|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
US7122542B2
(en)
|
2003-07-30 |
2006-10-17 |
Rigel Pharmaceuticals, Inc. |
Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
|
|
CA2584485C
(en)
*
|
2004-10-20 |
2013-12-31 |
Resverlogix Corp. |
Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
|
|
WO2006063164A2
(en)
*
|
2004-12-08 |
2006-06-15 |
Wisconsin Alumni Research Foundation |
Compositions and methods for treating neuroendocrine tumors
|
|
USRE46558E1
(en)
|
2005-04-28 |
2017-09-26 |
Paloma Pharmaceuticals, Inc. |
Compositions and methods to treat diseases characterized by cellular proliferation and angiogenesis
|
|
CA2610647C
(en)
*
|
2005-05-27 |
2015-02-03 |
Brian Smith |
Novel inhibitors of pyruvate kinase as therapeutic agents for cancer
|
|
RU2485106C2
(ru)
|
2005-06-08 |
2013-06-20 |
Райджел Фамэсьютикэлз, Инк. |
Соединения, проявляющие активность в отношении jak-киназы (варианты), способ лечения заболеваний, опосредованных jak-киназой, способ ингибирования активности jak-киназы (варианты), фармацевтическая композиция на основе указанных соединений
|
|
US20070203161A1
(en)
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
US7576053B2
(en)
|
2005-06-13 |
2009-08-18 |
Rigel Pharmaceuticals, Inc. |
Methods and compositions for treating degenerative bone disorders
|
|
PT1734251E
(pt)
*
|
2005-06-17 |
2007-03-30 |
Magneti Marelli Powertrain Spa |
Injector de combustível
|
|
CN101365446B
(zh)
|
2005-07-29 |
2013-05-22 |
雷斯弗洛吉克斯公司 |
预防和治疗复杂疾病的药物组合物及其经由可植入医药装置的递送
|
|
KR101391900B1
(ko)
|
2005-12-13 |
2014-05-02 |
인사이트 코포레이션 |
야누스 키나아제 억제제로서의 헤테로아릴 치환된 피롤로[2,3-b]피리딘 및 피롤로[2,3-b]피리미딘
|
|
US20090081318A1
(en)
*
|
2005-12-23 |
2009-03-26 |
Gelbard Harris A |
Treatment of neuroads using inhibitors of glycogen synthase kinase (gsk)-3
|
|
US8962643B2
(en)
|
2006-02-24 |
2015-02-24 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the JAK pathway
|
|
JP2009528381A
(ja)
*
|
2006-02-28 |
2009-08-06 |
パロマ ファーマシューティカルズ,インク. |
細胞増殖および血管新生を特徴とする疾患を治療する組成物および方法
|
|
RU2008139599A
(ru)
|
2006-03-07 |
2010-04-20 |
Эррэй Биофарма Инк. (Us) |
Гетеробициклические производные пиразола и способы их применения
|
|
JP5137818B2
(ja)
|
2006-03-20 |
2013-02-06 |
生化学工業株式会社 |
関節リウマチの処置剤
|
|
JP2009539878A
(ja)
*
|
2006-06-08 |
2009-11-19 |
アレイ バイオファーマ、インコーポレイテッド |
キノリン化合物および使用方法
|
|
EP2046119A2
(en)
*
|
2006-07-07 |
2009-04-15 |
Myriad Genetics, Inc. |
Treatment of psychiatric disorders
|
|
DK2118074T3
(en)
|
2007-02-01 |
2014-03-10 |
Resverlogix Corp |
Compounds for the prevention and treatment of cardiovascular diseases
|
|
WO2008157208A2
(en)
|
2007-06-13 |
2008-12-24 |
Incyte Corporation |
Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
|
|
HRP20170317T1
(hr)
|
2008-02-15 |
2017-04-21 |
Rigel Pharmaceuticals, Inc. |
Spojevi pirimidin-2-amina i njihova uporaba kao inhibitora jak kinaza
|
|
UY31684A
(es)
|
2008-03-03 |
2009-11-10 |
Takeda Pharmaceutical |
Farmaco combinado
|
|
WO2009111644A2
(en)
*
|
2008-03-05 |
2009-09-11 |
The Regents Of The University Of Michigan |
Compositions and methods for diagnosing and treating pancreatic cancer
|
|
MX2010010431A
(es)
*
|
2008-03-25 |
2010-11-25 |
Paloma Pharmaceuticals Inc |
Metodos para tratar desordenes fibroticos.
