle (4) is discharged, the fibrinogen solution does not coagulate in the chemical solution discharge nozzle (4) to cause clogging and can be reused after the application is stopped. Become.
The clogging is mostly caused by the chemical solution discharge nozzle (4) on the side where the relatively high fibrinogen solution is discharged, and the sterile gas flow groove (8) is provided in the chemical solution flow tube (6) on the thrombin solution side. If it is possible to limit the chemical solution distribution pipe (6) through which the fibrinogen solution flows, the sterile gas distribution groove (8) may be provided only in the chemical solution distribution pipe (6) through which the fibrinogen solution flows.
１ スプレーヘッド本体
２ 薬液注入口
３ 無菌ガス注入口
４ 薬液吐出ノズル
５ 無菌ガス噴出口
６ 薬液流通管
７ 被装管
８ 無菌ガス流通溝
９ 無菌フィルター
１０ シリンジ
１１ 薬液
１２ 無菌ガス
１３ 無菌ガス流通室
DESCRIPTION OF
Claims (1)
内部に無菌ガス流通室（１３）が形成され向かい合った平面が略三角形状のスプレーヘッド本体（１）と、
前記スプレーヘッド本体（１）の一方の平面に備えられ無菌ガス（１２）を前記無菌ガス流通室（１３）に注入可能な無菌ガス注入口（３）と、
前記スプレーヘッド本体（１）の後端部側に付設された２つの薬液注入口（２）と、
前記スプレーヘッド本体（１）の先端部側に付設された２つの薬液吐出ノズル（４）と、
前記各々の薬液吐出ノズル（４）に対して同軸且つ外周に略環状に配置され前記無菌ガス流通室（１３）と連通し無菌ガスを噴出する２つの無菌ガス噴出口（５）と、
を備え、
更に、前記無菌ガス流通室（１３）内において、前記２つの薬液注入口（２）と前記２つの薬液吐出ノズル（４）とを連結する２つの薬液流通管（６）と、前記２つの薬液流通管（６）を各々被装する少なくとも一つの被装管（７）とが形成されていると共に、前記薬液流通管（６）と前記被装管（７）との被装面の長軸方向に前記無菌ガス流通室（１３）と前記薬液流通管（６）内腔とを連通する少なくとも一つの無菌ガス流通溝（８）を有していることを特徴とする生体組織接着剤塗布用具。
A biological tissue adhesive applicator for mixing and spraying two types of chemicals,
A spray head body (1) in which a sterile gas circulation chamber (13) is formed and the opposing planes are substantially triangular;
A sterile gas inlet (3) provided on one plane of the spray head body (1) and capable of injecting a sterile gas (12) into the sterile gas flow chamber (13);
Two chemical liquid inlets (2) attached to the rear end side of the spray head body (1);
Two chemical liquid discharge nozzles (4) attached to the tip side of the spray head body (1);
Two aseptic gas jets (5) which are arranged coaxially with respect to each of the chemical solution discharge nozzles (4) and arranged in a substantially annular shape on the outer periphery thereof and which communicate with the aseptic gas circulation chamber (13) and eject aseptic gas;
With
Furthermore, in the aseptic gas circulation chamber (13), two chemical liquid flow pipes (6) connecting the two chemical liquid injection ports (2) and the two chemical liquid discharge nozzles (4), and the two chemical liquids At least one covered pipe (7) for covering the flow pipe (6) is formed, and the major axis of the mounting surface of the chemical liquid flow pipe (6) and the covered pipe (7) A biological tissue adhesive applicator characterized by having at least one sterile gas flow groove (8) communicating with the sterilized gas flow chamber (13) and the lumen of the chemical solution flow pipe (6) in a direction. .
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| WO2015004709A1 (en) * | 2013-07-08 | 2015-01-15 | テルモ株式会社 | Application tool |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001238887A (en) * | 2000-02-28 | 2001-09-04 | Sumitomo Bakelite Co Ltd | Instrument for applying tissue adhesive |
| JP2007252880A (en) * | 2006-02-22 | 2007-10-04 | Sumitomo Bakelite Co Ltd | Biological tissue adhesive applicator |
| JP2009131590A (en) * | 2007-11-08 | 2009-06-18 | Terumo Corp | Applicator |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001238887A (en) * | 2000-02-28 | 2001-09-04 | Sumitomo Bakelite Co Ltd | Instrument for applying tissue adhesive |
| JP2007252880A (en) * | 2006-02-22 | 2007-10-04 | Sumitomo Bakelite Co Ltd | Biological tissue adhesive applicator |
| JP2009131590A (en) * | 2007-11-08 | 2009-06-18 | Terumo Corp | Applicator |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2015004709A1 (en) * | 2013-07-08 | 2015-01-15 | テルモ株式会社 | Application tool |
| JPWO2015004709A1 (en) * | 2013-07-08 | 2017-02-23 | テルモ株式会社 | Applicator |
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