JP2006523437A5 - - Google Patents
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- Publication number
- JP2006523437A5 JP2006523437A5 JP2004570696A JP2004570696A JP2006523437A5 JP 2006523437 A5 JP2006523437 A5 JP 2006523437A5 JP 2004570696 A JP2004570696 A JP 2004570696A JP 2004570696 A JP2004570696 A JP 2004570696A JP 2006523437 A5 JP2006523437 A5 JP 2006523437A5
- Authority
- JP
- Japan
- Prior art keywords
- tcr
- complex according
- chain
- polypeptide
- tcr complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108091008874 T cell receptors Proteins 0.000 claims 48
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 48
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 125000003827 glycol group Chemical group 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 6
- 229920001515 polyalkylene glycol Polymers 0.000 claims 5
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 101000662909 Homo sapiens T cell receptor beta constant 1 Proteins 0.000 claims 1
- 101000662902 Homo sapiens T cell receptor beta constant 2 Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102100037272 T cell receptor beta constant 1 Human genes 0.000 claims 1
- 102100037298 T cell receptor beta constant 2 Human genes 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 229920001281 polyalkylene Polymers 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0228112A GB0228112D0 (en) | 2002-12-03 | 2002-12-03 | Receptors |
| GB0304090A GB0304090D0 (en) | 2003-02-22 | 2003-02-22 | Receptors |
| GB0308309A GB0308309D0 (en) | 2003-04-10 | 2003-04-10 | Receptors |
| US47590603P | 2003-06-05 | 2003-06-05 | |
| GB0314113A GB0314113D0 (en) | 2003-06-18 | 2003-06-18 | Receptors |
| GB0316354A GB0316354D0 (en) | 2003-07-11 | 2003-07-11 | Receptors |
| PCT/GB2003/005104 WO2004050705A2 (en) | 2002-12-03 | 2003-11-25 | Complexes of receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006523437A JP2006523437A (ja) | 2006-10-19 |
| JP2006523437A5 true JP2006523437A5 (https=) | 2006-12-14 |
Family
ID=32475869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004570696A Withdrawn JP2006523437A (ja) | 2002-12-03 | 2003-11-25 | レセプター複合体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20060135418A1 (https=) |
| EP (1) | EP1567553A2 (https=) |
| JP (1) | JP2006523437A (https=) |
| AU (1) | AU2003286263A1 (https=) |
| WO (1) | WO2004050705A2 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8772451B2 (en) * | 2003-11-10 | 2014-07-08 | Altor Bioscience Corporation | Soluble TCR molecules and methods of use |
| US20060122783A1 (en) * | 2004-08-24 | 2006-06-08 | Ishikawa Muriel Y | System and method for heightening a humoral immune response |
| US20060047434A1 (en) * | 2004-08-24 | 2006-03-02 | Ishikawa Muriel Y | System and method related to improving an immune system |
| US20060182742A1 (en) * | 2004-08-24 | 2006-08-17 | Ishikawa Muriel Y | System and method for magnifying a humoral immune response |
| US20060047435A1 (en) * | 2004-08-24 | 2006-03-02 | Ishikawa Muriel Y | System and method related to augmenting an immune system |
| US20060095211A1 (en) * | 2003-12-05 | 2006-05-04 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | System and method for modulating a cell mediated immune response |
| US20060116824A1 (en) * | 2004-12-01 | 2006-06-01 | Ishikawa Muriel Y | System and method for modulating a humoral immune response |
| US20060047433A1 (en) * | 2004-08-24 | 2006-03-02 | Ishikawa Muriel Y | System and method related to enhancing an immune system |
| US20060047437A1 (en) * | 2004-08-25 | 2006-03-02 | Ishikawa Muriel Y | System and method for heightening an immune response |
| US20060047436A1 (en) * | 2004-08-25 | 2006-03-02 | Ishikawa Muriel Y | System and method for magnifying an immune response |
| US20060122784A1 (en) * | 2004-12-03 | 2006-06-08 | Ishikawa Muriel Y | System and method for augmenting a humoral immune response |
| US20070196362A1 (en) * | 2004-08-24 | 2007-08-23 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational methods and systems to bolster an immune response |
| US20060047439A1 (en) * | 2004-08-24 | 2006-03-02 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | System and method for improving a humoral immune response |
| US20070265818A1 (en) * | 2004-08-24 | 2007-11-15 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational methods and systems for heightening cell-mediated immune response |
| US20070207492A1 (en) * | 2004-08-24 | 2007-09-06 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational methods and systems to adjust a humoral immune response |
