JP2006523698A - Ｐｐａｒ変調薬としての（３−｛３−（２，４−ビス−トリフルオロメチル−ベンジル）−（５−エチル−ピリミジン−２−イル）−アミノ−プロポキシ｝−フェニル）−酢酸および関連化合物、ならびに代謝性障害の処置方法 - Google Patents
Ｐｐａｒ変調薬としての（３−｛３−（２，４−ビス−トリフルオロメチル−ベンジル）−（５−エチル−ピリミジン−２−イル）−アミノ−プロポキシ｝−フェニル）−酢酸および関連化合物、ならびに代謝性障害の処置方法 Download PDFInfo
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- JP2006523698A JP2006523698A JP2006509849A JP2006509849A JP2006523698A JP 2006523698 A JP2006523698 A JP 2006523698A JP 2006509849 A JP2006509849 A JP 2006509849A JP 2006509849 A JP2006509849 A JP 2006509849A JP 2006523698 A JP2006523698 A JP 2006523698A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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| PCT/US2004/010970 WO2004093879A1 (en) | 2003-04-17 | 2004-04-07 | (3-{3-‘(2,4-bis-trifluormethyl-benzyl)-(5-ethyl-pyrimidin-2-yl)-amino!-propoxy}-phenyl)-acetic acid and related compounds as modulators of ppars and methods of treating metabolic disorders |
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| US7517884B2 (en) | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| US20070208026A1 (en) * | 2003-04-07 | 2007-09-06 | Liu Kevin | N-Containing Heteroaromatic Compounds As Modulators Of Ppars And Methods Of Treating Metabolic Disorders |
| WO2004092117A1 (en) * | 2003-04-07 | 2004-10-28 | Kalypsys, Inc. | Para-sulfonyl substituted phenyl compounds as modulators of ppars |
| ATE486055T1 (de) | 2004-05-05 | 2010-11-15 | High Point Pharmaceuticals Llc | Neue verbindungen, ihre herstellung und verwendung |
| ATE515494T1 (de) | 2004-05-05 | 2011-07-15 | High Point Pharmaceuticals Llc | Neue verbindungen, deren herstellung und verwendung |
| US20070190079A1 (en) * | 2004-10-29 | 2007-08-16 | Kalypsys, Inc. | Methods for the selective modulation of ppar |
| HUE039584T2 (hu) | 2004-10-29 | 2019-01-28 | Kalypsys Inc | PPAR-modulátor szulfonil-szubsztituált biciklusos vegyületek |
| TW200640887A (en) * | 2005-01-27 | 2006-12-01 | Kowa Co | PPAR-activating compound |
| US7301033B2 (en) | 2005-01-27 | 2007-11-27 | Kowa Co., Ltd. | PPAR-activating compound |
| RU2412935C2 (ru) | 2005-06-30 | 2011-02-27 | Хай Пойнт Фармасьютикалс, ЛЛС | Феноксиуксусные кислоты в качестве активаторов дельта рецепторов ppar |
| CN101272784A (zh) | 2005-09-29 | 2008-09-24 | 塞诺菲-安万特股份有限公司 | 苯基-和吡啶基-1,2,4-噁二唑酮衍生物、它们的制备方法和它们作为药物的用途 |
| WO2007051095A1 (en) | 2005-10-25 | 2007-05-03 | Kalypsys, Inc. | Salts of modulators of ppar and methods of treating metabolic disorders |
| WO2007071766A2 (en) | 2005-12-22 | 2007-06-28 | Transtech Pharma | Phenoxy acetic acids as ppar delta activators |
| CA2645719A1 (en) | 2006-03-09 | 2007-09-13 | High Point Pharmaceuticals, Llc | Compounds that modulate ppar activity, their preparation and use |
| US20070219193A1 (en) * | 2006-03-17 | 2007-09-20 | Kalypsys, Inc | Alkylamine-substituted bicyclic aryl compounds useful as modulators of ppar |
| US20070249519A1 (en) * | 2006-04-20 | 2007-10-25 | Kalypsys, Inc. | Methods for the upregulation of glut4 via modulation of ppar delta in adipose tissue and for the treatment of disease |
| TW200745059A (en) * | 2006-05-16 | 2007-12-16 | Kalypsys Inc | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| WO2008091863A1 (en) | 2007-01-23 | 2008-07-31 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
| CA2923422C (en) | 2013-09-09 | 2021-09-07 | Vtv Therapeutics Llc | Use of a ppar-delta agonist for treating muscle atrophy |
| WO2023147309A1 (en) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Use of ppar-delta agonists in the treatment of disease |
Citations (2)
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|---|---|---|---|---|
| WO2002046176A1 (en) * | 2000-12-05 | 2002-06-13 | Nippon Chemiphar Co., Ltd. | Ppar (peroxisome proliferator activated receptor) activators |
| WO2004058174A2 (en) * | 2002-12-20 | 2004-07-15 | Bayer Pharmaceuticals Corporation | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation |
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| GB9600464D0 (en) * | 1996-01-09 | 1996-03-13 | Smithkline Beecham Plc | Novel method |
| AU2003267041B2 (en) * | 2002-09-12 | 2007-03-29 | F. Hoffmann-La Roche Ag | N-substituted-1H-indol-5-propionic acid compounds as PPAR agonists useful for the treatment of diabetes |
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- 2004-04-07 WO PCT/US2004/010970 patent/WO2004093879A1/en not_active Ceased
- 2004-04-07 JP JP2006509849A patent/JP2006523698A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002046176A1 (en) * | 2000-12-05 | 2002-06-13 | Nippon Chemiphar Co., Ltd. | Ppar (peroxisome proliferator activated receptor) activators |
| WO2004058174A2 (en) * | 2002-12-20 | 2004-07-15 | Bayer Pharmaceuticals Corporation | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004002394T2 (de) | 2007-09-13 |
| DE602004002394D1 (de) | 2006-10-26 |
| CA2520908A1 (en) | 2004-11-04 |
| US20050070532A1 (en) | 2005-03-31 |
| BRPI0409763A (pt) | 2006-05-09 |
| KR20060082788A (ko) | 2006-07-19 |
| ATE339205T1 (de) | 2006-10-15 |
| WO2004093879A1 (en) | 2004-11-04 |
| ES2273282T3 (es) | 2007-05-01 |
| CN1791409A (zh) | 2006-06-21 |
| AU2004231554A1 (en) | 2004-11-04 |
| EP1613326A1 (en) | 2006-01-11 |
| MXPA05010812A (es) | 2006-03-30 |
| EP1613326B1 (en) | 2006-09-13 |
| KR100762762B1 (ko) | 2007-10-17 |
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