JP2006517802A - 外来性分子の一過性の発現もしくは安定な発現のための発現カセットおよび発現ベクター - Google Patents

外来性分子の一過性の発現もしくは安定な発現のための発現カセットおよび発現ベクター Download PDF

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Publication number
JP2006517802A
JP2006517802A JP2006503592A JP2006503592A JP2006517802A JP 2006517802 A JP2006517802 A JP 2006517802A JP 2006503592 A JP2006503592 A JP 2006503592A JP 2006503592 A JP2006503592 A JP 2006503592A JP 2006517802 A JP2006517802 A JP 2006517802A
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expression
expression cassette
sequence
vector
seq
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JP2006503592A
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Japanese (ja)
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JP2006517802A5 (https=
Inventor
ウィリアム ピー． シスク，
ホリー プレンティス，
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Biogen Inc
Biogen MA Inc
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Biogen Inc
Biogen Idec Inc
Biogen Idec MA Inc
Biogen MA Inc
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Publication of JP2006517802A publication Critical patent/JP2006517802A/ja
Publication of JP2006517802A5 publication Critical patent/JP2006517802A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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JP2006503592A 2003-02-14 2004-02-13 外来性分子の一過性の発現もしくは安定な発現のための発現カセットおよび発現ベクター Pending JP2006517802A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44817903P 2003-02-14 2003-02-14
PCT/US2004/004407 WO2004074439A2 (en) 2003-02-14 2004-02-13 An expression cassette and vector for transient or stable expression of exogenous molecules

Related Child Applications (1)

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JP2010114785A Division JP2010213718A (ja) 2003-02-14 2010-05-18 外来性分子の一過性の発現もしくは安定な発現のための発現カセットおよび発現ベクター

Publications (2)

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JP2006517802A true JP2006517802A (ja) 2006-08-03
JP2006517802A5 JP2006517802A5 (https=) 2007-03-29

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JP2006503592A Pending JP2006517802A (ja) 2003-02-14 2004-02-13 外来性分子の一過性の発現もしくは安定な発現のための発現カセットおよび発現ベクター
JP2010114785A Pending JP2010213718A (ja) 2003-02-14 2010-05-18 外来性分子の一過性の発現もしくは安定な発現のための発現カセットおよび発現ベクター

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Country Status (21)

Country Link
US (2) US7494805B2 (https=)
EP (1) EP1594955B1 (https=)
JP (2) JP2006517802A (https=)
KR (1) KR20050101554A (https=)
CN (1) CN1774500B (https=)
AT (1) ATE553185T1 (https=)
AU (1) AU2004213797B2 (https=)
BR (1) BRPI0407487A (https=)
CA (1) CA2515481A1 (https=)
DK (1) DK1594955T3 (https=)
EA (2) EA008439B1 (https=)
ES (1) ES2384973T3 (https=)
IL (1) IL170178A (https=)
IS (1) IS7974A (https=)
MX (1) MXPA05008523A (https=)
NO (1) NO20054202L (https=)
NZ (1) NZ542316A (https=)
PL (1) PL378110A1 (https=)
RS (1) RS20050614A (https=)
WO (1) WO2004074439A2 (https=)
ZA (1) ZA200506413B (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013514808A (ja) * 2009-12-21 2013-05-02 サノフイ トランスジェニック非ヒト動物およびその使用
WO2015162930A1 (ja) * 2014-04-24 2015-10-29 一般社団法人 医療産業イノベーション機構 タンパク質発現を向上させる方法およびタンパク質発現用組成物
JP2016163577A (ja) * 2009-12-21 2016-09-08 サノフイ トランスジェニック非ヒト動物およびその使用

