JP2006514099A5 - - Google Patents
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- Publication number
- JP2006514099A5 JP2006514099A5 JP2005501423A JP2005501423A JP2006514099A5 JP 2006514099 A5 JP2006514099 A5 JP 2006514099A5 JP 2005501423 A JP2005501423 A JP 2005501423A JP 2005501423 A JP2005501423 A JP 2005501423A JP 2006514099 A5 JP2006514099 A5 JP 2006514099A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- substituted
- phosphonate
- alkyl
- following structure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *c1c(*)c(*)nc(*)c1* Chemical compound *c1c(*)c(*)nc(*)c1* 0.000 description 41
- PBWVYZYNSCGBQV-UHFFFAOYSA-N CC(C)(C)OC(NC(C1)CN1C(Oc(c1c2nccc1)c(CN(Cc(cc1)ccc1F)C1=O)c1c2OC(c1ccccc1)c1ccccc1)=O)=O Chemical compound CC(C)(C)OC(NC(C1)CN1C(Oc(c1c2nccc1)c(CN(Cc(cc1)ccc1F)C1=O)c1c2OC(c1ccccc1)c1ccccc1)=O)=O PBWVYZYNSCGBQV-UHFFFAOYSA-N 0.000 description 1
- LKXSEJODFICBQQ-UHFFFAOYSA-N CC(c(c1c(c2c3cccn2)O)c3OC)N(Cc(cc2)ccc2F)C1=O Chemical compound CC(c(c1c(c2c3cccn2)O)c3OC)N(Cc(cc2)ccc2F)C1=O LKXSEJODFICBQQ-UHFFFAOYSA-N 0.000 description 1
- ZDKGMGOVBBVDPK-UHFFFAOYSA-N COCOc(c(nccc1)c1c(O)c1C(N2Cc(cc3)ccc3F)=O)c1C2=O Chemical compound COCOc(c(nccc1)c1c(O)c1C(N2Cc(cc3)ccc3F)=O)c1C2=O ZDKGMGOVBBVDPK-UHFFFAOYSA-N 0.000 description 1
- HDOLDXSQPDJGIJ-UHFFFAOYSA-N COCOc(c(nccc1)c1c(OCc1ccccc1)c1C(N2Cc(cc3)ccc3F)=O)c1C2=O Chemical compound COCOc(c(nccc1)c1c(OCc1ccccc1)c1C(N2Cc(cc3)ccc3F)=O)c1C2=O HDOLDXSQPDJGIJ-UHFFFAOYSA-N 0.000 description 1
- NRIFOPWNLUHYCG-UHFFFAOYSA-N COc(c1c2nccc1)c(C(N(Cc(cc1)ccc1F)C1=O)=C)c1c2O Chemical compound COc(c1c2nccc1)c(C(N(Cc(cc1)ccc1F)C1=O)=C)c1c2O NRIFOPWNLUHYCG-UHFFFAOYSA-N 0.000 description 1
- OOIDSMJGMNNWKG-UHFFFAOYSA-N C[O](C1)C1c(c1c2nccc1)c(C(N(Cc(cc1)ccc1F)C1=O)O)c1c2OC(c1ccccc1)c1ccccc1 Chemical compound C[O](C1)C1c(c1c2nccc1)c(C(N(Cc(cc1)ccc1F)C1=O)O)c1c2OC(c1ccccc1)c1ccccc1 OOIDSMJGMNNWKG-UHFFFAOYSA-N 0.000 description 1
- CPHVXWJDDJENTJ-UHFFFAOYSA-N C[Si](C)(C)CCOc(c1c2nccc1)c(CN(Cc(cc1)ccc1F)C1=O)c1c2OC(c1ccccc1)c1ccccc1 Chemical compound C[Si](C)(C)CCOc(c1c2nccc1)c(CN(Cc(cc1)ccc1F)C1=O)c1c2OC(c1ccccc1)c1ccccc1 CPHVXWJDDJENTJ-UHFFFAOYSA-N 0.000 description 1
- MEOUBBLFVJNUAF-UHFFFAOYSA-N C[n]1cnc(S(Cl)(=C)=O)c1 Chemical compound C[n]1cnc(S(Cl)(=C)=O)c1 MEOUBBLFVJNUAF-UHFFFAOYSA-N 0.000 description 1
- AVKNGPAMCBSNSO-UHFFFAOYSA-N NCC1CCCCC1 Chemical compound NCC1CCCCC1 AVKNGPAMCBSNSO-UHFFFAOYSA-N 0.000 description 1
- RSBUIZHXCPXOPI-UHFFFAOYSA-N O=C(CC1)N(B[AlH2])C1=O Chemical compound O=C(CC1)N(B[AlH2])C1=O RSBUIZHXCPXOPI-UHFFFAOYSA-N 0.000 description 1
- NEJCULBWOMKEQW-UHFFFAOYSA-N O=C(c(c1c2nccc1)c(CN(Cc(cc1)ccc1F)C1=O)c1c2OC(c1ccccc1)c1ccccc1)N1CCOCC1 Chemical compound O=C(c(c1c2nccc1)c(CN(Cc(cc1)ccc1F)C1=O)c1c2OC(c1ccccc1)c1ccccc1)N1CCOCC1 NEJCULBWOMKEQW-UHFFFAOYSA-N 0.000 description 1
- GHASJZKLEOZSIG-UHFFFAOYSA-N OCCCCCC(CCC1)CCN1C(Oc(c(CN1Cc(cc2)ccc2F)c2C1=O)c(cccn1)c1c2O)=O Chemical compound OCCCCCC(CCC1)CCN1C(Oc(c(CN1Cc(cc2)ccc2F)c2C1=O)c(cccn1)c1c2O)=O GHASJZKLEOZSIG-UHFFFAOYSA-N 0.000 description 1
- AWHRLSWFNXNGCA-UHFFFAOYSA-N Oc(c(nccc1)c1c(C(N1CCOCC1)=O)c1CN2Cc(cc3)ccc3F)c1C2=O Chemical compound Oc(c(nccc1)c1c(C(N1CCOCC1)=O)c1CN2Cc(cc3)ccc3F)c1C2=O AWHRLSWFNXNGCA-UHFFFAOYSA-N 0.000 description 1
