JP2006517932A5 - - Google Patents
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- Publication number
- JP2006517932A5 JP2006517932A5 JP2006501608A JP2006501608A JP2006517932A5 JP 2006517932 A5 JP2006517932 A5 JP 2006517932A5 JP 2006501608 A JP2006501608 A JP 2006501608A JP 2006501608 A JP2006501608 A JP 2006501608A JP 2006517932 A5 JP2006517932 A5 JP 2006517932A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- branched
- linear
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 4
- -1 acetylamino, sulfonylmethyl Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000005037 alkyl phenyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 125000005842 heteroatoms Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Claims (1)
- 有効量の式(I)
Xは、NHC(O)またはC(O)NH基であり、
R1は、水素またはハロゲン原子、またはアミノカルボニル、アセチルアミノ、スルフォニルメチル、アミノスルフォニルメチル、直鎖状または分枝状のC1-3アルキルまたはC1-3アルコキシ基であり、
R2は、水素原子または直鎖状または分枝状のC1-6アルキル基、または、上記の基が、選択的にハロゲン原子、C1-3アルキルおよびC1-3アルコキシを含む群から選ばれた1以上の置換基によって置換されたアリール(C1-3)アルキル基であり、
R3およびR4は、同一でも相異なってもよく、水素またはハロゲン原子、またはアミノ、ニトロ、ヒドロキシル、直鎖状または分枝状のC1-3アルキル、C1-3アルコキシ、ジ(C1-3)アルキルアミノ、アセチルアミノ、またはO-(C1-3)アルキルフェニル基、またはR3とR4とが共に5〜7員環を形成し、該員の1又は2つはN、S、およびOから選ばれるヘテロ原子でもよく、
R5, R6, R7およびR8は、同一でも相異なってもよく、Hまたはメチルである、
化合物、または該化合物の薬学的に許容できる酸との酸付加塩、および、
少なくとも一の薬学的に許容できる不活性配合剤を含む薬剤組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT000287A ITMI20030287A1 (it) | 2003-02-18 | 2003-02-18 | Indazolammidi dotate di attivita' analgesica metodo, per |
ITMI2003A000287 | 2003-02-18 | ||
PCT/EP2004/000647 WO2004074275A1 (en) | 2003-02-18 | 2004-01-26 | Indazolamides with analgesic activity |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2006517932A JP2006517932A (ja) | 2006-08-03 |
JP2006517932A5 true JP2006517932A5 (ja) | 2007-05-31 |
JP4724651B2 JP4724651B2 (ja) | 2011-07-13 |
Family
ID=32894157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006501608A Expired - Fee Related JP4724651B2 (ja) | 2003-02-18 | 2004-01-26 | 鎮痛作用を有するインダゾールアミド |
Country Status (23)
Country | Link |
---|---|
US (2) | US7632849B2 (ja) |
EP (1) | EP1594859B1 (ja) |
JP (1) | JP4724651B2 (ja) |
KR (1) | KR101108222B1 (ja) |
CN (2) | CN101139341B (ja) |
AR (1) | AR043186A1 (ja) |
AT (1) | ATE471934T1 (ja) |
AU (1) | AU2004213104B2 (ja) |
CA (1) | CA2511984C (ja) |
DE (1) | DE602004027792D1 (ja) |
DK (1) | DK1594859T3 (ja) |
EA (1) | EA009077B1 (ja) |
ES (1) | ES2345983T3 (ja) |
GE (1) | GEP20074075B (ja) |
HK (1) | HK1079199A1 (ja) |
IL (1) | IL169285A (ja) |
IT (1) | ITMI20030287A1 (ja) |
MX (1) | MXPA05008730A (ja) |
PL (1) | PL215870B1 (ja) |
PT (1) | PT1594859E (ja) |
SI (1) | SI1594859T1 (ja) |
UA (1) | UA79537C2 (ja) |
WO (1) | WO2004074275A1 (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20031468A1 (it) * | 2003-07-18 | 2005-01-19 | Acraf | Farmaco ativo nel dolore neuropatico |
GEP20094638B (en) * | 2004-06-15 | 2009-03-10 | Pfizer | Benzimidazolone carboxylic acid derivatives |
BRPI0910034B1 (pt) * | 2008-03-25 | 2022-02-08 | Affectis Pharmaceuticals Ag | Antagonistas do p2x7r e composições farmacêuticas que os compreendem |
US8815892B2 (en) | 2008-03-25 | 2014-08-26 | Affectis Pharmaceuticals Ag | P2X7R antagonists and their use |
EP2243772B1 (en) * | 2009-04-14 | 2012-01-18 | Affectis Pharmaceuticals AG | Novel P2X7R antagonists and their use |
KR102101702B1 (ko) | 2012-02-21 | 2020-04-20 | 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이 | 글리코겐 합성효소 키나아제 3 베타 억제제로서 1h-인다졸-3-카복사미드 화합물의 용도 |
EA024939B1 (ru) * | 2012-02-21 | 2016-11-30 | Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А. | 1h-индазол-3-карбоксамидные соединения в качестве ингибиторов гликогенсинтазы киназы 3-бета |
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
EP2970177A1 (en) | 2013-03-15 | 2016-01-20 | Pfizer Inc. | Indole compounds that activate ampk |
