JP2006514034A5 - - Google Patents
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- Publication number
- JP2006514034A5 JP2006514034A5 JP2004562241A JP2004562241A JP2006514034A5 JP 2006514034 A5 JP2006514034 A5 JP 2006514034A5 JP 2004562241 A JP2004562241 A JP 2004562241A JP 2004562241 A JP2004562241 A JP 2004562241A JP 2006514034 A5 JP2006514034 A5 JP 2006514034A5
- Authority
- JP
- Japan
- Prior art keywords
- blood cells
- blood
- cultured
- use according
- interleukin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000601 blood cell Anatomy 0.000 claims 13
- 238000000034 method Methods 0.000 claims 4
- 102000004127 Cytokines Human genes 0.000 claims 3
- 108090000695 Cytokines Proteins 0.000 claims 3
- 102000000588 Interleukin-2 Human genes 0.000 claims 3
- 108010002350 Interleukin-2 Proteins 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 239000002555 ionophore Substances 0.000 claims 3
- 230000000236 ionophoric effect Effects 0.000 claims 3
- 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 claims 2
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 239000012503 blood component Substances 0.000 claims 1
- 239000003710 calcium ionophore Substances 0.000 claims 1
- CJAONIOAQZUHPN-KKLWWLSJSA-N ethyl 12-[[2-[(2r,3r)-3-[2-[(12-ethoxy-12-oxododecyl)-methylamino]-2-oxoethoxy]butan-2-yl]oxyacetyl]-methylamino]dodecanoate Chemical compound CCOC(=O)CCCCCCCCCCCN(C)C(=O)CO[C@H](C)[C@@H](C)OCC(=O)N(C)CCCCCCCCCCCC(=O)OCC CJAONIOAQZUHPN-KKLWWLSJSA-N 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/159,148 | 2002-05-29 | ||
| US10/159,148 US7048922B2 (en) | 2002-05-29 | 2002-05-29 | Stimulation of hematopoiesis by ex vivo activated immune cells |
| PCT/US2003/014336 WO2004056397A1 (en) | 2002-05-29 | 2003-05-07 | Stimulation of hematopoiesis by ex vivo actived immune cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006514034A JP2006514034A (ja) | 2006-04-27 |
| JP2006514034A5 true JP2006514034A5 (enExample) | 2006-06-22 |
| JP4863620B2 JP4863620B2 (ja) | 2012-01-25 |
Family
ID=29582827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004562241A Expired - Fee Related JP4863620B2 (ja) | 2002-05-29 | 2003-05-07 | 抹消血単核細胞の培養方法及び該細胞を用いた薬剤組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7048922B2 (enExample) |
| EP (2) | EP1511515B1 (enExample) |
| JP (1) | JP4863620B2 (enExample) |
| DE (1) | DE60325967D1 (enExample) |
| ES (1) | ES2321189T3 (enExample) |
| WO (1) | WO2004056397A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7048922B2 (en) * | 2002-05-29 | 2006-05-23 | Demao Yang | Stimulation of hematopoiesis by ex vivo activated immune cells |
| US7332158B2 (en) | 2002-05-29 | 2008-02-19 | Demao Yang | Compositions and treatments for myelosuppression by ex vivo activated immune cells |
| ATE496118T1 (de) * | 2003-07-06 | 2011-02-15 | Roger Williams Medical Ct | Verfahren zur herstellung differenzierter hämatopoetischer zellen zur behandlung von zytopenie |
| JP2008512454A (ja) * | 2004-09-10 | 2008-04-24 | ヤング，デマオ | 骨髄抑制患者に対する体外活性化細胞療法の構成と応用 |
| US20060057121A1 (en) * | 2004-09-10 | 2006-03-16 | Demao Yang | Compositions and treatments using ex vivo activated cells for myelosuppressed patients |
| US20080195007A1 (en) * | 2007-02-12 | 2008-08-14 | Yury Podrazhansky | Method and device for using vibroacoustic stimulaton to enhance the production of adult stem cells in living organisms |
| GB0918615D0 (en) * | 2009-10-23 | 2009-12-09 | Cellerix Sa | Cell populations having immunoregulatory activity, methods for the preparation and uses thereof |
| US20130071437A1 (en) * | 2010-08-06 | 2013-03-21 | Canine-Lab.Inc. | Immunological function enhancing agent |
| WO2012048298A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| WO2015073918A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
| US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
| WO2016049421A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled feed |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| US11965175B2 (en) | 2016-05-25 | 2024-04-23 | Terumo Bct, Inc. | Cell expansion |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| US11629332B2 (en) | 2017-03-31 | 2023-04-18 | Terumo Bct, Inc. | Cell expansion |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| US12458249B2 (en) * | 2018-03-29 | 2025-11-04 | Demao Yang | Cell therapy for patients |
| GB2619893A (en) | 2021-03-23 | 2023-12-20 | Terumo Bct Inc | Cell capture and expansion |
| US12209689B2 (en) | 2022-02-28 | 2025-01-28 | Terumo Kabushiki Kaisha | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5766920A (en) | 1982-08-11 | 1998-06-16 | Cellcor, Inc. | Ex vivo activation of immune cells |
| US5047421A (en) | 1984-01-26 | 1991-09-10 | Oral-D | Orally effective ion chelators |
| US5550161A (en) | 1984-01-26 | 1996-08-27 | Oral-D | Substituted orally effective ION chelators related to deferoxamine |
