JP2789298B2 - Tube for applying biological tissue adhesive - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a living tissue bonding method for inserting a deep lumen tissue of a living body, such as the stomach, intestine, or bronchus, using an endoscope to bond a wound of the living tissue. The present invention relates to an agent application tube.

[0002]

2. Description of the Related Art Conventionally, as a tube for applying a living tissue adhesive of this kind, two fluid discharge passages are provided so as to vertically pass through a tube main body, and a syringe connecting member is provided at each base end side of the two liquid discharge passages. Are provided so that the two liquids can be ejected toward the wound. The tube contains two components that coagulate when mixed (eg, a solution containing factor XIII and fibrinogen,
A solution containing thrombin) is injected into the wound of the living tissue in a state where they are not mixed with each other, and the mixture is applied while being mixed at the wound site, and the deep lumen tissue of the living body can be treated without performing surgery. Is extremely effective.

[0003] The above two liquids have specific viscosities, and even if they are pumped using a syringe, they are only ejected in a rod-like form from the tip ejection port of the tube main body, or are discharged in a curtain-like manner. Depending on the position of the wound in the tissue, the solution did not reach and application became difficult, and it was difficult to apply the wound evenly and uniformly. Also, if you temporarily suspend the application of the wound and resume the work after a while,
There is a risk that the liquid remaining at the time of the first coating will agglomerate by the time the work is resumed, blocking the discharge port, making it impossible to perform subsequent coating.

In view of this, the present applicant has previously provided at least one gas ejection passage in addition to the two fluid ejection passages so as to vertically pass through the tube main body, and provided a base end side of each of the two liquid ejection passages. The present invention has proposed a living tissue adhesive application tube in which a syringe connecting member is provided, and an air source connecting member is provided at the base end side of the gas ejection path, so that the two liquids can be ejected in a spray form while being wound into a gas. . With this tube, not only can any one of the wounds of the living tissue be applied, but also it becomes possible to apply the wound uniformly and evenly. In addition, since the liquid is blown off by the gas, a part of the liquid does not remain at the liquid ejection port, so that it is possible to stop once during the coating operation and start the operation after a short time.

[0005]

However, in the above-mentioned tube for applying a living tissue adhesive, the adhesive discharged from the two fluid flow paths that vertically pass through the tube main body is used for the gas ejected from one gas flow path. The method of jetting while entraining by a jet stream can achieve a much better uniform coating than the conventional method of discharging only the liquid, but the adhesive cannot be entrained without pumping high-pressure gas. The particle size distribution is not uniform. There were problems such as that the main direction of spray did not match the axial direction of the tube.

SUMMARY OF THE INVENTION In view of the above, the present invention provides a living body capable of ejecting a uniform spray in the axial direction of a tube by relatively low-pressure gas when two kinds of liquids are ejected in the form of a spray while being entrained in a gas. It is intended to provide a tube for applying a tissue adhesive.

[0007]

In order to achieve the above object, the living tissue adhesive application tube according to the first aspect of the present invention comprises at least two liquid discharge paths, and a gas discharge path coaxial with each liquid discharge path. With. In the tube for applying a living tissue adhesive according to claim 2, the liquid discharge path has a circular discharge port, and the gas discharge path has a substantially annular discharge port outside the circular discharge port. In a third aspect of the present invention, the gas ejection path has a circular ejection port, and the liquid ejection path has a substantially annular ejection port outside the circular ejection port.

In the tube for applying a living tissue adhesive according to a fourth aspect of the present invention, a shape-retaining wire is vertically embedded in a thick portion of the main body of the tube. The tube for applying a biological tissue adhesive according to claim 5,
The liquid discharge path and the gas ejection path are formed by integral plastic molding.

[0009]

According to the first aspect, the liquid discharged from the liquid discharge port is entrained by the gas discharged from the gas discharge port in the same direction as the liquid, so that a spray having a uniform distribution is formed.
In the second aspect, the liquid discharged from the circular discharge port is mixed with the surrounding air jet jetted from the annular jet port to form a spray having a narrow angle and excellent directivity. In claim 3, the liquid jetted from the annular jet port is mixed with the air jet jetted from the central circular jet port to form a spray having a wide angle and excellent uniformity.

[0010] In claim 4, the posture of the tube main body bent in a desired direction is maintained by the shape retaining wire. In claim 5, the tube body is continuously manufactured in an unmanned process.

[0011]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below with reference to an embodiment based on the attached drawings. In the figure, a body 1 of a tube for applying a living tissue adhesive according to the present invention is composed of a base material 2 made of a plastic round bar and two liquid ejection paths 3, 4 and two gas ejection paths 5, 6 vertically. It is configured through.

