JP3474310B2 - Nozzle for spraying biological tissue adhesive - Google Patents

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a nozzle for spraying a biological tissue adhesive. More specifically, the present invention relates to a nozzle that applies an adhesive for adhering to living tissue, which is mainly composed of animal protein, to a human or an animal. The nozzle of the present invention is particularly suitable for treatment of lacerations and burns on the skin, hemostasis or skin transplantation.

[0002]

2. Description of the Related Art A biological tissue adhesive containing animal protein as a main component is formed by mixing a solution of a protein with a solution of a coagulation factor that promotes the clot formation of the protein. As this type of biological tissue adhesive, for example, one containing a solution containing factor XIII and fibrinogen and a thrombin-containing solution as two components is known, and is widely used as a biological tissue adhesive. .
As a method of applying the two components of these adhesives, different two components are stored in advance in two separate syringe bodies, and the two solutions stored in these syringe bodies are simultaneously poured out, A method of coating two solutions while mixing them has been proposed (Japanese Patent Laid-Open No. 64-25843).
JP, JP-A-64-40040, JP-A-5-5
No. 7009, No. 3-47609, No. 4-48198, No. 6-52839, etc.).

For example, in the device of Japanese Utility Model Publication No. 3-47609, the conical portions of two syringe bodies are connected by a collecting head including a conveyor flow path for each component of the biological tissue adhesive, and the plungers are operated integrally. By doing so, the solution is ejected from the two syringe bodies to the collecting head at the same time, and aseptic gas is supplied from the aseptic gas supply channel provided in the collecting head to be ejected to the collecting head.
It is designed to be able to spray the liquid in a mist state, and it is arranged so that the center lines of the spout of the aseptic gas supply channel intersect at a predetermined position in the front so that the adhesive can be applied in a wide range. Is characterized by. Also, the actual Kaihei 6-52839
The invention of the gazette is made by integrating two syringe bodies fitted with a spray head provided with a sterile gas supply passage, a small high-pressure cylinder and a pressure regulator, and connecting the spray head and the regulator with a tube, thereby reducing the size. ,
It is characterized by improved operability. In addition, JP-A-5
The invention of -57009 is a flexible tube provided with a drug solution spraying portion for application to surgery using an endoscope in the abdominal cavity or the like.

[0004]

However, in all of these conventional spray heads, when the nozzle of the spray head is bent, the inner cavity of the nozzle may be blocked (known as kink). When applying the bile duct to a complicated site in the body, the affected area had to be extirpated by surgery such as laparotomy and the adhesive had to be applied. The present invention has been made in view of such circumstances, and an object of the present invention is to provide a nozzle for spraying a biological tissue adhesive that does not cause kinking even when deformed according to the shape of an application site. Another object of the present invention is to provide a spray head that employs a biological tissue adhesive spray nozzle that does not cause kinks even when deformed.

[0005]

In order to solve the above-mentioned problems, the first invention of the present invention comprises a plastic tube which is bendable and deformable and which is provided with a plurality of ridges in the longitudinal direction of the lumen. A nozzle for spraying a living tissue adhesive is used which is composed of a bendable metal nozzle which is inserted into an inner cavity of a tube and supported by the plurality of ridges.
Here, in consideration of the spray state, it is preferable that the tip of the plastic tube is slightly projected from the tip of the metal nozzle, and the inner diameter of the projecting portion of the plastic tube tip is enlarged. Further, in consideration of coagulation of the chemical liquid at the tip of the spray nozzle, it is preferable that the tip of the metal nozzle be slightly projected from the tip of the plastic tube. Further, the second aspect of the present invention is a plastic tube that is bendable and deformable and has a plurality of ridges provided in the longitudinal direction of the inner cavity, and is inserted into the inner cavity of the tube and supported by the plurality of ridges. A spray head for a living tissue adhesive that includes a nozzle for spraying a living tissue adhesive that includes a metal nozzle that can be bent and deformed is adopted.
The spray head includes a spray head body and a biological tissue adhesive spray nozzle provided at the tip of the spray head body.
It can be configured to include a syringe connection part of a book, a gas supply source connection part in an intermediate part, and a spray nozzle connection part in a front end. The spray head main body consists of a chemical liquid passage that connects the inner cavity of the metal nozzle of the biological tissue adhesive spray nozzle with the inner cavity of the syringe connection part, and the plastic tube and metal nozzle of the biological tissue adhesive spray nozzle. It is preferable to have a gas passage communicating between the space formed in the above and the inner cavity of the gas supply source connecting portion.

