JP2006514068A5 - - Google Patents
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- Publication number
- JP2006514068A5 JP2006514068A5 JP2004566647A JP2004566647A JP2006514068A5 JP 2006514068 A5 JP2006514068 A5 JP 2006514068A5 JP 2004566647 A JP2004566647 A JP 2004566647A JP 2004566647 A JP2004566647 A JP 2004566647A JP 2006514068 A5 JP2006514068 A5 JP 2006514068A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- prostaglandin
- compound
- group
- solid dosage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002552 dosage form Substances 0.000 claims 15
- 239000007909 solid dosage form Substances 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 10
- 239000003961 penetration enhancing agent Substances 0.000 claims 9
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical group CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims 7
- -1 N-substituted amino Chemical group 0.000 claims 4
- GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 claims 3
- CBOMORHDRONZRN-QLOYDKTKSA-N prostaglandin E3 Chemical compound CC\C=C/C[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O CBOMORHDRONZRN-QLOYDKTKSA-N 0.000 claims 3
- 125000003259 prostaglandin group Chemical group 0.000 claims 3
- 230000000699 topical effect Effects 0.000 claims 3
- 239000013543 active substance Substances 0.000 claims 2
- 239000003125 aqueous solvent Substances 0.000 claims 2
- HSMMSDWNEJLVRY-INIZCTEOSA-N dodecyl (2s)-2-(dimethylamino)propanoate Chemical group CCCCCCCCCCCCOC(=O)[C@H](C)N(C)C HSMMSDWNEJLVRY-INIZCTEOSA-N 0.000 claims 2
- IPWWTXFQEUNUNX-UHFFFAOYSA-N dodecyl 2-(dimethylamino)propanoate;hydrochloride Chemical group Cl.CCCCCCCCCCCCOC(=O)C(C)N(C)C IPWWTXFQEUNUNX-UHFFFAOYSA-N 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 claims 1
- 229960000711 alprostadil Drugs 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/336,481 US6841574B2 (en) | 2003-01-03 | 2003-01-03 | Topical stabilized prostaglandin E compound dosage forms |
| PCT/US2003/041658 WO2004062632A1 (en) | 2003-01-03 | 2003-12-31 | Topical stabilized prostaglandin e compound dosage forms |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011200752A Division JP5395138B2 (ja) | 2003-01-03 | 2011-09-14 | 局所安定化プロスタグランジンｅ化合物剤形 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006514068A JP2006514068A (ja) | 2006-04-27 |
| JP2006514068A5 true JP2006514068A5 (https=) | 2007-02-22 |
Family
ID=32681022
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004566647A Pending JP2006514068A (ja) | 2003-01-03 | 2003-12-31 | 局所安定化プロスタグランジンｅ化合物剤形 |
| JP2011200752A Expired - Fee Related JP5395138B2 (ja) | 2003-01-03 | 2011-09-14 | 局所安定化プロスタグランジンｅ化合物剤形 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011200752A Expired - Fee Related JP5395138B2 (ja) | 2003-01-03 | 2011-09-14 | 局所安定化プロスタグランジンｅ化合物剤形 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6841574B2 (https=) |
| EP (1) | EP1585483B1 (https=) |
| JP (2) | JP2006514068A (https=) |
| KR (2) | KR20050098853A (https=) |
| CN (1) | CN100574763C (https=) |
| AT (1) | ATE468098T1 (https=) |
| AU (1) | AU2003300113B2 (https=) |
| BR (1) | BR0317924A (https=) |
| CA (1) | CA2512015C (https=) |
| DE (1) | DE60332656D1 (https=) |
| DK (1) | DK1585483T3 (https=) |
| ES (1) | ES2343246T3 (https=) |
| IL (1) | IL169425A (https=) |
| PT (1) | PT1585483E (https=) |
| WO (1) | WO2004062632A1 (https=) |
