JPH0557009A - Atomizer for living body bonding agent - Google Patents

Atomizer for living body bonding agent

Info

Publication number
JPH0557009A
JPH0557009A JP3244425A JP24442591A JPH0557009A JP H0557009 A JPH0557009 A JP H0557009A JP 3244425 A JP3244425 A JP 3244425A JP 24442591 A JP24442591 A JP 24442591A JP H0557009 A JPH0557009 A JP H0557009A
Authority
JP
Japan
Prior art keywords
air
tube
chemical
section
passage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3244425A
Other languages
Japanese (ja)
Other versions
JP3060644B2 (en
Inventor
Masahiko Mishima
雅彦 三島
Takahide Okamoto
隆英 岡本
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissho Corp
Original Assignee
Nissho Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissho Corp filed Critical Nissho Corp
Priority to JP3244425A priority Critical patent/JP3060644B2/en
Publication of JPH0557009A publication Critical patent/JPH0557009A/en
Application granted granted Critical
Publication of JP3060644B2 publication Critical patent/JP3060644B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Materials For Medical Uses (AREA)
  • Surgical Instruments (AREA)

Abstract

PURPOSE:To enable forceps or the like to be inserted via an introduction tube by connecting a chemical atomizing section to one end of a flexible tube having one air passage and two chemical passages separately formed, and an air supply section and a chemical feed syringe respectively to the other end of the tube in an atomizer used for operation or the like in a peritoneal cavity. CONSTITUTION:An air passage section 18 and chemical passage sections 21 and 22, are separately formed, thereby constituting a flexible tube 2. Also, a chemical atomizing section 1 comprising a division 13, bottom sections 14 at both sides thereof, a chemical flow outlet 16 and an air blowing outlet 17 is connected to one end of the flexible tube 2. Also, an air feed section 3 is connected to the air passage section 18, and respective syringes 4 are connected to the chemical passage sections 21 and 22 at the other end of the tube 2.

Description

【発明の詳細な説明】Detailed Description of the Invention

【0001】[0001]

【産業上の利用分野】本発明は生体接着剤用噴霧器に関
する。さらに詳しくは、腹腔内等における内視鏡使用に
よる手術に好適な生体接着剤用噴霧器に関する。
FIELD OF THE INVENTION The present invention relates to a bioadhesive atomizer. More specifically, the present invention relates to a bioadhesive sprayer suitable for surgery using an endoscope in the abdominal cavity or the like.

【0002】[0002]

【従来の技術】従来より生体接着剤用噴霧器としては、
たとえば、第XIII因子およびフィブリノ―ゲンを含有す
る溶液とトロンビン含有溶液の二液を噴霧して混合する
いわゆるスプレ―タイプのものが知られているが、これ
は薬液噴霧部を空気供給部およびシリンジの先端に直結
したものであり、開腹手術等の如く体外での手術におい
て、生体から胆嚢等を剔出後、該剔出部に生体接着剤を
噴霧して止血を行なうことを考慮したものである(特開
昭64-25843号公報および特開昭64-40040号公報参照)。
2. Description of the Related Art Conventionally, as a spray for bioadhesives,
For example, a so-called spray type of spraying and mixing two solutions of a solution containing factor XIII and fibrinogen and a thrombin-containing solution is known, which is a chemical solution spraying section with an air supply section and a syringe. It is directly connected to the distal end of the body, and it is considered to perform hemostasis by exfoliating the gallbladder etc. from the living body and then spraying a bioadhesive to the extruding portion in external surgery such as laparotomy. (See JP-A-64-25843 and JP-A-64-40040).

【0003】[0003]

【発明が解決しようとする課題】ところが、最近、従来
の外科的開腹術に比べ患者への侵襲が少なく回復が早い
等の利点を有する内視鏡使用による手術方法が開発され
ている。ところが、前記噴霧器では、噴霧部が空気供給
部およびシリンジの先端に直接接続されているため、該
噴霧器を内視鏡に接続して使用することができないとい
う問題があった。
However, recently, a surgical method using an endoscope has been developed which has advantages such as less invasion to a patient and quicker recovery than conventional surgical laparotomy. However, in the above nebulizer, since the nebulizer is directly connected to the air supply unit and the tip of the syringe, there is a problem that the nebulizer cannot be used by being connected to the endoscope.