[0006]

According to the first aspect of the invention, since no kink occurs when the nozzle for spraying the biological tissue adhesive is bent, the inner space of the metal nozzle and the space between the plastic tube and the metal nozzle. Is secured. That is,
Since the metal nozzle is made of a metal that can be bent and deformed, it does not cause a kink even when it is bent, and thus the inner cavity of the metal nozzle is secured. In addition, the space between the plastic tube and the metal nozzle is supported by the ridge of the plastic tube, and the space is defined by the inner wall of the plastic tube, the outer wall of the metal nozzle and the ridge. Therefore, even if the plastic tube is bent, a kink does not occur.

[0007]

Embodiments of the present invention will now be described with reference to the drawings. FIG. 1 is a vertical cross-sectional view according to an embodiment of the first invention, and FIG. 2 is a cross-sectional view taken along line XX of the biological tissue adhesive spray nozzle shown in FIG. 3 is a plan view according to an embodiment of the second invention, and FIG. 4 is a plan view of FIG.
5 is a partial cross-sectional enlarged plan view of the spray nozzle of FIG. 3, FIG. 6 is an enlarged cross-sectional view taken along line YY of FIG. 5, and FIG. 7 is a plan view of the base of the spray head main body of FIG. 8 is a sectional view taken along the line AA of FIG. 7, FIG. 9 is a sectional view taken along the line BB of FIG. 7, FIG. 10 is a plan view of the lid portion of the spray head body of FIG. 3, and FIG.
6 is a cross-sectional view taken along the line CC of FIG.

The living tissue adhesive spray nozzle 1 according to the first aspect of the present invention includes a plastic tube 11 and a metal nozzle 12 which is inserted and supported in an inner cavity 111 of the tube 11 and is bendable and deformable. It is a flexible nozzle. Plastic tube 11 and metal nozzle 1
2 is bendable and deformable, and a plurality of ridges 112 are provided in the inner wall of the tube 11 in the longitudinal direction.
2 supports the metal nozzle 12. When considering the spray state, the tip of the plastic tube 11 is
It is preferable to slightly project from the tip of the metal nozzle 12 and increase the inner diameter of the projected tip portion 113. Also,
In consideration of coagulation of the chemical liquid, the tip of the metal nozzle 12 may be slightly projected from the tip of the plastic tube 11.

The plastic tube 11 is a flexible and bendable tube made of soft plastic, and has a plurality of ridges 11 in the longitudinal direction (longitudinal direction) on its inner wall.
2 is provided, and its tip is preferably slightly projected from the tip of the inserted metal pipe 12, and the projected tip portion 113 is enlarged in diameter. When the inner diameter of the protruding tip portion 113 is rapidly expanded, the chemical solution is likely to be atomized. However, when it is used more than once, the chemical may coagulate at the tip of the spray nozzle 1, so that the coagulation of the chemical does not easily occur, and even if the chemical coagulates, the coagulated chemical For easy removal, the tip of the metal nozzle 12 may be slightly projected from the tip of the plastic tube 11. The ridge 112 is in close contact with the outer wall of the metal nozzle 12 inserted into the inner cavity 111 to support and fix it (if necessary, it may be fixed using an adhesive), and the living tissue adhesive This is to prevent kinks when the spray nozzle 1 is bent. Examples of the soft plastic material forming the tube 11 include polyethylene, olefin elastomer, styrene elastomer, silicone rubber,
Although ethylene-propylene copolymer, ethylene-polytetrafluoroethylene copolymer and the like can be suitably adopted,
From the viewpoint of flexibility and cost, polyethylene, olefin elastomers, and styrene elastomers are preferable.