PT3790873T (pt) | 2018-05-07 | 2022-05-11 | Acraf | Compostos de 1h-indazole-3-carboxamida como inibidores da glicogénio sintase cinase 3 beta |
CN109336890B (zh) * | 2018-11-17 | 2020-03-20 | 重庆文理学院 | 一种吲唑类衍生物的合成方法及抗肿瘤应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3705175A (en) | 1969-04-01 | 1972-12-05 | Egyt Gyogyszervegyeszeti Gyar | Indazole-3-carboxylic amides |
US5654320A (en) * | 1995-03-16 | 1997-08-05 | Eli Lilly And Company | Indazolecarboxamides |
IL117438A (en) | 1995-03-16 | 2001-12-23 | Lilly Co Eli | Indazolecarboxamides, their preparation and pharmaceutical compositions containing them |
CA2222532A1 (en) * | 1995-05-31 | 1996-12-05 | Nisshin Flour Milling Co., Ltd. | Indazole derivatives having monocyclic amine |
EP0802067B1 (en) * | 1995-11-08 | 2002-04-24 | Toray Industries, Inc. | Direct drawing type waterless planographic original form plate |
TR199900321T2 (xx) | 1996-08-16 | 1999-04-21 | Smithkline Beecham P.L.C. | N-(1-nbutil - 4 - piperidil)metil) -3,4-dihidro -2H- (1,3) oksazino (3.2A) indol-10- Karboksamit haz�rlama prosesi ve prosesteki tuzlar ve ara �r�nler. |
IT1291569B1 (it) | 1997-04-15 | 1999-01-11 | Angelini Ricerche Spa | Indazolammidi come agenti serotoninergici |
US6339087B1 (en) * | 1997-08-18 | 2002-01-15 | Syntex (U.S.A.) Llc | Cyclic amine derivatives-CCR-3 receptor antagonists |
US6069152A (en) | 1997-10-07 | 2000-05-30 | Eli Lilly And Company | 5-HT4 agonists and antagonists |
US6407103B2 (en) * | 1998-04-21 | 2002-06-18 | Bristol-Myers Squibb Pharma Company | Indeno [1,2-c] pyrazol-4-ones and their uses |
AU767409B2 (en) * | 1998-04-21 | 2003-11-06 | Du Pont Pharmaceuticals Company | 5-aminoindeno(1,2-C)pyrazol-4-ones as anti-cancer and anti-proliferative agents |
-
2003
- 2003-02-18 IT IT000287A patent/ITMI20030287A1/it unknown
-
2004
- 2004-01-26 DK DK04705070.3T patent/DK1594859T3/da active
- 2004-01-26 DE DE602004027792T patent/DE602004027792D1/de not_active Expired - Lifetime
- 2004-01-26 EA EA200501164A patent/EA009077B1/ru not_active IP Right Cessation
- 2004-01-26 KR KR1020057014055A patent/KR101108222B1/ko not_active IP Right Cessation
- 2004-01-26 CA CA2511984A patent/CA2511984C/en not_active Expired - Fee Related
- 2004-01-26 PT PT04705070T patent/PT1594859E/pt unknown
- 2004-01-26 JP JP2006501608A patent/JP4724651B2/ja not_active Expired - Fee Related
- 2004-01-26 ES ES04705070T patent/ES2345983T3/es not_active Expired - Lifetime
- 2004-01-26 AT AT04705070T patent/ATE471934T1/de active
- 2004-01-26 GE GEAP20048983A patent/GEP20074075B/en unknown
- 2004-01-26 CN CN2007101801011A patent/CN101139341B/zh not_active Expired - Fee Related
- 2004-01-26 US US10/541,209 patent/US7632849B2/en not_active Expired - Fee Related
- 2004-01-26 CN CNB2004800025681A patent/CN100347168C/zh not_active Expired - Fee Related
- 2004-01-26 WO PCT/EP2004/000647 patent/WO2004074275A1/en active Application Filing
- 2004-01-26 UA UAA200508163A patent/UA79537C2/uk unknown
- 2004-01-26 AU AU2004213104A patent/AU2004213104B2/en not_active Ceased
- 2004-01-26 SI SI200431488T patent/SI1594859T1/sl unknown
- 2004-01-26 EP EP04705070A patent/EP1594859B1/en not_active Expired - Lifetime
- 2004-01-26 PL PL377236A patent/PL215870B1/pl unknown
- 2004-01-26 MX MXPA05008730A patent/MXPA05008730A/es active IP Right Grant
- 2004-02-16 AR ARP040100467A patent/AR043186A1/es not_active Application Discontinuation
-
2005
- 2005-06-20 IL IL169285A patent/IL169285A/en not_active IP Right Cessation
- 2005-12-06 HK HK05111137.6A patent/HK1079199A1/xx not_active IP Right Cessation
-
2009
- 2009-10-28 US US12/607,463 patent/US8519139B2/en not_active Expired - Fee Related
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