JP2006520611A - eIF−5A1の発現を抑制するための、アンチセンス・オリゴヌクレオチド又はsiRNAの使用 - Google Patents
eIF−5A1の発現を抑制するための、アンチセンス・オリゴヌクレオチド又はsiRNAの使用 Download PDFInfo
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- JP2006520611A JP2006520611A JP2006509126A JP2006509126A JP2006520611A JP 2006520611 A JP2006520611 A JP 2006520611A JP 2006509126 A JP2006509126 A JP 2006509126A JP 2006509126 A JP2006509126 A JP 2006509126A JP 2006520611 A JP2006520611 A JP 2006520611A
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
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- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
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- General Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
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- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45167703P | 2003-03-05 | 2003-03-05 | |
| US10/383,614 US7381708B2 (en) | 2001-07-23 | 2003-03-10 | Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye |
| US47619403P | 2003-06-06 | 2003-06-06 | |
| US50473103P | 2003-09-22 | 2003-09-22 | |
| PCT/US2004/006598 WO2004078940A2 (en) | 2003-03-05 | 2004-03-05 | USE OF ANTISENSE OLIGONUCLEOTIDES OR siRNA TO SUPPRESS EXPRESSION OF eIF-5A1 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010229103A Division JP5566250B2 (ja) | 2003-03-05 | 2010-10-08 | eIF−5A1の発現を抑制するための、アンチセンス・オリゴヌクレオチド又はsiRNAの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006520611A true JP2006520611A (ja) | 2006-09-14 |
| JP2006520611A5 JP2006520611A5 (enExample) | 2007-05-31 |
Family
ID=32966688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006509126A Pending JP2006520611A (ja) | 2003-03-05 | 2004-03-05 | eIF−5A1の発現を抑制するための、アンチセンス・オリゴヌクレオチド又はsiRNAの使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US20100168047A9 (enExample) |
| EP (1) | EP1601767B1 (enExample) |
| JP (1) | JP2006520611A (enExample) |
| KR (1) | KR20050098954A (enExample) |
| AU (1) | AU2004217437B2 (enExample) |
| CA (1) | CA2517974A1 (enExample) |
| NZ (1) | NZ542665A (enExample) |
| TW (1) | TW200427695A (enExample) |
| WO (1) | WO2004078940A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009144933A1 (ja) * | 2008-05-27 | 2009-12-03 | 国立大学法人東京大学 | アポトーシス誘導薬 |
| JP2011026343A (ja) * | 2003-03-05 | 2011-02-10 | Senesco Technologies Inc | eIF−5A1の発現を抑制するための、アンチセンス・オリゴヌクレオチド又はsiRNAの使用 |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7381708B2 (en) | 2001-07-23 | 2008-06-03 | Sensco Technologies, Inc. | Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye |
| AU2004217437B2 (en) | 2003-03-05 | 2009-11-19 | Senesco Technologies, Inc. | Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1 |
| NZ574973A (en) * | 2003-06-06 | 2010-10-29 | Senesco Technologies Inc | Inhibition of apoptosis-specific eIF-5A ("eIF-5A1") with antisense oligonucleotides and siRNAs as anti-inflammatory therapeutics |
| US20140371299A1 (en) * | 2004-06-07 | 2014-12-18 | Senesco Technologies, Inc. | Use of Apoptosis-Specific elF-5A siRNA to Down Regulate Expression of Proinflammatory Cytokines to Treat Sepsis |
| AR049999A1 (es) * | 2004-07-20 | 2006-09-20 | Senesco Technologies Inc | Uso de siarn de eif-5a y polinucleotidos antisentido especificos de la apoptosis para inhibir/suprimir una respuesta inflamatoria. |