The metal nozzle 12 is in the form of a pipe that can be bent and deformed, and is made of a highly ductile metal material for medical use, and preferably has a large plasticity. As such a metal material, stainless steel, particularly J
SUS316L specified in IS-G4303 is preferable, and when stainless steel is used, a pipe obtained in the manufacturing process of an injection needle is annealed at a high temperature of 200 ° C. or higher for 90 minutes or more.

Next, the spray head for a living tissue adhesive of the second invention will be described. As shown in FIGS. 3 and 4, the spray head according to the present invention includes a plastic tube 11 made of a bendable and deformable material having a plurality of ridges 112 provided in a longitudinal direction of an inner cavity 111, and the tube 1.
1. The spray nozzle 1 comprises a bendable metal nozzle 12 which is inserted into the inner cavity 111 and supported by a plurality of ridges 112. The spray nozzle includes a spray head main body 2 and the spray head main body 2. Nozzle 1 for spraying attached to the tip of 2 and two syringe connection parts 31 and 32 provided at the rear end of the spray head main body 2,
It is composed of a gas supply source connecting portion 4 provided at an intermediate portion of the spray head main body 2.

As shown in FIG. 5, the spray nozzle 1 has a bendable and deformable tube 11 made of soft plastic, such as polyethylene, and a bendable and deformable tube 11 inserted in an inner cavity 111 of the tube 11. Two nozzle parts 14, 15 consisting of a simple metal nozzle 12
And the nozzle portion 1 at the rear end of the nozzle portions 14 and 15.
It is composed of a connecting portion 13 to the spray head main body 2 which is integrally formed with the spray heads 4 and 15. In the longitudinal direction of the inner wall of the tube 11, as shown in FIG. 6, a plurality of protrusions 112 for supporting and fixing the metal nozzle 12 and securing a space between the inner wall of the tube 11 and the metal nozzle 12 are provided. The tip of the tube 11 is preferably a metal nozzle 1
2 is slightly protruded from the tip of the second end, and the inner diameter of the protruding tip portion 113 is enlarged at an appropriate angle. The rapidly ejected chemical liquid becomes a mist due to the relative negative pressure when it goes out into a wide space, but the mist becomes easier as the angle increases. However, in consideration of the coagulation of the chemical liquid at the tip of the spray nozzle 1, the tip of the metal nozzle 12 may be slightly projected from the tip of the tube 11.

As shown in FIGS. 7 to 11, the spray head main body 2 is a housing composed of a base portion 21 and a lid portion 22, and is made of plastic such as polyethylene, polypropylene, polyester, ABS resin or the like. Further, the rear end is provided with two syringe connection parts 31 and 32, the intermediate part is provided with the gas supply source connection part 4, and the front end is provided with the spray nozzle connection part 5. As shown in FIGS. 7 to 9, the base portion 21 includes the inner cavities of the metal nozzles 12 of the two nozzle portions 14 and 15 of the spray nozzle 1 and the inner cavities 33 and 34 of the syringe connection portions 31 and 32. Are provided via the chemical liquid passages 51 and 52 of the spray nozzle connecting portion 5, respectively, and the tube 1 of the nozzle portions 14 and 15 of the spray nozzle 1 is provided.
A gas passage 25 is provided that connects a space between the inner wall 1 and the metal nozzle 12 to the gas supply source connecting portion 4 via the gas passage 53 and the space 26 of the spray nozzle connecting portion 5. On the other hand, the mouth portion 41 of the gas supply source connection portion 4 is opened in the lid portion 22, and aseptic gas from a gas supply source (not shown) enters the space 26 formed between the base portion 21 and the lid portion 22. The gas is supplied to the spray nozzle 1 through the gas passages 25 and 53.

