JP2007063288A5 - - Google Patents
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- Publication number
- JP2007063288A5 JP2007063288A5 JP2006302712A JP2006302712A JP2007063288A5 JP 2007063288 A5 JP2007063288 A5 JP 2007063288A5 JP 2006302712 A JP2006302712 A JP 2006302712A JP 2006302712 A JP2006302712 A JP 2006302712A JP 2007063288 A5 JP2007063288 A5 JP 2007063288A5
- Authority
- JP
- Japan
- Prior art keywords
- alkylene
- pharmaceutical composition
- lower alkyl
- aryl
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000002947 alkylene group Chemical group 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000003118 aryl group Chemical group 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000004450 alkenylene group Chemical group 0.000 claims 9
- 125000003710 aryl alkyl group Chemical group 0.000 claims 9
- 125000001188 haloalkyl group Chemical group 0.000 claims 9
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 8
- 206010065687 Bone loss Diseases 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 125000004994 halo alkoxy alkyl group Chemical group 0.000 claims 5
- 125000005343 heterocyclic alkyl group Chemical group 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 229940122361 Bisphosphonate Drugs 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 150000004663 bisphosphonates Chemical group 0.000 claims 3
- 125000004663 dialkyl amino group Chemical group 0.000 claims 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 3
- 102000017914 EDNRA Human genes 0.000 claims 2
- 101150062404 EDNRA gene Proteins 0.000 claims 2
- 102000002045 Endothelin Human genes 0.000 claims 2
- 108050009340 Endothelin Proteins 0.000 claims 2
- 125000005081 alkoxyalkoxyalkyl group Chemical group 0.000 claims 2
- -1 alkoxyhaloalkyl Chemical group 0.000 claims 2
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 2
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 239000002464 receptor antagonist Substances 0.000 claims 2
- 229940044551 receptor antagonist Drugs 0.000 claims 2
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 1
- 125000004689 alkyl amino carbonyl alkyl group Chemical group 0.000 claims 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 1
- 125000005097 aminocarbonylalkyl group Chemical group 0.000 claims 1
- 125000005127 aryl alkoxy alkyl group Chemical group 0.000 claims 1
- 230000004097 bone metabolism Effects 0.000 claims 1
- 125000001589 carboacyl group Chemical group 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims 1
- 125000000262 haloalkenyl group Chemical group 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000005020 hydroxyalkenyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 0 C*C(*)C(*)C(*)*N(C)* Chemical compound C*C(*)C(*)C(*)*N(C)* 0.000 description 6
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63338900A | 2000-08-07 | 2000-08-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002517050A Division JP4217068B2 (ja) | 2000-08-07 | 2001-08-06 | エンドセリンアンタゴニストを用いる癌及び癌関連痛の治療方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007063288A JP2007063288A (ja) | 2007-03-15 |
| JP2007063288A5 true JP2007063288A5 (cg-RX-API-DMAC10.html) | 2008-07-31 |
Family
ID=24539436
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002517050A Expired - Fee Related JP4217068B2 (ja) | 2000-08-07 | 2001-08-06 | エンドセリンアンタゴニストを用いる癌及び癌関連痛の治療方法 |
| JP2006302713A Pending JP2007084564A (ja) | 2000-08-07 | 2006-11-08 | エンドセリンアンタゴニストを用いる癌及び癌関連痛の治療方法 |
| JP2006302712A Pending JP2007063288A (ja) | 2000-08-07 | 2006-11-08 | エンドセリンアンタゴニストを用いる癌及び癌関連痛の治療方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002517050A Expired - Fee Related JP4217068B2 (ja) | 2000-08-07 | 2001-08-06 | エンドセリンアンタゴニストを用いる癌及び癌関連痛の治療方法 |
