JP2006524242A - Ｃｘｃｒ４アンタゴニストおよびそれらの使用方法 - Google Patents
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- 229940116362 tragacanth Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- JEJAMASKDTUEBZ-UHFFFAOYSA-N tris(1,1,3-tribromo-2,2-dimethylpropyl) phosphate Chemical compound BrCC(C)(C)C(Br)(Br)OP(=O)(OC(Br)(Br)C(C)(C)CBr)OC(Br)(Br)C(C)(C)CBr JEJAMASKDTUEBZ-UHFFFAOYSA-N 0.000 description 1
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- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- CILBMBUYJCWATM-PYGJLNRPSA-N vinorelbine ditartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC CILBMBUYJCWATM-PYGJLNRPSA-N 0.000 description 1
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- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45821703P | 2003-03-27 | 2003-03-27 | |
| PCT/US2004/009570 WO2004087068A2 (en) | 2003-03-27 | 2004-03-26 | Cxcr4 antagonists and methods of their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006524242A true JP2006524242A (ja) | 2006-10-26 |
| JP2006524242A5 JP2006524242A5 (enExample) | 2007-05-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006509429A Pending JP2006524242A (ja) | 2003-03-27 | 2004-03-26 | Ｃｘｃｒ４アンタゴニストおよびそれらの使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20070258893A1 (enExample) |
| EP (1) | EP1608318A4 (enExample) |
| JP (1) | JP2006524242A (enExample) |
| CA (1) | CA2520406A1 (enExample) |
| WO (1) | WO2004087068A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018510154A (ja) * | 2015-04-02 | 2018-04-12 | プロキシマジェン リミティド | 癌の新治療法 |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1635910A (zh) | 2001-05-02 | 2005-07-06 | 普渡研究基金会 | 巨噬细胞介导的疾病的治疗和诊断 |
| US8043603B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| US8043602B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| AU2003261723A1 (en) | 2002-08-27 | 2004-03-19 | Takeda Chemical Industries, Ltd. | Cxcr4 antagonist and use thereof |
| WO2005103721A1 (en) * | 2004-04-20 | 2005-11-03 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with cxc chemokine receptor 4 (cxcr4) |
| JP2008535779A (ja) | 2005-01-07 | 2008-09-04 | エモリー・ユニバーシテイ | Ｈｉｖ感染治療のためのｃｘｃｒ４拮抗薬 |
| WO2006091112A1 (en) * | 2005-02-22 | 2006-08-31 | Genesis Reasearch And Development Corporation Limited | Compositions for the delivery of rna interference molecules and methods for their use |
| US8569280B2 (en) | 2005-04-25 | 2013-10-29 | Immune Disease Institute | Methods for the treatment of multiple myeloma |