Here, the liquid discharge path 3 and the gas discharge path 5,
The liquid discharge path 4 and the gas discharge path 6 are coaxially configured at least at their outlets (the discharge port 3A and the discharge port 5B, and the discharge port 4A and the discharge port 6B). Further, the discharge ports 3A, 4A and the ejection ports 5B, 6B may be coaxial, and one of them is not required to be located inside or outside. That is, in the first embodiment of FIG. 1, the gas ejection ports 5B, 6B are located outside the liquid ejection ports 3A, 4A, and in the second embodiment of FIG. 2, the gas ejection ports 5B, 6B are located outside the gas ejection paths 5B, 6B. Liquid discharge paths 3A, 4
A is located.

In the first embodiment, the circular discharge ports 3A (4
The liquid discharged from A) is an annular gas outlet 5B.
It is configured such that gas-liquid mixing is performed from the surroundings by the air jets jetted from (6B). Therefore, this first
In the embodiment, the spray angle is a narrow angle, and a spray excellent in straightness is formed. In contrast,
In the second embodiment, the liquid discharged from the discharge port 3A (4A) of the ring is the gas outlet 5B located inside the ring.
It is configured to be gas-liquid mixed with the air jet ejected from (6B). Therefore, in the second embodiment, the spray angle is wide, and a spray with excellent uniformity is formed.

The outer shape of the base material 2 must be a round shape that does not damage the living body.
The first and second embodiments have a circular cross section, and the third embodiment of FIG. 3 has an oval cross section. The dimensions of the substrate 2 are generally about 5 to 3 mm in diameter and about 100 to 2000 mm in length, and the material is preferably vinyl chloride, polyethylene, or the like. The base material 2 has an appropriate flexibility, and when inserted into a living body luminal tissue using an endoscope, it can approach a target diseased part by appropriate deformation. Of course.

The liquid discharge passages 3 and 4 and the gas ejection passages 5 and 6 are formed integrally with the substrate 2 by plastic. Therefore, the tube main body 1 can be manufactured in an unmanned and sterile environment, and the reliability of the tube of the present application as a medical device can be improved. R is a rib configured to form an annular gap with the base material 2 around the inner pipe (liquid or gas flow path).

Syringe connecting members 14 and 15 are connected to the base end sides of the liquid discharge paths 3 and 4, respectively. The adhesives in the syringe S (the solution containing the above-described factor XIII and fibrinogen and the thrombin are used). Containing solution)
Can be discharged from the front end discharge port.
The syringe connection members 14 and 15 are configured such that a tapered connection end St protruding from an end surface of the syringe S can be directly connected. An air source connecting member 16 is provided at the base end side of the gas ejection paths 5 and 6 to which an output tube end At extending from the air source A can be directly connected.

A hood 7 is provided on the distal end side of the tube body 1, that is, on the outer periphery of the liquid discharge ports 3A, 4A and the gas ejection ports 5B, 6B.
It is possible to regulate the spray angle of the gas ejected while entraining various kinds of liquids.

FIG. 5A shows an example in which a straight hood 7 conforming to the outer shape of the tube body 1 is used, and an optimal spray angle is formed according to the size of the wound of the living tissue H. . FIG. 5B shows an example in which an inward cone hood 7 having an outlet opening smaller than the outer shape of the tube main body 1 is used. It is effective to fly a distance.

The hood 7 is made of a thin material that does not deform when inserted into a living body, for example, a material having a bending strength such as high-density polyethylene. The tube body may be adhered with an adhesive, or may be attached by mechanical coupling means. Alternatively, as shown in FIG. 5C, the protrusion amount of the hood 7 from the distal end surface of the tube body 1 may be set by one-touch by providing the tube body 1 so as to be slidable in the axial direction.

Reference numeral 8 denotes a shape-retaining wire. The shape-retaining wire 8 extends vertically through the thick portion of the base material 2. The shape retaining wire 8
Is made of a flexible metal (for example, soft iron or the like) having excellent shape retention properties. When the tube body 1 is bent toward the affected part while looking at the endoscope, the bending It is configured so that the posture can be maintained.

Next, an embodiment in which two separately prepared thin tubes and an attachment are combined as a simple manufacturing type of the tube 1 of the present invention will be described. In FIGS. 6A and 6B, the two thin tubes X and Y are connected to the syringe S, respectively, with the syringe connecting members 14 and 15 being connected to the base end side. That is, the thin tubes X and Y constitute members corresponding to the liquid discharge paths 3 and 4 in the first embodiment.

The attachment Z is connected to an air source connecting member 16 which can be directly connected to an output tube end At extending from the air source A on the side surface thereof, and the thin tubes X and Y are provided on the front surface thereof.
Are provided. The opening Z1,
Z2 is configured to be larger in diameter than the thin tubes X and Y, and has a rib R of a height corresponding to the difference in radius on its inner peripheral surface. Can be formed. Such a configuration is suitable for easily creating the type shown in the first embodiment in which the inside is the liquid ejection path and the outside is the gas ejection path.