|
|
PT2323993E
(pt)
|
2008-04-16 |
2015-10-12 |
Portola Pharm Inc |
2,6-diamino-pirimidina-5-il-carboxamidas como inibidores de quinasses syk ou jak
|
|
US8138339B2
(en)
|
2008-04-16 |
2012-03-20 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
US8258144B2
(en)
|
2008-04-22 |
2012-09-04 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
ES2532402T3
(es)
|
2008-06-26 |
2015-03-26 |
Resverlogix Corporation |
Métodos de preparación de derivados de quinazolinona
|
|
CN102143744B
(zh)
*
|
2008-07-25 |
2016-08-31 |
爱默蕾大学 |
7,8-二羟基黄酮及其衍生物在制备治疗抑郁的药物中的用途
|
|
JP2012501188A
(ja)
*
|
2008-08-29 |
2012-01-19 |
ジェネンテック, インコーポレイテッド |
Vegf非依存性腫瘍についての診断薬および治療
|
|
US20120046242A1
(en)
*
|
2008-12-24 |
2012-02-23 |
Massachusetts Institute Of Technology |
Molecular activators of the wnt/beta-catenin pathway
|
|
JP5635535B2
(ja)
|
2009-01-08 |
2014-12-03 |
レスバーロジックス コーポレイション |
心血管疾患の予防および治療のための化合物
|
|
EP2396307B1
(en)
|
2009-02-11 |
2014-10-15 |
Merck Patent GmbH |
Novel amino azaheterocyclic carboxamides
|
|
CN105859639A
(zh)
|
2009-03-18 |
2016-08-17 |
雷斯韦洛吉克斯公司 |
新的抗炎剂
|
|
CN107252429B
(zh)
|
2009-04-22 |
2023-06-16 |
雷斯韦洛吉克斯公司 |
新抗炎剂
|
|
TW201100429A
(en)
|
2009-05-22 |
2011-01-01 |
Incyte Corp |
N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
DK2432472T3
(da)
|
2009-05-22 |
2019-11-18 |
Incyte Holdings Corp |
3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octan- eller heptan-nitril som jak-inhibitorer
|
|
EP2462141B1
(en)
|
2009-08-07 |
2017-09-27 |
Merck Patent GmbH |
Novel azaheterocyclic compounds
|
|
TW201113285A
(en)
|
2009-09-01 |
2011-04-16 |
Incyte Corp |
Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
JP5806672B2
(ja)
*
|
2009-10-30 |
2015-11-10 |
ドメイン・セラピューティクス |
新規オキシム誘導体及び代謝型グルタミン酸受容体のアロステリック調節因子としての利用
|
|
PH12015502575A1
(en)
|
2010-03-10 |
2017-04-24 |
Incyte Corp |
Piperidin-4-yl azetidine derivatives as jak1 inhibitors
|
|
EP3087972A1
(en)
|
2010-05-21 |
2016-11-02 |
Incyte Holdings Corporation |
Topical formulation for a jak inhibitor
|
|
CN105566272A
(zh)
|
2010-06-09 |
2016-05-11 |
爱默蕾大学 |
TrkB激动剂及其用途
|
|
UA110113C2
(xx)
|
2010-07-29 |
2015-11-25 |
|
Біциклічні азагетероциклічні карбоксаміди
|
|
ES2729754T3
(es)
|
2010-07-29 |
2019-11-06 |
Merck Patent Gmbh |
Carboxamidas azaheterocíclicas de aminas cíclicas
|
|
EP2975027A1
(en)
|
2010-11-01 |
2016-01-20 |
Portola Pharmaceuticals, Inc. |
Nicotinamides as jak kinase modulators
|
|
US9198911B2
(en)
*
|
2010-11-02 |
2015-12-01 |
The Trustees Of Columbia University In The City Of New York |
Methods for treating hair loss disorders
|
|
CN103415515B
(zh)
|
2010-11-19 |
2015-08-26 |