| WO2006116185A2 (en) * | 2005-04-25 | 2006-11-02 | Cbr Institute For Biomedical Research, Inc. | Methods for the treatment of multiple myeloma |
| DE102005023170A1 (de) * | 2005-05-19 | 2006-11-23 | Curevac Gmbh | Optimierte Formulierung für mRNA |
| US9034814B2 (en) | 2005-05-25 | 2015-05-19 | Hadasit Medical Research Services And Development Ltd. | CXCR4 antagonists for wound healing and re-epithelialization |
| WO2007006041A2 (en) | 2005-07-05 | 2007-01-11 | Purdue Research Foundation | Imaging and therapeutic method using monocytes |
| US20070043012A1 (en) | 2005-08-19 | 2007-02-22 | Bridger Gary J | Methods to enhance chemotherapy |
| EP1940473A2 (en) | 2005-09-23 | 2008-07-09 | Purdue Research Foundation | Multiphoton in vivo flow cytometry method and device |
| WO2007058322A1 (ja) | 2005-11-18 | 2007-05-24 | Ono Pharmaceutical Co., Ltd. | 塩基性基を含有する化合物およびその用途 |
| EP2397148A3 (en) * | 2006-02-02 | 2012-04-25 | Allergan, Inc. | Compositions and methods for the treatment of ophthalmic disease |
| CA2643744A1 (en) | 2006-02-27 | 2007-08-30 | Technische Universitaet Muenchen | Cancer imaging and treatment |
| TW200808328A (en) * | 2006-06-02 | 2008-02-16 | Alcon Mfg Ltd | RNAi-mediated inhibition of stromal cell-derived factor 1-related targets for treatment of neovascularization-related conditions |
| WO2008008854A2 (en) | 2006-07-11 | 2008-01-17 | Emory University | Cxcr4 antagonists including diazine and triazine structures for the treatment of medical disorders |
| CA2668197A1 (en) | 2006-11-03 | 2008-05-15 | Philip S. Low | Ex vivo flow cytometry method and device |
| EP2094274A4 (en) | 2006-12-21 | 2011-05-11 | Biokine Therapeutics Ltd | T-140 PEPTIDE ANALOGUE WITH CXCR4 SUPERAGONIST ACTIVITY FOR BONE MARROW RECOVERY |
| JP5869205B2 (ja) | 2007-02-07 | 2016-02-24 | パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | ポジトロン放射断層画像法 |
| US8961926B2 (en) | 2007-05-25 | 2015-02-24 | Purdue Research Foundation | Method of imaging localized infections |
| CA2699100A1 (en) * | 2007-09-11 | 2009-04-02 | Dorian Bevec | Use of a peptide as a therapeutic agent |
| CN102015717A (zh) | 2008-03-28 | 2011-04-13 | 奥蒂瑞斯治疗公司 | 趋化因子受体调节剂 |
| KR20110093832A (ko) | 2008-11-04 | 2011-08-18 | 앵커 테라퓨틱스, 인코포레이티드 | Ｃｘｃｒ4 수용체 화합물 |
| CN102481332A (zh) * | 2009-06-14 | 2012-05-30 | 拜欧肯疗法有限公司 | 用于提高血小板水平的肽疗法 |
| WO2011094389A2 (en) * | 2010-01-27 | 2011-08-04 | Emory University | Cxcr4 antagonists for imaging of cancer and inflammatory disorders |
