JP2006520331A5 - - Google Patents
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- Publication number
- JP2006520331A5 JP2006520331A5 JP2006504216A JP2006504216A JP2006520331A5 JP 2006520331 A5 JP2006520331 A5 JP 2006520331A5 JP 2006504216 A JP2006504216 A JP 2006504216A JP 2006504216 A JP2006504216 A JP 2006504216A JP 2006520331 A5 JP2006520331 A5 JP 2006520331A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- fatty acids
- pharmaceutical composition
- royal
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 11
- 235000006595 Roystonea elata Nutrition 0.000 claims description 10
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 10
- 239000000194 fatty acid Substances 0.000 claims description 10
- 229930195729 fatty acid Natural products 0.000 claims description 10
- 150000004665 fatty acids Chemical class 0.000 claims description 10
- 235000013399 edible fruits Nutrition 0.000 claims description 9
- 239000000284 extract Substances 0.000 claims description 9
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 6
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 6
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 6
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 6
- SECPZKHBENQXJG-FPLPWBNLSA-N palmitoleic acid Chemical compound CCCCCC\C=C/CCCCCCCC(O)=O SECPZKHBENQXJG-FPLPWBNLSA-N 0.000 claims description 6
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 5
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 5
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 5
- 239000005642 Oleic acid Substances 0.000 claims description 5
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 5
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 5
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 5
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 claims description 3
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims description 3
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims description 3
- 239000005639 Lauric acid Substances 0.000 claims description 3
- 235000021360 Myristic acid Nutrition 0.000 claims description 3
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims description 3
- 235000021314 Palmitic acid Nutrition 0.000 claims description 3
- 235000021319 Palmitoleic acid Nutrition 0.000 claims description 3
- 235000021355 Stearic acid Nutrition 0.000 claims description 3
- SECPZKHBENQXJG-UHFFFAOYSA-N cis-palmitoleic acid Natural products CCCCCCC=CCCCCCCCC(O)=O SECPZKHBENQXJG-UHFFFAOYSA-N 0.000 claims description 3
- 150000002632 lipids Chemical class 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 3
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 3
- 229960002446 octanoic acid Drugs 0.000 claims description 3
- 239000008117 stearic acid Substances 0.000 claims description 3
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims description 2
- 241000899648 Roystonea Species 0.000 claims description 2
- 235000008947 Roystonea oleracea Nutrition 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims description 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 235000020778 linoleic acid Nutrition 0.000 claims description 2
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims description 2
- 229960004488 linolenic acid Drugs 0.000 claims description 2
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 201000004384 Alopecia Diseases 0.000 claims 3
- 206010020112 Hirsutism Diseases 0.000 claims 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 3
- 240000007186 Roystonea regia Species 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 238000000605 extraction Methods 0.000 claims 3
- 208000024963 hair loss Diseases 0.000 claims 3
- 230000003676 hair loss Effects 0.000 claims 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 201000007094 prostatitis Diseases 0.000 claims 3