【0004】本発明は、かかる事情に鑑み、腹腔内等で
の内視鏡使用による手術において、鉗子等の導入管より
腹腔部まで挿入できる生体接着剤用噴霧器を提供するこ
とを目的とする。
In view of such circumstances, it is an object of the present invention to provide a bio-adhesive sprayer which can be inserted into the abdominal cavity from an introducing tube such as forceps in an operation using an endoscope in the abdominal cavity or the like.

【0005】[0005]

【課題を解決するための手段】本発明の生体接着剤用噴
霧器は、1つの空気通路および少なくとも2つの薬液通
路が個別に形成された可撓性チュ―ブと、該可撓性チュ
―ブの一端に設けられた薬液噴霧部と、前記可撓性チュ
―ブの他端に接続されており、前記空気通路に空気を供
給するための空気供給部および前記薬液通路に薬液を供
給するためのシリンジとからなることを特徴とする。
SUMMARY OF THE INVENTION A bioadhesive atomizer of the present invention comprises a flexible tube in which one air passage and at least two chemical liquid passages are individually formed, and the flexible tube. And a chemical liquid spraying portion provided at one end of the flexible tube and an air supplying portion for supplying air to the air passage and a chemical liquid to the chemical liquid passage. And a syringe.

【0006】[0006]

【作用】本発明では、内視鏡の鉗子等の導入管から噴霧
部の先端を挿入すると、チュ―ブの可撓性により、何ら
抵抗なく噴霧部の先端を生体剔出箇所まで到達させるこ
とができる。この状態で噴霧部に空気および薬液を供給
すると、剔出箇所に生体接着剤が噴霧され該剔出箇所の
止血をすることができる。また、止血すべき剔出箇所の
位置に応じてチュ―ブを所望の長さに設定することがで
きる。
In the present invention, when the tip of the spray section is inserted from the introduction tube such as the forceps of the endoscope, the flexibility of the tube allows the tip of the spray section to reach the living body ejection point without any resistance. You can When air and a chemical solution are supplied to the spraying part in this state, the bioadhesive is sprayed on the extruded part and the hemostasis of the extruded part can be stopped. In addition, the tube can be set to a desired length according to the position of the bleeding site where hemostasis is to be performed.

【0007】[0007]

【実施例】つぎに本発明の実施例を説明する。図1には
本発明の一実施例である生体接着剤用噴霧器Aが示され
ている。この生体接着剤用噴霧器Aは、概略的には、噴
霧部1、チュ―ブ2、空気供給部3およびシリンジ4か
ら構成されている。
EXAMPLES Next, examples of the present invention will be described. FIG. 1 shows a bioadhesive sprayer A which is an embodiment of the present invention. The bio-adhesive sprayer A is roughly composed of a spraying section 1, a tube 2, an air supply section 3 and a syringe 4.

【0008】前記噴霧部1は、先端の薬液噴霧部11と該
薬液噴霧部11と一体形成された円柱体の内部に空気通路
および薬液通路が個別に形成された空気薬液通路部12と
から構成されている。図2〜図5に示されるように、薬
液噴霧部11は、円柱体の一端を次の如く成形したもので
ある。すなわち、円柱体の軸方向においては、横断面が
略逆T字形となるように中央に仕切板13を形成し、該中
央仕切板13の両側には中央仕切板13と垂直な底面14が形
成されている。また、円柱体の軸方向に垂直な方向にお
いては、前記中央仕切板13と底面14に垂直な背面15が形
成されている。そして、底面14には薬液流出口16が、背
面15には空気吹出口17が中央仕切板13の両側にそれぞれ
形成されている。
The spraying section 1 is composed of a chemical spraying section 11 at the tip and an air chemical solution passage section 12 in which an air passage and a chemical solution passage are individually formed inside a cylindrical body integrally formed with the chemical spraying section 11. Has been done. As shown in FIGS. 2 to 5, the chemical liquid spraying portion 11 is formed by molding one end of a cylindrical body as follows. That is, in the axial direction of the columnar body, a partition plate 13 is formed in the center so that the cross section has a substantially inverted T shape, and a bottom surface 14 perpendicular to the center partition plate 13 is formed on both sides of the center partition plate 13. Has been done. Further, in the direction perpendicular to the axial direction of the columnar body, the central partition plate 13 and the back surface 15 perpendicular to the bottom surface 14 are formed. A chemical solution outlet 16 is formed on the bottom surface 14, and an air outlet 17 is formed on the back surface 15 on both sides of the central partition plate 13.

