AU2004229489B2 - Substituted quinobenzoxazine analogs - Google Patents
Substituted quinobenzoxazine analogs Download PDFInfo
- Publication number
- AU2004229489B2 AU2004229489B2 AU2004229489A AU2004229489A AU2004229489B2 AU 2004229489 B2 AU2004229489 B2 AU 2004229489B2 AU 2004229489 A AU2004229489 A AU 2004229489A AU 2004229489 A AU2004229489 A AU 2004229489A AU 2004229489 B2 AU2004229489 B2 AU 2004229489B2
- Authority
- AU
- Australia
- Prior art keywords
- pct
- myc
- hella
- compound
- chiral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 150000001875 compounds Chemical class 0.000 claims description 143
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- 238000000034 method Methods 0.000 claims description 43
- 125000000623 heterocyclic group Chemical group 0.000 claims description 41
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 40
- 229910052757 nitrogen Inorganic materials 0.000 claims description 37
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 33
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 28
- 125000000217 alkyl group Chemical group 0.000 claims description 27
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 26
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 26
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 24
- -1 acyclic amine Chemical class 0.000 claims description 22
- 125000003118 aryl group Chemical group 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 20
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- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical group N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims description 4
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Communicable Diseases (AREA)
- Hematology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (9)
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| US46317103P | 2003-04-15 | 2003-04-15 | |
| US60/463,171 | 2003-04-15 | ||
| US51953503P | 2003-11-12 | 2003-11-12 | |
| US60/519,535 | 2003-11-12 | ||
| US53272703P | 2003-12-23 | 2003-12-23 | |
| US60/532,727 | 2003-12-23 | ||
| PCT/US2004/011108 WO2004091504A2 (en) | 2003-04-07 | 2004-04-07 | Substituted quinobenzoxazine analogs |
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| AU2004229489A1 AU2004229489A1 (en) | 2004-10-28 |
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| AU (1) | AU2004229489B2 (enExample) |
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| CA (1) | CA2521810A1 (enExample) |
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| KR100944600B1 (ko) | 2003-04-07 | 2010-02-25 | 사일린 파마슈티칼스, 인크 | 치환된 퀴노벤족사진 유사체 |
| US7354916B2 (en) | 2003-04-07 | 2008-04-08 | Cylene Pharmaceuticals | Substituted quinobenzoxazine analogs |
| US7507727B2 (en) * | 2003-04-07 | 2009-03-24 | Cylene Pharmaceuticals, Inc. | Substituted quinobenzoxazine analogs and methods of using thereof |
| WO2005037997A2 (en) * | 2003-10-14 | 2005-04-28 | Cylene Pharmaceuticals, Inc. | Competition assay for identifying modulators of quadruplex nucleic acids |
| DE102004035203A1 (de) * | 2004-07-21 | 2006-02-16 | Bayer Healthcare Ag | Substituierte Chinolone |
| US7652134B2 (en) | 2004-09-17 | 2010-01-26 | Cylene Pharmaceuticals, Inc. | Methods for converting quinolone esters into quinolone amides |
| MX2007003282A (es) * | 2004-09-17 | 2007-10-16 | Cylene Pharmaceuticals Inc | Analogos de quinolona. |
| WO2006113509A2 (en) * | 2005-04-15 | 2006-10-26 | Cylene Pharmaceuticals, Inc. | Quinobenzoxazine analogs and methods of using thereof |
| US7610985B2 (en) * | 2005-05-18 | 2009-11-03 | Kanzaki Kokyukoki Mfg. Co., Ltd. | HST unit |
| DE102006005861A1 (de) | 2006-02-09 | 2007-08-23 | Aicuris Gmbh & Co. Kg | Substituierte Chinolone III |
| US8481529B2 (en) * | 2006-05-16 | 2013-07-09 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Combination cancer chemotherapy |
| EP2023935A4 (en) * | 2006-06-03 | 2010-12-22 | Cylene Pharmaceuticals Inc | METHODS OF DRUG DELIVERY |
| US8410070B2 (en) * | 2008-09-12 | 2013-04-02 | University Of Louisville Research Foundation, Inc. | Compositions and methods for treating cancer, inhibiting proliferation, and inducing cell death |
| TW201120037A (en) | 2009-10-26 | 2011-06-16 | Sunesis Pharmaceuticals Inc | Compounds and methods for treatment of cancer |
| US9730609B2 (en) * | 2011-12-15 | 2017-08-15 | Siemens Healthcare Gmbh | Method and system for aortic valve calcification evaluation |
| JP6249436B2 (ja) * | 2012-08-31 | 2017-12-20 | 国立大学法人東京農工大学 | 四重らせんｄｎａ検出プローブ及びそれを用いた四重らせん構造の検出方法 |
