JP2006514988A5 - - Google Patents
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- Publication number
- JP2006514988A5 JP2006514988A5 JP2005504461A JP2005504461A JP2006514988A5 JP 2006514988 A5 JP2006514988 A5 JP 2006514988A5 JP 2005504461 A JP2005504461 A JP 2005504461A JP 2005504461 A JP2005504461 A JP 2005504461A JP 2006514988 A5 JP2006514988 A5 JP 2006514988A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- opioid antagonist
- coating
- coats
- substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 239000011248 coating agent Substances 0.000 claims 9
- 238000000576 coating method Methods 0.000 claims 9
- 239000000463 material Substances 0.000 claims 9
- 239000003401 opiate antagonist Substances 0.000 claims 9
- 239000000758 substrate Substances 0.000 claims 9
- 230000002209 hydrophobic effect Effects 0.000 claims 6
- 229920006318 anionic polymer Polymers 0.000 claims 5
- 230000004888 barrier function Effects 0.000 claims 5
- 238000009792 diffusion process Methods 0.000 claims 5
- 239000000014 opioid analgesic Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 229920006243 acrylic copolymer Polymers 0.000 claims 2
- 239000011324 bead Substances 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 229920002301 cellulose acetate Polymers 0.000 claims 2
- 238000013270 controlled release Methods 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 239000002702 enteric coating Substances 0.000 claims 2
- 238000009505 enteric coating Methods 0.000 claims 2
- 125000005395 methacrylic acid group Chemical group 0.000 claims 2
- 229920000058 polyacrylate Polymers 0.000 claims 2
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- FMTQGBMMIVVKSN-UHFFFAOYSA-N acetic acid;terephthalic acid Chemical compound CC(O)=O.OC(=O)C1=CC=C(C(O)=O)C=C1 FMTQGBMMIVVKSN-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 1
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 1
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 claims 1
- 229960004127 naloxone Drugs 0.000 claims 1
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 claims 1
- 229960003086 naltrexone Drugs 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims 1
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000009919 sequestration Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40371102P | 2002-08-15 | 2002-08-15 | |
| US60/403,711 | 2002-08-15 | ||
| PCT/US2003/025601 WO2005007135A1 (en) | 2002-08-15 | 2003-08-15 | Pharmaceutical compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006514988A JP2006514988A (ja) | 2006-05-18 |
| JP2006514988A5 true JP2006514988A5 (enExample) | 2006-10-05 |
| JP4790415B2 JP4790415B2 (ja) | 2011-10-12 |
Family
ID=34078931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005504461A Expired - Fee Related JP4790415B2 (ja) | 2002-08-15 | 2003-08-15 | 医薬組成物 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20050266072A1 (enExample) |
| EP (2) | EP1542658B1 (enExample) |
| JP (1) | JP4790415B2 (enExample) |
| KR (1) | KR20050086409A (enExample) |
| CN (1) | CN1674873A (enExample) |
| AT (2) | ATE491439T1 (enExample) |
| BR (1) | BR0313627A (enExample) |
| CA (1) | CA2495564A1 (enExample) |
| CY (2) | CY1111825T1 (enExample) |
| DE (2) | DE60335557D1 (enExample) |
| DK (2) | DK1542658T3 (enExample) |
| ES (2) | ES2358151T3 (enExample) |
| IL (1) | IL166561A0 (enExample) |
| MX (1) | MXPA05001826A (enExample) |