| US5015664A (en) | 1984-01-26 | 1991-05-14 | Oral D | Orally effective ion chelators related to deferoxamine |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US5108760A (en) | 1989-07-21 | 1992-04-28 | Terumo Corporation | Enhances lak cell activation by treatment of human peripheral blood mononuclear cells with amino acid amides |
| US5525232A (en) | 1990-03-02 | 1996-06-11 | The Liposome Company, Inc. | Method for entrapment of cationic species in lemellar vesicles |
| DK0633929T3 (da) | 1992-04-01 | 2004-06-28 | Univ Rockefeller | Fremgangsmåde til in vitro proliferation af dendritcelleforstadier og deres anvendelse til at producere immunogener |
| US5738849A (en) | 1992-11-24 | 1998-04-14 | G. D. Searle & Co. | Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them |
| US5312831A (en) | 1993-05-12 | 1994-05-17 | American Cyanamid Company | Urethanes and ureas that induce cytokine production |
| EP0641776A3 (en) | 1993-09-08 | 1997-05-02 | Takeda Chemical Industries Ltd | Thioglycerol derivatives. |
| AU1524095A (en) | 1994-01-27 | 1995-08-15 | Cellcor, Inc. | Ex vivo activation of immune cells |
| US5631219A (en) | 1994-03-08 | 1997-05-20 | Somatogen, Inc. | Method of stimulating hematopoiesis with hemoglobin |
| US5948820A (en) | 1994-08-22 | 1999-09-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzene compound and pharmaceutical use thereof |
| US6033661A (en) | 1995-06-07 | 2000-03-07 | Thomas Jefferson University | Composition and method for allogenetic mononuclear cell immunotherapy |
| US6010905A (en) * | 1995-01-27 | 2000-01-04 | The United States Of America As Represented By The Department Of Health & Human Services | Method for inducing monocytes to exhibit the phenotype of activated myeloid dendritic cells |
| US5643786A (en) | 1995-01-27 | 1997-07-01 | The United States Of America As Represented By The Department Of Health And Human Services | Method for isolating dendritic cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US6008042A (en) | 1996-05-16 | 1999-12-28 | Smithkline Beecham Corporation | Interleukin-1 beta converting enzyme like apoptotic protease-7 |
| US6010878A (en) | 1996-05-20 | 2000-01-04 | Smithkline Beecham Corporation | Interleukin-1 β converting enzyme like apoptotic protease-6 |
| US5968513A (en) | 1996-06-24 | 1999-10-19 | University Of Maryland Biotechnology Institute | Method of promoting hematopoiesis using derivatives of human chorionic gonadotropin |
| WO1998006823A2 (en) | 1996-08-14 | 1998-02-19 | Nexell Therapeutics Inc. | Cytokine-free culture of dendritic cells |
| WO1998026747A2 (en) | 1996-12-17 | 1998-06-25 | Terman David S | Superantigen based methods and compositions for treatment of diseases |
| US6231880B1 (en) | 1997-05-30 | 2001-05-15 | Susan P. Perrine | Compositions and administration of compositions for the treatment of blood disorders |
| US5932446A (en) | 1997-08-18 | 1999-08-03 | Smithkline Beecham Corporation | Hmvab41 |
| CA2346769C (en) | 1997-10-10 | 2004-09-14 | The Regents Of The University Of California | Implants comprising combinations of allogeneic cells for use in cancer treatment |
| EP1064354A4 (en) * | 1998-03-20 | 2002-06-12 | Genzyme Corp | COMPOSITIONS AND METHODS FOR CAUSING T CELL RESPONSE WITH GENE-BASED VACCINES |
| US6555374B1 (en) | 1999-08-19 | 2003-04-29 | Artecel Sciences, Inc. | Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof |
| WO2001034788A1 (en) | 1999-11-10 | 2001-05-17 | Yoreh Biotechnologies Ltd. | In-vitro assay for assessment of cytotoxicity of a candidate agent |
| WO2001062092A1 (en) | 2000-02-25 | 2001-08-30 | Thomas Jefferson University | Formulations and methods for using the same to elicit an immune response |
| AU2002218019A1 (en) | 2000-11-03 | 2002-05-15 | Nexell Therapeutics Inc. | Methods for depleting and isolating alloreactive and antigen-reactive t cells from hematopoietic donor cells |
| US7745140B2 (en) | 2002-01-03 | 2010-06-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool |
| US7332158B2 (en) | 2002-05-29 | 2008-02-19 | Demao Yang | Compositions and treatments for myelosuppression by ex vivo activated immune cells |
| US7048922B2 (en) | 2002-05-29 | 2006-05-23 | Demao Yang | Stimulation of hematopoiesis by ex vivo activated immune cells |
-
2002
- 2002-05-29 US US10/159,148 patent/US7048922B2/en not_active Expired - Fee Related
-
2003
- 2003-05-07 EP EP03811648A patent/EP1511515B1/en not_active Expired - Lifetime
- 2003-05-07 WO PCT/US2003/014336 patent/WO2004056397A1/en not_active Ceased
- 2003-05-07 DE DE60325967T patent/DE60325967D1/de not_active Expired - Lifetime
- 2003-05-07 JP JP2004562241A patent/JP4863620B2/ja not_active Expired - Fee Related
- 2003-05-07 ES ES03811648T patent/ES2321189T3/es not_active Expired - Lifetime
- 2003-05-07 EP EP08167283A patent/EP2011863A1/en not_active Withdrawn
-
2004
- 2004-11-09 US US10/984,183 patent/US20050130303A1/en not_active Abandoned
-
2008
- 2008-07-30 US US12/220,989 patent/US7758857B2/en not_active Expired - Fee Related
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