| EP2019142A3 (en) * | 2004-12-03 | 2009-04-01 | Senesco Technologies, Inc. | Isoforms of elF-5A and methods of using same |
| AR051786A1 (es) * | 2004-12-03 | 2007-02-07 | Senesco Technologies Inc | Eif-5a especifico de la apoptosis y polinucleotidos que codifican el mismo |
| NZ560320A (en) | 2005-01-25 | 2011-02-25 | Prolexys Pharmaceuticals Inc | Quinoxaline derivatives as antitumor agents |
| DE102005005528A1 (de) * | 2005-01-30 | 2006-08-03 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Injizierbares Mittel zur zielgerichteten Behandlung von retinalen Ganglienzellen |
| US8105611B2 (en) * | 2005-06-17 | 2012-01-31 | Allergan, Inc. | Treatment of autoimmune disorder with a neurotoxin |
| US20070154457A1 (en) * | 2005-12-13 | 2007-07-05 | Senesco Technologies, Inc. | Use of eIF-5A to kill multiple myeloma cells |
| CA2637137A1 (en) * | 2006-03-20 | 2007-09-27 | Senesco Technologies, Inc. | A novel method of protecting islet cells from apoptosis during the donor harvesting process |
| WO2007109674A2 (en) * | 2006-03-20 | 2007-09-27 | Senesco Technologies, Inc. | Use of eif-5a1 sirna and antisense to treat sepsis or haemorrhagic shock |
| US20070238691A1 (en) * | 2006-03-29 | 2007-10-11 | Senesco Technologies, Inc. | Inhibition of HIV replication and expression of p24 with eIF-5A |
| ATE508191T1 (de) | 2006-11-01 | 2011-05-15 | Medical Res And Infrastructure Fund Of The Tel Aviv Sourasky Medical Ct | Adipozytenspezifische konstrukte und verfahren zur hemmung der expression von blutplättchen-typ- 12-lipoxygenase |
| WO2008065429A1 (en) * | 2006-11-30 | 2008-06-05 | Ucl Business Plc | Method for delivering gene therapy vectors to the optic nerve head |
| CN101126098B (zh) * | 2007-07-05 | 2012-07-11 | 深圳市第二人民医院 | 特异性抑制gfap蛋白表达的小干扰rna分子表达载体及其构建方法与用途 |
| US8703929B2 (en) | 2008-03-07 | 2014-04-22 | Senesco Technologies, Inc. | Compositions comprising siRNA and plasmids |
| US8946239B2 (en) | 2008-07-10 | 2015-02-03 | Duquesne University Of The Holy Spirit | Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof |
| US8445638B2 (en) | 2008-09-03 | 2013-05-21 | Senesco Technologies, Inc. | Use of a truncated eIF-5A1 polynucleotide to induce apoptosis in cancer cells |
| WO2010048352A2 (en) * | 2008-10-22 | 2010-04-29 | Quark Pharmaceuticals, Inc. | Methods for treating eye disorders |
| WO2010118224A1 (en) * | 2009-04-08 | 2010-10-14 | Indiana University Research And Technology Corporation | Preventing islet inflammation and dysfunction and maintaining proper glucose levels by controlling elf5a and its hypusination |
| RS58405B1 (sr) | 2009-12-01 | 2019-04-30 | Translate Bio Inc | Stereoidni derivati za isporuku irnk u humanim genetskim oboljenjima |
| JP6184945B2 (ja) | 2011-06-08 | 2017-08-23 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | mRNA送達のための脂質ナノ粒子組成物および方法 |
| US20150267192A1 (en) | 2012-06-08 | 2015-09-24 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
| WO2014153052A2 (en) | 2013-03-14 | 2014-09-25 | Shire Human Genetic Therapies, Inc. | Cftr mrna compositions and related methods and uses |
| EP2970955B1 (en) | 2013-03-14 | 2018-11-14 | Translate Bio, Inc. | Methods for purification of messenger rna |
