JP2741323B2 - Tube for applying biological tissue adhesive - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a biological tissue adhesive which is inserted into deep luminal tissues of a living body such as the stomach, intestine and bronchus using an endoscope and is used for bonding wounds of the living tissue. The present invention relates to an application tube.

[0002]

2. Description of the Related Art Conventionally, as a tube for applying a biological tissue adhesive of this kind, two liquid flow paths are provided so as to vertically pass through a tube main body, and a syringe connecting member is provided at a base end side of each of the two liquid flow paths. Those with were known. This tube contains two components that coagulate when mixed (eg, XII
A solution containing factor I and fibrinogen and a solution containing thrombin) are injected into the wound of the living tissue in a state where they are not mixed with each other, and applied while being mixed at the wound site without surgery. This is extremely effective in that deep luminal tissue of a living body can be treated.

[0003] The above two liquids have specific viscosities. Even if the two liquids are pressure-fed using a syringe, they are only ejected in a rod-like shape from the tip ejection port of the tube main body, or are extruded in a curtain shape. Fluid does not reach depending on the location of the wound in the tissue,
Application was difficult, and it was difficult to apply evenly and uniformly to the wound. In addition, during the application to the wound, if the operation is temporarily stopped and resumed after a short time, the liquid remaining in the ejection port at the first application will coagulate by the time the operation is resumed, and the ejection port May be blocked, and subsequent coating may not be possible.

Accordingly, the applicant of the present application has disclosed that at least one liquid flow path is provided in addition to the two liquid flow paths provided so as to pass through the tube main body.
We have proposed a tube for applying a biological tissue adhesive in which two gas channels are provided and two liquids can be ejected in a spray form while being entrained in a gas. As a result, it has become possible not only to apply the composition at any position of the wound of the living tissue, but also to apply the composition uniformly to the wound. Moreover,
Since the liquid is blown off by the gas, a part of the liquid does not remain at the liquid ejection port, so that it is possible to stop once during the coating operation and restart the operation after a short time.

[0005]

However, the gas ejected in the form of a spray while entraining two liquids is diffused in the ejecting direction, but the diffusion angle is always constant, so that the wound of the living tissue is not affected. It was necessary to change the diffusion angle depending on the size or the distance between the ejection port and the wound.

An object of the present invention is to solve the above-mentioned problem, and a novel liquid-jet nozzle having an optimum diffusion angle can be obtained when two liquids are ejected in the form of a spray while being entrained in a gas. An object of the present invention is to provide a tube for applying a biological tissue adhesive.

[0007]

Means for Solving the Problems In order to achieve this object, the present invention includes two liquid flow path stringer the tube body, it is provided at least one gas flow path, of the liquid flow path the syringe connecting member proximally of the gas flow path
The base end side each comprise an air source connection members, and, prior to
Feed the liquid through the liquid flow path to the distal end of the tube body.
Gas to be sent out through the gas flow path
And the liquid
A tube for applying a biological tissue adhesive is provided, which is provided with a tubular hood for restricting the ejection angle of the gas .

[0008]

According to the present invention, the tube body is inserted from the distal end to the wound of the deep lumen tissue of the living body such as the stomach, intestine and bronchus while using the endoscope. And an air source connection member provided on the base end side of at least one gas flow path,
Each syringe, which is connected to an air source and has two components that coagulate when mixed, is connected to a syringe connection member. Thereafter, both fluids are injected from both syringes toward the wound of the luminal tissue, and at the same time, air is opened and air is blown. As a result, the two solutions having a certain degree of viscosity are also entangled and blown off by this, but due to a hood that regulates the diffusion angle, the diffusion state is unlimitedly spread,
Without narrowing, it adheres evenly and uniformly to the wound in accordance with the size of the wound in the living tissue or the relationship between the distance between the spout and the wound.

[0009]

Next, an embodiment of the present invention will be described with reference to the drawings. FIG. 1 is a configuration diagram of a tube for applying a biological tissue adhesive according to an embodiment of the present invention, FIG. 2 is an enlarged cross-sectional view of a tube main body, and FIGS. It is an expanded sectional view of.

The tube body 10 shown in FIGS. 1 to 3 has two liquid channels 11 and 12 and one gas channel 13. The tube body 10 is made of a resin material having a bending strength such as polyvinyl chloride, polypropylene, and polyethylene. In this case, as shown in FIG. 2, it is manufactured by an extrusion method as having two holes for the liquid flow path and one hole for the gas flow path in the cross section. Needless to say, it may be manufactured such that the single tube and the single tube for the gas channel are integrated and integrated.

The outer diameter of the tube body 10 is preferably about 5 mm, and when three liquid passages 11 and 12 and three gas passages 13 are provided in the cross section, the inner diameter of each tube is set to about 0.7 mm. Is preferred. However, the present invention is not limited to this numerical value. Note that the liquid flow paths 11, 12
Need to have the same diameter in order to inject two liquids in the same amount, but the gas flow path does not necessarily have to have the same diameter as the liquid flow path.