| US9155795B2 (en) | 2010-02-26 | 2015-10-13 | Anchor Therapeutics, Inc. | CXCR4 receptor compounds |
| US20130310442A1 (en) * | 2010-09-09 | 2013-11-21 | Noxxon Pharma Ag | SDF-1 Binding Nucleic Acids and the use Thereof in Cancer Treatment |
| WO2012095849A1 (en) | 2011-01-10 | 2012-07-19 | Biokine Therapeutics Ltd. | Peptides and compositions for the treatment of neuroectodermal derived tumors and retinoblastoma |
| EP2476441A1 (en) | 2011-01-13 | 2012-07-18 | Universitat Autònoma De Barcelona | Methods and reagents for efficient and targeted delivery of therapeutic molecules to CXCR4 cells |
| EP2771484A1 (en) | 2011-10-28 | 2014-09-03 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
| WO2013160895A1 (en) | 2012-04-24 | 2013-10-31 | Biokine Therapeutics Ltd. | Peptides and use thereof in the treatment of large cell lung cancer |
| JP6294459B2 (ja) | 2013-03-24 | 2018-03-14 | バイオカイン・セラピューティクス・リミテッドＢｉｏｋｉｎｅ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｔｄ． | 骨髄性白血病の処置方法 |
| JP6505681B2 (ja) | 2013-10-31 | 2019-04-24 | バイオカイン セラピューティックス リミテッド | Ｆｌｔ３変異を有する急性骨髄性白血病を治療するための医薬組成物 |
| CN106470699A (zh) | 2014-02-03 | 2017-03-01 | 耶路撒冷希伯来大学的益生研究开发有限公司 | 使用酪蛋白激酶i抑制剂以消耗干细胞的用途 |
| KR101700946B1 (ko) * | 2014-11-11 | 2017-02-02 | 연세대학교 산학협력단 | Ｃｘｃｒ４ 길항제를 포함하는 피부 색소침착의 예방 또는 개선용 조성물 |
| WO2017011517A1 (en) | 2015-07-16 | 2017-01-19 | Emory University | Bis-amines, compositions, and uses related to cxcr4 inhibition |
| WO2017009842A2 (en) | 2015-07-16 | 2017-01-19 | Biokine Therapeutics Ltd. | Compositions and methods for treating cancer |
| WO2017023999A1 (en) | 2015-08-03 | 2017-02-09 | Emory University | Methylsulfonamide derivatives and uses related thereto |
| BR112018016924A2 (pt) | 2016-02-23 | 2019-01-02 | Biokine Therapeutics Ltd | método de seleção de regime de tratamento para indivíduo que tem leucemia mieloide aguda (lma), método de maximização de resposta ao tratamento de leucemia mieloide aguda (lma), método de tratamento de lma, antagonista de cxcr4 e agente quimioterápico no tratamento de lma |
| EP3856225A1 (en) | 2018-09-25 | 2021-08-04 | BioLineRx Ltd. | Methods of selecting treatment for cxcr4-associated cancer |
| CN110590744B (zh) * | 2019-07-03 | 2021-11-02 | 河南省人民医院 | 一种靶向趋化因子受体cxcr4的小分子类pet显像剂 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000009152A1 (en) * | 1998-08-14 | 2000-02-24 | The University Of British Columbia | Therapeutic chemokine receptor antagonists |