【0009】また、空気薬液通路部12には、円柱体の内
部上方に空気通路18と空気溜19と該空気溜19の空気を二
分割する2本の空気通路20が形成されており、さらに円
柱体の内部下方には薬液通路21が形成されている。そし
て、空気通路20の先端は前記空気吹出口17を、薬液通路
21の先端は前記薬液流出口16をそれぞれ形成している。
なお、空気溜19は直方体であり、空気通路18から流入し
た空気を一旦蓄えた後該空気を二分割するものである
が、空気に乱流を起こさせることにより、空気によって
噴霧される二液の流れに乱れを生じさせ、その結果二液
が良く混じり合うようにする働きを有している。
Further, in the air chemical liquid passage portion 12, an air passage 18, an air reservoir 19 and two air passages 20 for dividing the air in the air reservoir 19 into two are formed above the inside of the cylindrical body. A chemical liquid passage 21 is formed below the inside of the cylindrical body. The tip of the air passage 20 is connected to the air outlet 17 and
The tips of 21 respectively form the chemical liquid outlets 16.
It should be noted that the air reservoir 19 is a rectangular parallelepiped, which temporarily stores the air that has flowed in from the air passage 18 and then divides the air into two parts. Has the function of causing turbulence in the flow of the liquid and, as a result, allowing the two liquids to mix well.

【0010】上記噴霧部1の材質としては、生体適合性
が高く、加工性に優れているものであればよく、たとえ
ばポリプロピレン、ポリエチレン、ABS樹脂、ポリ塩
化ビニ―ル、ポリエステル、ポリスチレン等の熱可塑性
樹脂やステンレス等の金属が用いられる。
The spray section 1 may be made of any material as long as it has high biocompatibility and excellent workability, such as polypropylene, polyethylene, ABS resin, polyvinyl chloride, polyester, polystyrene or the like. A metal such as a plastic resin or stainless steel is used.

【0011】噴霧部1の後端には、外径約3〜15mm、長
さ約 300〜 500mmの円柱状の可撓性チュ―ブ2が接続さ
れている。該チュ―ブ2の内部は、図6に示されるよう
に空気通路18と2本の薬液通路21・22が、それぞれ軸方
向に貫通して形成されており、その先端が噴霧部1の空
気通路18と薬液通路21・22にそれぞれ接続されている
(図7参照)。噴霧部1とチュ―ブ2との接続は、図7
に示されるようにチュ―ブ2の先端を噴霧部1の後端に
差し込み、さらに適宜の接着剤等で固定して行なう。な
お、チュ―ブ2の太さおよび長さは用途に応じて任意に
選定することができ、また、該チュ―ブ2の薬液通路21
用の小孔を増加することにより三液または四液等の薬液
を混合することも可能である。さらに、空気通路18及び
薬液通路21・22は、図6に示すように円柱状のチュ―ブ
2内に形成したが、円筒状のチュ―ブの中空部分に後述
のエア―ライン31および薬液ライン41・42を挿通するよ
うにしてもよい。チュ―ブ2の材質としては、腹腔等へ
の挿入に際して容易に変形可能な柔軟性と、適当な剛性
を有するものが好適であり、たとえばポリエチレン
や、、軟質のポリ塩化ビニ―ル、ポリエステル、シリコ
―ンゴム、ポリウレタンゴム等の熱可塑性樹脂が好適で
ある。
A cylindrical flexible tube 2 having an outer diameter of about 3 to 15 mm and a length of about 300 to 500 mm is connected to the rear end of the spray section 1. As shown in FIG. 6, an air passage 18 and two chemical liquid passages 21 and 22 are formed axially through the inside of the tube 2, and the tip of the air passage 18 and the two chemical liquid passages 21 and 22 are formed in the spray section 1. It is connected to the passage 18 and the chemical liquid passages 21 and 22, respectively (see FIG. 7). The connection between the spray unit 1 and the tube 2 is shown in FIG.
As shown in FIG. 1, the tip of the tube 2 is inserted into the rear end of the spraying section 1 and further fixed with an appropriate adhesive or the like. The thickness and length of the tube 2 can be arbitrarily selected according to the application, and the chemical liquid passage 21 of the tube 2 can be selected.
It is also possible to mix chemical liquids such as three liquids or four liquids by increasing the number of small holes for use. Further, although the air passage 18 and the chemical liquid passages 21 and 22 are formed in the cylindrical tube 2 as shown in FIG. 6, the air line 31 and the chemical liquid which will be described later are provided in the hollow portion of the cylindrical tube. The lines 41, 42 may be inserted. The material of the tube 2 is preferably one that has a flexibility such that it can be easily deformed when it is inserted into the abdominal cavity or the like, and has an appropriate rigidity. For example, polyethylene, soft polyvinyl chloride, polyester, Thermoplastic resins such as silicone rubber and polyurethane rubber are suitable.

