JP2006525796A - インフルエンザウイルス感染を処置および検出するために有用な核酸分子、ポリペプチド、抗体、およびそれらを含有する組成物 - Google Patents

インフルエンザウイルス感染を処置および検出するために有用な核酸分子、ポリペプチド、抗体、およびそれらを含有する組成物 Download PDF

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JP2006525796A
JP2006525796A JP2006502644A JP2006502644A JP2006525796A JP 2006525796 A JP2006525796 A JP 2006525796A JP 2006502644 A JP2006502644 A JP 2006502644A JP 2006502644 A JP2006502644 A JP 2006502644A JP 2006525796 A JP2006525796 A JP 2006525796A
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seq
polypeptide
amino acid
nucleic acid
polynucleotide sequence
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JP2006525796A5 (https=
Inventor
ルース アルノン,
スン−ホ ジオン,
バシャク カヤン,
タマル ベン−イエディディヤ,
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Yeda Research and Development Co Ltd
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Yeda Research and Development Co Ltd
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08RNA viruses
    • C07K14/11Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/16Aptamers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3222'-R Modification
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/11Orthomyxoviridae, e.g. influenza virus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Plant Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
JP2006502644A 2003-02-27 2004-02-24 インフルエンザウイルス感染を処置および検出するために有用な核酸分子、ポリペプチド、抗体、およびそれらを含有する組成物 Pending JP2006525796A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44986303P 2003-02-27 2003-02-27
PCT/IL2004/000182 WO2004076621A2 (en) 2003-02-27 2004-02-24 Compositions of nucleic acids for treating and detecting influenza virus

Related Child Applications (1)

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JP2010180666A Division JP2010279385A (ja) 2003-02-27 2010-08-12 インフルエンザウイルス感染を処置および検出するために有用な核酸分子、ポリペプチド、抗体、およびそれらを含有する組成物

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JP2006525796A true JP2006525796A (ja) 2006-11-16
JP2006525796A5 JP2006525796A5 (https=) 2007-02-01

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JP2006502644A Pending JP2006525796A (ja) 2003-02-27 2004-02-24 インフルエンザウイルス感染を処置および検出するために有用な核酸分子、ポリペプチド、抗体、およびそれらを含有する組成物
JP2010180666A Pending JP2010279385A (ja) 2003-02-27 2010-08-12 インフルエンザウイルス感染を処置および検出するために有用な核酸分子、ポリペプチド、抗体、およびそれらを含有する組成物

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Country Status (7)

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US (3) US7786279B2 (https=)
EP (1) EP1597350B1 (https=)
JP (2) JP2006525796A (https=)
KR (1) KR101130181B1 (https=)
AU (1) AU2004215133B2 (https=)
CA (1) CA2517074A1 (https=)
WO (1) WO2004076621A2 (https=)

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WO2009096581A1 (ja) * 2008-02-01 2009-08-06 Kunihiro Kaihatsu 膜融合阻害剤
JP2010279385A (ja) * 2003-02-27 2010-12-16 Yeda Res & Dev Co Ltd インフルエンザウイルス感染を処置および検出するために有用な核酸分子、ポリペプチド、抗体、およびそれらを含有する組成物
JP2012100636A (ja) * 2010-11-15 2012-05-31 National Institute Of Advanced Industrial Science & Technology 新型インフルエンザウイルスのヘマグルチニンに結合するアプタマー
JPWO2013183383A1 (ja) * 2012-06-04 2016-01-28 Necソリューションイノベータ株式会社 インフルエンザウイルスに結合する核酸分子およびその用途
US9801850B2 (en) 2009-07-31 2017-10-31 Osaka University Antibacterial agent
KR20210025861A (ko) * 2019-08-28 2021-03-10 성균관대학교산학협력단 바이러스 외피를 손상시키는 m2 단백질 유래 항바이러스 펩타이드 및 그의 용도

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GB0702183D0 (en) * 2007-02-05 2007-03-14 Iti Scotland Ltd Pathogen binding
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KR101034490B1 (ko) 2009-06-23 2011-05-17 한밭대학교 산학협력단 생체 안전성이 뛰어난 인플루엔자 바이러스 백신용 항원성 에피토프로서의 재조합 헤마글루티닌 단백질
WO2010150982A2 (ko) * 2009-06-23 2010-12-29 한밭대학교 산학협력단 안전성이 뛰어난 인플루엔자 바이러스 백신용 재조합 헤마글루티닌 단백질 및 이를 함유하는 생분해성 plga 미립자의 제조 방법
EP2507381A4 (en) * 2009-12-04 2016-07-20 Hoffmann La Roche MULTISPECIFIC ANTIBODIES, ANTIBODY ANALOGS, COMPOSITIONS AND METHODS
JP5996837B2 (ja) * 2010-05-28 2016-09-21 小林製薬株式会社 インフルエンザウイルスの感染抑制剤
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JP6180425B2 (ja) 2011-11-23 2017-08-23 メディミューン,エルエルシー Her3に特異的な結合分子及びそれらの使用
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CN107106688A (zh) * 2014-11-14 2017-08-29 豪夫迈·罗氏有限公司 预测对vegf拮抗剂的响应
NZ732073A (en) * 2014-12-08 2019-04-26 1Globe Biomedical Co Ltd Soluble universal adcc-enhancing synthetic fusion gene and peptide technology and its use thereof
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Cited By (10)

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JP2010279385A (ja) * 2003-02-27 2010-12-16 Yeda Res & Dev Co Ltd インフルエンザウイルス感染を処置および検出するために有用な核酸分子、ポリペプチド、抗体、およびそれらを含有する組成物
WO2009096581A1 (ja) * 2008-02-01 2009-08-06 Kunihiro Kaihatsu 膜融合阻害剤
JP5579449B2 (ja) * 2008-02-01 2014-08-27 株式会社プロテクティア 膜融合阻害剤
US8952055B2 (en) 2008-02-01 2015-02-10 Protectea, Ltd. Membrane fusion inhibitor
US9901565B2 (en) 2008-02-01 2018-02-27 Protectea, Ltd. Membrane fusion inhibitor
US9801850B2 (en) 2009-07-31 2017-10-31 Osaka University Antibacterial agent
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KR102393872B1 (ko) 2019-08-28 2022-05-04 엠브릭스 주식회사 바이러스 외피를 손상시키는 m2 단백질 유래 항바이러스 펩타이드 및 그의 용도

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AU2004215133B2 (en) 2010-10-14
KR101130181B1 (ko) 2012-03-28
EP1597350A2 (en) 2005-11-23
US20130079390A1 (en) 2013-03-28
US20100021489A1 (en) 2010-01-28
US8357789B2 (en) 2013-01-22
EP1597350A4 (en) 2010-03-24
CA2517074A1 (en) 2004-09-10
JP2010279385A (ja) 2010-12-16
AU2004215133A1 (en) 2004-09-10
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US20070059806A1 (en) 2007-03-15
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