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1594955T3 (da) * 2003-02-14 2012-06-25 Biogen Idec Inc Ekspressionskassette og vektor til transient eller stabil ekspression af eksogene molekyler
WO2005042478A2 (en) 2003-09-19 2005-05-12 Janssen Pharmaceutica, N.V. 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
WO2005038020A1 (en) * 2003-10-14 2005-04-28 Biogen Idec Ma Inc. Flp-mediated recombination
CA2559280A1 (en) * 2004-03-15 2005-09-29 Biogen Idec Ma Inc. Methods and constructs for expressing polypeptide multimers in eukaryotic cells using alternative splicing
MY147518A (en) 2004-09-15 2012-12-31 Janssen Pharmaceutica Nv 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
JO3006B1 (ar) 2005-09-14 2016-09-05 Janssen Pharmaceutica Nv املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك
GB0606190D0 (en) 2006-03-28 2006-05-10 Isis Innovation Construct
PE20080188A1 (es) 2006-04-18 2008-03-10 Janssen Pharmaceutica Nv Derivados del acido benzoazepin-oxi-acetico como agonistas de ppar-delta usados para aumentar hdl-c, reducir ldl-c y reducir colesterol
WO2008073184A2 (en) * 2006-10-18 2008-06-19 The Scripps Research Institute Genetic incorporation of unnatural amino acids into proteins in mammalian cells
WO2011017319A1 (en) 2009-08-03 2011-02-10 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods of treating disorders associated with protein polymerization
US8809617B2 (en) * 2009-11-05 2014-08-19 The University of Pittsburgh—Of the Commonwealth System of Higher Education Automated high-content live animal drug screening using C. elegans
US9072772B2 (en) 2009-11-05 2015-07-07 University of Pittsburgh—of the Commonwealth System of Higher Education Methods of treating disorders associated with protein aggregation
US8993316B2 (en) 2011-11-16 2015-03-31 Brian P. Hanley Methods and compositions for gene therapy and GHRH therapy
US20150064137A1 (en) 2012-04-17 2015-03-05 Kythera Biopharmaceuticals, Inc. Use of engineered viruses to specifically kill senescent cells
CN104812901B (zh) 2012-09-13 2018-08-10 美国印第安纳大学研究和技术公司 赋予植物抗病性的组合物和系统及其使用方法
AU2013359419B2 (en) 2012-12-10 2018-03-15 Biogen Ma Inc. Anti-blood dendritic cell antigen 2 antibodies and uses thereof
AU2014246731A1 (en) * 2013-03-30 2015-11-19 Usha Biotech Limited Methods and constructs for expressing biologically active proteins in mammalian cells
TWI747098B (zh) 2018-12-21 2021-11-21 美商美國禮來大藥廠 抗angptl3/8複合物抗體及其使用方法
US11415263B2 (en) * 2020-03-20 2022-08-16 Edwards Vacuum Llc Conversion kit for a support frame, a support frame and an integrated vacuum system mounted in a support frame

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194176B1 (en) * 1996-01-19 2001-02-27 Board Of Regents, The University Of Texas System Recombinant expression of proteins from secretory cell lines
JP2002513556A (ja) * 1998-04-30 2002-05-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 改善された生産性を有するＦＡＰα−特異的抗体
JP2002233374A (ja) * 2001-02-06 2002-08-20 Japan Science & Technology Corp 遺伝子導入及び／又は遺伝子欠損非ヒト動物作製用ベクター
JP2003512053A (ja) * 1999-10-16 2003-04-02 アルテミス・ファーマシューティカルズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 遺伝子破壊用条件付遺伝子トラッピング構築物