Next, the use of the spray head of the present invention will be described. First, the tips (not shown) of two syringes respectively containing two different components are attached to the syringe connection portions 31 and 32 of the biological tissue adhesive spray head, and a gas cylinder (for example, a gas cylinder () is attached to the gas supply source connection portion. Gas source (not shown).
Next, if the nozzle portions 14 and 15 of the spray nozzle 1 are deformed into an appropriate shape according to the shape of the application site and the plunger of the syringe is pushed while the sterile gas is being supplied to eject the two liquid chemicals, the two liquid chemicals It is atomized, mixed and applied.

[0015]

As is apparent from the above description, by adopting the biological tissue adhesive spray nozzle of the present invention, the shape of the spray nozzle can be changed according to the shape of the application site. Therefore, when applying the biological tissue adhesive to a complicated site, it is not necessary to perform surgery such as squeezing out the application site due to surgery, etc., and it is possible to greatly save the labor of the medical staff and the pain of the patient. It can be reduced significantly. Also, the operation of applying the adhesive is easy.

[Brief description of drawings]

FIG. 1 is a vertical sectional view according to an embodiment of the present first invention.

FIG. 2 is a cross-sectional view taken along line XX of the biological tissue adhesive spray nozzle shown in FIG.

FIG. 3 is a plan view according to an embodiment of the second invention.

FIG. 4 is a side view of FIG.

5 is a partially enlarged cross-sectional plan view of the spray nozzle of FIG.

6 is an enlarged cross-sectional view taken along line YY of FIG.

7 is a plan view of the base of the spray head body of FIG.

8 is a cross-sectional view taken along the line AA of FIG.

9 is a cross-sectional view taken along the line BB of FIG.

10 is a plan view of a cover portion of the spray head main body of FIG. 3.

11 is a sectional view taken along line CC of FIG.

[Explanation of symbols]

Nozzle for 1 spray 11 plastic tubes 12 Metal nozzle 112 ridges 2 spray head body 23, 24 chemical passage 25 gas passage 31, 32 Syringe connection part 4 Gas supply connection 5 Spray nozzle connection 51, 52 chemical passage 53 gas passage

Continuation of front page (56) Reference JP-A-57-19069 (JP, A) JP-A-6-205831 (JP, A) JP-A-8-19619 (JP, A) JP-A-6-277290 (JP , A) Jitsukaihei 6-52839 (JP, U) Japanese Patent Publication 3-71894 (JP, B2) International Publication 94/07420 (WO, A1) (58) Fields investigated (Int.Cl. ⁷ , DB name) ) B05B 1/00-1/36 A61L 26/00

Claims (6)

(57) [Claims] 1. A plastic tube that is bendable and deformable and has a plurality of ridges provided in the longitudinal direction of the inner cavity.
A nozzle for spraying a biological tissue adhesive, comprising a bendable metal nozzle that is inserted into the inner cavity of the tube and is supported by the plurality of ridges. 2. The spray nozzle according to claim 1, wherein the tip of the plastic tube is slightly projected from the tip of the metal nozzle, and the inner diameter of the projecting portion of the tip of the plastic tube is enlarged. 3. The spray nozzle according to claim 1, wherein the tip of the metal nozzle slightly projects from the tip of the plastic tube. 4. A biological tissue adhesive spray head comprising the biological tissue adhesive spray nozzle according to claim 1. 5. A spray head main body and a biological tissue adhesive spray nozzle provided at the tip of the spray head main body, the spray head main body having two syringe connecting portions at the rear end, and an intermediate portion. 5. The spray head according to claim 4, further comprising a gas supply source connecting part, and a spray nozzle connecting part at a front end. 6. A spray head main body, two drug solution passages connecting the inner cavity of a metal nozzle of a living tissue adhesive spray nozzle and the inner cavity of a syringe connection portion, and a plastic of the living tissue adhesive spray nozzle. The spray head according to claim 5, further comprising a gas passage that connects a space formed between the tube made of metal and the nozzle made of metal and an inner cavity of the gas supply source connecting portion.