JP2007022941A - ゲル状経口製剤 - Google Patents
ゲル状経口製剤 Download PDFInfo
- Publication number
- JP2007022941A JP2007022941A JP2005204552A JP2005204552A JP2007022941A JP 2007022941 A JP2007022941 A JP 2007022941A JP 2005204552 A JP2005204552 A JP 2005204552A JP 2005204552 A JP2005204552 A JP 2005204552A JP 2007022941 A JP2007022941 A JP 2007022941A
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- Prior art keywords
- acid
- oral preparation
- hmg
- gel
- coa reductase
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Physiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
医療現場において、錠剤、顆粒及び液剤の剤形で高脂血症及び高コレステロール患者に投与されているHMG−CoA還元酵素阻害剤、所謂スタチン系化合物の服用性を向上させたゲル状の経口製剤の提供。
【解決手段】
HMG−CoA還元酵素阻害剤又は製薬学的に許容される塩、ゲル化剤、高分子化合物、緩衝剤、保存剤、甘味剤、基剤及び水からなり、スタチン系化合物の不快な味を感じさせず、保存時の離漿が少なく、保型性が良好で容器から取り出しやすく、服用性を向上させたことを特徴とするゲル状の医薬組成物。
【選択図】 なし
Description
(1)調製槽に水と緩衝剤を秤取し、室温又は適当に加熱して撹拌・溶解する。
(2)HMG−CoA還元酵素阻害剤を添加する
(3)ゲル化剤と高分子化合物を添加し加熱(75から95℃)・撹拌・溶解する
(4)防腐剤、香料、甘味剤等を添加後、pHを7から10に調整し、加熱殺菌する
(5)調製槽内の薬液温度を適当な温度に保持しつつ、任意の容器に分注充填する
(6)適当な冷却装置又は方法により冷却し固化させ、包装し、製品とする。
Claims (6)
- HMG−CoA還元酵素阻害剤、ゲル化剤、高分子化合物、緩衝剤、甘味剤、基剤及び水からなりpHが7から10であるゲル状経口製剤
- 前記のHMG−CoA還元酵素阻害剤が、プラバスタチン、ロバスタチン、シンバスタチン、フルバスタチン、リバスタチン、アトルバスタチン、ロスバスタチン、ピタバスタチン又はその薬理上許容される塩である、請求項1に記載のゲル状経口製剤
- 前記のゲル化剤がカラギーナン及びローカストビーンガムと、カンテン、非イオン性多糖類、硫酸基及び/又はカルボキシル基を有する多糖類、アミノ多糖類、セルロース誘導体及び蛋白質から選ばれる1種又は2種以上のゲル化剤の併用である請求項1記載のゲル状経口製剤
- 前記の高分子化合物がセルロース誘導体、ポリビニル系化合物、多糖類、デンプン誘導体、マクロゴール、アルギン酸及びその誘導体から選ばれる1種又は2種以上の水溶性高分子との併用である請求項1記載のゲル状経口製剤
- 緩衝剤が乳酸、クエン酸、酒石酸、リンゴ酸、アジピン酸等の有機酸及び/又はリン酸等の無機酸とカリウムイオン、ナトリウムイオン、カルシウムイオン及びマグネシウムイオン等の金属イオンとの塩及び/又はそれら金属イオンの水酸化物との組み合わせからなる請求項1記載のゲル状経口製剤
- 前記甘味剤がサッカリンナトリウム、ステビア、アスパルテーム、グリチルリチン酸及びそれらの誘導体から選ばれる1種又は2種以上の組み合わせで、HMG−CoA還元酵素阻害剤と甘味剤の重量比が1:0.001から1:40である請求項1記載のゲル状経口製剤
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005204552A JP4987261B2 (ja) | 2005-07-13 | 2005-07-13 | ゲル状経口製剤 |
US12/010,741 US20080160087A1 (en) | 2005-07-13 | 2008-01-29 | Gel preparation for oral administration |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005204552A JP4987261B2 (ja) | 2005-07-13 | 2005-07-13 | ゲル状経口製剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007022941A true JP2007022941A (ja) | 2007-02-01 |
JP4987261B2 JP4987261B2 (ja) | 2012-07-25 |
Family
ID=37784184
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005204552A Expired - Fee Related JP4987261B2 (ja) | 2005-07-13 | 2005-07-13 | ゲル状経口製剤 |
Country Status (2)
Country | Link |
---|---|
US (1) | US20080160087A1 (ja) |
JP (1) | JP4987261B2 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011077843A1 (ja) * | 2009-12-25 | 2011-06-30 | 沢井製薬株式会社 | アトルバスタチン含有被覆製剤 |
WO2012029913A1 (ja) * | 2010-09-01 | 2012-03-08 | 興和株式会社 | 経口剤 |
JP2012046506A (ja) * | 2010-07-29 | 2012-03-08 | Teijin Pharma Ltd | ビスホスホン酸の経口ゼリー状製剤 |
JP2015536136A (ja) * | 2012-10-25 | 2015-12-21 | ネステク ソシエテ アノニム | カプセル化された苦味ペプチド、苦味ペプチドをカプセル化する方法、及びカプセル化された苦味ペプチドを含む栄養組成物 |
JP2017178882A (ja) * | 2016-03-31 | 2017-10-05 | 小林製薬株式会社 | 粘性経口組成物 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0516604D0 (en) * | 2005-08-12 | 2005-09-21 | Sandoz Ag | Rapidly dispersing/disintegrating compositions |
