JP2006521088A - 抗活性化ｒａｓ抗体 - Google Patents

抗活性化ｒａｓ抗体 Download PDF

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Publication number
JP2006521088A
JP2006521088A JP2004570301A JP2004570301A JP2006521088A JP 2006521088 A JP2006521088 A JP 2006521088A JP 2004570301 A JP2004570301 A JP 2004570301A JP 2004570301 A JP2004570301 A JP 2004570301A JP 2006521088 A JP2006521088 A JP 2006521088A
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JP
Japan
Prior art keywords
seq
antibody
sequence
ras
variable domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2004570301A
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English (en)
Japanese (ja)
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JP2006521088A5 (https=
Inventor
ラビッツ，テレンス，ハワード
智之 田中
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical Research Council
Original Assignee
Medical Research Council
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Filing date
Publication date
Priority claimed from GB0226728A external-priority patent/GB0226728D0/en
Priority claimed from GB0226731A external-priority patent/GB0226731D0/en
Priority claimed from GB0226723A external-priority patent/GB0226723D0/en
Priority claimed from GBGB0226729.2A external-priority patent/GB0226729D0/en
Priority claimed from GBGB0226727.6A external-priority patent/GB0226727D0/en
Priority claimed from GB0316680A external-priority patent/GB0316680D0/en
Application filed by Medical Research Council filed Critical Medical Research Council
Publication of JP2006521088A publication Critical patent/JP2006521088A/ja
Publication of JP2006521088A5 publication Critical patent/JP2006521088A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2004570301A 2002-11-15 2003-11-14 抗活性化ｒａｓ抗体 Withdrawn JP2006521088A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0226728A GB0226728D0 (en) 2002-11-15 2002-11-15 Anti-activated RAS antibodies
GB0226731A GB0226731D0 (en) 2002-11-15 2002-11-15 Method for generating immunoglobulin genes
GB0226723A GB0226723D0 (en) 2002-11-15 2002-11-15 Antibodies for in vitro use
GBGB0226729.2A GB0226729D0 (en) 2002-11-15 2002-11-15 Intracellular antibodies
GBGB0226727.6A GB0226727D0 (en) 2002-11-15 2002-11-15 Intrabodies
GB0316680A GB0316680D0 (en) 2003-07-16 2003-07-16 Anti-activated RAS antibodies
PCT/GB2003/004953 WO2004046188A2 (en) 2002-11-15 2003-11-14 Anti-activated ras antibodies

Publications (2)

Publication Number Publication Date
JP2006521088A true JP2006521088A (ja) 2006-09-21
JP2006521088A5 JP2006521088A5 (https=) 2006-11-30

Family

ID=32330172

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004570301A Withdrawn JP2006521088A (ja) 2002-11-15 2003-11-14 抗活性化ｒａｓ抗体

Country Status (6)

Country Link
US (1) US20050288492A1 (https=)
EP (1) EP1565495A2 (https=)
JP (1) JP2006521088A (https=)
AU (1) AU2003282247A1 (https=)
CA (1) CA2506128A1 (https=)
WO (1) WO2004046188A2 (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8532164B2 (en) 2008-03-12 2013-09-10 Panasonic Corporation Wireless communication apparatus, wireless communication system, and wireless communication method
JP2017529870A (ja) * 2014-07-22 2017-10-12 オルム セラピューティクス インコーポレイテッドＯｒｕｍ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 完全型免疫グロブリン形態の細胞質浸透能を有する抗体を利用して細胞内活性化されたｒａｓを抑制する方法及びその利用
US10787487B2 (en) 2018-06-21 2020-09-29 Orum Therapeutics Inc. Cell/tissue-specific cell-penetrating antibodies
US10844136B2 (en) 2014-07-22 2020-11-24 Orum Therapeutics Inc. Method for positioning, in cytoplasm, antibody having complete immunoglobulin form by penetrating antibody through cell membrane, and use for same
US11155641B2 (en) 2016-05-27 2021-10-26 Orum Therapeutics Inc. Cytosol-penetrating antibody and use thereof
JP2023525164A (ja) * 2020-05-12 2023-06-14 オックスフォード・ユニバーシティ・イノベイション・リミテッド 標的特異的分解剤及びそれらの医学的使用

