JP2006515159A - Mk2相互作用タンパク質 - Google Patents

Mk2相互作用タンパク質 Download PDF

Info

Publication number
JP2006515159A
JP2006515159A JP2004526272A JP2004526272A JP2006515159A JP 2006515159 A JP2006515159 A JP 2006515159A JP 2004526272 A JP2004526272 A JP 2004526272A JP 2004526272 A JP2004526272 A JP 2004526272A JP 2006515159 A JP2006515159 A JP 2006515159A
Authority
JP
Japan
Prior art keywords
protein
complex
shc
proteins
hph2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2004526272A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006515159A5 (https=
Inventor
リー−リン リン,
イヴォンヌ エム. ヤンノニ,
Original Assignee
ワイエス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ワイエス filed Critical ワイエス
Publication of JP2006515159A publication Critical patent/JP2006515159A/ja
Publication of JP2006515159A5 publication Critical patent/JP2006515159A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205Phosphotransferases in general
    • G01N2333/9121Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
    • G01N2333/91215Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases with a definite EC number (2.7.1.-)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Rehabilitation Therapy (AREA)
JP2004526272A 2002-08-02 2003-08-01 Mk2相互作用タンパク質 Withdrawn JP2006515159A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40004402P 2002-08-02 2002-08-02
PCT/US2003/023981 WO2004012660A2 (en) 2002-08-02 2003-08-01 Mk2 interacting proteins

Publications (2)

Publication Number Publication Date
JP2006515159A true JP2006515159A (ja) 2006-05-25
JP2006515159A5 JP2006515159A5 (https=) 2006-08-31

Family

ID=31495774

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004526272A Withdrawn JP2006515159A (ja) 2002-08-02 2003-08-01 Mk2相互作用タンパク質

Country Status (10)

Country Link
US (1) US7364870B2 (https=)
EP (1) EP1572092A4 (https=)
JP (1) JP2006515159A (https=)
CN (1) CN1735687A (https=)
AU (1) AU2003257962A1 (https=)
BR (1) BR0313209A (https=)
CA (1) CA2494577A1 (https=)
IL (1) IL166610A0 (https=)
MX (1) MXPA05001364A (https=)
WO (1) WO2004012660A2 (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012511583A (ja) * 2008-12-10 2012-05-24 パーデュー・リサーチ・ファウンデーション 細胞透過性ペプチドを用いたキナーゼ阻害剤
WO2013084950A1 (ja) * 2011-12-05 2013-06-13 Amalgaam有限会社 タンパク質間相互作用の検出方法
US9447158B2 (en) 2007-01-10 2016-09-20 Purdue Research Foundation Kinase inhibitors and uses thereof
US9452218B2 (en) 2012-03-09 2016-09-27 Purdue Research Foundation Compositions and methods for delivery of kinase inhibiting peptides
US9493508B2 (en) 2007-01-10 2016-11-15 Purdue Research Foundation Polypeptide inhibitors of HSP27 kinase and uses therefor
US9890195B2 (en) 2009-07-27 2018-02-13 Purdue Research Foundation MK2 inhibitor compositions and methods to enhance neurite outgrowth, neuroprotection, and nerve regeneration

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5904638B2 (ja) * 2012-04-11 2016-04-13 株式会社日本マイクロニクス 多層配線基板とその製造方法
US11726081B2 (en) 2019-02-15 2023-08-15 Regents Of The University Of Minnesota Methods to identify modulators of tau protein structure
US11656221B2 (en) * 2019-06-11 2023-05-23 Regents Of The University Of Minnesota Methods to identify modulators of actin-binding proteins
WO2025215156A1 (en) * 2024-04-11 2025-10-16 Universitetet I Tromsø - Norges Arktiske Universitet Biomarker of mk2 activity

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
EP0098110B1 (en) 1982-06-24 1989-10-18 NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JAPAN CHEMICAL RESEARCH CO., LTD Long-acting composition
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
AU597574B2 (en) 1986-03-07 1990-06-07 Massachusetts Institute Of Technology Method for enhancing glycoprotein stability
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US5116944A (en) 1989-12-29 1992-05-26 Neorx Corporation Conjugates having improved characteristics for in vivo administration
US5414135A (en) 1991-12-30 1995-05-09 Sterling Winthrop Inc. Vinyl sulfone coupling of polyoxyalkylenes to proteins
US5624899A (en) 1994-07-20 1997-04-29 Genentech Inc. Method for using Htk ligand
US6420338B1 (en) * 1997-06-13 2002-07-16 New York University Medical Center Inhibition of the Src kinase family pathway as a method of treating HBV infection and hepatocellular carcinoma