【0012】前記チュ―ブ2の後端の空気通路18には図
1に示されるようにエア―ライン31が接続され、該エア
―ライン31は、ジョイント32により別のエア―ライン33
を介して図示していない空気供給装置に接続されてお
り、これらが空気供給部3を構成している。そして、エ
ア―ライン33・31、空気通路18を通って空気が空気吹出
口17から放出されるようになっている。
An air line 31 is connected to the air passage 18 at the rear end of the tube 2 as shown in FIG. 1, and the air line 31 is connected to another air line 33 by a joint 32.
Is connected to an air supply device (not shown) via the, and these constitute the air supply unit 3. Then, the air is discharged from the air outlet 17 through the air lines 33, 31 and the air passage 18.

【0013】また、チュ―ブ2の後端の薬液通路21・22
には、薬液ライン41・42が接続され、該薬液ライン41・
42の後端は、シリンジ4の先端部43・44にそれぞれ接続
されている。前記シリンジ4は薬液筒45・46とプランジ
ャ―47・48によって構成された薬液供給手段である。薬
液筒45・46は、そのフランジ49・50の近傍において止め
具51により一体化されており、プランジャ―47・48は、
その終端部において止め具52により一体化されている。
また、チュ―ブ2とエア―ライン31および薬液ライン41
・42との接続は、図8に示されるようにエア―ライン31
および薬液ライン41・42の先端をそれぞれチュ―ブ2の
空気通路18及び薬液通路21・22の後端に差し込み、さら
に接着剤等で接着することにより固定されている。した
がって、医師等がシリンジ4のプランジャ―47・48を押
せば、一方の薬液は、薬液ライン41・薬液通路21を通っ
て、また他方の薬液は、薬液ライン42・薬液通路22を通
って、それぞれ薬液流出口16a 、16b から噴出する。そ
して、このとき、それぞれの薬液流出口16a 、16b から
噴出した薬液は空気吹出口17から噴出する空気によって
霧化されるとともに混合されて、生体接着剤として噴霧
される。なお、噴霧部1とチュ―ブ2を一体成形して一
ユニットとした構造であってもよい。
Further, the chemical liquid passages 21 and 22 at the rear end of the tube 2
The chemical liquid lines 41 and 42 are connected to the chemical liquid lines 41 and 42, respectively.
The rear ends of 42 are connected to the front ends 43 and 44 of the syringe 4, respectively. The syringe 4 is a liquid medicine supply means composed of liquid medicine cylinders 45 and 46 and plungers 47 and 48. The chemical liquid cylinders 45 and 46 are integrated by a stopper 51 in the vicinity of the flanges 49 and 50, and the plungers 47 and 48 are
It is integrated by a stopper 52 at its terminal end.
In addition, the tube 2 and the air line 31 and the chemical liquid line 41
・ Connect with 42 as shown in Fig. 8 Air line 31
The tip ends of the chemical liquid lines 41 and 42 are inserted into the rear ends of the air passage 18 and the chemical liquid passages 21 and 22 of the tube 2, respectively, and further fixed by bonding with an adhesive or the like. Therefore, if a doctor or the like pushes the plungers 47 and 48 of the syringe 4, one of the liquid medicines passes through the liquid medicine line 41 and the liquid medicine passage 21, and the other liquid medicine passes through the liquid medicine line 42 and the medicine liquid passage 22, It is ejected from the chemical liquid outlets 16a and 16b, respectively. Then, at this time, the chemical liquids ejected from the respective chemical liquid outlets 16a and 16b are atomized and mixed by the air ejected from the air outlet 17 and sprayed as a bioadhesive. Alternatively, the spraying section 1 and the tube 2 may be integrally formed into one unit.

