JP2006523437A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006523437A5 JP2006523437A5 JP2004570696A JP2004570696A JP2006523437A5 JP 2006523437 A5 JP2006523437 A5 JP 2006523437A5 JP 2004570696 A JP2004570696 A JP 2004570696A JP 2004570696 A JP2004570696 A JP 2004570696A JP 2006523437 A5 JP2006523437 A5 JP 2006523437A5
- Authority
- JP
- Japan
- Prior art keywords
- tcr
- complex according
- chain
- polypeptide
- tcr complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108091008874 T cell receptors Proteins 0.000 claims 48
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 48
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 125000003827 glycol group Chemical group 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 6
- 229920001515 polyalkylene glycol Polymers 0.000 claims 5
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 101000662909 Homo sapiens T cell receptor beta constant 1 Proteins 0.000 claims 1
- 101000662902 Homo sapiens T cell receptor beta constant 2 Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102100037272 T cell receptor beta constant 1 Human genes 0.000 claims 1
- 102100037298 T cell receptor beta constant 2 Human genes 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 229920001281 polyalkylene Polymers 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0228112A GB0228112D0 (en) | 2002-12-03 | 2002-12-03 | Receptors |
| GB0304090A GB0304090D0 (en) | 2003-02-22 | 2003-02-22 | Receptors |
| GB0308309A GB0308309D0 (en) | 2003-04-10 | 2003-04-10 | Receptors |
| US47590603P | 2003-06-05 | 2003-06-05 | |
| GB0314113A GB0314113D0 (en) | 2003-06-18 | 2003-06-18 | Receptors |
| GB0316354A GB0316354D0 (en) | 2003-07-11 | 2003-07-11 | Receptors |
| PCT/GB2003/005104 WO2004050705A2 (en) | 2002-12-03 | 2003-11-25 | Complexes of receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006523437A JP2006523437A (ja) | 2006-10-19 |
| JP2006523437A5 true JP2006523437A5 (https=) | 2006-12-14 |
Family
ID=32475869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004570696A Withdrawn JP2006523437A (ja) | 2002-12-03 | 2003-11-25 | レセプター複合体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20060135418A1 (https=) |
| EP (1) | EP1567553A2 (https=) |
| JP (1) | JP2006523437A (https=) |
| AU (1) | AU2003286263A1 (https=) |
| WO (1) | WO2004050705A2 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101131297B1 (ko) * | 2003-11-10 | 2012-03-30 | 알토 바이오사이언스 코포레이션 | 가용성 티씨알 분자 및 이용 방법 |
| US20060116824A1 (en) * | 2004-12-01 | 2006-06-01 | Ishikawa Muriel Y | System and method for modulating a humoral immune response |
| US20060047433A1 (en) * | 2004-08-24 | 2006-03-02 | Ishikawa Muriel Y | System and method related to enhancing an immune system |
| US20060095211A1 (en) * | 2003-12-05 | 2006-05-04 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | System and method for modulating a cell mediated immune response |
| US20060047437A1 (en) * | 2004-08-25 | 2006-03-02 | Ishikawa Muriel Y | System and method for heightening an immune response |
| US20060047436A1 (en) * | 2004-08-25 | 2006-03-02 | Ishikawa Muriel Y | System and method for magnifying an immune response |
| US20060122784A1 (en) * | 2004-12-03 | 2006-06-08 | Ishikawa Muriel Y | System and method for augmenting a humoral immune response |
| US20060182742A1 (en) * | 2004-08-24 | 2006-08-17 | Ishikawa Muriel Y | System and method for magnifying a humoral immune response |
| US20060047434A1 (en) * | 2004-08-24 | 2006-03-02 | Ishikawa Muriel Y | System and method related to improving an immune system |
| US20060122783A1 (en) * | 2004-08-24 | 2006-06-08 | Ishikawa Muriel Y | System and method for heightening a humoral immune response |
| US20060047435A1 (en) * | 2004-08-24 | 2006-03-02 | Ishikawa Muriel Y | System and method related to augmenting an immune system |
| US20070265818A1 (en) * | 2004-08-24 | 2007-11-15 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational methods and systems for heightening cell-mediated immune response |
| US20070196362A1 (en) * | 2004-08-24 | 2007-08-23 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational methods and systems to bolster an immune response |
| US20060047439A1 (en) * | 2004-08-24 | 2006-03-02 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | System and method for improving a humoral immune response |
| US20070198196A1 (en) * | 2004-08-24 | 2007-08-23 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational systems and methods relating to ameliorating an immune system |