| AU2003261723A1 (en) * | 2002-08-27 | 2004-03-19 | Takeda Chemical Industries, Ltd. | Cxcr4 antagonist and use thereof |
-
2004
- 2004-03-26 JP JP2006509429A patent/JP2006524242A/ja active Pending
- 2004-03-26 WO PCT/US2004/009570 patent/WO2004087068A2/en not_active Ceased
- 2004-03-26 EP EP04758528A patent/EP1608318A4/en not_active Withdrawn
- 2004-03-26 CA CA002520406A patent/CA2520406A1/en not_active Abandoned
-
2007
- 2007-04-16 US US11/787,366 patent/US20070258893A1/en not_active Abandoned
Non-Patent Citations (8)
| Title |
|---|
| JPN6010022043, Ｔａｍａｍｕｒａ，Ｈ． ｅｔ ａｌ．, "Ｐｈａｒｍａｃｏｐｈｏｒｅ ｉｄｅｎｔｉｆｉｃａｔｉｏｎ ｏｆ ａ ｓｐｅｃｉｆｉｃ ＣＸＣＲ４ ｉｎｈｉｂｉｔｏｒ， Ｔ１４０， ｌｅａｄｓ ｔｏ ｄｅｖｅｌｏｐｍｅｎｔ ｏｆ ｅｆｆｅｃｔｉｖｅ", Ｂｉｏｏｒｇ． Ｍｅｄ． Ｃｈｅｍ． Ｌｅｔｔ．, 20001204, Ｖｏｌ．１０，Ｎｏ．２３, Ｐ．２６３３−２６３７ * |
| JPN6010022047, Ｔａｍａｍｕｒａ，Ｈ． ｅｔ ａｌ．, "Ｄｅｖｅｌｏｐｍｅｎｔ ｏｆ ｓｐｅｃｉｆｉｃ ＣＸＣＲ４ ｉｎｈｉｂｉｔｏｒｓ ｐｏｓｓｅｓｓｉｎｇ ｈｉｇｈ ｓｅｌｅｃｔｉｖｉｔｙ ｉｎｄｅｘｅｓ ａｓ ｗｅｌｌ ａｓ ｃｏｍｐｌｅｔｅ ｓｔａ", Ｂｉｏｏｒｇ． Ｍｅｄ． Ｃｈｅｍ． Ｌｅｔｔ．, 20010723, Ｖｏｌ．１１，Ｎｏ．１４, Ｐ．１８９７−１９０２ * |
| JPN6010022051, 玉村啓和, "ＨＩＶ侵入の第二受容体に対する特異的拮抗財の発見と応用に関する研究", 薬学雑誌, 200111, Ｖｏｌ．１２１，Ｎｏ．１１, Ｐ．７８１−７９２, JP * |
| JPN6010022054, Ｓｅｈｇａｌ，Ａ． ｅｔ ａｌ．, "ＣＸＣＲ−４， ａ ｃｈｅｍｏｋｉｎｅ ｒｅｃｅｐｔｏｒ， ｉｓ ｏｖｅｒｅｘｐｒｅｓｓｅｄ ｉｎ ａｎｄ ｒｅｑｕｉｒｅｄ ｆｏｒ ｐｒｏｌｉｆｅｒａｔｉｏｎ ｏｆ ｇｌｉｏｂｌａｓｔｏｍａ ｔｕｍ", Ｊ． Ｓｕｒｇ． Ｏｎｃｏｌ．, 199810, Ｖｏｌ．６９，Ｎｏ．２, Ｐ．９９−１０４ * |
| JPN7010001245, Ｍｕｒａｋａｍｉ，Ｔ． ｅｔ ａｌ．, "Ｅｘｐｒｅｓｓｉｏｎ ｏｆ ＣＸＣ ｃｈｅｍｏｋｉｎｅ ｒｅｃｅｐｔｏｒ−４ ｅｎｈａｎｃｅｓ ｔｈｅ ｐｕｌｍｏｎａｒｙ ｍｅｔａｓｔａｔｉｃ ｐｏｔｅｎｔｉａｌ ｏｆ ｍｕｒｉｎｅ Ｂ１６ ｍｅｌ", Ｃａｎｃｅｒ Ｒｅｓ．, 20021215, Ｖｏｌ．６２，Ｎｏ．２４, Ｐ．７３２８−７３３４ * |
| JPN7010001246, Ｏｈ，Ｊ．Ｗ． ｅｔ ａｌ．, "ＣＸＣ ｃｈｅｍｏｋｉｎｅ ｒｅｃｅｐｔｏｒ−４ Ｅｘｐｒｅｓｓｉｏｎ ａｎｄ ｆｕｎｃｔｉｏｎ ｉｎ ｈｕｍａｎ ａｓｔｒｏｇｌｉｏｍａ ｃｅｌｌｓ", Ｊ． Ｉｍｍｕｎｏｌ．, 20010215, Ｖｏｌ．１６６，Ｎｏ．４, Ｐ．２６９５−２７０４ * |
| JPN7010001247, Ｋｏｓｈｉｂａ．Ｔ． ｅｔ ａｌ．, "Ｅｘｐｒｅｓｓｉｏｎ ｏｆ ｓｔｒｏｍａｌ ｃｅｌｌ−ｄｅｒｉｖｅｄ ｆａｃｔｏｒ １ ａｎｄ ＣＸＣＲ４ ｌｉｇａｎｄ ｒｅｃｅｐｔｏｒ ｓｙｓｔｅｍ ｉｎ ｐａｎｃｒｅａｔｉｃ ｃａｎｃｅｒ： Ａ", Ｃｌｉｎ． Ｃａｎｃｅｒ Ｒｅｓ．, 20000901, Ｖｏｌ．６，Ｎｏ．９, Ｐ．３５３０−３５３５ * |
| JPN7010001248, Ｔａｉｃｈｍａｎ，Ｒ．Ｓ． ｅｔ ａｌ．, "Ｕｓｅ ｏｆ ｔｈｅ ｓｔｒｏｍａｌ ｃｅｌｌ−ｄｅｒｉｖｅｄ ｆａｃｔｏｒ−１／ＣＸＣＲ４ ｐａｔｈｗａｙ ｉｎ ｐｒｏｓｔａｔｅ ｃａｎｃｅｒ ｍｅｔａｓｔａｓｉｓｔ ｔｏ ｂｏｎｅ", Ｃａｎｃｅｒ Ｒｅｓ．, 20020315, Ｖｏｌ．６２，Ｎｏ．６, Ｐ．１８３２−１８３ * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018510154A (ja) * | 2015-04-02 | 2018-04-12 | プロキシマジェン リミティド | 癌の新治療法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2520406A1 (en) | 2004-10-14 |
| WO2004087068A2 (en) | 2004-10-14 |
| US20070258893A1 (en) | 2007-11-08 |
| EP1608318A2 (en) | 2005-12-28 |
| EP1608318A4 (en) | 2009-07-29 |
| WO2004087068A3 (en) | 2006-02-02 |
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