| BR112016026150B1 (pt) | 2014-05-09 | 2019-11-05 | Pimera Inc | compostos carboxílicos e seu uso na preparação de medicamentos ou composições farmacêuticas para tratar câncer |
| US9758518B2 (en) | 2015-03-04 | 2017-09-12 | Pimera, Inc. | Compositions, uses and methods for making them |
| EP3601286A4 (en) | 2017-03-28 | 2020-09-23 | Pimera, Inc. | NEW CRYSTALLINE FORMS OF A POL1 INHIBITOR |
| US11071727B2 (en) | 2018-01-26 | 2021-07-27 | Northwestern University | Therapeutic targeting of proteolytic cleavage of the mixed lineage leukemia gene product (MLL1) by taspase1 using kinase inhibitors |
| CN114716373B (zh) * | 2022-04-14 | 2023-01-10 | 内蒙古源宏精细化工有限公司 | 一种加替沙星环合酯的制备方法 |
| CN116023263A (zh) * | 2022-11-17 | 2023-04-28 | 苏州汉德创宏生化科技有限公司 | 一种中间体3-(3,5-二氯苯基)-3-氧代丙酸乙酯的合成方法 |
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| US4725595A (en) * | 1986-01-15 | 1988-02-16 | Bayer Aktiengesellschaft | 1,8-bridged 4-quinolone-3-carboxylic acid antibacterials |
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| WO1999040093A2 (en) * | 1998-02-04 | 1999-08-12 | Board Of Regents, The University Of Texas System | Synthesis of quinobenzoxazine analogues with topoisomerase ii and quadruplex interactions for use as antineoplastic agents |
| EP1602841A2 (en) * | 2004-05-31 | 2005-12-07 | Nissan Motor Co., Ltd. | Connecting rod for internal combustion engines |
| EP1623331A1 (en) * | 2003-05-07 | 2006-02-08 | Koninklijke Philips Electronics N.V. | Processing system and method for transmitting data |
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-
2004
- 2004-04-07 KR KR20057019057A patent/KR100944600B1/ko not_active Expired - Fee Related
- 2004-04-07 JP JP2006509898A patent/JP2006522827A/ja active Pending
- 2004-04-07 EP EP04759406A patent/EP1610759A4/en not_active Withdrawn
- 2004-04-07 WO PCT/US2004/011108 patent/WO2004091504A2/en not_active Ceased
- 2004-04-07 NZ NZ543006A patent/NZ543006A/en not_active IP Right Cessation
- 2004-04-07 BR BRPI0409105-1A patent/BRPI0409105A/pt not_active IP Right Cessation
- 2004-04-07 AU AU2004229489A patent/AU2004229489B2/en not_active Ceased
- 2004-04-07 US US10/821,243 patent/US7141565B1/en not_active Expired - Fee Related
- 2004-04-07 CA CA002521810A patent/CA2521810A1/en not_active Abandoned
- 2004-04-07 MX MXPA05010776A patent/MXPA05010776A/es active IP Right Grant
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2005
- 2005-10-11 NO NO20054669A patent/NO20054669L/no not_active Application Discontinuation
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2006
- 2006-03-28 US US11/390,810 patent/US7326702B2/en not_active Expired - Fee Related
- 2006-05-10 US US11/431,602 patent/US7381720B2/en not_active Expired - Fee Related
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2007
- 2007-03-30 US US11/694,682 patent/US20120122804A1/en not_active Abandoned
-
2008
- 2008-01-14 US US12/013,961 patent/US7612063B2/en not_active Expired - Fee Related
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| US4725595A (en) * | 1986-01-15 | 1988-02-16 | Bayer Aktiengesellschaft | 1,8-bridged 4-quinolone-3-carboxylic acid antibacterials |
| US5318965A (en) * | 1990-08-24 | 1994-06-07 | Abbott Laboratories | Quinobenzoxazine, antineoplastic agents |
| WO1999040093A2 (en) * | 1998-02-04 | 1999-08-12 | Board Of Regents, The University Of Texas System | Synthesis of quinobenzoxazine analogues with topoisomerase ii and quadruplex interactions for use as antineoplastic agents |
| EP1623331A1 (en) * | 2003-05-07 | 2006-02-08 | Koninklijke Philips Electronics N.V. | Processing system and method for transmitting data |
| EP1602841A2 (en) * | 2004-05-31 | 2005-12-07 | Nissan Motor Co., Ltd. | Connecting rod for internal combustion engines |
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| US20120122804A1 (en) | 2012-05-17 |
| US20060229303A1 (en) | 2006-10-12 |
| NO20054669L (no) | 2005-11-14 |
| WO2004091504A2 (en) | 2004-10-28 |
| US7612063B2 (en) | 2009-11-03 |
| US7326702B2 (en) | 2008-02-05 |
| US20070043039A1 (en) | 2007-02-22 |
| BRPI0409105A (pt) | 2006-04-25 |
| US7141565B1 (en) | 2006-11-28 |
| KR100944600B1 (ko) | 2010-02-25 |
| US20080261963A1 (en) | 2008-10-23 |
| EP1610759A4 (en) | 2007-04-25 |
| JP2006522827A (ja) | 2006-10-05 |
| AU2004229489A1 (en) | 2004-10-28 |
| US7381720B2 (en) | 2008-06-03 |
| KR20060029210A (ko) | 2006-04-05 |
| EP1610759A2 (en) | 2006-01-04 |
| MXPA05010776A (es) | 2006-05-25 |
| NO20054669D0 (no) | 2005-10-11 |
| CA2521810A1 (en) | 2004-10-28 |
| NZ543006A (en) | 2009-03-31 |
| WO2004091504A3 (en) | 2006-01-05 |
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