JP2007091685A - 心不全治療薬 - Google Patents
心不全治療薬 Download PDFInfo
- Publication number
- JP2007091685A JP2007091685A JP2005286284A JP2005286284A JP2007091685A JP 2007091685 A JP2007091685 A JP 2007091685A JP 2005286284 A JP2005286284 A JP 2005286284A JP 2005286284 A JP2005286284 A JP 2005286284A JP 2007091685 A JP2007091685 A JP 2007091685A
- Authority
- JP
- Japan
- Prior art keywords
- heart failure
- treatment
- therapeutic agent
- cholinesterase inhibitor
- rat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
【解決手段】 コリンエステラーゼ阻害薬を有効成分とする心不全治療薬である。
【選択図】 なし
Description
(A)試験
(B)結果
(1)梗塞サイズ
(2)24時間平均心拍数
(3)24時間平均血圧
(4)体重
(5)右心房圧
(6)左室拡張末期圧
(7)左室最大圧変化率(LV+dP/dtmax)
(8)心拍出量係数
(9)心室重量
(10)血漿ノルエピネフリン濃度
(11)心内血栓合併率
Claims (5)
- コリンエステラーゼ阻害薬を有効成分とする心不全治療薬。
- 前記コリンエステラーゼ阻害薬は、ドネペジル、タクリン、リバスチグミン、ガランタミン、ピリドスチグミンおよびネオスチグミンからなる群より選ばれる少なくとも1つの化合物またはその生理的に許容される塩である、請求項1に記載の心不全治療薬。
- 前記コリンエステラーゼ阻害薬は、ドネペジルまたはその生理的に許容される塩である、請求項1に記載の心不全治療薬。
- 前記心不全は、慢性心不全である、請求項1〜3のいずれか1項に記載の心不全治療薬。
- 前記心不全は、心筋梗塞後心不全である、請求項1〜4のいずれか1項に記載の心不全治療薬。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005286284A JP4872044B2 (ja) | 2005-09-30 | 2005-09-30 | 心臓リモデリング抑制薬および心不全治療薬 |
PCT/JP2006/319249 WO2007040128A1 (ja) | 2005-09-30 | 2006-09-28 | 心不全治療薬 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005286284A JP4872044B2 (ja) | 2005-09-30 | 2005-09-30 | 心臓リモデリング抑制薬および心不全治療薬 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007091685A true JP2007091685A (ja) | 2007-04-12 |
JP4872044B2 JP4872044B2 (ja) | 2012-02-08 |
Family
ID=37906171
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005286284A Expired - Fee Related JP4872044B2 (ja) | 2005-09-30 | 2005-09-30 | 心臓リモデリング抑制薬および心不全治療薬 |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP4872044B2 (ja) |
WO (1) | WO2007040128A1 (ja) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003092606A2 (en) * | 2002-05-01 | 2003-11-13 | Eisai Co., Ltd. | Cholinesterase inhibitors to prevent injuries caused by chemicals |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6610713B2 (en) * | 2000-05-23 | 2003-08-26 | North Shore - Long Island Jewish Research Institute | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
-
2005
- 2005-09-30 JP JP2005286284A patent/JP4872044B2/ja not_active Expired - Fee Related
-
2006
- 2006-09-28 WO PCT/JP2006/319249 patent/WO2007040128A1/ja active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003092606A2 (en) * | 2002-05-01 | 2003-11-13 | Eisai Co., Ltd. | Cholinesterase inhibitors to prevent injuries caused by chemicals |
Also Published As
Publication number | Publication date |
---|---|
WO2007040128A1 (ja) | 2007-04-12 |
JP4872044B2 (ja) | 2012-02-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TWI519298B (zh) | 決奈達隆(dronedarone)於製備用於預防心血管疾病住院或死亡之藥劑之用途 | |
US20090318986A1 (en) | Systems, Methods and Apparatus for Treating Cardiac Dysfunction with Neurostimulation | |
AU2009259009A1 (en) | Dronedarone for the Prevention of Permanent Atrial Fibrillation | |
US20200375951A1 (en) | Dantrolene and analogs thereof for the chronic treatment and prevention of dyssynchronous cardiac dysfunction | |
JP2018528251A (ja) | 心房細動の予防及び治療のためのドフェチリドとメキシレチンの組合せ | |
CN102065857A (zh) | 决奈达隆或其可药用盐在制备用于调节血钾水平的药物中的用途 | |
Waagstein et al. | Clinical results with prenalterol in patients with heart failure | |
KR20110026421A (ko) | 심장율동전환의 예방을 위한 드로네다론 | |
TW201313679A (zh) | 吲哚氫胺酸和吲哚啉氫胺酸於治療心臟衰竭或神經損傷的用途 | |
JP4872044B2 (ja) | 心臓リモデリング抑制薬および心不全治療薬 | |
EP1732551B1 (en) | Perhexilin for treating chronic heart failure | |
JP2011517694A (ja) | ドロネダロンと少なくとも1つの利尿薬の組み合わせおよびこの治療的使用 | |
JP4635339B2 (ja) | 心拡張障害治療剤 | |
WO2023005002A1 (zh) | 枸橼酸爱地那非在制备预防和或治疗肺动脉高压的药物中的用途 | |
GB2105992A (en) | Pharmaceutical composition for treatment of cardio-vascular diseases | |
JP7137852B2 (ja) | 9‐β‐D‐アラビノフラノシルヒポキサンチンによる不整脈治療 | |
US6110927A (en) | Loratadine for use as an antiarrhythmic | |
KR19990023705A (ko) | 심부전증 치료용 약학 조성물 | |
WO2004037256A1 (fr) | Composition pharmaceutique associant le tenatoprazole et un antagoniste des recepteurs h2 a l'histamine | |
US20090247572A1 (en) | Agent for treating atrial fibrillation | |
WO2012020377A1 (en) | Use of dronedarone for the preparation of a medicament for rhythm- and rate-controlling in patients with atrial fibrillation | |
WO2021261598A1 (ja) | 薬剤誘発性徐脈および徐脈性不整脈治療薬 | |
JP4733348B2 (ja) | 心不全、他の加齢関連臓器機能不全および加齢関連障害の予防のための、ならびに寿命を延長するための、ナトリウム−水素交換阻害剤であるカリポライドとace阻害剤との組み合わせ製剤 | |
De Silva et al. | An unusual cause of completely reversed complete heart block “uncontrolled hypothyroidism” | |
KR20200044380A (ko) | 심장 질환 치료용 조성물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080908 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110614 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110815 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20110816 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20110920 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20110929 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20141202 Year of fee payment: 3 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |