JP2006516140A5 - - Google Patents
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- Publication number
- JP2006516140A5 JP2006516140A5 JP2004563641A JP2004563641A JP2006516140A5 JP 2006516140 A5 JP2006516140 A5 JP 2006516140A5 JP 2004563641 A JP2004563641 A JP 2004563641A JP 2004563641 A JP2004563641 A JP 2004563641A JP 2006516140 A5 JP2006516140 A5 JP 2006516140A5
- Authority
- JP
- Japan
- Prior art keywords
- tested
- compounds
- found
- examples
- above assay
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43510202P | 2002-12-20 | 2002-12-20 | |
| PCT/US2003/040126 WO2004058148A2 (en) | 2002-12-20 | 2003-12-16 | Mitotic kinesin inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006516140A JP2006516140A (ja) | 2006-06-22 |
| JP2006516140A5 true JP2006516140A5 (https=) | 2010-07-15 |
Family
ID=32682157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004563641A Ceased JP2006516140A (ja) | 2002-12-20 | 2003-12-16 | 有糸分裂キネシン阻害剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7622468B2 (https=) |
| EP (1) | EP1581497A4 (https=) |
| JP (1) | JP2006516140A (https=) |
| AU (1) | AU2003297230B2 (https=) |
| CA (1) | CA2509212A1 (https=) |
| WO (1) | WO2004058148A2 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7622489B2 (en) * | 2002-12-20 | 2009-11-24 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| US20070134660A1 (en) * | 2003-05-30 | 2007-06-14 | Rosetta Inpharmatics Llc | Methods for identifying modulators of kinesin activity |
| ES2382814T3 (es) | 2005-05-17 | 2012-06-13 | Merck Sharp & Dohme Ltd. | Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer |
| GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| JP4611444B2 (ja) | 2007-01-10 | 2011-01-12 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー | ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）阻害剤としてのアミド置換インダゾール |
| TW200934785A (en) | 2007-10-19 | 2009-08-16 | Schering Corp | Compounds for inhibiting KSP kinesin activity |
| WO2010114780A1 (en) | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| PE20121172A1 (es) | 2009-10-14 | 2012-09-05 | Merck Sharp & Dohme | Piperidinas sustituidas con actividad en la hdm2 |
| WO2011163330A1 (en) | 2010-06-24 | 2011-12-29 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
| EP3330377A1 (en) | 2010-08-02 | 2018-06-06 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina) |
| US9029341B2 (en) | 2010-08-17 | 2015-05-12 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA) |
| EP2613782B1 (en) | 2010-09-01 | 2016-11-02 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as erk inhibitors |
| WO2012058210A1 (en) | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA) |
| WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
| EP2770987B1 (en) | 2011-10-27 | 2018-04-04 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
| US20150299696A1 (en) | 2012-05-02 | 2015-10-22 | Sirna Therapeutics, Inc. | SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS |
| RU2660429C2 (ru) | 2012-09-28 | 2018-07-06 | Мерк Шарп И Доум Корп. | Новые соединения, которые являются ингибиторами erk |
| CN103804283B (zh) * | 2012-11-06 | 2016-04-20 | 中国科学院大连化学物理研究所 | 一种制备1,2-二氢吡啶衍生物的方法 |
| RS56680B1 (sr) | 2012-11-28 | 2018-03-30 | Merck Sharp & Dohme | Kompozicije i postupci za lečenje kancera |
| KR102196882B1 (ko) | 2012-12-20 | 2020-12-30 | 머크 샤프 앤드 돔 코포레이션 | Hdm2 억제제로서의 치환된 이미다조피리딘 |
| WO2014120748A1 (en) | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
| WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| CN104756984B (zh) * | 2015-03-30 | 2016-08-17 | 上海应用技术学院 | 多取代顺式二苯乙烯类化合物作为农用杀菌剂的应用 |
| JOP20190055A1 (ar) | 2016-09-26 | 2019-03-24 | Merck Sharp & Dohme | أجسام مضادة ضد cd27 |
| EP3525785B1 (en) | 2016-10-12 | 2025-08-27 | Merck Sharp & Dohme LLC | Kdm5 inhibitors |
| KR102702926B1 (ko) | 2017-04-13 | 2024-09-06 | 사이로파 비.브이. | 항-sirp 알파 항체 |
| US10947234B2 (en) | 2017-11-08 | 2021-03-16 | Merck Sharp & Dohme Corp. | PRMT5 inhibitors |
| EP3706747B1 (en) | 2017-11-08 | 2025-09-03 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
| WO2019148412A1 (en) | 2018-02-01 | 2019-08-08 | Merck Sharp & Dohme Corp. | Anti-pd-1/lag3 bispecific antibodies |
| US12173026B2 (en) | 2018-08-07 | 2024-12-24 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
| US11981701B2 (en) | 2018-08-07 | 2024-05-14 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
| EP3833668B1 (en) | 2018-08-07 | 2025-03-19 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
| US12552826B2 (en) | 2018-08-07 | 2026-02-17 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
| US12441730B2 (en) | 2019-12-17 | 2025-10-14 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
| BR112022012015A2 (pt) | 2019-12-17 | 2022-08-30 | Merck Sharp & Dohme Llc | Inibidores de prmt5 |
| US12595248B2 (en) | 2019-12-17 | 2026-04-07 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
| WO2021126731A1 (en) | 2019-12-17 | 2021-06-24 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
| WO2026027944A1 (en) | 2024-07-30 | 2026-02-05 | Sairopa B.V. | Anti-sirp alpha antibody formulations and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8714789D0 (en) * | 1987-06-24 | 1987-07-29 | Lundbeck & Co As H | Heterocyclic compounds |
| EP0322034A3 (en) * | 1987-12-22 | 1991-01-02 | Merck Sharp & Dohme Ltd. | Methyl tetrahydropyridyl oxadiazoles |
| FR2662442A1 (fr) | 1990-05-23 | 1991-11-29 | Midy Spa | Trifluoromethylphenyltetrahydropyridines n-substituees procede pour leur preparation, intermediaires du procede et compositions pharmaceutiques les contenant. |
| EP0459568A3 (en) * | 1990-05-31 | 1992-09-30 | Merck Sharp & Dohme Ltd. | Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use |
| JP2000119250A (ja) * | 1998-08-11 | 2000-04-25 | Takeda Chem Ind Ltd | 環状アミド化合物、その製造法、中間体及び除草剤 |
| EP1515724B1 (en) | 2002-06-14 | 2009-10-21 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| WO2004037171A2 (en) * | 2002-10-18 | 2004-05-06 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| US7622489B2 (en) * | 2002-12-20 | 2009-11-24 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
-
2003
- 2003-12-16 CA CA002509212A patent/CA2509212A1/en not_active Abandoned
- 2003-12-16 WO PCT/US2003/040126 patent/WO2004058148A2/en not_active Ceased
- 2003-12-16 EP EP03814073A patent/EP1581497A4/en not_active Withdrawn
- 2003-12-16 AU AU2003297230A patent/AU2003297230B2/en not_active Ceased
- 2003-12-16 US US10/539,531 patent/US7622468B2/en not_active Expired - Fee Related
- 2003-12-16 JP JP2004563641A patent/JP2006516140A/ja not_active Ceased
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