JP2006514928A5 - - Google Patents
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- Publication number
- JP2006514928A5 JP2006514928A5 JP2004552734A JP2004552734A JP2006514928A5 JP 2006514928 A5 JP2006514928 A5 JP 2006514928A5 JP 2004552734 A JP2004552734 A JP 2004552734A JP 2004552734 A JP2004552734 A JP 2004552734A JP 2006514928 A5 JP2006514928 A5 JP 2006514928A5
- Authority
- JP
- Japan
- Prior art keywords
- iodo
- hydroxyquinoline
- chloro
- complex
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- FXDUXBIZVCPXPZ-UHFFFAOYSA-N 2-iodoquinolin-8-ol Chemical compound C1=C(I)N=C2C(O)=CC=CC2=C1 FXDUXBIZVCPXPZ-UHFFFAOYSA-N 0.000 claims 19
- QCDFBFJGMNKBDO-UHFFFAOYSA-N Clioquinol Chemical compound C1=CN=C2C(O)=C(I)C=C(Cl)C2=C1 QCDFBFJGMNKBDO-UHFFFAOYSA-N 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 12
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 12
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims 11
- 230000002285 radioactive effect Effects 0.000 claims 10
- NJRFGEVCJFLFSV-KXMUYVCJSA-N 5-chloro-7-fluoranylquinolin-8-ol Chemical compound C1=CN=C2C(O)=C([18F])C=C(Cl)C2=C1 NJRFGEVCJFLFSV-KXMUYVCJSA-N 0.000 claims 9
- RXOMAZJOFNMVRA-LMANFOLPSA-N 5-fluoranyl-7-iodoquinolin-8-ol Chemical compound C1=CN=C2C(O)=C(I)C=C([18F])C2=C1 RXOMAZJOFNMVRA-LMANFOLPSA-N 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- -1 rare earth cation Chemical class 0.000 claims 8
- 229930182480 glucuronide Natural products 0.000 claims 7
- 229910052751 metal Inorganic materials 0.000 claims 7
- 239000002184 metal Substances 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 229910052761 rare earth metal Inorganic materials 0.000 claims 7
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 6
- 239000005725 8-Hydroxyquinoline Substances 0.000 claims 6
- 125000000837 carbohydrate group Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- 229960003540 oxyquinoline Drugs 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- YODYZPGSHFTXFY-BJUDXGSMSA-N 5-chloro-7-iodo-8-methoxyquinoline Chemical compound C1=CN=C2C(O[11CH3])=C(I)C=C(Cl)C2=C1 YODYZPGSHFTXFY-BJUDXGSMSA-N 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 150000003248 quinolines Chemical class 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- QCDFBFJGMNKBDO-GQCOAOBCSA-N 5-chloro-7-(125I)iodanylquinolin-8-ol Chemical compound ClC1=C2C=CC=NC2=C(C(=C1)[125I])O QCDFBFJGMNKBDO-GQCOAOBCSA-N 0.000 claims 4
- 210000003169 central nervous system Anatomy 0.000 claims 4
- 238000003745 diagnosis Methods 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 238000012544 monitoring process Methods 0.000 claims 4
- ZTQNUTNKGQGWCM-UHFFFAOYSA-N 2-methoxyquinoline Chemical compound C1=CC=CC2=NC(OC)=CC=C21 ZTQNUTNKGQGWCM-UHFFFAOYSA-N 0.000 claims 3
- 208000037259 Amyloid Plaque Diseases 0.000 claims 3
- 102000009091 Amyloidogenic Proteins Human genes 0.000 claims 3
- 108010048112 Amyloidogenic Proteins Proteins 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 239000013522 chelant Substances 0.000 claims 3
- 230000008021 deposition Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- VNPWYVBBSDRTCO-UHFFFAOYSA-N 2,7-diiodoquinolin-8-ol Chemical compound C1=C(I)N=C2C(O)=C(I)C=CC2=C1 VNPWYVBBSDRTCO-UHFFFAOYSA-N 0.000 claims 2
- QCDFBFJGMNKBDO-ZEWNHULJSA-N 5-chloro-7-iodanylquinolin-8-ol Chemical compound C1=CN=C2C(O)=C([124I])C=C(Cl)C2=C1 QCDFBFJGMNKBDO-ZEWNHULJSA-N 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 206010002022 amyloidosis Diseases 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 230000003647 oxidation Effects 0.000 claims 2
- 238000007254 oxidation reaction Methods 0.000 claims 2
- ROYJBPYBFBUWBZ-UHFFFAOYSA-N 5-chloro-2-iodoquinolin-8-ol Chemical compound C1=C(I)N=C2C(O)=CC=C(Cl)C2=C1 ROYJBPYBFBUWBZ-UHFFFAOYSA-N 0.000 claims 1
- QCDFBFJGMNKBDO-YZLMXVJLSA-N 5-chloro-7-(131I)iodanylquinolin-8-ol Chemical compound ClC1=C2C=CC=NC2=C(C(=C1)[131I])O QCDFBFJGMNKBDO-YZLMXVJLSA-N 0.000 claims 1
- QCDFBFJGMNKBDO-PJUGFYCSSA-N 5-chloro-7-iodanylquinolin-8-ol Chemical compound C1=CN=C2C(O)=C([123I])C=C(Cl)C2=C1 QCDFBFJGMNKBDO-PJUGFYCSSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000003808 Amyloid Neuropathies Diseases 0.000 claims 1
- 206010007509 Cardiac amyloidosis Diseases 0.000 claims 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 claims 1
- GYWLSMZEFUGFJS-FVHWHDSJSA-N ClC1=C2C=CC=NC2=C(C(=C1)I)O[11CH3].[18F]C1=C2C=CC=NC2=C(C(=C1)I)O.ClC1=C2C=CC=NC2=C(C(=C1)[18F])O.IC1=NC2=C(C=CC=C2C=C1)O Chemical compound ClC1=C2C=CC=NC2=C(C(=C1)I)O[11CH3].[18F]C1=C2C=CC=NC2=C(C(=C1)I)O.ClC1=C2C=CC=NC2=C(C(=C1)[18F])O.IC1=NC2=C(C=CC=C2C=C1)O GYWLSMZEFUGFJS-FVHWHDSJSA-N 0.000 claims 1
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims 1