| EP2986599A1 (en) | 2013-04-17 | 2016-02-24 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| CN103421791B (zh) * | 2013-06-24 | 2015-04-15 | 广西医科大学 | 一种抑制人-单核巨噬细胞TLR2表达的siRNA及其应用 |
| BR112016009014B1 (pt) | 2013-10-22 | 2024-02-06 | Translate Bio, Inc | USO DE COMPOSIÇÃO COMPREENDENDO mRNA PARA DEFICIÊNCIA DE ARGININOSSUCINATO SINTETASE |
| MX2016005239A (es) | 2013-10-22 | 2016-08-12 | Shire Human Genetic Therapies | Tratamiento con acido ribonucleico mensajero para la fenilcetonuria. |
| SG11201608725YA (en) | 2014-04-25 | 2016-11-29 | Shire Human Genetic Therapies | Methods for purification of messenger rna |
| AU2018224326B2 (en) | 2017-02-27 | 2024-01-04 | Translate Bio, Inc. | Novel codon-optimized CFTR mRNA |
| IL270631B2 (en) | 2017-05-16 | 2024-03-01 | Translate Bio Inc | Treatment of cystic fibrosis through the administration of mRNA with an optimal codon encoding ctfr |
| CN111565752A (zh) * | 2017-11-18 | 2020-08-21 | 恩佐拉·德马加尔海斯 | 在肿瘤治疗中使用基于gc7(n1-甲脒基-1,7-二氨基庚烷)的抗原结合缀合物的产品和方法 |
| CN112930396B (zh) | 2018-08-24 | 2024-05-24 | 川斯勒佰尔公司 | 用于纯化信使rna的方法 |
| US20200157157A1 (en) | 2018-11-21 | 2020-05-21 | Translate Bio, Inc. | TREATMENT OF CYSTIC FIBROSIS BY DELIVERY OF NEBULIZED mRNA ENCODING CFTR |
| CN114231551B (zh) * | 2021-12-24 | 2023-09-29 | 云南大学 | 蛋白在促进昆虫淋巴细胞凋亡和/或防治害虫中的应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003010286A2 (en) * | 2001-07-23 | 2003-02-06 | Senesco, Inc. | Nucleic acids, polypeptides, and methods for modulating apoptosis |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP9801681A3 (en) | 1995-02-13 | 2000-10-30 | Novartis Ag | Mutant proteins |
| ATE294583T1 (de) * | 1996-09-13 | 2005-05-15 | Univ Florida | Verfahren zur hemmung von eif5a-biosynthese |
| EP1002079A2 (en) | 1997-06-30 | 2000-05-24 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Novel inhibitor of cellular proliferation |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| US7358418B2 (en) | 1999-07-06 | 2008-04-15 | Senesco Technologies, Inc. | Isoforms of eIF-5A: senescence-induced eLF5A; wounding-induced eIF-4A; growth eIF-5A; and DHS |
| AU6401200A (en) | 1999-08-06 | 2001-03-05 | Pharmacia & Upjohn Company | Crystallization and structure determination of staphylococcus aureus elongation factor |
| KR20080023768A (ko) * | 2000-03-30 | 2008-03-14 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | Rna 간섭의 rna 서열 특이적인 매개체 |
| KR100909681B1 (ko) * | 2000-12-01 | 2009-07-29 | 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. | Rna 간섭을 매개하는 작은 rna 분자 |
| US7381708B2 (en) * | 2001-07-23 | 2008-06-03 | Sensco Technologies, Inc. | Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye |
| US7968523B2 (en) * | 2001-07-23 | 2011-06-28 | Senesco Technologies, Inc. | Method for inducing apoptosis using apoptosis-specific EIF5-A |
| JP2003037457A (ja) * | 2001-07-23 | 2003-02-07 | Niigata Seimitsu Kk | 増幅回路 |
| US7217517B2 (en) * | 2001-07-23 | 2007-05-15 | Senesco Technologies, Inc. | Nucleic acids, polypeptides, and methods for modulating apoptosis |
| WO2003016572A1 (en) * | 2001-08-17 | 2003-02-27 | Eli Lilly And Company | Oligonucleotide therapeutics for treating hepatitis c virus infections |