| US20070265819A1 (en) * | 2004-08-24 | 2007-11-15 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational methods and systems for improving cell-mediated immune response |
| US20070207492A1 (en) * | 2004-08-24 | 2007-09-06 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational methods and systems to adjust a humoral immune response |
| JP2008514685A (ja) * | 2004-10-01 | 2008-05-08 | メディジーン リミテッド | 治療剤に連結した、非天然型ジスルフィド鎖間結合を含有するｔ細胞レセプター |
| GB0427585D0 (en) * | 2004-12-16 | 2005-01-19 | Avidex Ltd | Assay |
| EP1699826B1 (en) | 2005-01-05 | 2009-03-11 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions |
| GB0511124D0 (en) * | 2005-06-01 | 2005-07-06 | Avidex Ltd | High affinity melan-a t cell receptors |
| WO2007073147A1 (en) * | 2005-12-20 | 2007-06-28 | Erasmus University Medical Center Rotterdam | Apoptosis-inducing protein complexes and therapeutic use thereof |
| EP1870418A1 (en) | 2006-06-20 | 2007-12-26 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Allorestricted peptide-specific T cells |
| AT503889B1 (de) | 2006-07-05 | 2011-12-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | Multivalente immunglobuline |
| AT503861B1 (de) | 2006-07-05 | 2008-06-15 | F Star Biotech Forsch & Entw | Verfahren zur manipulation von t-zell-rezeptoren |
| US8088379B2 (en) | 2006-09-26 | 2012-01-03 | The United States Of America As Represented By The Department Of Health And Human Services | Modified T cell receptors and related materials and methods |
| ES2627223T3 (es) | 2007-06-26 | 2017-07-27 | F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H | Presentación de agentes de unión |
| GB0712670D0 (en) | 2007-06-29 | 2007-08-08 | King S College London | Isolated peptides and uses thereof |
| EP2113255A1 (en) | 2008-05-02 | 2009-11-04 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Cytotoxic immunoglobulin |
| GB0816096D0 (en) * | 2008-09-04 | 2008-10-15 | Medigene Ltd | Diabetes t cell receptors |
| CA2822938A1 (en) * | 2010-12-27 | 2012-07-05 | Apo-T B.V. | A polypeptide that binds aberrant cells and induces apoptosis |
| WO2012091564A2 (en) | 2010-12-27 | 2012-07-05 | Apo-T B.V. | A cross-linking polypeptide that induces apoptosis |
| WO2013048243A1 (en) | 2011-09-29 | 2013-04-04 | Apo-T B.V. | Multi-specific binding molecules targeting aberrant cells |
| CA2860914A1 (en) | 2012-01-13 | 2013-07-18 | Apo-T B.V. | Aberrant cell-restricted immunoglobulins provided with a toxic moiety |
| CN106279404A (zh) * | 2015-05-20 | 2017-01-04 | 广州市香雪制药股份有限公司 | 一种可溶且稳定的异质二聚tcr |
| JP2020501508A (ja) * | 2016-09-15 | 2020-01-23 | クアドルセプト バイオ リミテッド | 多量体、四量体および八量体 |
| WO2020018715A1 (en) | 2018-07-17 | 2020-01-23 | Massachusetts Institute Of Technology | Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4625275A (en) * | 1984-04-03 | 1986-11-25 | Republic Money Orders, Inc. | Apparatus for dispensing money orders |
| NZ331688A (en) * | 1996-03-28 | 2000-02-28 | Univ Johns Hopkins | Soluble divalent and multivalent heterodimeric analogs of proteins |
| US6211342B1 (en) * | 1996-07-18 | 2001-04-03 | Children's Hospital Medical Center | Multivalent MHC complex peptide fusion protein complex for stimulating specific T cell function |
| WO1998039482A1 (en) * | 1997-03-07 | 1998-09-11 | Sunol Molecular Corporation | Fusion proteins comprising bacteriophage coat protein and a single-chain t cell receptor |
| WO1999060120A2 (en) * | 1998-05-19 | 1999-11-25 | Avidex Limited | Soluble t cell receptor |
| DE69936927T2 (de) * | 1998-10-21 | 2008-05-15 | Altor Bioscience Corp., Miramar | Polyspezifische bindemoleküle und deren verwendung |
| EP1259601A2 (en) * | 2000-02-22 | 2002-11-27 | Ahuva Nissim | Chimeric and tcr phage display libraries, chimeric and tcr reagents and methods of use thereof |
| AU7524601A (en) * | 2000-06-05 | 2001-12-17 | Sunol Molecular Corp | T cell receptor fusions and conjugates and methods of use thereof |
| US6811785B2 (en) * | 2001-05-07 | 2004-11-02 | Mount Sinai School Of Medicine Of New York University | Multivalent MHC class II—peptide chimeras |
-
2003
- 2003-11-25 EP EP03777006A patent/EP1567553A2/en not_active Withdrawn
- 2003-11-25 US US10/535,965 patent/US20060135418A1/en not_active Abandoned
- 2003-11-25 JP JP2004570696A patent/JP2006523437A/ja not_active Withdrawn
- 2003-11-25 AU AU2003286263A patent/AU2003286263A1/en not_active Abandoned
- 2003-11-25 WO PCT/GB2003/005104 patent/WO2004050705A2/en not_active Ceased