JP2006526386A5 - - Google Patents

Info

Publication number

JP2006526386A5

JP2006526386A5 JP2004561676A JP2004561676A JP2006526386A5 JP 2006526386 A5 JP2006526386 A5 JP 2006526386A5 JP 2004561676 A JP2004561676 A JP 2004561676A JP 2004561676 A JP2004561676 A JP 2004561676A JP 2006526386 A5 JP2006526386 A5 JP 2006526386A5

Authority

JP

Japan

Prior art keywords

polypeptide

seq

nucleic acid

disease

acid molecule

Prior art date

2003-12-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
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• 229920001184 polypeptide Polymers 0.000 claims 53
• 102000004196 processed proteins & peptides Human genes 0.000 claims 52
• 108090000765 processed proteins & peptides Proteins 0.000 claims 52
• 150000007523 nucleic acids Chemical class 0.000 claims 37
• 102000039446 nucleic acids Human genes 0.000 claims 35
• 108020004707 nucleic acids Proteins 0.000 claims 35
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 30
• 201000010099 disease Diseases 0.000 claims 28
• 238000000034 method Methods 0.000 claims 24
• 150000001875 compounds Chemical class 0.000 claims 16
• 239000003446 ligand Substances 0.000 claims 11
• 230000000694 effects Effects 0.000 claims 10
• 239000000523 sample Substances 0.000 claims 9
• 102000019034 Chemokines Human genes 0.000 claims 8
• 108010012236 Chemokines Proteins 0.000 claims 8
• 125000003275 alpha amino acid group Chemical group 0.000 claims 7
• 239000012634 fragment Substances 0.000 claims 7
• 239000013068 control sample Substances 0.000 claims 5
• 230000035772 mutation Effects 0.000 claims 5
• 108090000623 proteins and genes Proteins 0.000 claims 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 201000004681 Psoriasis Diseases 0.000 claims 4
• 206010040047 Sepsis Diseases 0.000 claims 4
• 230000000890 antigenic effect Effects 0.000 claims 4
• 208000006673 asthma Diseases 0.000 claims 4
• 238000003745 diagnosis Methods 0.000 claims 4
• 208000015181 infectious disease Diseases 0.000 claims 4
• 108020004711 Nucleic Acid Probes Proteins 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• 239000002853 nucleic acid probe Substances 0.000 claims 3
• 239000013610 patient sample Substances 0.000 claims 3
• 239000008196 pharmacological composition Substances 0.000 claims 3
• 208000030507 AIDS Diseases 0.000 claims 2
• 208000024827 Alzheimer disease Diseases 0.000 claims 2
• 206010002383 Angina Pectoris Diseases 0.000 claims 2
• 208000023275 Autoimmune disease Diseases 0.000 claims 2
• 208000035143 Bacterial infection Diseases 0.000 claims 2
• 208000024172 Cardiovascular disease Diseases 0.000 claims 2
• 208000014912 Central Nervous System Infections Diseases 0.000 claims 2
• 206010009900 Colitis ulcerative Diseases 0.000 claims 2
• 206010014568 Empyema Diseases 0.000 claims 2
• 208000037487 Endotoxemia Diseases 0.000 claims 2
• 206010017533 Fungal infection Diseases 0.000 claims 2
• 206010056663 Gastric infection Diseases 0.000 claims 2
• 206010018364 Glomerulonephritis Diseases 0.000 claims 2
• 208000032759 Hemolytic-Uremic Syndrome Diseases 0.000 claims 2
• 206010020751 Hypersensitivity Diseases 0.000 claims 2
• 206010020772 Hypertension Diseases 0.000 claims 2
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
• 241001465754 Metazoa Species 0.000 claims 2
• 208000031888 Mycoses Diseases 0.000 claims 2
• 208000014767 Myeloproliferative disease Diseases 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 208000012902 Nervous system disease Diseases 0.000 claims 2
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
• 208000008589 Obesity Diseases 0.000 claims 2
• 206010030113 Oedema Diseases 0.000 claims 2
• 208000001132 Osteoporosis Diseases 0.000 claims 2