| ZA (1) | ZA200505321B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050004226A1 (en) * | 1998-12-10 | 2005-01-06 | Nexmed (Holdings), Inc. | Compositions and methods for amelioration of human female sexual dysfunction |
| GB0222522D0 (en) | 2002-09-27 | 2002-11-06 | Controlled Therapeutics Sct | Water-swellable polymers |
| US20050181030A1 (en) * | 2003-01-03 | 2005-08-18 | Mo Y. J. | Topical stabilized prostaglandin E compound dosage forms |
| BRPI0408454A (pt) | 2003-03-21 | 2006-04-04 | Nexmed Holdings Inc | composição tópica, método de tratar a ejaculação precoce, e, uso da composição |
| WO2005051960A2 (en) * | 2003-11-22 | 2005-06-09 | Midwest Research Laboratories, Llc | Hydrocarbyl aminohydrocarbonoates and aminohydrocarbonol hydrocarbonoates as antimicrobial and antiviral agents |
| GB0417401D0 (en) * | 2004-08-05 | 2004-09-08 | Controlled Therapeutics Sct | Stabilised prostaglandin composition |
| CA2610465A1 (en) * | 2005-06-03 | 2006-12-14 | Duramed Pharmaceuticals, Inc. | Pharmaceutical compositions comprising prostanoid-receptor agonists and methods of making and using the same |
| ITMI20051417A1 (it) * | 2005-07-22 | 2007-01-23 | Mipharm S P A | Formulazione topica in forma di gel contenente come ingredienti attivi ciclovit e lidocaina |
| CA2630261A1 (en) * | 2005-12-06 | 2007-06-14 | Monosol Rx, Llc | Topical film compositions for delivery of actives |
| GB0613333D0 (en) | 2006-07-05 | 2006-08-16 | Controlled Therapeutics Sct | Hydrophilic polyurethane compositions |
| GB0613638D0 (en) | 2006-07-08 | 2006-08-16 | Controlled Therapeutics Sct | Polyurethane elastomers |
| US7560489B2 (en) * | 2006-10-11 | 2009-07-14 | Nexmed Holdings, Inc. | Stabilized prostaglandin E composition |
| GB0620685D0 (en) | 2006-10-18 | 2006-11-29 | Controlled Therapeutics Sct | Bioresorbable polymers |
| EP2437684B1 (en) | 2009-06-03 | 2022-06-15 | ForSight Vision5, Inc. | Anterior segment drug delivery |
| WO2012139033A1 (en) | 2011-04-07 | 2012-10-11 | Nexmed Holdings, Inc. | Methods and compositions for treating raynaud's disease |
| EP2755615B1 (en) | 2011-09-14 | 2022-04-06 | Forsight Vision5, Inc. | Ocular insert apparatus |
| DK2911623T3 (da) | 2012-10-26 | 2019-10-28 | Forsight Vision5 Inc | Oftalmisk system til langvarig frigivelse af lægemiddel til øjet |
| US8900625B2 (en) | 2012-12-15 | 2014-12-02 | Nexmed Holdings, Inc. | Antimicrobial compounds and methods of use |
| US20160296532A1 (en) | 2015-04-13 | 2016-10-13 | Forsight Vision5, Inc. | Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent |
| WO2019142015A1 (es) * | 2018-01-18 | 2019-07-25 | Caicedo Pinto, David Felipe | Composicion farmaceutica para la disfuncion erectil de administracion transdermica via uretral en gotas |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3883576A (en) * | 1971-02-02 | 1975-05-13 | Upjohn Co | Prostaglandin E{HD 3 {B analogs |
| US3826823A (en) * | 1972-09-25 | 1974-07-30 | Syntex Inc | Stabilized prostaglandin preparations |
| US3875300A (en) * | 1972-12-18 | 1975-04-01 | Ortho Pharma Corp | Composition for sustained release of a medicament and method of using same |
| US4136162A (en) * | 1974-07-05 | 1979-01-23 | Schering Aktiengesellschaft | Medicament carriers in the form of film having active substance incorporated therein |
| US5017382A (en) * | 1979-03-21 | 1991-05-21 | National Research Development Corporation | Controlled release compositions (II) |
| JPS5770816A (en) * | 1980-10-17 | 1982-05-01 | Ono Pharmaceut Co Ltd | Multilayered film preparation of prostagladin of prolonged action |