| NZ (1) | NZ537763A (enExample) |
| PT (2) | PT1542658E (enExample) |
| SI (2) | SI1894562T1 (enExample) |
| WO (1) | WO2005007135A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
| EP2295043A1 (en) | 1999-10-29 | 2011-03-16 | Euro-Celtique S.A. | Controlled release hydrocodone formulations |
| WO2001058447A1 (en) | 2000-02-08 | 2001-08-16 | Euro-Celtique, S.A. | Controlled-release compositions containing opioid agonist and antagonist |
| EP2932964A1 (en) | 2000-10-30 | 2015-10-21 | Euro-Celtique S.A. | Controlled release hydrocodone formulations |
| US20060264458A1 (en) * | 2005-05-03 | 2006-11-23 | Jie Du | Quinine dosage forms and methods of use thereof |
| US20070077313A1 (en) * | 2005-10-04 | 2007-04-05 | U.S. Pharmaceutical Corporation | Toleration iron supplement compositions |
| FR2894143B1 (fr) * | 2005-12-01 | 2008-05-02 | Pierre Fabre Medicament Sa | Composition a liberation prolongee de l'actif, son procede de preparation et son utilisation. |
| KR100912680B1 (ko) * | 2006-03-16 | 2009-08-19 | (주) 벡스코아 | 제어 방출 제형 |
| US20080119501A1 (en) * | 2006-04-28 | 2008-05-22 | Hein William A | Immediate release oxymorphone compositions and methods of using same |
| TW200806282A (en) * | 2006-05-05 | 2008-02-01 | Wyeth Corp | Solid dosage formulations |
| US20080069891A1 (en) | 2006-09-15 | 2008-03-20 | Cima Labs, Inc. | Abuse resistant drug formulation |
| PT2484346T (pt) * | 2006-06-19 | 2017-04-26 | Alpharma Pharmaceuticals Llc | Composições farmacêuticas |
| US7674479B2 (en) | 2006-07-25 | 2010-03-09 | Intelgenx Corp. | Sustained-release bupropion and bupropion/mecamylamine tablets |
| US8703191B2 (en) * | 2006-07-25 | 2014-04-22 | Intelgenx Corp. | Controlled-release pharmaceutical tablets |
| PT2046300E (pt) * | 2006-08-04 | 2010-07-01 | Ethypharm Sa | Comprimido multicamadas de desintegraão oral |
| US8445018B2 (en) | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
| CN105534936B (zh) * | 2007-08-13 | 2020-07-31 | Ohemo 生命科学股份有限公司 | 抗滥用药物、使用方法和制备方法 |
| JP5714910B2 (ja) * | 2008-01-09 | 2015-05-07 | チャールストン ラボラトリーズ，インコーポレイテッド | 薬学的組成物 |
| US9226907B2 (en) | 2008-02-01 | 2016-01-05 | Abbvie Inc. | Extended release hydrocodone acetaminophen and related methods and uses thereof |
| US10610528B2 (en) | 2009-12-08 | 2020-04-07 | Intelgenx Corp. | Solid oral film dosage forms and methods for making same |
| US20110136815A1 (en) | 2009-12-08 | 2011-06-09 | Horst Zerbe | Solid oral film dosage forms and methods for making same |
| US20110150986A1 (en) * | 2009-12-18 | 2011-06-23 | Kristin Arnold | Quinine formulations, method of making, and metho of use thereof |
| US8927025B2 (en) | 2010-05-11 | 2015-01-06 | Cima Labs Inc. | Alcohol-resistant metoprolol-containing extended-release oral dosage forms |
| US20140275149A1 (en) | 2013-03-15 | 2014-09-18 | Inspirion Delivery Technologies, Llc | Abuse deterrent compositions and methods of use |
| US10751287B2 (en) * | 2013-03-15 | 2020-08-25 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
| JP6539274B2 (ja) | 2013-08-12 | 2019-07-03 | ファーマシューティカル マニュファクチュアリング リサーチ サービシズ，インコーポレーテッド | 押出成形された即放性乱用抑止性丸剤 |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| EP3169315B1 (en) | 2014-07-17 | 2020-06-24 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| US10729685B2 (en) | 2014-09-15 | 2020-08-04 | Ohemo Life Sciences Inc. | Orally administrable compositions and methods of deterring abuse by intranasal administration |