• 208000002193 Pain Diseases 0.000 claims 2
• 206010033645 Pancreatitis Diseases 0.000 claims 2
• 206010033647 Pancreatitis acute Diseases 0.000 claims 2
• 208000030852 Parasitic disease Diseases 0.000 claims 2
• 201000005702 Pertussis Diseases 0.000 claims 2
• 206010037660 Pyrexia Diseases 0.000 claims 2
• 206010063837 Reperfusion injury Diseases 0.000 claims 2
• 206010040070 Septic Shock Diseases 0.000 claims 2
• 208000007536 Thrombosis Diseases 0.000 claims 2
• 206010052779 Transplant rejections Diseases 0.000 claims 2
• 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
• 208000036142 Viral infection Diseases 0.000 claims 2
• 201000003229 acute pancreatitis Diseases 0.000 claims 2
• 208000037883 airway inflammation Diseases 0.000 claims 2
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• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
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• 230000001363 autoimmune Effects 0.000 claims 2
• 208000022362 bacterial infectious disease Diseases 0.000 claims 2
• 238000009739 binding Methods 0.000 claims 2
• 208000029028 brain injury Diseases 0.000 claims 2
• 210000000481 breast Anatomy 0.000 claims 2
• 208000015114 central nervous system disease Diseases 0.000 claims 2
• 239000003153 chemical reaction reagent Substances 0.000 claims 2
• 230000007423 decrease Effects 0.000 claims 2
• 230000009547 development abnormality Effects 0.000 claims 2
• 206010012601 diabetes mellitus Diseases 0.000 claims 2
• 208000035475 disorder Diseases 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 210000003128 head Anatomy 0.000 claims 2
• 208000027866 inflammatory disease Diseases 0.000 claims 2
• 208000028867 ischemia Diseases 0.000 claims 2
• 208000017169 kidney disease Diseases 0.000 claims 2
• 208000032839 leukemia Diseases 0.000 claims 2
• 201000002364 leukopenia Diseases 0.000 claims 2
• 231100001022 leukopenia Toxicity 0.000 claims 2
• 210000004072 lung Anatomy 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 201000001441 melanoma Diseases 0.000 claims 2
• 208000037941 meningococcal disease Diseases 0.000 claims 2
• 208000030159 metabolic disease Diseases 0.000 claims 2
• 230000000813 microbial effect Effects 0.000 claims 2
• 210000003739 neck Anatomy 0.000 claims 2
• 230000001613 neoplastic effect Effects 0.000 claims 2
• 235000020824 obesity Nutrition 0.000 claims 2
• 210000000056 organ Anatomy 0.000 claims 2
• 210000000496 pancreas Anatomy 0.000 claims 2
• 206010034674 peritonitis Diseases 0.000 claims 2
• 230000002062 proliferating effect Effects 0.000 claims 2
• 230000000306 recurrent effect Effects 0.000 claims 2
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
• 230000036303 septic shock Effects 0.000 claims 2
• 230000035939 shock Effects 0.000 claims 2
• 206010043554 thrombocytopenia Diseases 0.000 claims 2
• 230000009261 transgenic effect Effects 0.000 claims 2
• 230000009385 viral infection Effects 0.000 claims 2
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
• 208000034189 Sclerosis Diseases 0.000 claims 1
• 239000000556 agonist Substances 0.000 claims 1
• 208000026935 allergic disease Diseases 0.000 claims 1
• 230000033115 angiogenesis Effects 0.000 claims 1
• 239000005557 antagonist Substances 0.000 claims 1
• 210000001367 artery Anatomy 0.000 claims 1
• 230000004071 biological effect Effects 0.000 claims 1
• 239000012472 biological sample Substances 0.000 claims 1
• 238000001514 detection method Methods 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 238000000746 purification Methods 0.000 claims 1
• 238000012216 screening Methods 0.000 claims 1
• 239000000758 substrate Substances 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 229960005486 vaccine Drugs 0.000 claims 1