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8717430D0 (en) * 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
ES2198025T3 (es) 1991-10-25 2004-01-16 Immunex Corporation Anticuerpos contra cd40-l.
AU678154B2 (en) 1992-04-02 1997-05-22 Sembiosys Genetics Inc. Oil-body protein cis-elements as regulatory signals
AU698739B2 (en) 1995-06-06 1998-11-05 Isis Pharmaceuticals, Inc. Oligonucleotides having phosphorothioate linkages of high chiral purity
IL122174A (en) 1995-06-07 2004-07-25 Immunex Corp Dna encoding a cd40l mutein and a cd40l polypeptide encoded by said dna
US5985662A (en) 1995-07-13 1999-11-16 Isis Pharmaceuticals Inc. Antisense inhibition of hepatitis B virus replication
EP0914441A2 (en) * 1996-04-23 1999-05-12 The Wistar Institute Of Anatomy And Biology Novel human cytomegalovirus dna constructs and uses therefor
AU8589998A (en) 1997-07-24 1999-02-16 Valentis, Inc. Ghrh expression system and methods of use
AU2324999A (en) * 1998-01-16 1999-08-02 California Pacific Medical Center Research Institute Methods and compositions for gene delivery
US6455677B1 (en) * 1998-04-30 2002-09-24 Boehringer Ingelheim International Gmbh FAPα-specific antibody with improved producibility
WO1999061066A2 (en) * 1998-05-27 1999-12-02 Avigen, Inc. Convection-enhanced delivery of aav vectors
EP1292686A1 (en) 2000-06-07 2003-03-19 Smittskyddsinstitutet Gene expression cassette and its use
JP2004502426A (ja) 2000-07-05 2004-01-29 トランジェーヌ、ソシエテ、アノニム 平滑筋の発現を制御するキメラプロモーター
DE10133407A1 (de) 2001-07-13 2003-01-23 Basf Ag Expressionskassetten zur transgenen Expression von Nukleinsäuren
US20030235823A1 (en) * 2002-06-24 2003-12-25 The University Of Alabama Nucleotide sequences that code for torsin genes, torsin proteins, and methods of using the same to treat protein-aggregation
DK1594955T3 (da) 2003-02-14 2012-06-25 Biogen Idec Inc Ekspressionskassette og vektor til transient eller stabil ekspression af eksogene molekyler

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194176B1 (en) * 1996-01-19 2001-02-27 Board Of Regents, The University Of Texas System Recombinant expression of proteins from secretory cell lines
JP2002513556A (ja) * 1998-04-30 2002-05-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 改善された生産性を有するＦＡＰα−特異的抗体
JP2003512053A (ja) * 1999-10-16 2003-04-02 アルテミス・ファーマシューティカルズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 遺伝子破壊用条件付遺伝子トラッピング構築物
JP2002233374A (ja) * 2001-02-06 2002-08-20 Japan Science & Technology Corp 遺伝子導入及び／又は遺伝子欠損非ヒト動物作製用ベクター

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013514808A (ja) * 2009-12-21 2013-05-02 サノフイ トランスジェニック非ヒト動物およびその使用
JP2016163577A (ja) * 2009-12-21 2016-09-08 サノフイ トランスジェニック非ヒト動物およびその使用
WO2015162930A1 (ja) * 2014-04-24 2015-10-29 一般社団法人 医療産業イノベーション機構 タンパク質発現を向上させる方法およびタンパク質発現用組成物
JPWO2015162930A1 (ja) * 2014-04-24 2017-04-13 アキュルナ株式会社 タンパク質発現を向上させる方法およびタンパク質発現用組成物

Also Published As

Publication number Publication date
NO20054202D0 (no) 2005-09-09
IL170178A (en) 2011-12-29
EP1594955A4 (en) 2006-07-19
PL378110A1 (pl) 2006-03-06
KR20050101554A (ko) 2005-10-24
ATE553185T1 (de) 2012-04-15
BRPI0407487A (pt) 2006-02-14
MXPA05008523A (es) 2005-10-20
ZA200506413B (en) 2006-04-26
NZ542316A (en) 2006-04-28
CN1774500B (zh) 2011-03-02
EP1594955B1 (en) 2012-04-11
AU2004213797B2 (en) 2009-09-17
WO2004074439A9 (en) 2004-12-23
IS7974A (is) 2005-08-11
DK1594955T3 (da) 2012-06-25
US20060141625A1 (en) 2006-06-29
RS20050614A (sr) 2007-12-31
WO2004074439A2 (en) 2004-09-02
EA200501296A1 (ru) 2006-04-28
WO2004074439A3 (en) 2004-10-28
EA200700469A1 (ru) 2008-10-30
US20100158879A1 (en) 2010-06-24
US7494805B2 (en) 2009-02-24
CA2515481A1 (en) 2004-09-02
EA008439B1 (ru) 2007-06-29
JP2010213718A (ja) 2010-09-30
EP1594955A2 (en) 2005-11-16
HK1084690A1 (en) 2006-08-04
NO20054202L (no) 2005-11-11
AU2004213797A1 (en) 2004-09-02
CN1774500A (zh) 2006-05-17
ES2384973T3 (es) 2012-07-16

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