【0014】つぎに、本実施例の生体接着剤用噴霧器A
の使用方法を説明する。まず、内視鏡の鉗子等の導入管
から噴霧部1の先端を挿入しチュ―ブ2の途中を手で持
ってゆっくり押し込む。そして、該噴霧部1の先端が生
体剔出箇所に到達したとき、シリンジ4のプランジャ―
47・48を止め具52を介して同時に押して二種類の薬液を
薬液流出口16a 、16b から噴出させるとともに、空気供
給装置から送られた空気を空気吹出口17から噴出させ、
薬液噴霧部11で薬液を霧状に混合して噴霧する。そうす
ることによって生体接着剤が生体剔出箇所に噴霧され、
止血を行なうことができる。さらに、噴霧後は、内視鏡
の鉗子等の導入管を通って容易に噴霧部1の先端を取り
出すことができるため、生体の内壁等を傷つけることも
ない。
Next, the bioadhesive atomizer A of this embodiment is used.
How to use is explained. First, the tip of the spraying section 1 is inserted from an introduction tube such as forceps of an endoscope, and the tube 2 is held in the middle by hand and pushed in slowly. Then, when the tip of the spraying section 1 reaches the living body ejection portion, the plunger of the syringe 4
47 and 48 are simultaneously pushed through the stopper 52 to eject two types of chemicals from the chemical outlets 16a and 16b, and the air sent from the air supply device is ejected from the air outlet 17.
The chemical liquid spraying section 11 mixes and sprays the chemical liquid in a mist state. By doing so, the bio-adhesive is sprayed on the living-body exfoliation site,
Hemostasis can be performed. Further, after the spraying, the tip of the spraying section 1 can be easily taken out through the introducing tube such as the forceps of the endoscope, so that the inner wall of the living body is not damaged.

【0015】[0015]

【発明の効果】本発明によれば、内視鏡使用による手術
において噴霧部の先端を腹腔内等の生体剔出箇所まで容
易に到達させて生体接着剤を噴霧することができるので
腹腔内等の剔出箇所の止血を簡単に行なうことができ
る。また、チュ―ブを所望の長さに選定することができ
るため、広範囲の内視鏡使用による手術に使用すること
ができる。
According to the present invention, in the operation using an endoscope, the tip of the spraying portion can easily reach the living body extruding portion such as the abdominal cavity and the bioadhesive can be sprayed. It is possible to easily stop the bleeding of the blood. In addition, since the tube can be selected to have a desired length, it can be used for surgery using a wide range of endoscopes.

【図面の簡単な説明】[Brief description of drawings]

【図1】本発明の一実施例にかかわる生体接着剤用噴霧
器の全体図である。
FIG. 1 is an overall view of a bioadhesive sprayer according to an embodiment of the present invention.

【図2】図1で示された生体接着剤用噴霧器の噴霧部の
斜視図である。
FIG. 2 is a perspective view of a spraying section of the bioadhesive sprayer shown in FIG.

【図3】図1で示された生体接着剤用噴霧器の噴霧部の
正面図である。
3 is a front view of a spraying section of the bioadhesive sprayer shown in FIG. 1. FIG.

【図4】図1で示された生体接着剤用噴霧器の噴霧部の
側面図である。
4 is a side view of a spraying section of the bioadhesive sprayer shown in FIG. 1. FIG.

【図5】図1で示された生体接着剤用噴霧器の噴霧部の
平面図である。
5 is a plan view of a spraying section of the bioadhesive sprayer shown in FIG. 1. FIG.

【図6】図1で示された生体接着剤用噴霧器のチュ―ブ
のVI−VI断面図である。
6 is a cross-sectional view of the tube of the bioadhesive sprayer shown in FIG. 1, taken along line VI-VI.

【図7】図1で示された生体接着剤用噴霧器の噴霧部と
チュ―ブの接続部断面図である。
FIG. 7 is a cross-sectional view of the connection between the spray section and the tube of the bioadhesive sprayer shown in FIG.