| WO2003064621A2 (en) * | 2002-02-01 | 2003-08-07 | Ambion, Inc. | HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES |
| EP2213738B1 (en) * | 2002-11-14 | 2012-10-10 | Dharmacon, Inc. | siRNA molecules targeting Bcl-2 |
| AU2004217437B2 (en) * | 2003-03-05 | 2009-11-19 | Senesco Technologies, Inc. | Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1 |
| NZ574973A (en) | 2003-06-06 | 2010-10-29 | Senesco Technologies Inc | Inhibition of apoptosis-specific eIF-5A ("eIF-5A1") with antisense oligonucleotides and siRNAs as anti-inflammatory therapeutics |
-
2004
- 2004-03-05 AU AU2004217437A patent/AU2004217437B2/en not_active Ceased
- 2004-03-05 TW TW093105908A patent/TW200427695A/zh unknown
- 2004-03-05 CA CA002517974A patent/CA2517974A1/en not_active Abandoned
- 2004-03-05 JP JP2006509126A patent/JP2006520611A/ja active Pending
- 2004-03-05 NZ NZ542665A patent/NZ542665A/en unknown
- 2004-03-05 KR KR1020057015276A patent/KR20050098954A/ko not_active Ceased
- 2004-03-05 EP EP04717933A patent/EP1601767B1/en not_active Expired - Lifetime
- 2004-03-05 WO PCT/US2004/006598 patent/WO2004078940A2/en not_active Ceased
-
2005
- 2005-05-23 US US11/134,445 patent/US20100168047A9/en not_active Abandoned
- 2005-11-28 US US11/287,460 patent/US7662796B2/en not_active Expired - Fee Related
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2009
- 2009-12-17 US US12/640,148 patent/US8242256B2/en not_active Expired - Fee Related
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2011
- 2011-05-02 US US13/099,171 patent/US8754057B2/en not_active Expired - Fee Related
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2012
- 2012-08-10 US US13/572,123 patent/US20130066058A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003010286A2 (en) * | 2001-07-23 | 2003-02-06 | Senesco, Inc. | Nucleic acids, polypeptides, and methods for modulating apoptosis |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011026343A (ja) * | 2003-03-05 | 2011-02-10 | Senesco Technologies Inc | eIF−5A1の発現を抑制するための、アンチセンス・オリゴヌクレオチド又はsiRNAの使用 |
| WO2009144933A1 (ja) * | 2008-05-27 | 2009-12-03 | 国立大学法人東京大学 | アポトーシス誘導薬 |
| US8492521B2 (en) | 2008-05-27 | 2013-07-23 | Yoshinori Seko | Oxidative stress responsive apoptosis inducing protein eIF5A |
| US9321819B2 (en) | 2008-05-27 | 2016-04-26 | Yoshinori Seko | Oxidative stress responsive apoptosis inducing protein eIF5A |
Also Published As
| Publication number | Publication date |
|---|---|
| US20060094677A1 (en) | 2006-05-04 |
| NZ542665A (en) | 2008-05-30 |
| WO2004078940A2 (en) | 2004-09-16 |
| US20120129910A1 (en) | 2012-05-24 |
| TW200427695A (en) | 2004-12-16 |
| WO2004078940A8 (en) | 2005-10-27 |
| US8754057B2 (en) | 2014-06-17 |
| US20060178330A1 (en) | 2006-08-10 |
| US7662796B2 (en) | 2010-02-16 |
| US20110098460A1 (en) | 2011-04-28 |
| US8242256B2 (en) | 2012-08-14 |
| US20130066058A1 (en) | 2013-03-14 |
| AU2004217437A1 (en) | 2004-09-16 |
| WO2004078940A3 (en) | 2004-12-16 |
| CA2517974A1 (en) | 2004-09-16 |
| EP1601767A2 (en) | 2005-12-07 |
| AU2004217437B2 (en) | 2009-11-19 |
| EP1601767B1 (en) | 2012-04-25 |
| KR20050098954A (ko) | 2005-10-12 |
| US20100168047A9 (en) | 2010-07-01 |
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