JP2006514643A5 - - Google Patents
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- Publication number
- JP2006514643A5 JP2006514643A5 JP2004560325A JP2004560325A JP2006514643A5 JP 2006514643 A5 JP2006514643 A5 JP 2006514643A5 JP 2004560325 A JP2004560325 A JP 2004560325A JP 2004560325 A JP2004560325 A JP 2004560325A JP 2006514643 A5 JP2006514643 A5 JP 2006514643A5
- Authority
- JP
- Japan
- Prior art keywords
- blood
- hemoglobin
- composition
- nitrite
- inorganic nitrite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010054147 Hemoglobins Proteins 0.000 claims 14
- 102000001554 Hemoglobins Human genes 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 13
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims 10
- 210000003743 erythrocyte Anatomy 0.000 claims 9
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 8
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 6
- 210000004369 blood Anatomy 0.000 claims 6
- 239000008280 blood Substances 0.000 claims 6
- 239000003633 blood substitute Substances 0.000 claims 6
- 239000010836 blood and blood product Substances 0.000 claims 4
- 229940125691 blood product Drugs 0.000 claims 4
- 229910052742 iron Inorganic materials 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 238000001802 infusion Methods 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 102000007513 Hemoglobin A Human genes 0.000 claims 1
- DCDCJJSNSWFVBG-UHFFFAOYSA-N azanylidyneoxidanium;iron Chemical group [Fe].[O+]#N.[O+]#N DCDCJJSNSWFVBG-UHFFFAOYSA-N 0.000 claims 1
- 150000002826 nitrites Chemical class 0.000 claims 1
- 108010042248 nitrosyl hemoglobin Proteins 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- -1 red blood cell Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43261602P | 2002-12-12 | 2002-12-12 | |
| US60/432,616 | 2002-12-12 | ||
| PCT/US2003/037081 WO2004054433A2 (en) | 2002-12-12 | 2003-12-10 | Forming iron nitrosyl hemoglobin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010039447A Division JP2010120971A (ja) | 2002-12-12 | 2010-02-24 | 鉄ニトロシル化ヘモグロビンの生成 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006514643A JP2006514643A (ja) | 2006-05-11 |
| JP2006514643A5 true JP2006514643A5 (https=) | 2006-12-14 |
| JP5305554B2 JP5305554B2 (ja) | 2013-10-02 |
Family
ID=32595081
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004560325A Expired - Fee Related JP5305554B2 (ja) | 2002-12-12 | 2003-12-10 | 鉄ニトロシル化ヘモグロビンの生成 |
| JP2010039447A Withdrawn JP2010120971A (ja) | 2002-12-12 | 2010-02-24 | 鉄ニトロシル化ヘモグロビンの生成 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010039447A Withdrawn JP2010120971A (ja) | 2002-12-12 | 2010-02-24 | 鉄ニトロシル化ヘモグロビンの生成 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8075922B2 (https=) |
| EP (1) | EP1575419B1 (https=) |
| JP (2) | JP5305554B2 (https=) |
| AU (2) | AU2003295697B2 (https=) |
| CA (1) | CA2509817C (https=) |
| WO (1) | WO2004054433A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5564158B2 (ja) | 2003-07-09 | 2014-07-30 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 亜硝酸塩によって特定の心臓血管状態を処置する方法 |
| WO2006096774A2 (en) * | 2005-03-07 | 2006-09-14 | Sangart, Inc. | Composition and methods for delivering carbon monoxide (co) and nitric ozide (no) co to tissue using heme proteins as carriers |
| CN1325518C (zh) * | 2005-09-09 | 2007-07-11 | 李勇 | 人细胞膜抗原的保存方法及磁性粒子包被人细胞膜抗原 |
| DE102007026071A1 (de) * | 2007-05-24 | 2008-11-27 | Seereal Technologies S.A. | Richtungsgesteuerte Beleuchtungseinheit für ein autostereoskopisches Display |
| US8551536B2 (en) | 2007-08-31 | 2013-10-08 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitrite and nitrite-metheme therapy to detoxify stroma-free hemoglobin based blood substitutes |
| WO2009038796A1 (en) | 2007-09-20 | 2009-03-26 | Wake Forest University Health Sciences | Methods of treatment for hemolysis |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4820269A (en) * | 1983-03-07 | 1989-04-11 | Vanderbilt University | Mixer apparatus for controlling intravenous drug infusion |
| US6291424B1 (en) * | 1991-11-14 | 2001-09-18 | Brigham And Women's Hospital | Nitrosated and nitrosylated heme proteins |
| WO1996030006A1 (en) * | 1995-03-24 | 1996-10-03 | Brigham And Women's Hospital | Nitrosylated blood substitutes |
| US6153186A (en) | 1995-09-15 | 2000-11-28 | Duke University Medical Center | Red blood cells loaded with S-nitrosothiol and uses therefor |
| AT405135B (de) * | 1997-01-17 | 1999-05-25 | Immuno Ag | Präparation umfassend thiolgruppen-hältige proteine |
| JP2002513400A (ja) * | 1997-02-06 | 2002-05-08 | デューク ユニバーシティ メディカル センター | Ｎｏ修飾ヘモグロビンおよびそのための使用 |
| US6087087A (en) * | 1997-07-03 | 2000-07-11 | Takashi Yonetani | Treatment of hemoglobin with nitric oxide |
| CA2680378C (en) * | 1999-08-02 | 2013-09-24 | Duke University | Method for determining physiological effects of hemoglobin |
| US20060088942A1 (en) | 2002-05-29 | 2006-04-27 | Stamler Jonathan S | Measuring nitric oxide in blood gases and treatments based thereon |
-
2003
- 2003-12-10 JP JP2004560325A patent/JP5305554B2/ja not_active Expired - Fee Related
- 2003-12-10 AU AU2003295697A patent/AU2003295697B2/en not_active Ceased
- 2003-12-10 US US10/538,404 patent/US8075922B2/en active Active
- 2003-12-10 EP EP03786898.1A patent/EP1575419B1/en not_active Expired - Lifetime
- 2003-12-10 CA CA2509817A patent/CA2509817C/en not_active Expired - Fee Related
- 2003-12-10 WO PCT/US2003/037081 patent/WO2004054433A2/en not_active Ceased
-
2010
- 2010-02-24 JP JP2010039447A patent/JP2010120971A/ja not_active Withdrawn
- 2010-03-23 AU AU2010201151A patent/AU2010201151B2/en not_active Ceased
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