【図8】図1で示された生体接着剤用噴霧器のチュ―ブ
とエア―ライン及び薬液ラインの接続部断面図である。
8 is a cross-sectional view of the tube of the bioadhesive sprayer shown in FIG. 1 and a connecting portion of an air line and a chemical liquid line.

【符号の説明】[Explanation of symbols]

1 噴霧部 2 チュ―ブ 3 空気供給部 4 シリンジ 18 空気通路 21 薬液通路 22 薬液通路 1 Spraying unit 2 Tube 3 Air supply unit 4 Syringe 18 Air passage 21 Chemical liquid passage 22 Chemical liquid passage

Claims (1)

【特許請求の範囲】[Claims] 【請求項1】1つの空気通路および少なくとも2つの薬
液通路が個別に形成された可撓性チュ―ブと、該可撓性
チュ―ブの一端に設けられた薬液噴霧部と、前記可撓性
チュ―ブの他端に接続されており、前記空気通路に空気
を供給するための空気供給部および前記薬液通路に薬液
を供給するためのシリンジとからなることを特徴とする
生体接着剤用噴霧器。
1. A flexible tube in which one air passage and at least two chemical liquid passages are individually formed, a chemical liquid spraying portion provided at one end of the flexible tube, and the flexible tube. A bioadhesive, which is connected to the other end of the sex tube and comprises an air supply unit for supplying air to the air passage and a syringe for supplying a drug solution to the drug solution passage. Atomizer.
JP3244425A 1991-08-29 1991-08-29 Nebulizer for bioadhesive Expired - Fee Related JP3060644B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3244425A JP3060644B2 (en) 1991-08-29 1991-08-29 Nebulizer for bioadhesive

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3244425A JP3060644B2 (en) 1991-08-29 1991-08-29 Nebulizer for bioadhesive

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JPH0557009A true JPH0557009A (en) 1993-03-09
JP3060644B2 JP3060644B2 (en) 2000-07-10

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06205831A (en) * 1992-12-21 1994-07-26 Ishikawa Seisakusho:Kk Tube for application of in vivo tissue adhesive
US6960340B2 (en) 1993-03-23 2005-11-01 Focal, Inc Apparatus and method for local application of polymeric material to tissue
WO2006061883A1 (en) * 2004-12-07 2006-06-15 Nakanishi Inc. Biopolymer powder gelating/jetting apparatus
JP2008114060A (en) * 2006-10-18 2008-05-22 Ethicon Endo Surgery Inc Biosurgical adhesives used as expansive agent
JP2010075286A (en) * 2008-09-24 2010-04-08 Terumo Corp Applicator
JP2011120927A (en) * 1998-08-26 2011-06-23 Neomend Inc Composition, system, and method for creating in situ, chemically crosslinked, mechanical barrier or covering structure
WO2013046710A1 (en) * 2011-09-30 2013-04-04 住友ベークライト株式会社 Bioadhesive application tool and nozzle head
JPWO2015098465A1 (en) * 2013-12-27 2017-03-23 ニプロ株式会社 Spray head for biological drug-containing solution administration device

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06205831A (en) * 1992-12-21 1994-07-26 Ishikawa Seisakusho:Kk Tube for application of in vivo tissue adhesive
US6960340B2 (en) 1993-03-23 2005-11-01 Focal, Inc Apparatus and method for local application of polymeric material to tissue
US7037490B2 (en) 1993-03-23 2006-05-02 Genzyme Corporation Apparatus and method for local application of polymeric material to tissue
JP2011120927A (en) * 1998-08-26 2011-06-23 Neomend Inc Composition, system, and method for creating in situ, chemically crosslinked, mechanical barrier or covering structure
WO2006061883A1 (en) * 2004-12-07 2006-06-15 Nakanishi Inc. Biopolymer powder gelating/jetting apparatus
JP2008114060A (en) * 2006-10-18 2008-05-22 Ethicon Endo Surgery Inc Biosurgical adhesives used as expansive agent
JP2010075286A (en) * 2008-09-24 2010-04-08 Terumo Corp Applicator
WO2013046710A1 (en) * 2011-09-30 2013-04-04 住友ベークライト株式会社 Bioadhesive application tool and nozzle head
JPWO2015098465A1 (en) * 2013-12-27 2017-03-23 ニプロ株式会社 Spray head for biological drug-containing solution administration device

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