| US20160106737A1 (en) | 2014-10-20 | 2016-04-21 | Pharmaceutical Manufacturing Research Services, Inc. | Extended Release Abuse Deterrent Liquid Fill Dosage Form |
| JP2019507181A (ja) * | 2016-03-04 | 2019-03-14 | チャールストン ラボラトリーズ，インコーポレイテッド | 医薬組成物 |
| TW201940171A (zh) * | 2018-02-08 | 2019-10-16 | 景凱生物科技股份有限公司 | 類鴉片受體拮抗劑之固體劑型用之醫藥劑型 |
| EP4225312A1 (en) * | 2020-10-06 | 2023-08-16 | Scilex Holding Company | Oral delayed burst formulation of low-dose naltrexone or naloxone used for treating fibromyalgia and long covid |
| EP4176724A1 (en) | 2021-11-09 | 2023-05-10 | Universität Hohenheim | Use of an oleogel as a layer or coating |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916889A (en) | 1973-09-28 | 1975-11-04 | Sandoz Ag | Patient ventilator apparatus |
| GB1478759A (en) | 1974-11-18 | 1977-07-06 | Alza Corp | Process for forming outlet passageways in pills using a laser |
| US4063064A (en) | 1976-02-23 | 1977-12-13 | Coherent Radiation | Apparatus for tracking moving workpiece by a laser beam |
| US5330766A (en) * | 1989-01-06 | 1994-07-19 | F. H. Faulding & Co. Limited | Sustained release pharmaceutical composition |
| US5273760A (en) | 1991-12-24 | 1993-12-28 | Euroceltigue, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
| US5472712A (en) | 1991-12-24 | 1995-12-05 | Euroceltique, S.A. | Controlled-release formulations coated with aqueous dispersions of ethylcellulose |
| US5286493A (en) | 1992-01-27 | 1994-02-15 | Euroceltique, S.A. | Stabilized controlled release formulations having acrylic polymer coating |
| US5681585A (en) | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| GB9407386D0 (en) * | 1994-04-14 | 1994-06-08 | Smithkline Beecham Plc | Pharmaceutical formulation |
| EP0828489A4 (en) * | 1996-03-13 | 2001-04-04 | Univ Yale | Smoking cessation treatments using naltrexone and related compounds |
| DE19630035A1 (de) * | 1996-07-25 | 1998-01-29 | Asta Medica Ag | Tramadol Multiple Unit Formulierungen |
| US6120806A (en) * | 1997-06-25 | 2000-09-19 | Whitmire; David R. | Oral formulations for controlled release of alcohol deterrents |
| RS49982B (sr) * | 1997-09-17 | 2008-09-29 | Euro-Celtique S.A., | Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2 |
| US6274591B1 (en) * | 1997-11-03 | 2001-08-14 | Joseph F. Foss | Use of methylnaltrexone and related compounds |
| PT1685839E (pt) * | 1997-12-22 | 2013-07-08 | Euro Celtique Sa | Forma de dosagem farmacêutica por via oral compreendendo uma combinação de um agonista opióide e de um antagonista opióide |
| US6375957B1 (en) * | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
| US6270805B1 (en) * | 1998-11-06 | 2001-08-07 | Andrx Pharmaceuticals, Inc. | Two pellet controlled release formulation for water soluble drugs which contains an alkaline metal stearate |
| US6765010B2 (en) * | 1999-05-06 | 2004-07-20 | Pain Therapeutics, Inc. | Compositions and methods for enhancing analgesic potency of tramadol and attenuating its adverse side effects |
| WO2001058447A1 (en) | 2000-02-08 | 2001-08-16 | Euro-Celtique, S.A. | Controlled-release compositions containing opioid agonist and antagonist |
| US6716449B2 (en) * | 2000-02-08 | 2004-04-06 | Euro-Celtique S.A. | Controlled-release compositions containing opioid agonist and antagonist |
| AU5945801A (en) * | 2000-05-05 | 2001-11-20 | Pain Therapeutics Inc | Opoid antagonist compositions and dosage forms |
| US20030157168A1 (en) * | 2001-08-06 | 2003-08-21 | Christopher Breder | Sequestered antagonist formulations |
| US7842307B2 (en) * | 2001-08-06 | 2010-11-30 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and gelling agent |
| ES2326794T3 (es) * | 2001-08-06 | 2009-10-20 | Euro-Celtique S.A. | Formulaciones de agonistas opioides con antagonista liberable y secuestrado. |
| US7332182B2 (en) * | 2001-08-06 | 2008-02-19 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant |
| BR0212019A (pt) * | 2001-08-06 | 2005-08-09 | Euro Celtique Sa | Formas de dosagem, métodos para o tratamento da dor, métodos de preparação de uma forma de dosagem e métodos para impedir o abuso de uma forma de dosagem |
| US7144587B2 (en) * | 2001-08-06 | 2006-12-05 | Euro-Celtique S.A. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and bittering agent |
| ES2616981T3 (es) * | 2002-03-14 | 2017-06-15 | Euro-Celtique S.A. | Composiciones de hidrocloruro de naltrexona |
| US20030191147A1 (en) * | 2002-04-09 | 2003-10-09 | Barry Sherman | Opioid antagonist compositions and dosage forms |
| US20040192715A1 (en) * | 2003-02-05 | 2004-09-30 | Mark Chasin | Methods of administering opioid antagonists and compositions thereof |
| MY135852A (en) * | 2003-04-21 | 2008-07-31 | Euro Celtique Sa | Pharmaceutical products |
-
2003
- 2003-08-15 CA CA002495564A patent/CA2495564A1/en not_active Abandoned
- 2003-08-15 DK DK03751860.2T patent/DK1542658T3/da active
- 2003-08-15 ES ES07121574T patent/ES2358151T3/es not_active Expired - Lifetime
- 2003-08-15 AT AT07121574T patent/ATE491439T1/de active
- 2003-08-15 SI SI200331958T patent/SI1894562T1/sl unknown
- 2003-08-15 SI SI200331957T patent/SI1542658T1/sl unknown
- 2003-08-15 BR BR0313627-2A patent/BR0313627A/pt not_active IP Right Cessation
- 2003-08-15 AT AT03751860T patent/ATE493115T1/de active
- 2003-08-15 WO PCT/US2003/025601 patent/WO2005007135A1/en not_active Ceased
- 2003-08-15 US US10/524,334 patent/US20050266072A1/en not_active Abandoned
- 2003-08-15 MX MXPA05001826A patent/MXPA05001826A/es unknown
- 2003-08-15 DE DE60335557T patent/DE60335557D1/de not_active Expired - Lifetime
- 2003-08-15 DK DK07121574.3T patent/DK1894562T3/da active
- 2003-08-15 DE DE60335426T patent/DE60335426D1/de not_active Expired - Lifetime
- 2003-08-15 PT PT03751860T patent/PT1542658E/pt unknown
- 2003-08-15 EP EP03751860A patent/EP1542658B1/en not_active Expired - Lifetime
- 2003-08-15 PT PT07121574T patent/PT1894562E/pt unknown
- 2003-08-15 EP EP07121574A patent/EP1894562B1/en not_active Expired - Lifetime
- 2003-08-15 KR KR1020057002452A patent/KR20050086409A/ko not_active Withdrawn
- 2003-08-15 JP JP2005504461A patent/JP4790415B2/ja not_active Expired - Fee Related
- 2003-08-15 ES ES03751860T patent/ES2358896T3/es not_active Expired - Lifetime
- 2003-08-15 CN CNA038194732A patent/CN1674873A/zh active Pending
- 2003-08-18 NZ NZ537763A patent/NZ537763A/en unknown
-
2005
- 2005-01-27 IL IL16656105A patent/IL166561A0/xx unknown
-
2011
- 2011-03-04 CY CY20111100260T patent/CY1111825T1/el unknown
- 2011-03-22 CY CY20111100311T patent/CY1111821T1/el unknown
-
2016
- 2016-05-06 US US15/148,228 patent/US20160317456A1/en not_active Abandoned
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