- POHHXIQQPHVHOE-UHFFFAOYSA-N Oc(c(nccc1)c1c(C(NCI)=O)c1CN2Cc(cc3)ccc3F)c1C2=O Chemical compound Oc(c(nccc1)c1c(C(NCI)=O)c1CN2Cc(cc3)ccc3F)c1C2=O POHHXIQQPHVHOE-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41896302P | 2002-10-16 | 2002-10-16 | |
| US47878303P | 2003-06-16 | 2003-06-16 | |
| PCT/US2003/032666 WO2004035576A2 (en) | 2002-10-16 | 2003-10-16 | Pre-organized tricyclic integrase inhibitor compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006514099A JP2006514099A (ja) | 2006-04-27 |
| JP2006514099A5 true JP2006514099A5 (enExample) | 2007-01-25 |
Family
ID=32110203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005501423A Pending JP2006514099A (ja) | 2002-10-16 | 2003-10-16 | 組織化前の三環系インテグラーゼインヒビター化合物 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20040157804A1 (enExample) |
| EP (1) | EP1558613A2 (enExample) |
| JP (1) | JP2006514099A (enExample) |
| KR (1) | KR20050087787A (enExample) |
| CN (1) | CN100374438C (enExample) |
| AP (1) | AP1858A (enExample) |
| AU (2) | AU2003301439A1 (enExample) |
| BR (1) | BR0315405A (enExample) |
| CA (1) | CA2501881A1 (enExample) |
| EA (1) | EA011399B1 (enExample) |
| HR (1) | HRP20050431A2 (enExample) |
| IS (1) | IS7845A (enExample) |
| MX (1) | MXPA05003950A (enExample) |
| NO (1) | NO20052378L (enExample) |
| NZ (1) | NZ539264A (enExample) |
| OA (1) | OA13079A (enExample) |
| PL (1) | PL377966A1 (enExample) |
| UA (1) | UA79830C2 (enExample) |
| WO (2) | WO2004035577A2 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60041399D1 (de) * | 1999-05-19 | 2009-03-05 | Painceptor Pharma Corp | Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen |
| US20060211724A1 (en) * | 2003-04-28 | 2006-09-21 | Verschueren Gaston W | Hiv integrase inhibitors |
| WO2005028478A1 (en) * | 2003-09-19 | 2005-03-31 | Gilead Sciences, Inc. | Aza-quinolinol phosphonate integrase inhibitor compounds |
| WO2005056613A2 (en) * | 2003-12-08 | 2005-06-23 | The Research Foundation Of State University Of New York | Site selectively tagged and templated molecularly imprinted polymers for sensor applications |
| EP1694686A1 (en) | 2003-12-19 | 2006-08-30 | Takeda San Diego, Inc. | Kinase inhibitors |
| EP1706728A4 (en) * | 2004-01-07 | 2008-03-12 | Univ New York State Res Found | PROTEIN IMPREGNATED POLYMERS WITH INTEGRATED TRANSMISSION SITES |
| DK1742642T3 (da) * | 2004-04-14 | 2009-02-16 | Gilead Sciences Inc | Phosphonatanaloge af HIV-integraseinhibitorforbindelser |
| CN1964975B (zh) * | 2004-05-07 | 2011-11-30 | 默沙东公司 | Hiv整合酶抑制剂 |
| CA2568389A1 (en) * | 2004-06-09 | 2005-12-22 | Merck & Co., Inc. | Hiv integrase inhibitors |
| JP2008510734A (ja) | 2004-08-18 | 2008-04-10 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
| US7745459B2 (en) | 2004-09-21 | 2010-06-29 | Japan Tobacco Inc. | Quinolizinone compound and use thereof as HIV integrase inhibitor |
| EP1812439B2 (en) | 2004-10-15 | 2017-12-06 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| WO2006125048A2 (en) * | 2005-05-16 | 2006-11-23 | Gilead Sciences, Inc. | Hiv-integrase inhibitor compounds |
| JP5289046B2 (ja) | 2005-05-19 | 2013-09-11 | メルク カナダ インコーポレイテッド | Ep4アンタゴニストとしてのキノリン誘導体 |
| CA2616314A1 (en) * | 2005-07-27 | 2007-02-01 | Gilead Sciences, Inc. | Antiviral phosphonate conjugates for inhibition of hiv |
| WO2007019130A2 (en) * | 2005-08-04 | 2007-02-15 | Smithkline Beecham Corporation | Hiv integrase inhibitors |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| WO2007076005A2 (en) * | 2005-12-21 | 2007-07-05 | Gilead Sciences, Inc. | Processes and intermediates useful for preparing integrase inhibitor compounds |
| SG170796A1 (en) | 2005-12-30 | 2011-05-30 | Gilead Sciences Inc Us | Methods for improving the pharmacokinetics of hiv integrase inhibitors |
| US20090233964A1 (en) * | 2005-12-30 | 2009-09-17 | Gilead Sciences, Inc. | Methods for improving the pharmacokinetics of hiv integrase inhibitors |
| NZ572367A (en) * | 2006-05-16 | 2011-09-30 | Gilead Sciences Inc | Fused cyclic compounds as integrase inhibitors |
| JP2010505962A (ja) | 2006-10-09 | 2010-02-25 | 武田薬品工業株式会社 | キナーゼ阻害剤 |
| US20090291921A1 (en) * | 2007-11-20 | 2009-11-26 | Gilead Sciences, Inc. | Integrase inhibitors |
| MX2010008148A (es) | 2008-01-25 | 2010-10-20 | Chimerix Inc | Métodos de tratamiento de infecciones virales. |
| EP2320909B8 (en) | 2008-07-25 | 2016-03-30 | VIIV Healthcare Company | Chemical compounds |
| JP2011529502A (ja) * | 2008-07-28 | 2011-12-08 | ポリメディックス・インコーポレーテッド | 抗マラリア化合物 |
| EP3210603A1 (en) | 2008-12-11 | 2017-08-30 | Shionogi & Co., Ltd | Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates |
| WO2010068262A1 (en) | 2008-12-11 | 2010-06-17 | Glaxosmithkline Llc | Processes and intermediates for carbamoylpyridone hiv integrase inhibitors |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| EP2270021A1 (en) * | 2009-06-18 | 2011-01-05 | Centre National de la Recherche Scientifique | Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability |
| WO2011011483A1 (en) * | 2009-07-22 | 2011-01-27 | Glaxosmithkline Llc | Chemical compounds |
| EA019558B1 (ru) | 2009-10-13 | 2014-04-30 | Эланко Энимал Хэлс Аиэлэнд Лимитед | Макроциклические ингибиторы интегразы |
| JP5745869B2 (ja) * | 2010-01-22 | 2015-07-08 | 富山化学工業株式会社 | アルアルキル基を有する複素環化合物 |
| US8283366B2 (en) | 2010-01-22 | 2012-10-09 | Ambrilia Biopharma, Inc. | Derivatives of pyridoxine for inhibiting HIV integrase |
| WO2011100698A2 (en) | 2010-02-12 | 2011-08-18 | Chimerix, Inc. | Methods of treating viral infection |
| TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Viiv醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
| TWI503323B (zh) | 2010-03-29 | 2015-10-11 | Oncotherapy Science Inc | 三環化合物以及含此化合物之pbk抑制劑 |
| RU2567385C2 (ru) | 2010-04-02 | 2015-11-10 | ЯНССЕН Ар ЭНД Ди АЙРЛЭНД | Макроциклические ингибиторы интегразы |
| JP5767393B2 (ja) | 2011-03-31 | 2015-08-19 | ファイザー・インク | 新規二環式ピリジノン |
| EP2785184B1 (en) | 2011-11-30 | 2020-06-10 | Emory University | Compositions comprising jak inhibitors and haart drugs for use in the prevention or treatment of hiv |
| KR101365849B1 (ko) * | 2012-03-28 | 2014-02-24 | 경동제약 주식회사 | 솔리페나신 또는 그의 염의 제조방법 및 이에 사용되는 신규 중간체 |
| UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| US10260089B2 (en) | 2012-10-29 | 2019-04-16 | The Research Foundation Of The State University Of New York | Compositions and methods for recognition of RNA using triple helical peptide nucleic acids |