| JPS58134019A (ja) * | 1982-02-05 | 1983-08-10 | Ono Pharmaceut Co Ltd | プロスタグランジン含有持続放出型三層状フイルム製剤及びその製造方法 |
| JPS5948409A (ja) * | 1982-09-10 | 1984-03-19 | Teikoku Seiyaku Kk | 矯正的歯牙移動促進剤 |
| JPS6185315A (ja) * | 1984-10-04 | 1986-04-30 | Teikoku Seiyaku Kk | シ−ト状製剤 |
| IE59361B1 (en) * | 1986-01-24 | 1994-02-09 | Akzo Nv | Pharmaceutical preparation for obtaining a highly viscous hydrogel or suspension |
| US5219885A (en) * | 1987-02-16 | 1993-06-15 | Froelich Juergen | Prostaglandin E1 derivatives as pharmaceutically active agents, and pharmaceutical compositions containing these compounds, especially for transcutaneous administration |
| BR9203277A (pt) * | 1992-08-21 | 1994-03-01 | Cesar Roberto Dias Nahoum | Utilizaccao de drogas eretogenicas e respectivas metodologias de aplicacao |
| US5380760A (en) * | 1993-11-19 | 1995-01-10 | Minnesota Mining And Manufacturing Company | Transdermal prostaglandin composition |
| SE503432C2 (sv) * | 1995-05-05 | 1996-06-10 | Perstorp Ab | Omläggningsset |
| US6593369B2 (en) * | 1997-10-20 | 2003-07-15 | Vivus, Inc. | Methods, compositions, and kits for enhancing female sexual desire and responsiveness |
| US20020004529A1 (en) * | 1997-10-20 | 2002-01-10 | Gary W. Neal | Methods, compositions, and kits for enhancing female sexual desire and responsiveness |
| US6046244A (en) * | 1997-11-05 | 2000-04-04 | Nexmed Holdings, Inc. | Topical compositions for prostaglandin E1 delivery |
| US6414028B1 (en) * | 1997-11-05 | 2002-07-02 | Nexmed Holdings, Inc. | Topical compositions containing prostaglandin E1 |
| US5942545A (en) * | 1998-06-15 | 1999-08-24 | Macrochem Corporation | Composition and method for treating penile erectile dysfunction |
| JP2002518417A (ja) * | 1998-06-25 | 2002-06-25 | ラヴィファム ラボラトリーズ インコーポレーテッド | 勃起機能不全の治療装具及び方法 |
| US6323241B1 (en) * | 2000-01-10 | 2001-11-27 | Nexmed (Holdings) Inc. | Prostaglandin compositions and methods of treatment for male erectile dysfunction |
| KR100402334B1 (ko) * | 2000-06-23 | 2003-10-22 | 환인제약 주식회사 | 알프로스타딜 외용제 |
-
2003
- 2003-01-03 US US10/336,481 patent/US6841574B2/en not_active Expired - Lifetime
- 2003-12-31 BR BR0317924-9A patent/BR0317924A/pt not_active Application Discontinuation
- 2003-12-31 DK DK03800371.1T patent/DK1585483T3/da active
- 2003-12-31 AT AT03800371T patent/ATE468098T1/de active
- 2003-12-31 DE DE60332656T patent/DE60332656D1/de not_active Expired - Lifetime
- 2003-12-31 ES ES03800371T patent/ES2343246T3/es not_active Expired - Lifetime
- 2003-12-31 KR KR1020057012502A patent/KR20050098853A/ko not_active Withdrawn
- 2003-12-31 JP JP2004566647A patent/JP2006514068A/ja active Pending
- 2003-12-31 CN CN200380110112A patent/CN100574763C/zh not_active Expired - Fee Related
- 2003-12-31 PT PT03800371T patent/PT1585483E/pt unknown
- 2003-12-31 KR KR1020117008180A patent/KR101174788B1/ko not_active Expired - Fee Related
- 2003-12-31 CA CA2512015A patent/CA2512015C/en not_active Expired - Lifetime
- 2003-12-31 WO PCT/US2003/041658 patent/WO2004062632A1/en not_active Ceased
- 2003-12-31 AU AU2003300113A patent/AU2003300113B2/en not_active Expired
- 2003-12-31 EP EP03800371A patent/EP1585483B1/en not_active Expired - Lifetime
-
2005
- 2005-06-27 IL IL169425A patent/IL169425A/en unknown
- 2005-06-30 ZA ZA200505321A patent/ZA200505321B/en unknown
-
2011
- 2011-09-14 JP JP2011200752A patent/JP5395138B2/ja not_active Expired - Fee Related
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