| US20070198196A1 (en) * | 2004-08-24 | 2007-08-23 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational systems and methods relating to ameliorating an immune system |
| US20070265819A1 (en) * | 2004-08-24 | 2007-11-15 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational methods and systems for improving cell-mediated immune response |
| AU2005291039A1 (en) * | 2004-10-01 | 2006-04-13 | Avidex Ltd. | T-cell receptors containing a non-native disulfide interchain bond linked to therapeutic agents |
| GB0427585D0 (en) * | 2004-12-16 | 2005-01-19 | Avidex Ltd | Assay |
| CN103555733A (zh) | 2005-01-05 | 2014-02-05 | F-星生物技术研究与开发有限公司 | 分子中互补决定区以外的区域中工程改造了的具有结合特性的合成免疫球蛋白结构域 |
| GB0511124D0 (en) * | 2005-06-01 | 2005-07-06 | Avidex Ltd | High affinity melan-a t cell receptors |
| CA2634292A1 (en) * | 2005-12-20 | 2007-06-28 | Erasmus University Medical Center Rotterdam | Apoptosis-inducing protein complexes and therapeutic use thereof |
| EP1870418A1 (en) | 2006-06-20 | 2007-12-26 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Allorestricted peptide-specific T cells |
| AT503889B1 (de) | 2006-07-05 | 2011-12-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | Multivalente immunglobuline |
| AT503861B1 (de) | 2006-07-05 | 2008-06-15 | F Star Biotech Forsch & Entw | Verfahren zur manipulation von t-zell-rezeptoren |
| WO2008039818A2 (en) | 2006-09-26 | 2008-04-03 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Modified t cell receptors and related materials and methods |
| EP3241842B1 (en) | 2007-06-26 | 2024-01-31 | F-star Therapeutics Limited | Display of binding agents |
| GB0712670D0 (en) | 2007-06-29 | 2007-08-08 | King S College London | Isolated peptides and uses thereof |
| EP2113255A1 (en) | 2008-05-02 | 2009-11-04 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Cytotoxic immunoglobulin |
| GB0816096D0 (en) * | 2008-09-04 | 2008-10-15 | Medigene Ltd | Diabetes t cell receptors |
| US9821073B2 (en) | 2010-12-27 | 2017-11-21 | Apo-T B.V. | Polypeptide that binds aberrant cells and induces apoptosis |
| WO2012091564A2 (en) | 2010-12-27 | 2012-07-05 | Apo-T B.V. | A cross-linking polypeptide that induces apoptosis |
| EP2760892A1 (en) | 2011-09-29 | 2014-08-06 | Apo-T B.V. | Multi-specific binding molecules targeting aberrant cells |
| AU2013208364B2 (en) | 2012-01-13 | 2017-10-26 | Apo-T B.V. | Aberrant cell-restricted immunoglobulins provided with a toxic moiety |
| CN106279404A (zh) * | 2015-05-20 | 2017-01-04 | 广州市香雪制药股份有限公司 | 一种可溶且稳定的异质二聚tcr |
| US11453726B2 (en) * | 2016-09-15 | 2022-09-27 | Quadrucept Bio Limited | Multimers, tetramers and octamers |
| US20220275043A1 (en) | 2018-07-17 | 2022-09-01 | Massachusetts Institute Of Technology | Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4625275A (en) * | 1984-04-03 | 1986-11-25 | Republic Money Orders, Inc. | Apparatus for dispensing money orders |
| CA2250166A1 (en) * | 1996-03-28 | 1997-10-02 | The Johns Hopkins University | Soluble divalent and multivalent heterodimeric analogs of proteins |
| US6211342B1 (en) * | 1996-07-18 | 2001-04-03 | Children's Hospital Medical Center | Multivalent MHC complex peptide fusion protein complex for stimulating specific T cell function |
| AU6685698A (en) * | 1997-03-07 | 1998-09-22 | Sunol Molecular Corporation | Fusion proteins comprising bacteriophage coat protein and a single-chain t cell receptor |
| WO1999060120A2 (en) * | 1998-05-19 | 1999-11-25 | Avidex Limited | Soluble t cell receptor |
| ES2293748T3 (es) * | 1998-10-21 | 2008-03-16 | Altor Bioscience Corporation | Moleculas de fijacion poliespecificas y usos de las mismas. |
| WO2001062908A2 (en) * | 2000-02-22 | 2001-08-30 | Ahuva Nissim | Chimeric and tcr phage display libraries, chimeric and tcr reagents and methods of use thereof |
| EP2322228B1 (en) * | 2000-06-05 | 2018-01-10 | Altor BioScience Corporation | T cell receptor fusion proteins and conjugates and methods of use thereof |
| US6811785B2 (en) * | 2001-05-07 | 2004-11-02 | Mount Sinai School Of Medicine Of New York University | Multivalent MHC class II—peptide chimeras |
-
2003
- 2003-11-25 JP JP2004570696A patent/JP2006523437A/ja not_active Withdrawn
- 2003-11-25 AU AU2003286263A patent/AU2003286263A1/en not_active Abandoned
- 2003-11-25 WO PCT/GB2003/005104 patent/WO2004050705A2/en not_active Ceased
- 2003-11-25 US US10/535,965 patent/US20060135418A1/en not_active Abandoned
- 2003-11-25 EP EP03777006A patent/EP1567553A2/en not_active Withdrawn
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