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2336323A3 (en) * 2005-03-25 2012-05-23 National Research Council Of Canada Method for isolation of soluble polypeptides
EP1867661A1 (en) * 2006-06-12 2007-12-19 Diatos Compositions and methods for delivering anti-activated ras antibodies into cells
AU2010238346A1 (en) * 2009-04-14 2011-11-03 Trojan Technologies Ltd. Therapeutic Antennapedia-antibody molecules and methods of use thereof
GB201103631D0 (en) * 2011-03-03 2011-04-13 Univ Leeds Identification of candidate therapeutics
HRP20251426T1 (hr) 2013-05-06 2026-01-02 Scholar Rock, Inc. Sastavi i postupci za modulaciju faktora rasta
WO2016013871A1 (ko) * 2014-07-22 2016-01-28 아주대학교산학협력단 완전한 이뮤노글로불린 형태의 세포질 침투능을 갖는 항체를 이용하여 세포내 활성화된 ras를 억제하는 방법 및 그의 이용
US9879087B2 (en) 2014-11-12 2018-01-30 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
IL313511A (en) 2014-11-12 2024-08-01 Seagen Inc Compounds acting on glycans and methods of using them
EP3373969A4 (en) 2015-11-12 2019-08-14 Siamab Therapeutics, Inc. GLYCANINTERAGING COMPOUNDS AND METHOD OF USE
EP3541847A4 (en) 2016-11-17 2020-07-08 Seattle Genetics, Inc. COMPOUNDS INTERACTING WITH GLYCANE AND METHODS OF USE
KR102653141B1 (ko) 2017-03-03 2024-04-01 씨젠 인크. 글리칸-상호작용 화합물 및 사용 방법
CN118240025A (zh) 2017-07-10 2024-06-25 斯坦福国际研究院 用于治疗癌症的肽皂草素缀合物
US11965004B2 (en) 2017-07-10 2024-04-23 Sri International Molecular guide system peptides and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003219277A1 (en) * 2002-03-14 2003-09-29 Medical Research Council Intracellular antibodies

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11129144B2 (en) 2008-03-12 2021-09-21 Panasonic Intellectual Property Corporation Of America Integrated circuit
US8942277B2 (en) 2008-03-12 2015-01-27 Panasonic Intellectual Property Corporation Of America Wireless communication apparatus and wireless communication method
US9276706B2 (en) 2008-03-12 2016-03-01 Panasonic Intellectual Property Corporation Of America Communication apparatus and communication method
US8532164B2 (en) 2008-03-12 2013-09-10 Panasonic Corporation Wireless communication apparatus, wireless communication system, and wireless communication method
US10206198B2 (en) 2008-03-12 2019-02-12 Panasonic Intellectual Property Corporation Of America Communication apparatus and communication method
US10694506B2 (en) 2008-03-12 2020-06-23 Panasonic Intellectual Property Corporation Of America Integrated circuit
JP2017529870A (ja) * 2014-07-22 2017-10-12 オルム セラピューティクス インコーポレイテッドＯｒｕｍ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 完全型免疫グロブリン形態の細胞質浸透能を有する抗体を利用して細胞内活性化されたｒａｓを抑制する方法及びその利用
US10844136B2 (en) 2014-07-22 2020-11-24 Orum Therapeutics Inc. Method for positioning, in cytoplasm, antibody having complete immunoglobulin form by penetrating antibody through cell membrane, and use for same
US10851177B2 (en) 2014-07-22 2020-12-01 Orum Therapeutics Inc. Method for inhibiting intracellular activated RAS using intact immunoglobulin-type antibody having cytosol-penetrating ability and use thereof
US11155641B2 (en) 2016-05-27 2021-10-26 Orum Therapeutics Inc. Cytosol-penetrating antibody and use thereof
US10787487B2 (en) 2018-06-21 2020-09-29 Orum Therapeutics Inc. Cell/tissue-specific cell-penetrating antibodies
JP2023525164A (ja) * 2020-05-12 2023-06-14 オックスフォード・ユニバーシティ・イノベイション・リミテッド 標的特異的分解剤及びそれらの医学的使用
JP7779861B2 (ja) 2020-05-12 2025-12-03 オックスフォード・ユニバーシティ・イノベイション・リミテッド 標的特異的分解剤及びそれらの医学的使用

Also Published As

Publication number Publication date
EP1565495A2 (en) 2005-08-24
WO2004046188A3 (en) 2004-09-16
US20050288492A1 (en) 2005-12-29
CA2506128A1 (en) 2004-06-03
WO2004046188A2 (en) 2004-06-03
AU2003282247A1 (en) 2004-06-15

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