因塞特公司 |
作为jak抑制剂的环丁基取代的吡咯并吡啶和吡咯并嘧啶衍生物
|
|
CA2818545C
(en)
|
2010-11-19 |
2019-04-16 |
Incyte Corporation |
Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
|
|
EP2643313B9
(en)
|
2010-11-24 |
2017-02-22 |
Merck Patent GmbH |
Quinazoline carboxamide azetidines
|
|
WO2012112791A1
(en)
|
2011-02-16 |
2012-08-23 |
Paloma Pharmaceuticals, Inc. |
Radiation countermeasure agents
|
|
US9493436B2
(en)
|
2011-04-26 |
2016-11-15 |
Indiana University Research And Technology Corporation |
Tyrosine phosphatase inhibitors and uses thereof to modulate the activity of enzymes involved in the pathology of Mycobacterium tuberculosis
|
|
US8691807B2
(en)
|
2011-06-20 |
2014-04-08 |
Incyte Corporation |
Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為jak抑制劑之環己基氮雜環丁烷衍生物
|
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
|
US9145392B2
(en)
|
2011-09-12 |
2015-09-29 |
Merck Patent Gmbh |
Imidazole amines as modulators of kinase activity
|
|
DK2755958T3
(en)
|
2011-09-12 |
2017-09-25 |
Merck Patent Gmbh |
AMINOPYRIMIDINE DERIVATIVES USED AS MODULATORS OF KINASE ACTIVITY
|
|
JP5992049B2
(ja)
|
2011-11-01 |
2016-09-14 |
レスバーロジックス コーポレイション |
置換されたキナゾリノンのための経口速放性製剤
|
|
US8877760B2
(en)
|
2011-11-23 |
2014-11-04 |
Portola Pharmaceuticals, Inc. |
Substituted pyrazine-2-carboxamide kinase inhibitors
|
|
WO2013096194A1
(en)
|
2011-12-22 |
2013-06-27 |
Merck Patent Gmbh |
Novel heterocyclic carboxamides as modulators of kinase activity
|
|
CN104582705A
(zh)
*
|
2012-01-10 |
2015-04-29 |
林伯士艾瑞斯公司 |
白介素-1受体相关激酶(irak)抑制剂和其用途
|
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
|
TW201406761A
(zh)
|
2012-05-18 |
2014-02-16 |
Incyte Corp |
做爲jak抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
|
|
EP2877461B1
(en)
|
2012-07-27 |
2018-05-09 |
Emory University |
Heterocyclic flavone derivatives, compositions, and methods related thereto
|
|
EP2903970A4
(en)
|
2012-10-08 |
2016-11-30 |
Portola Pharm Inc |
SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS
|
|
EP3949953A1
(en)
|
2012-11-15 |
2022-02-09 |
Incyte Holdings Corporation |
Sustained-release dosage forms of ruxolitinib
|
|
CN105102435A
(zh)
|
2012-11-16 |
2015-11-25 |
默克专利有限公司 |
用作激酶活性调节剂的新颖的咪唑-哌啶基衍生物
|
|
CA2890288A1
(en)
|
2012-11-16 |
2014-05-22 |
Merck Patent Gmbh |
Novel heterocyclic derivatives as modulators of kinase activity
|
|
WO2014080290A2
(en)
|
2012-11-21 |
2014-05-30 |
Rvx Therapeutics Inc. |
Cyclic amines as bromodomain inhibitors
|
|
WO2014080291A2
(en)
|
2012-11-21 |
2014-05-30 |
Rvx Therapeutics Inc. |
Biaryl derivatives as bromodomain inhibitors
|
|
CN105793254B
(zh)
|
2012-11-29 |
2020-10-23 |