Syringe connecting members 14 and 15 are provided at the base ends of the liquid flow paths 11 and 12, respectively. The syringe connection members 14 and 15 are configured such that a tapered connection end St protruding from an end face of the syringe S can be directly connected. An air source connection member 16 is provided at the base end side of the gas flow path 13 so that the output tube end At extending from the air source A can be directly connected.

A hood 17 is provided on the distal end side of the tube body 10, that is, on the outer periphery of the liquid ejection ports 11a and 12a and the gas ejection port 13a, and regulates the ejection angle of gas ejected while involving two liquids. . That is, FIG.
(A) shows a straight hood that matches the outer diameter of the tube body. This forms an optimal diffusion state according to the size of the wound in the living tissue H.

FIG. 3B shows a cone-shaped hood narrowed down in the jetting direction. This is effective when it is desired to fly the two liquids far, such as when the distal end of the tube main body cannot be inserted near the wound of the living tissue H.

The regulating hood 17 is made of a thin material that does not deform when inserted into a living body, for example, a material having a bending strength such as high-density polyethylene. The tube body 10 may be attached to the tube body 10 with an adhesive or by mechanical coupling. Also, as shown in FIG. 3C, the tube body 10 may be provided so as to be movable in the axial direction so that the amount of protrusion of the hood 17 from the distal end surface of the tube body 10 can be selected with one touch.

Next, the specific operation of the tube for applying a biological tissue adhesive according to this embodiment will be described. First, the tube main body 10 is inserted by using an endoscope toward a wound of a deep lumen tissue of a living body such as a stomach, an intestine, or a bronchus. Thereafter, the terminal of the air output tube extending from the air source A is connected to the air source connection member 16 provided on the base end side of the gas flow path 13. Then, two components that coagulate when mixed (for example, the above-mentioned first solution containing factor XIII and fibrinogen and the second solution containing thrombin) are taken into each syringe S, and the syringe S is tapered to its taper. Connecting members 14 and 15 provided on the base end sides of the two liquid flow paths via the cylindrical connection end St, respectively.
Connect to

When the preparatory work is completed, the two syringes are operated in parallel to pour both liquids separately through the liquid flow paths 11 and 12 while looking through the endoscope, and at the same time, the valve Av of the air source A is opened. Open and pressurized air is injected through the gas flow path 13. As a result, the air is regulated by the hood 17 from the air outlet at the tip of the tube body 10 and is sprayed in a diffused manner, so that the two liquids fly as if being entrained in this. Therefore, the two liquids are sprayed in a diffused manner to the wound while being mixed, so that they are uniformly and uniformly applied to the wound.

In addition, the two liquids which are entangled in the air and jetted out do not remain at the jetting port because they are blown off by the air even if the coating is once stopped during the jetting. Therefore,
While the application operation is stopped, the two liquids do not mix and coagulate near the ejection port, and the ejection port is not blocked, so that the application operation can be continuously performed thereafter.

In the present embodiment, two liquid flow paths,
Although the description has been given of the case where a total of three flow paths are provided with one gas flow path, the present invention is not limited to this, and two liquid flow paths and two gas flow paths may be used, or a total of four flow paths may be provided. May be more than that.

[0020]

As described above, the tube for applying a biological tissue adhesive according to the present invention is provided with two liquid flow paths vertically passing through the tube body and at least one gas flow path.
A syringe connecting member on the base end side of the liquid flow path ,
Each includes <br/> the air source connecting member to the proximal end side of the gas passage, and the liquid flow on the distal side of the tube body
The liquid sent out through the passage is sent through the gas passage.
The space becomes a space to be caught in the gas
Because characterized in that a cylindrical hood for restricting the ejection angle of the gas involving liquid, with the two liquids to clot when mixed can separately injected respectively toward the wound of living tissue, these two solutions Of the wound
Can be evenly distributed according to the size
This is an excellent effect .

[Brief description of the drawings]

FIG. 1 is a configuration diagram of a tube for applying a biological tissue adhesive according to an embodiment of the present invention.

FIG. 2 is an enlarged sectional view of a tube main body.

FIGS. 3A, 3B, and 3C are enlarged cross-sectional views showing a regulation hood.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 10 Tube main body 11 Liquid flow path 11a Spout port 12 Liquid flow path 12a Spout port 13 Gas flow path 13a Spout port 14 Syringe connection member 15 Syringe connection member 16 Air source connection member 17 Hood S Syringe St Connection terminal A Air source At output tube End Av Valve H Living tissue

Claims (1)

(57) [Claims] And 1. A two liquid flow path stringer the tube body, it is provided at least one gas passage, the syringe connecting member to the base end side of the liquid flow passage, the air passage
The base end side each comprise an air source connection members, and, prior to
Feed the liquid through the liquid flow path to the distal end of the tube body.
Gas to be sent out through the gas flow path
And the liquid
A tube for applying a biological tissue adhesive, comprising a cylindrical hood for restricting a jet angle of gas .