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 229930195733 hydrocarbon Natural products 0.000 claims 2
- 150000002430 hydrocarbons Chemical class 0.000 claims 2
- 230000007062 hydrolysis Effects 0.000 claims 2
- 238000006460 hydrolysis reaction Methods 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 2
- 238000007127 saponification reaction Methods 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 239000000908 ammonium hydroxide Substances 0.000 claims 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims 1
- 239000000920 calcium hydroxide Substances 0.000 claims 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 238000010931 ester hydrolysis Methods 0.000 claims 1
- 235000021588 free fatty acids Nutrition 0.000 claims 1
- 238000000227 grinding Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- 150000004679 hydroxides Chemical class 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 239000002453 shampoo Substances 0.000 claims 1
- 238000007873 sieving Methods 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 25
- 229960003604 testosterone Drugs 0.000 description 12
- 210000002307 prostate Anatomy 0.000 description 6
- 244000208347 Roystonea elata Species 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 4
- 239000013642 negative control Substances 0.000 description 4
- 239000010018 saw palmetto extract Substances 0.000 description 4
- 238000000585 Mann–Whitney U test Methods 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 240000006661 Serenoa repens Species 0.000 description 3
- 235000005318 Serenoa repens Nutrition 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 description 3
- 239000008158 vegetable oil Substances 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229940063845 saw palmetto extract Drugs 0.000 description 1
- 229940018044 saw palmetto fruit extract Drugs 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU2003-0062 | 2003-03-20 | ||
| CU20030062A CU23256A1 (es) | 2003-03-20 | 2003-03-20 | EXTRACTO OBTENIDO A PARTIR DE FRUTOS DE ROYSTONEA REGIA UTILIZADO CONTRA LA HIPERPLASIA PROSTáTICA Y LA PROSTATITIS |
| PCT/CU2004/000004 WO2004082696A1 (es) | 2003-03-20 | 2004-03-15 | Composición farmacéutica y procedimiento para el tratamiento y prevención de la hiperplasia prostática y la prostatitis a partir de los frutos de roystones regia (palma real) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006520331A JP2006520331A (ja) | 2006-09-07 |
| JP2006520331A5 true JP2006520331A5 (enExample) | 2006-10-19 |
| JP4693766B2 JP4693766B2 (ja) | 2011-06-01 |
Family
ID=40210497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006504216A Expired - Fee Related JP4693766B2 (ja) | 2003-03-20 | 2004-03-15 | ローヤル・パーム（Ｒｏｙｓｔｏｎｅａｒｅｇｉａ）果実由来の薬剤組成物並びに前立腺肥大および前立腺炎を治療および予防する方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US20060228429A1 (enExample) |
| EP (1) | EP1623740B1 (enExample) |
| JP (1) | JP4693766B2 (enExample) |
| KR (1) | KR100758256B1 (enExample) |
| CN (1) | CN100366246C (enExample) |
| AT (1) | ATE394139T1 (enExample) |
| AU (1) | AU2004222693B2 (enExample) |
| BR (1) | BRPI0409056A (enExample) |
| CA (1) | CA2519410C (enExample) |
| CR (1) | CR8001A (enExample) |
| CU (1) | CU23256A1 (enExample) |
| DE (1) | DE602004013572D1 (enExample) |
| DK (1) | DK1623740T3 (enExample) |
| EC (1) | ECSP056028A (enExample) |
| ES (1) | ES2306999T3 (enExample) |
| IL (1) | IL170997A (enExample) |
| MX (1) | MXPA05009905A (enExample) |
| NO (1) | NO333290B1 (enExample) |
| NZ (1) | NZ542361A (enExample) |
| PT (1) | PT1623740E (enExample) |
| RU (1) | RU2331434C2 (enExample) |
| UA (1) | UA82224C2 (enExample) |
| WO (1) | WO2004082696A1 (enExample) |
| ZA (1) | ZA200507575B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4926395B2 (ja) * | 2004-11-30 | 2012-05-09 | 学校法人 名城大学 | 抗ｍｒｓａ用組成物 |
| KR100769412B1 (ko) * | 2006-09-13 | 2007-10-22 | 주식회사 벤스랩 | Ｐｒ-119 복합생약 추출물을 함유하는 전립선 비대증의예방 및 치료용조성물 |