| SG11201705069YA (en) | 2014-12-26 | 2017-07-28 | Univ Emory | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| EA033423B1 (ru) | 2015-02-03 | 2019-10-31 | Pfizer | Циклопропанбензофуранилпиридопиразиндионы |
| CN104803905B (zh) * | 2015-04-17 | 2017-10-10 | 复旦大学 | 一种合成异吲哚啉‑1‑酮衍生物的方法 |
| WO2017133517A1 (zh) * | 2016-02-03 | 2017-08-10 | 四川海思科制药有限公司 | 一种磷酰胺衍生物及制备方法和用途 |
| CN109305990B (zh) * | 2017-07-28 | 2021-02-26 | 四川海思科制药有限公司 | 一种磷酸衍生物及制备方法和用途 |
| CN109305989B (zh) * | 2017-07-28 | 2021-02-26 | 四川海思科制药有限公司 | 一种磷酰胺衍生物及制备方法和用途 |
| PL3706762T3 (pl) | 2017-12-07 | 2025-02-10 | Emory University | N4-hydroksycytydyna i pochodne oraz związane z nimi zastosowania przeciwwirusowe |
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| CH385846A (de) * | 1960-03-31 | 1964-12-31 | Geigy Ag J R | Verfahren zur Herstellung von neuen 7-Acyl-8-hydroxy-chinolinen und ihre Verwendung als Fungizide und Bakterizide im Pflanzen- und Materialschutz |
| US4816570A (en) * | 1982-11-30 | 1989-03-28 | The Board Of Regents Of The University Of Texas System | Biologically reversible phosphate and phosphonate protective groups |
| US4968788A (en) * | 1986-04-04 | 1990-11-06 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective gruops |
| DE69115694T2 (de) | 1990-06-13 | 1996-10-17 | Arnold Newton Mass. Glazier | Phosphorylierte prodrugs |
| DE10399025I2 (de) * | 1990-09-14 | 2007-11-08 | Acad Of Science Czech Republic | Wirkstoffvorläufer von Phosphonaten |
| DK0498722T3 (da) * | 1991-02-07 | 1998-03-09 | Roussel Uclaf | Nye bicycliske nitrogenforbindelser substitueret med en benzylgruppe, fremgangsmåde til deres fremstilling, de opnåede nye intermediærer, deres anvendelse som lægemidler og de pharmaceutiske præparater som de indgår i |
| EP0520573A1 (en) * | 1991-06-27 | 1992-12-30 | Glaxo Inc. | Cyclic imide derivatives |
| US5639881A (en) * | 1991-11-08 | 1997-06-17 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Synthesis and elucidation of pyrimido (4,5-Q) quinazoline derivatives |
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| US5538988A (en) * | 1994-04-26 | 1996-07-23 | Martinez; Gregory R. | Benzocycloalkylazolethione derivatives |
| US5854275A (en) * | 1996-05-16 | 1998-12-29 | Pfizer Inc. | Cyclic imide derivatives |
| AU4172197A (en) * | 1996-09-10 | 1998-04-02 | Pharmacia & Upjohn Company | 8-hydroxy-7-substituted quinolines as anti-viral agents |
| US6329375B1 (en) * | 1997-08-05 | 2001-12-11 | Sugen, Inc. | Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors |
| US6312662B1 (en) * | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
| WO1999062513A1 (en) | 1998-06-03 | 1999-12-09 | Merck & Co., Inc. | Hiv integrase inhibitors |
| EP1082121A4 (en) | 1998-06-03 | 2003-02-05 | Merck & Co Inc | HIV integrase |
| CA2331794A1 (en) * | 1998-06-10 | 1999-12-16 | Tadayuki Koda | Acetylcholine enhancers |
| US6187907B1 (en) * | 1998-08-31 | 2001-02-13 | James Chen | Triple helix coil template having a biologically active ligand |
| WO2000036132A1 (en) | 1998-12-14 | 2000-06-22 | Merck & Co., Inc. | Hiv integrase inhibitors |
