JP2006522827A - 置換キノベンゾオキサジン類似体 - Google Patents

置換キノベンゾオキサジン類似体 Download PDF

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JP2006522827A
JP2006522827A JP2006509898A JP2006509898A JP2006522827A JP 2006522827 A JP2006522827 A JP 2006522827A JP 2006509898 A JP2006509898 A JP 2006509898A JP 2006509898 A JP2006509898 A JP 2006509898A JP 2006522827 A JP2006522827 A JP 2006522827A
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compound
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substituted
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JP2006522827A5 (enExample
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ジェフリー ピー． ホイッテン
マイケル シュワエベ
アダム シディキ−ジャイン
テランス モーラン
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サイリーン ファーマシューティカルズ インコーポレーティッド
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Publication of JP2006522827A publication Critical patent/JP2006522827A/ja
Publication of JP2006522827A5 publication Critical patent/JP2006522827A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2006509898A 2003-04-07 2004-04-07 置換キノベンゾオキサジン類似体 Pending JP2006522827A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US46127103P 2003-04-07 2003-04-07
US46317103P 2003-04-15 2003-04-15
US51953503P 2003-11-12 2003-11-12
US53272703P 2003-12-23 2003-12-23
PCT/US2004/011108 WO2004091504A2 (en) 2003-04-07 2004-04-07 Substituted quinobenzoxazine analogs

Publications (2)

Publication Number Publication Date
JP2006522827A true JP2006522827A (ja) 2006-10-05
JP2006522827A5 JP2006522827A5 (enExample) 2007-05-31

Family

ID=33304104

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006509898A Pending JP2006522827A (ja) 2003-04-07 2004-04-07 置換キノベンゾオキサジン類似体

Country Status (11)

Country Link
US (5) US7141565B1 (enExample)
EP (1) EP1610759A4 (enExample)
JP (1) JP2006522827A (enExample)
KR (1) KR100944600B1 (enExample)
AU (1) AU2004229489B2 (enExample)
BR (1) BRPI0409105A (enExample)
CA (1) CA2521810A1 (enExample)
MX (1) MXPA05010776A (enExample)
NO (1) NO20054669L (enExample)
NZ (1) NZ543006A (enExample)
WO (1) WO2004091504A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008508311A (ja) * 2004-07-30 2008-03-21 サイリーン ファーマシューティカルズ インコーポレーティッド 置換キノベンゾキサジン類似体およびそれを用いる方法

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NZ543006A (en) * 2003-04-07 2009-03-31 Cylene Pharmaceuticals Inc Substituted quinobenzoxazine analogs
US7354916B2 (en) * 2003-04-07 2008-04-08 Cylene Pharmaceuticals Substituted quinobenzoxazine analogs
US20080032286A1 (en) * 2003-10-14 2008-02-07 Cylene Pharaceuticals, Inc. Competition Assay for Identifying Modulators of Quadruplex Nucleic Acids
DE102004035203A1 (de) * 2004-07-21 2006-02-16 Bayer Healthcare Ag Substituierte Chinolone
MX2007003282A (es) * 2004-09-17 2007-10-16 Cylene Pharmaceuticals Inc Analogos de quinolona.
US7652134B2 (en) * 2004-09-17 2010-01-26 Cylene Pharmaceuticals, Inc. Methods for converting quinolone esters into quinolone amides
CA2604787A1 (en) * 2005-04-15 2006-10-26 Cylene Pharmaceuticals, Inc. Quinobenzoxazine analogs and methods of using thereof
US7610985B2 (en) * 2005-05-18 2009-11-03 Kanzaki Kokyukoki Mfg. Co., Ltd. HST unit
DE102006005861A1 (de) 2006-02-09 2007-08-23 Aicuris Gmbh & Co. Kg Substituierte Chinolone III
US8481529B2 (en) * 2006-05-16 2013-07-09 The Arizona Board Of Regents On Behalf Of The University Of Arizona Combination cancer chemotherapy
EP2023935A4 (en) * 2006-06-03 2010-12-22 Cylene Pharmaceuticals Inc METHODS OF DRUG DELIVERY
US8410070B2 (en) * 2008-09-12 2013-04-02 University Of Louisville Research Foundation, Inc. Compositions and methods for treating cancer, inhibiting proliferation, and inducing cell death
US8470817B2 (en) 2009-10-26 2013-06-25 Sunesis Pharmaceuticals, Inc. Compounds and methods for treatment of cancer
US9730609B2 (en) * 2011-12-15 2017-08-15 Siemens Healthcare Gmbh Method and system for aortic valve calcification evaluation
JP6249436B2 (ja) * 2012-08-31 2017-12-20 国立大学法人東京農工大学 四重らせんｄｎａ検出プローブ及びそれを用いた四重らせん構造の検出方法
US9758518B2 (en) 2015-03-04 2017-09-12 Pimera, Inc. Compositions, uses and methods for making them
CA2948173C (en) 2014-05-09 2018-06-19 Pimera, Inc. Quinoline compounds and uses thereof
CN110709400A (zh) 2017-03-28 2020-01-17 皮梅拉股份有限公司 Pol1抑制剂的新型晶体形式
US11071727B2 (en) 2018-01-26 2021-07-27 Northwestern University Therapeutic targeting of proteolytic cleavage of the mixed lineage leukemia gene product (MLL1) by taspase1 using kinase inhibitors
CN114716373B (zh) * 2022-04-14 2023-01-10 内蒙古源宏精细化工有限公司 一种加替沙星环合酯的制备方法
CN116023263A (zh) * 2022-11-17 2023-04-28 苏州汉德创宏生化科技有限公司 一种中间体3-(3,5-二氯苯基)-3-氧代丙酸乙酯的合成方法

Citations (7)