| WO2010118362A1 (en) | 2009-04-09 | 2010-10-14 | The Regents Of The University Of Colorado, A Body Corporate | Methods and compositions for inducing physiological hypertrophy |
| CU24143B1 (es) * | 2012-06-19 | 2016-01-29 | Cnic Ct Nac Investigaciones | Ingrediente activo para el tratamiento y la prevención de la inflamación y el estrés oxidativo, así como su procedimiento de obtención a partir de los frutos de acrocomina crispa y/o acrocomia aculeata |
| CA2957363C (en) * | 2014-08-12 | 2022-06-21 | Institut de Recherche en Semiochimie et Ethologie Appliquee | Palmitoleic acid for use in inhibiting the attachment of sea lice to fish |
| KR102273967B1 (ko) * | 2014-10-31 | 2021-07-08 | (주)아모레퍼시픽 | 인삼씨유를 함유하여 전립선 비대증을 예방 및 치료하는 조성물 |
| JP2017214342A (ja) * | 2016-06-02 | 2017-12-07 | 日清オイリオグループ株式会社 | 排尿障害の予防用又は改善用組成物 |
| JP6628946B2 (ja) | 2017-12-26 | 2020-01-15 | 大太朗 福岡 | 増毛、頭皮若しくは皮膚の改質、創傷治癒、骨形成促進、または毛髪の改質に用いるための医薬組成物 |
| AU2019212513B2 (en) | 2018-01-26 | 2024-10-31 | Fluidx Medical Technology, Llc | Apparatus and method of using in situ solidifying complex coacervates for vascular occlusion |
| EP4082518A1 (en) | 2021-04-28 | 2022-11-02 | Cnce Innovacion, S.L. | Fatty acid compositions for the treatment and prevention of hair loss and alopecia |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU21519A1 (en) * | 1983-03-23 | 1987-06-09 | Inst De Quimica Y Biolog Ex | Procedure to facilitate the grinding of roystonea regia fruits |
| TW408127B (en) * | 1993-09-17 | 2000-10-11 | Glaxo Inc | Androstenones |
| CN1184670A (zh) * | 1997-12-23 | 1998-06-17 | 张冰 | 一种治疗前列腺增生、前列腺炎的药物组合物 |
| RU2140265C1 (ru) * | 1998-10-27 | 1999-10-27 | Чернобаев Николай Евгеньевич | Средство для лечения и профилактики доброкачественной гиперплазии простаты (дгп), простатита, импотенции, бесплодия и рака предстательной железы |
-
2003
- 2003-03-20 CU CU20030062A patent/CU23256A1/es unknown
-
2004
- 2004-03-15 PT PT04720576T patent/PT1623740E/pt unknown
- 2004-03-15 CN CNB2004800071887A patent/CN100366246C/zh not_active Expired - Lifetime
- 2004-03-15 RU RU2005130746/15A patent/RU2331434C2/ru not_active Application Discontinuation
- 2004-03-15 AU AU2004222693A patent/AU2004222693B2/en not_active Expired
- 2004-03-15 KR KR1020057017600A patent/KR100758256B1/ko not_active Expired - Lifetime
- 2004-03-15 JP JP2006504216A patent/JP4693766B2/ja not_active Expired - Fee Related
- 2004-03-15 UA UAA200508900A patent/UA82224C2/uk unknown
- 2004-03-15 MX MXPA05009905A patent/MXPA05009905A/es active IP Right Grant
- 2004-03-15 DK DK04720576T patent/DK1623740T3/da active
- 2004-03-15 NZ NZ542361A patent/NZ542361A/xx not_active IP Right Cessation
- 2004-03-15 BR BRPI0409056-0A patent/BRPI0409056A/pt not_active IP Right Cessation
- 2004-03-15 CA CA2519410A patent/CA2519410C/en not_active Expired - Fee Related
- 2004-03-15 ES ES04720576T patent/ES2306999T3/es not_active Expired - Lifetime
- 2004-03-15 EP EP04720576A patent/EP1623740B1/en not_active Expired - Lifetime
- 2004-03-15 AT AT04720576T patent/ATE394139T1/de active
- 2004-03-15 US US10/549,740 patent/US20060228429A1/en not_active Abandoned
- 2004-03-15 DE DE602004013572T patent/DE602004013572D1/de not_active Expired - Lifetime
- 2004-03-15 WO PCT/CU2004/000004 patent/WO2004082696A1/es not_active Ceased
-
2005
- 2005-09-19 ZA ZA200507575A patent/ZA200507575B/xx unknown
- 2005-09-20 EC EC2005006028A patent/ECSP056028A/es unknown
- 2005-09-20 IL IL170997A patent/IL170997A/en not_active IP Right Cessation
- 2005-09-20 CR CR8001A patent/CR8001A/es unknown
- 2005-10-20 NO NO20054847A patent/NO333290B1/no not_active IP Right Cessation
-
2009
- 2009-10-08 US US12/575,584 patent/US20100022649A1/en not_active Abandoned
- 2009-10-08 US US12/575,575 patent/US20100021574A1/en not_active Abandoned
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