Hereinafter, how to use the tube of the present invention will be described. In the above embodiment, first, the tube 1 of the present application is inserted from the stomach, intestine, bronchus, or the like using an endoscope, and the tip of the tube is brought close to the wound of the living tissue. At this time,
An appropriate external force is applied to the tube 1, and the posture is maintained constant by the shape retaining force of the shape retaining wire 8.

Next, the piston P is pressed to discharge the liquid (adhesive) in the syringe S to the syringe connection members 14 and 15, and the air source A is started to start the output tube end A.
Pressurized air is fed to t. The discharged liquid is discharged from the discharge ports 3A, 4A through the liquid discharge paths 3, 4 in the tube 1. On the other hand, the pressure-fed air passes through the gas ejection paths 5 and 6 in the tube 1 and is ejected from the ejection ports 5A and 6A.

Here, in the first embodiment, the discharge port 3
Since the liquid discharged from A and 4A is stirred by the annular air jet wrapping around, the spray having a narrow angle and excellent directivity is formed, and the two liquids are uniformly applied to the target wound. . Further, in the second embodiment, since the liquid discharged from the discharge ports 3A and 4A is involved in the gas ejected along the axial center, a spray having excellent uniformity at a wide angle is formed, and the target wound is formed. Is uniformly applied to the two liquids.

[0026]

As described above, the tube for applying a biological tissue adhesive according to the first aspect has at least two liquid ejection paths and a gas ejection path coaxial with each of the liquid ejection paths. And the jetting gas are jetted in the same direction, so that the uniformly mixed spray can be applied to the affected part.

According to a second aspect of the present invention, in the tube for applying a biological tissue adhesive, the liquid discharge path has a circular discharge port, and the gas discharge path has a substantially annular discharge port outside the circular discharge port. Therefore, the discharged liquid is mixed so as to be wrapped in the annular airflow, and a spray having a narrow spray angle with excellent straightness can be formed. In the tube for applying a biological tissue adhesive according to claim 3, the gas ejection path has a circular ejection port, and the liquid ejection path has a substantially annular ejection port outside the circular ejection port. Then, the discharged liquid is mixed so as to be diffused from the inside, so that a spray having a uniform and wide spray angle can be formed.

In the tube for applying a living tissue adhesive according to a fourth aspect of the present invention, the shape-retaining wire is vertically embedded in the thick portion of the main body of the tube, so that the adhesive is formed by bending the tube main body in a desired direction. Can be kept constant. In the tube for applying a biological tissue adhesive according to the fifth aspect, since the liquid discharge path and the gas discharge path are formed integrally with plastic, clean and low-cost production can be performed in an unmanned environment.

[Brief description of the drawings]

FIG. 1 is a cross-sectional view showing a first embodiment in which a gas ejection port is provided on an outer peripheral portion of a liquid ejection port.

FIG. 2 is a cross-sectional view showing a second embodiment in which a liquid ejection port is provided on an outer peripheral portion of a gas ejection port.

FIG. 3 is a cross-sectional view showing a shape-retaining wire vertically embedded in a thick portion.

FIG. 4 is a perspective view showing an entire configuration of a tube for applying a biological tissue adhesive, and an enlarged view showing a gas ejection port and a liquid ejection port.

FIG. 5A is a cross-sectional view showing a hood forming a constant spray angle. (B) It is sectional drawing which shows the hood which forms a narrow spray angle. (C) It is sectional drawing which shows the hood from which a spray angle is variable.

FIG. 6 (a) is a longitudinal sectional view showing an embodiment of a simple type combining two thin tubes and an attachment. (B) It is a cross-sectional view which shows the Example of the simple type which combined two thin tubes and the attachment.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Tube main body 2 Base material 3, 4 Liquid discharge path 3A, 4A Liquid discharge port 5, 6 Gas ejection path 5B, 6B Gas ejection port 7 Hood 8 Shape retaining wire 14, 15 Syringe connection member 16 Air source connection member R rib S Syringe H Living tissue X, Y Capillary tube Z Attachment Z1, Z2 Gas outlet

Continuation of the front page (58) Fields investigated (Int. Cl. ⁶ , DB name) A61M 31/00 A61B 17/00-17/115 A61L 25/00 A61M 11/00-11/08

Claims (5)

(57) [Claims] 1. A living tissue adhesive application tube, comprising: at least two liquid discharge paths; and a gas discharge path coaxial at least at an outlet with respect to each liquid discharge path. 2. The living tissue adhesion according to claim 1, wherein the liquid discharge passage has a discharge port having a circular cross section, and the gas discharge path has a substantially annular discharge port outside the circular discharge port. Tube for applying agent. 3. The gas ejection path has a circular discharge port,
2. The living tissue adhesive application tube according to claim 1, wherein the liquid ejection path has a substantially annular ejection port outside the circular ejection port. 4. The tube for applying a biological tissue adhesive according to claim 1, wherein a shape retaining wire is vertically buried in a thick portion of the main body of the tube. 5. The tube for applying a biological tissue adhesive according to claim 1, wherein the liquid ejection path and the gas ejection path are formed integrally with plastic.