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Publication number Priority date Publication date Assignee Title
JPS60233089A (ja) * 1984-04-26 1985-11-19 アボツト　ラボラトリーズ キノリン‐ベノキサジン抗菌性化合物
JPS60233093A (ja) * 1984-04-26 1985-11-19 アボツト　ラボラトリーズ キノリン‐ベンゾチアジン抗菌性化合物
JPS62175482A (ja) * 1986-01-15 1987-08-01 バイエル・アクチエンゲゼルシヤフト １，８−橋かけ４−キノロン−３−カルボン酸及びこれらの化合物を含有する薬物
WO1992003136A1 (en) * 1990-08-24 1992-03-05 Abbott Laboratories Quinobenzoxazine, quinobenzothiazine, and pyrido-acridine antineoplastic agents
WO1999040093A2 (en) * 1998-02-04 1999-08-12 Board Of Regents, The University Of Texas System Synthesis of quinobenzoxazine analogues with topoisomerase ii and quadruplex interactions for use as antineoplastic agents
WO2000068229A2 (en) * 1999-05-07 2000-11-16 Wockhardt Limited (s)-benzoquinolizine carboxylic acids and their use as antibacterial agents
WO2002004462A1 (en) * 2000-07-12 2002-01-17 Pharmacia & Upjohn Company Oxazinoquinolones useful for the treatment of viral infections

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LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
CA1267649A (en) * 1984-04-26 1990-04-10 Daniel Tim-Wo Chu Quino-benzothiazine antibacterial compounds
US4607032A (en) * 1984-04-26 1986-08-19 Abbott Laboratories Quino-benoxazine antibacterial compounds
US4533663A (en) 1984-04-26 1985-08-06 Abbott Laboratories Quino-benzothiazine antibacterial compounds
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
JPH0240379A (ja) 1988-07-28 1990-02-09 Wakunaga Pharmaceut Co Ltd 新規キノロン誘導体
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
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US5318965A (en) * 1990-08-24 1994-06-07 Abbott Laboratories Quinobenzoxazine, antineoplastic agents
US5225418A (en) 1991-12-17 1993-07-06 Du Pont Merck Pharmaceutical Company 5H-(1,2)benzisothiazolo[2,3-a]quinoline-5-ones and analogs as antiinflammatory agents
ATE357663T1 (de) 1996-04-25 2007-04-15 Genicon Sciences Corp Teilchenförmiges markierungsmittel verwendendes analytassay
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US8163769B2 (en) 2002-03-12 2012-04-24 Abbott Laboratories Antibacterial compounds
US6818654B2 (en) 2002-03-12 2004-11-16 Abbott Laboratories Antibacterial compounds
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EP1610795A4 (en) 2003-04-07 2007-10-24 Cylene Pharmaceuticals Inc SUBSTITUTED 1,4-DIHYDRO-4-OXO-1,8-NAPHTHPYRIDINE HETEROCYCLIC ANALOGUES
US7354916B2 (en) * 2003-04-07 2008-04-08 Cylene Pharmaceuticals Substituted quinobenzoxazine analogs
NZ543006A (en) * 2003-04-07 2009-03-31 Cylene Pharmaceuticals Inc Substituted quinobenzoxazine analogs
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Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60233089A (ja) * 1984-04-26 1985-11-19 アボツト　ラボラトリーズ キノリン‐ベノキサジン抗菌性化合物
JPS60233093A (ja) * 1984-04-26 1985-11-19 アボツト　ラボラトリーズ キノリン‐ベンゾチアジン抗菌性化合物
JPS62175482A (ja) * 1986-01-15 1987-08-01 バイエル・アクチエンゲゼルシヤフト １，８−橋かけ４−キノロン−３−カルボン酸及びこれらの化合物を含有する薬物
WO1992003136A1 (en) * 1990-08-24 1992-03-05 Abbott Laboratories Quinobenzoxazine, quinobenzothiazine, and pyrido-acridine antineoplastic agents
WO1999040093A2 (en) * 1998-02-04 1999-08-12 Board Of Regents, The University Of Texas System Synthesis of quinobenzoxazine analogues with topoisomerase ii and quadruplex interactions for use as antineoplastic agents
WO2000068229A2 (en) * 1999-05-07 2000-11-16 Wockhardt Limited (s)-benzoquinolizine carboxylic acids and their use as antibacterial agents
WO2002004462A1 (en) * 2000-07-12 2002-01-17 Pharmacia & Upjohn Company Oxazinoquinolones useful for the treatment of viral infections

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008508311A (ja) * 2004-07-30 2008-03-21 サイリーン ファーマシューティカルズ インコーポレーティッド 置換キノベンゾキサジン類似体およびそれを用いる方法

Also Published As

Publication number Publication date
AU2004229489A1 (en) 2004-10-28
US20120122804A1 (en) 2012-05-17
US7326702B2 (en) 2008-02-05
US20080261963A1 (en) 2008-10-23
WO2004091504A3 (en) 2006-01-05
NO20054669L (no) 2005-11-14
KR20060029210A (ko) 2006-04-05
KR100944600B1 (ko) 2010-02-25
WO2004091504A2 (en) 2004-10-28
AU2004229489B2 (en) 2010-03-04
US7381720B2 (en) 2008-06-03
US7141565B1 (en) 2006-11-28
CA2521810A1 (en) 2004-10-28
US7612063B2 (en) 2009-11-03
MXPA05010776A (es) 2006-05-25
NO20054669D0 (no) 2005-10-11
NZ543006A (en) 2009-03-31
EP1610759A2 (en) 2006-01-04
EP1610759A4 (en) 2007-04-25
US20070043039A1 (en) 2007-02-22
BRPI0409105A (pt) 2006-04-25
US20060229303A1 (en) 2006-10-12

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