EP2543366B1 (en) * | 2010-03-03 | 2018-10-24 | Kyukyu Pharmaceutical Co., Ltd. | Film preparation containing medicament with unpleasant taste |
FR2968998B1 (fr) * | 2010-12-21 | 2013-04-05 | Lubmedlab | Gel universel d'aide a la prise de medicament par voie orale |
BR112014009547A8 (pt) | 2011-10-19 | 2018-01-23 | Scherer Technologies Llc R P | composição farmacêutica para administração oral, e, sistema de liberação para a administração oral de uma composição farmacêutica bifásica |
AU2013235266B2 (en) | 2012-03-20 | 2017-10-19 | Particle Dynamics International, Llc | Gelling agent-based dosage form |
PL2895298T3 (pl) | 2012-09-05 | 2022-03-07 | Mirka Oy | Elastyczny produkt szlifujący z płaską powierzchnią i sposób jego wytwarzania |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002064120A1 (fr) * | 2001-02-13 | 2002-08-22 | Taisho Pharmaceutical Co., Ltd. | Preparations de gel a usage interne |
JP2004099558A (ja) * | 2002-09-11 | 2004-04-02 | Medorekkusu:Kk | 医薬用ゼリー組成物 |
JP2005538097A (ja) * | 2002-07-25 | 2005-12-15 | ノバルティス アクチエンゲゼルシャフト | Hmg−coaレダクターゼインヒビターを含む組成物 |
JP2007008852A (ja) * | 2005-06-30 | 2007-01-18 | Towa Yakuhin Kk | プラバスタチンを含有する水性製剤の安定化方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4803082A (en) * | 1987-10-28 | 1989-02-07 | Warner-Lambert Company | Flavor and sweetness enhancement delivery systems and method of preparation |
-
2005
- 2005-07-13 JP JP2005204552A patent/JP4987261B2/ja not_active Expired - Fee Related
-
2008
- 2008-01-29 US US12/010,741 patent/US20080160087A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002064120A1 (fr) * | 2001-02-13 | 2002-08-22 | Taisho Pharmaceutical Co., Ltd. | Preparations de gel a usage interne |
JP2005538097A (ja) * | 2002-07-25 | 2005-12-15 | ノバルティス アクチエンゲゼルシャフト | Hmg−coaレダクターゼインヒビターを含む組成物 |
JP2004099558A (ja) * | 2002-09-11 | 2004-04-02 | Medorekkusu:Kk | 医薬用ゼリー組成物 |
JP2007008852A (ja) * | 2005-06-30 | 2007-01-18 | Towa Yakuhin Kk | プラバスタチンを含有する水性製剤の安定化方法 |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011077843A1 (ja) * | 2009-12-25 | 2011-06-30 | 沢井製薬株式会社 | アトルバスタチン含有被覆製剤 |
JP5764070B2 (ja) * | 2009-12-25 | 2015-08-12 | 沢井製薬株式会社 | アトルバスタチン含有被覆製剤 |
JP2012046506A (ja) * | 2010-07-29 | 2012-03-08 | Teijin Pharma Ltd | ビスホスホン酸の経口ゼリー状製剤 |
JP2016020383A (ja) * | 2010-07-29 | 2016-02-04 | 帝人ファーマ株式会社 | ビスホスホン酸の経口ゼリー状製剤 |
WO2012029913A1 (ja) * | 2010-09-01 | 2012-03-08 | 興和株式会社 | 経口剤 |
JP2013144717A (ja) * | 2010-09-01 | 2013-07-25 | Kowa Co | ピタバスタチン又はその塩の苦味抑制方法 |
JP5259880B2 (ja) * | 2010-09-01 | 2013-08-07 | 興和株式会社 | 経口剤 |
JPWO2012029913A1 (ja) * | 2010-09-01 | 2013-10-31 | 興和株式会社 | 経口剤 |
JP2015536136A (ja) * | 2012-10-25 | 2015-12-21 | ネステク ソシエテ アノニム | カプセル化された苦味ペプチド、苦味ペプチドをカプセル化する方法、及びカプセル化された苦味ペプチドを含む栄養組成物 |
JP2017178882A (ja) * | 2016-03-31 | 2017-10-05 | 小林製薬株式会社 | 粘性経口組成物 |
Also Published As
Publication number | Publication date |
---|---|
US20080160087A1 (en) | 2008-07-03 |
JP4987261B2 (ja) | 2012-07-25 |
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