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims 1
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 206010053776 Eosinophilic cellulitis Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000037196 Medullary thyroid carcinoma Diseases 0.000 claims 1
- 208000026072 Motor neurone disease Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 208000008526 Wells syndrome Diseases 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 238000000502 dialysis Methods 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 230000002140 halogenating effect Effects 0.000 claims 1
- 201000008319 inclusion body myositis Diseases 0.000 claims 1
- 208000023356 medullary thyroid gland carcinoma Diseases 0.000 claims 1
- 150000002739 metals Chemical class 0.000 claims 1
- 208000005264 motor neuron disease Diseases 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 238000010534 nucleophilic substitution reaction Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical group C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 208000013818 thyroid gland medullary carcinoma Diseases 0.000 claims 1
- 230000009261 transgenic effect Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 208000027121 wild type ATTR amyloidosis Diseases 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/ES2002/000537 WO2004045651A1 (es) | 2002-11-18 | 2002-11-18 | Compuestos utiles para el diagnostico y seguimiento de enfermedades relacionadas con la formación de fibrilas proteicas amiloides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006514928A JP2006514928A (ja) | 2006-05-18 |
| JP2006514928A5 true JP2006514928A5 (https=) | 2006-07-27 |
Family
ID=32319763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004552734A Pending JP2006514928A (ja) | 2002-11-18 | 2002-11-18 | アミロイドタンパク質線維の形成に関連する疾患を診断および監視するために利用できる化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20080063599A1 (https=) |
| EP (1) | EP1563852B1 (https=) |
| JP (1) | JP2006514928A (https=) |
| AU (1) | AU2002350751C1 (https=) |
| CA (1) | CA2505506C (https=) |
| DE (1) | DE60223729T2 (https=) |
| ES (1) | ES2297024T3 (https=) |
| WO (1) | WO2004045651A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005216949B2 (en) | 2004-02-24 | 2011-09-22 | The General Hospital Corporation | Catalytic radiofluorination |
| US8257680B1 (en) | 2004-02-24 | 2012-09-04 | The General Hospital Corporation | Catalytic radiofluorination |
| US9017724B2 (en) | 2004-02-24 | 2015-04-28 | The General Hospital Corporation | Catalytic radiofluorination |
| JP5603074B2 (ja) | 2006-09-08 | 2014-10-08 | ピラマル イメージング ソシエテ アノニム | １８ｆ標識物質のための化合物と方法 |
| CA2978149C (en) | 2008-03-21 | 2019-02-12 | The General Hospital Corporation | Inositol derivatives for the detection and treatment of alzheimer's disease and related disorders |
| US10781178B2 (en) | 2015-08-12 | 2020-09-22 | The General Hospital Corporation | 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents |
| CN110759952B (zh) * | 2019-09-27 | 2021-04-20 | 广西师范大学 | 基于8-甲氧基喹啉构筑的钴配合物及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4279887A (en) * | 1978-11-29 | 1981-07-21 | Medi-Physics, Inc. | Amides useful as brain imaging agents |
| US4360509A (en) * | 1979-12-19 | 1982-11-23 | Byk-Mallinckrodt Cil B.V. | Vivo radioassay process |
| US5045303A (en) * | 1985-05-17 | 1991-09-03 | Neorx Corporation | Radiohalogenated small molecules for protein labeling |
| AU720643B2 (en) * | 1996-08-13 | 2000-06-08 | P.N. Gerolymatos S.A. | Use of the chelating agent clioquinol for the manufacture of a pharmaceutical composition for the treatment of Alzheimer's disease |
| JP3772506B2 (ja) * | 1998-01-19 | 2006-05-10 | 三菱化学株式会社 | キノリノール誘導体、その金属錯体およびそれを用いた有機電界発光素子 |
| US20020025944A1 (en) * | 2000-04-28 | 2002-02-28 | Bush Ashley I. | Use of clioquinol for the therapy of Alzheimer's disease |
| US6589504B1 (en) * | 2000-09-22 | 2003-07-08 | Pharmacia & Upjohn Company | Compounds and methods for diagnosing and treating amyloid-related conditions |
-
2002
- 2002-01-14 US US10/534,749 patent/US20080063599A1/en not_active Abandoned
- 2002-11-18 WO PCT/ES2002/000537 patent/WO2004045651A1/es not_active Ceased
- 2002-11-18 ES ES02785448T patent/ES2297024T3/es not_active Expired - Lifetime
- 2002-11-18 EP EP02785448A patent/EP1563852B1/en not_active Expired - Lifetime
- 2002-11-18 JP JP2004552734A patent/JP2006514928A/ja active Pending
- 2002-11-18 DE DE60223729T patent/DE60223729T2/de not_active Expired - Lifetime
- 2002-11-18 CA CA002505506A patent/CA2505506C/en not_active Expired - Fee Related
- 2002-11-18 AU AU2002350751A patent/AU2002350751C1/en not_active Ceased
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