| JP2006302713A Pending JP2007084564A (ja) | 2000-08-07 | 2006-11-08 | エンドセリンアンタゴニストを用いる癌及び癌関連痛の治療方法 |
Country Status (22)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0219660D0 (en) | 2002-08-23 | 2002-10-02 | Astrazeneca Ab | Therapeutic use |
| GB0403744D0 (en) | 2004-02-20 | 2004-03-24 | Astrazeneca Ab | Chemical process |
| CN101022826A (zh) * | 2004-06-07 | 2007-08-22 | 哈罗尔·戴维·贡 | 用于癌症治疗的细菌组合物 |
| US9107864B2 (en) | 2004-06-07 | 2015-08-18 | Qu Biologics Inc. | Tissue targeted antigenic activation of the immune response to treat cancers |
| CA2697057A1 (en) | 2007-08-22 | 2009-02-26 | Gilead Colorado, Inc. | Therapy for complications of diabetes |
| WO2011114103A1 (en) | 2010-03-18 | 2011-09-22 | Biolipox Ab | Pyrimidinones for use as medicaments |
| PL2598165T3 (pl) | 2010-07-26 | 2018-02-28 | Qu Biologics Inc. | Immunogenne kompozycje przeciwzapalne |
| CN102485238A (zh) * | 2010-12-06 | 2012-06-06 | 陈炯华 | 芎芷镇痛方 |
| CN106456740B (zh) | 2014-05-02 | 2021-06-08 | Qu生物制药公司 | 抗微生物免疫调节 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6063911A (en) * | 1993-12-01 | 2000-05-16 | Marine Polymer Technologies, Inc. | Methods and compositions for treatment of cell proliferative disorders |
| ES2259803T3 (es) * | 1996-02-13 | 2006-10-16 | Abbott Laboratories | Nuevos derivados de pirrolidina sustituidos con benzo-1,3-dioxolilo y benzofuranilo como antagonistas de endostelina. |
| HUP0003484A3 (en) | 1997-08-04 | 2002-02-28 | Abbott Lab | Pyrrolidine-3-crboxylic acid derivatives and their use as endothelin antagonists |
| WO2000036198A1 (en) * | 1998-12-11 | 2000-06-22 | Mactapes Limited | Curtain heading tape manufacture |
| US6545048B1 (en) * | 1999-06-29 | 2003-04-08 | California Institute Of Technology | Compositions and methods of treating cancer using compositions comprising an inhibitor or endothelin receptor activity |
-
2001
- 2001-07-24 TW TW090118053A patent/TWI306760B/zh active
- 2001-08-06 CA CA002416879A patent/CA2416879C/en not_active Expired - Fee Related
- 2001-08-06 IL IL15376901A patent/IL153769A0/xx unknown
- 2001-08-06 KR KR10-2003-7001735A patent/KR20030027007A/ko not_active Ceased
- 2001-08-06 SK SK178-2003A patent/SK1782003A3/sk unknown
- 2001-08-06 EP EP01959595A patent/EP1347751B1/en not_active Expired - Lifetime
- 2001-08-06 MX MXPA03000984A patent/MXPA03000984A/es active IP Right Grant
- 2001-08-06 AT AT01959595T patent/ATE465728T1/de not_active IP Right Cessation
- 2001-08-06 HU HU0302977A patent/HUP0302977A2/hu unknown
- 2001-08-06 AU AU8113401A patent/AU8113401A/xx active Pending
- 2001-08-06 JP JP2002517050A patent/JP4217068B2/ja not_active Expired - Fee Related
- 2001-08-06 BR BR0108865-3A patent/BR0108865A/pt not_active Application Discontinuation
- 2001-08-06 NZ NZ523562A patent/NZ523562A/en unknown
- 2001-08-06 AU AU2001281134A patent/AU2001281134B2/en not_active Ceased
- 2001-08-06 PL PL01366160A patent/PL366160A1/xx unknown
- 2001-08-06 PE PE2001000782A patent/PE20020273A1/es not_active Application Discontinuation
- 2001-08-06 DE DE60141979T patent/DE60141979D1/de not_active Expired - Lifetime
- 2001-08-06 CN CNA018169929A patent/CN1635878A/zh active Pending
- 2001-08-06 WO PCT/US2001/024716 patent/WO2002011713A2/en not_active Ceased
- 2001-08-06 AR ARP010103755A patent/AR031122A1/es not_active Application Discontinuation
-
2003
- 2003-01-09 ZA ZA200300253A patent/ZA200300253B/en unknown
- 2003-02-06 NO NO20030593A patent/NO20030593L/no not_active Application Discontinuation
- 2003-02-21 BG BG107577A patent/BG107577A/bg unknown
-
2006
- 2006-11-08 JP JP2006302713A patent/JP2007084564A/ja active Pending
- 2006-11-08 JP JP2006302712A patent/JP2007063288A/ja active Pending
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