JP2011503137A5 - - Google Patents

Info

Publication number

JP2011503137A5

JP2011503137A5 JP2010533548A JP2010533548A JP2011503137A5 JP 2011503137 A5 JP2011503137 A5 JP 2011503137A5 JP 2010533548 A JP2010533548 A JP 2010533548A JP 2010533548 A JP2010533548 A JP 2010533548A JP 2011503137 A5 JP2011503137 A5 JP 2011503137A5

Authority

JP

Japan

Prior art keywords

vitro

interleukin

incubating

analogues

microorganism

Prior art date

2008-11-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims 5
• 238000000338 in vitro Methods 0.000 claims 4
• 244000005700 microbiome Species 0.000 claims 4
• 102000007644 Colony-Stimulating Factors Human genes 0.000 claims 2
• 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 2
• 102000000589 Interleukin-1 Human genes 0.000 claims 2
• 108010002352 Interleukin-1 Proteins 0.000 claims 2
• 102000004889 Interleukin-6 Human genes 0.000 claims 2
• 108090001005 Interleukin-6 Proteins 0.000 claims 2
• 102000004890 Interleukin-8 Human genes 0.000 claims 2
• 108090001007 Interleukin-8 Proteins 0.000 claims 2
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
• 229940047120 colony stimulating factors Drugs 0.000 claims 2
• 239000012634 fragment Substances 0.000 claims 2
• 229940100601 interleukin-6 Drugs 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 239000000126 substance Substances 0.000 claims 2
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
• 241000894006 Bacteria Species 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 241000233866 Fungi Species 0.000 claims 1
• 241000700605 Viruses Species 0.000 claims 1
• 230000003110 anti-inflammatory effect Effects 0.000 claims 1
• 230000000845 anti-microbial effect Effects 0.000 claims 1
• 230000016396 cytokine production Effects 0.000 claims 1
• 229940096397 interleukin-8 Drugs 0.000 claims 1
• XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1