默克专利有限公司 |
氮杂喹唑啉羧酰胺衍生物
|
|
AU2013365926B9
(en)
|
2012-12-21 |
2019-01-17 |
Zenith Epigenetics Ltd. |
Novel heterocyclic compounds as bromodomain inhibitors
|
|
BR112015021458B1
(pt)
|
2013-03-06 |
2022-06-07 |
Incyte Holdings Corporation |
"processos e intermediários para preparar {1-{1-[3-flúor2-(trifluormetil)isonicotinoil] piperidin-4-il}-3-[4-(7hpirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]azetidin-3-il}acetonitrila, útil no tratamento de doenças relacionadas com a atividade de janus quinases
|
|
HK1218756A1
(zh)
|
2013-03-11 |
2017-03-10 |
默克专利有限公司 |
用作激酶活性调节剂的6-[4-(1h-咪唑-2-基)哌啶-1-基]嘧啶-4-胺衍生物
|
|
WO2015021153A1
(en)
|
2013-08-07 |
2015-02-12 |
Incyte Corporation |
Sustained release dosage forms for a jak1 inhibitor
|
|
EP3122900A1
(en)
|
2014-03-24 |
2017-02-01 |
F. Hoffmann-La Roche AG |
Cancer treatment with c-met antagonists and correlation of the latter with hgf expression
|
|
RU2733401C2
(ru)
|
2014-04-03 |
2020-10-01 |
Мерк Патент Гмбх |
Комбинации противораковых лекарств
|
|
WO2015184305A1
(en)
|
2014-05-30 |
2015-12-03 |
Incyte Corporation |
TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
|
|
SMT201900152T1
(it)
|
2014-08-27 |
2019-05-10 |
Prexton Therapeutics Sa |
Nuovo derivato di cromone ossima e suo uso come modulatore allosterico di recettori metabotropici del glutammato
|
|
CN114984016A
(zh)
|
2015-03-13 |
2022-09-02 |
雷斯韦洛吉克斯公司 |
用于治疗补体相关疾病之组合物及治疗方法
|
|
AU2016313138A1
(en)
|
2015-08-27 |
2018-03-15 |
Prexton Therapeutics Sa |
Brain-penetrant chromone oxime derivative for the therapy of levodopa-induced dyskinesia
|
|
GB201516905D0
(en)
*
|
2015-09-24 |
2015-11-11 |
Stratified Medical Ltd |
Treatment of Neurodegenerative diseases
|
|
EP3260445A1
(en)
|
2016-06-24 |
2017-12-27 |
Universität Konstanz |
Compounds for use as an anti-bacterial or anti-fungal agent and as a zinc sensor
|
|
US10759865B2
(en)
|
2017-08-22 |
2020-09-01 |
Eyal Levit |
Treatment of diabetes mellitus
|
|
TW201924683A
(zh)
|
2017-12-08 |
2019-07-01 |
美商英塞特公司 |
用於治療骨髓增生性贅瘤的低劑量組合療法
|
|
EP3502095A1
(en)
|
2017-12-22 |
2019-06-26 |
Universität Konstanz |
Compound for use against pathogenic neisseria and haemophilus species and moraxella catarrhalis
|
|
DK3746429T3
(da)
|
2018-01-30 |
2022-05-02 |
Incyte Corp |
Fremgangsmåder til fremstilling af (1-(3-fluor-2-(trifluormethyl)isonicotinyl)piperidin-4-on)
|
|
CN112423759A
(zh)
|
2018-03-30 |
2021-02-26 |
因赛特公司 |
使用jak抑制剂治疗化脓性汗腺炎
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
WO2022101459A1
(en)
|
2020-11-16 |
2022-05-19 |
Merck Patent Gmbh |
Kinase inhibitor combinations for cancer treatment
|