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9447158B2 (en) 2007-01-10 2016-09-20 Purdue Research Foundation Kinase inhibitors and uses thereof
US9649354B2 (en) 2007-01-10 2017-05-16 Purdue Research Foundation Polypeptide inhibitors of HSP27 kinase and uses therfor
US9493508B2 (en) 2007-01-10 2016-11-15 Purdue Research Foundation Polypeptide inhibitors of HSP27 kinase and uses therefor
JP2016028019A (ja) * 2008-12-10 2016-02-25 パーデュー・リサーチ・ファウンデーションPurdue Research Foundation 細胞透過性ペプチドを用いたキナーゼ阻害剤
US9327008B2 (en) 2008-12-10 2016-05-03 Purdue Research Foundation Cell-permeant peptide-based inhibitor of kinases
JP2012511583A (ja) * 2008-12-10 2012-05-24 パーデュー・リサーチ・ファウンデーション 細胞透過性ペプチドを用いたキナーゼ阻害剤
US9890195B2 (en) 2009-07-27 2018-02-13 Purdue Research Foundation MK2 inhibitor compositions and methods to enhance neurite outgrowth, neuroprotection, and nerve regeneration
US9494595B2 (en) 2011-12-05 2016-11-15 Medical & Biological Laboratories Co., Ltd. Method for detecting protein-protein interaction
JPWO2013084950A1 (ja) * 2011-12-05 2015-04-27 株式会社医学生物学研究所 タンパク質間相互作用の検出方法
WO2013084950A1 (ja) * 2011-12-05 2013-06-13 Amalgaam有限会社 タンパク質間相互作用の検出方法
US9766250B2 (en) 2011-12-05 2017-09-19 Medical & Biological Laboratories Co., Ltd. Method for detecting protein-protein interaction
US9452218B2 (en) 2012-03-09 2016-09-27 Purdue Research Foundation Compositions and methods for delivery of kinase inhibiting peptides
US10034839B2 (en) 2012-03-09 2018-07-31 Purdue Research Foundation Compositions and methods for delivery of kinase inhibiting peptides

Also Published As

Publication number Publication date
AU2003257962A1 (en) 2004-02-23
US7364870B2 (en) 2008-04-29
EP1572092A4 (en) 2007-09-05
IL166610A0 (en) 2006-01-15
EP1572092A2 (en) 2005-09-14
BR0313209A (pt) 2007-07-24
US20060094101A1 (en) 2006-05-04
WO2004012660A2 (en) 2004-02-12
WO2004012660A3 (en) 2005-10-20
CA2494577A1 (en) 2004-02-12
MXPA05001364A (es) 2005-08-03
CN1735687A (zh) 2006-02-15

Similar Documents

Publication Publication Date Title
Matsuoka et al. p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
US20080220455A1 (en) p53-DEPENDENT APOPTOSIS-INDUCING PROTEIN AND METHOD OF SCREENING FOR APOPTOSIS REGULATOR
EP1990413B1 (en) Screening method for candidate drugs
US7364870B2 (en) MK2 interacting proteins
AU2001265947B2 (en) Enzymatic assays for screening anti-cancer agents
JP4033490B2 (ja) ホスファターゼモデュレーター
AU2001265947A1 (en) Enzymatic assays for screening anti-cancer agents
US6475775B1 (en) PARG, a GTPase activating protein which interacts with PTPL1
AU2001274026A1 (en) Protein complexes and assays for screening anti-cancer agents
JP2001510684A (ja) アッセイ、治療法及び治療手段
EP1234880B1 (en) Novel protein tab2
JP2003523723A (ja) ヘルマンスキー−パドラック症候群タンパク質相互作用タンパク質およびその使用の方法
JP4469938B2 (ja) 高酵素活性型smydファミリー変異ポリペプチドを用いたスクリーニング方法
JP2002516394A (ja) E2f活性を調節するためのアッセイ、方法及び手段
Latoo et al. Phosphorylation state of S6K1 is redundant for its interaction with F actin
JP2005192567A (ja) チロシンキナーゼ遺伝子およびその遺伝子産物

Legal Events

Date Code Title Description
A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20060712

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060712

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090702

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20090728