| US6620841B1 (en) | 1998-12-25 | 2003-09-16 | Shionogi & Co., Ltd. | Aromatic heterocycle compounds having HIV integrase inhibiting activities |
| CN1367784A (zh) | 1999-06-02 | 2002-09-04 | 盐野义制药株式会社 | 新的取代丙烯酮衍生物的制备方法 |
| AU5880600A (en) | 1999-06-25 | 2001-01-31 | Merck & Co., Inc. | 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof |
| US6245806B1 (en) | 1999-08-03 | 2001-06-12 | Merck & Co., Inc. | HIV integrase inhibitors |
| AU8009900A (en) * | 1999-10-13 | 2001-04-23 | Merck & Co., Inc. | Hiv integrase inhibitors |
| EP1326610B1 (en) | 2000-10-12 | 2006-11-15 | Merck & Co., Inc. | Aza-and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
| US20050010048A1 (en) | 2000-10-12 | 2005-01-13 | Linghang Zhuang | Aza-and polyaza-naphthalenly ketones useful as hiv integrase inhibitors |
| WO2002030931A2 (en) * | 2000-10-12 | 2002-04-18 | Merck & Co., Inc. | Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
| ATE364385T1 (de) * | 2000-10-12 | 2007-07-15 | Merck & Co Inc | Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer |
| AU2002215018A1 (en) * | 2000-10-13 | 2002-04-22 | Bayer Aktiengesellschaft | Human histone deacetylase gene |
| US6518767B1 (en) * | 2000-10-19 | 2003-02-11 | Schweitzer Engineering Laboratories, Inc. | Line differential protection system for a power transmission line |
| DK1742642T3 (da) * | 2004-04-14 | 2009-02-16 | Gilead Sciences Inc | Phosphonatanaloge af HIV-integraseinhibitorforbindelser |
-
2003
- 2003-10-15 WO PCT/US2003/032866 patent/WO2004035577A2/en not_active Ceased
- 2003-10-15 US US10/687,374 patent/US20040157804A1/en not_active Abandoned
- 2003-10-15 AU AU2003301439A patent/AU2003301439A1/en not_active Abandoned
- 2003-10-16 EP EP03809030A patent/EP1558613A2/en not_active Withdrawn
- 2003-10-16 CN CNB2003801061816A patent/CN100374438C/zh not_active Expired - Fee Related
- 2003-10-16 OA OA1200500108A patent/OA13079A/en unknown
- 2003-10-16 KR KR1020057006668A patent/KR20050087787A/ko not_active Ceased
- 2003-10-16 WO PCT/US2003/032666 patent/WO2004035576A2/en not_active Ceased
- 2003-10-16 PL PL377966A patent/PL377966A1/pl not_active Application Discontinuation
- 2003-10-16 UA UAA200504480A patent/UA79830C2/uk unknown
- 2003-10-16 CA CA002501881A patent/CA2501881A1/en not_active Abandoned
- 2003-10-16 AP AP2005003279A patent/AP1858A/xx active
- 2003-10-16 BR BR0315405-0A patent/BR0315405A/pt not_active IP Right Cessation
- 2003-10-16 JP JP2005501423A patent/JP2006514099A/ja active Pending
- 2003-10-16 HR HR20050431A patent/HRP20050431A2/hr not_active Application Discontinuation
- 2003-10-16 NZ NZ539264A patent/NZ539264A/en not_active IP Right Cessation
- 2003-10-16 MX MXPA05003950A patent/MXPA05003950A/es active IP Right Grant
- 2003-10-16 AU AU2003301306A patent/AU2003301306A1/en not_active Abandoned
- 2003-10-16 US US10/687,373 patent/US7253180B2/en not_active Expired - Fee Related
- 2003-10-16 EA EA200500660A patent/EA011399B1/ru not_active IP Right Cessation
-
2005
- 2005-05-13 IS IS7845A patent/IS7845A/is unknown
- 2005-05-13 NO NO20052378A patent/NO20052378L/no not_active Application Discontinuation
-
2007
- 2007-05-25 US US11/807,303 patent/US20090029939A1/en not_active Abandoned
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