JP2006525333A - 高親水性で正電荷に帯電した薬剤を取り込んだ生分解性ナノ粒子 - Google Patents

高親水性で正電荷に帯電した薬剤を取り込んだ生分解性ナノ粒子 Download PDF

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JP2006525333A
JP2006525333A JP2006513310A JP2006513310A JP2006525333A JP 2006525333 A JP2006525333 A JP 2006525333A JP 2006513310 A JP2006513310 A JP 2006513310A JP 2006513310 A JP2006513310 A JP 2006513310A JP 2006525333 A JP2006525333 A JP 2006525333A
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Prior art keywords
polymer
composition
treatment
polysaccharide
aminoglycoside
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Japanese (ja)
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JP2006525333A5 (enExample
Inventor
カルメン ポペスク，
ハヤト オニウクセル，
Original Assignee
ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ
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Publication of JP2006525333A publication Critical patent/JP2006525333A/ja
Publication of JP2006525333A5 publication Critical patent/JP2006525333A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2006513310A 2003-05-02 2004-04-26 高親水性で正電荷に帯電した薬剤を取り込んだ生分解性ナノ粒子 Withdrawn JP2006525333A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46740003P 2003-05-02 2003-05-02
PCT/US2004/012755 WO2004098564A2 (en) 2003-05-02 2004-04-26 Biodegradable nanoparticles comprising an aminoglycoside and a polymer like a polysaccharide

Publications (2)

Publication Number Publication Date
JP2006525333A true JP2006525333A (ja) 2006-11-09
JP2006525333A5 JP2006525333A5 (enExample) 2007-06-21

Family

ID=33435069

Family Applications (1)

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JP2006513310A Withdrawn JP2006525333A (ja) 2003-05-02 2004-04-26 高親水性で正電荷に帯電した薬剤を取り込んだ生分解性ナノ粒子

Country Status (5)

Country Link
US (2) US20040247683A1 (enExample)
EP (1) EP1620078A2 (enExample)
JP (1) JP2006525333A (enExample)
CA (1) CA2524368A1 (enExample)
WO (1) WO2004098564A2 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2226567B1 (es) * 2003-06-20 2006-07-01 Universidad De Santiago De Compostela Nanoparticulas de acido hialuronico.
WO2005027873A2 (en) * 2003-06-20 2005-03-31 Alnis Biosciences, Inc. Therapeutic aminoglycoside-containing hydrogel nanoparticles
US8628690B2 (en) * 2004-02-23 2014-01-14 The Texas A&M University System Nanoemulsion compositions and methods of use thereof
US7780873B2 (en) * 2004-02-23 2010-08-24 Texas A&M University System Bioactive complexes compositions and methods of use thereof
US9119782B2 (en) 2006-03-20 2015-09-01 Mary P. McCourt Drug delivery means
US20090061006A1 (en) * 2006-03-31 2009-03-05 Carola Leuschner Layered Nanoparticles for Sustained Release of Small Molecules
WO2007149868A2 (en) * 2006-06-20 2007-12-27 The Regents Of The University Of California Controlled release encapsulated anti-bacterial and anti-inflammatory nanoparticles
US20080102127A1 (en) * 2006-10-26 2008-05-01 Gao Hai Y Hybrid lipid-polymer nanoparticulate delivery composition
CA2729582C (en) * 2008-07-01 2017-09-19 University Of Chicago Particles containing an opioid receptor antagonist and methods of use
JP6343147B2 (ja) 2010-08-30 2018-06-13 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 狭窄病変および血栓溶解療法のための剪断による制御放出
US9161962B2 (en) * 2010-11-01 2015-10-20 Nanoderm Sciences, Inc. Targeted therapeutic nanoparticles
US20180028684A1 (en) 2010-11-01 2018-02-01 Nanoderm Sciences, Inc. Targeted nanoparticles
WO2012059936A1 (en) 2010-11-03 2012-05-10 Padma Venkitachalam Devarajan Pharmaceutical compositions for colloidal drug delivery
JP6035633B2 (ja) 2010-12-02 2016-11-30 グリーンマーク バイオメディカル インコーポレイテッドＧｒｅｅｎＭａｒｋ Ｂｉｏｍｅｄｉｃａｌ， Ｉｎｃ． アプタマーバイオコンジュゲート薬物送達システム
CN105164143B (zh) 2013-03-14 2019-02-19 杰罗米.J.申塔格 用于将分子引入到乳糜微粒中的胆固醇体囊泡
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
CA3004363A1 (en) 2015-11-06 2017-05-11 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Composition comprising a biocompatible and biodegradable polymer, nanocarries and a drug and methods of making and using the same
CN105664259B (zh) * 2016-01-18 2018-09-14 铜仁学院 医用钛合金植入物表面药物缓释系统的构建方法
CN106596922B (zh) * 2016-12-06 2018-06-15 湖南大学 用于检测卡那霉素的检测试剂及其制备方法和应用
CA3090303A1 (en) 2018-03-28 2019-10-03 Greenmark Biomedical Inc. Phosphate crosslinked starch nanoparticle and dental treatments
KR20230088732A (ko) 2020-09-29 2023-06-20 옥스포드 유니버시티 이노베이션 리미티드 뇌졸중 치료
CN113069554B (zh) * 2021-04-13 2022-10-21 河南中医药大学 一种齐墩果酸季铵盐-肝素-壳聚糖纳米粒的制备方法及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2594374A (en) * 1949-10-11 1952-04-29 Usa Streptomycin-polymyxin-bacitracin composition
FR2631826B1 (fr) * 1988-05-27 1992-06-19 Centre Nat Rech Scient Vecteur particulaire utile notamment pour le transport de molecules a activite biologique et procede pour sa preparation
CA2084194C (en) * 1991-04-02 2003-05-20 Gregory John Russell-Jones Oral delivery systems for microparticles

Also Published As

Publication number Publication date
CA2524368A1 (en) 2004-11-18
WO2004098564A2 (en) 2004-11-18
EP1620078A2 (en) 2006-02-01
US20040247683A1 (en) 2004-12-09
US20080241257A1 (en) 2008-10-02
WO2004098564A3 (en) 2005-02-10

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