JP2006513209A5 - - Google Patents
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- Publication number
- JP2006513209A5 JP2006513209A5 JP2004563632A JP2004563632A JP2006513209A5 JP 2006513209 A5 JP2006513209 A5 JP 2006513209A5 JP 2004563632 A JP2004563632 A JP 2004563632A JP 2004563632 A JP2004563632 A JP 2004563632A JP 2006513209 A5 JP2006513209 A5 JP 2006513209A5
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- JP
- Japan
- Prior art keywords
- oxo
- pharmaceutical composition
- compound
- compound according
- croh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000005282 allenyl group Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 206010062016 Immunosuppression Diseases 0.000 claims 2
- 230000001506 immunosuppresive effect Effects 0.000 claims 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 0 CC(C(*)*)[C@](*1)([C@@]1[C@]1*2)C(*)(*)[C@](C3)([C@]3C3)[C@]12[C@@](C)(CC1(*)*)[C@@]3C(CO2)=C1C2=O Chemical compound CC(C(*)*)[C@](*1)([C@@]1[C@]1*2)C(*)(*)[C@](C3)([C@]3C3)[C@]12[C@@](C)(CC1(*)*)[C@@]3C(CO2)=C1C2=O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43420302P | 2002-12-17 | 2002-12-17 | |
| PCT/US2003/040104 WO2004058246A1 (en) | 2002-12-17 | 2003-12-16 | Triptolide derivatives as immunomodulator and anticancer agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006513209A JP2006513209A (ja) | 2006-04-20 |
| JP2006513209A5 true JP2006513209A5 (enExample) | 2007-01-18 |
Family
ID=32682009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004563632A Pending JP2006513209A (ja) | 2002-12-17 | 2003-12-16 | 免疫調節因子および抗癌剤としてのトリプトライド誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7019151B2 (enExample) |
| EP (1) | EP1581208A1 (enExample) |
| JP (1) | JP2006513209A (enExample) |
| CN (1) | CN1726025A (enExample) |
| AU (1) | AU2003297211A1 (enExample) |
| CA (1) | CA2508217A1 (enExample) |
| WO (1) | WO2004058246A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4680589B2 (ja) * | 2002-05-31 | 2011-05-11 | ファーマジェネシス， インコーポレイテッド | アポトーシスおよび免疫抑制の調節のためのトリプトリド誘導体 |
| US7820834B2 (en) * | 2003-12-24 | 2010-10-26 | Pharmagenesis, Inc. | Triptolide 5,6-derivatives as immunomodulators and anticancer agents |
| CN1917893A (zh) * | 2004-02-09 | 2007-02-21 | 美国泛华医药公司 | 从雷公藤多苷中分离雷公藤内酯醇化合物的方法 |
| DK1732536T3 (da) * | 2004-03-02 | 2012-06-25 | Pharmagenesis Inc | Tripolidlactonringderivater som immunomodulatorer og anticancermidler |
| WO2005115455A2 (en) * | 2004-05-17 | 2005-12-08 | Combinatorx, Incorporated | Methods and reagents for the treatment of immunoinflammatory disorders |
| WO2006012204A2 (en) * | 2004-06-25 | 2006-02-02 | Pharmagenesis, Inc. | Method for treatment of inflammatory disorders using triptolide compounds |
| US8617906B2 (en) | 2004-10-13 | 2013-12-31 | Pharmagenesis, Inc. | Identification and screening of triptolide target molecules |
| CN101352434B (zh) * | 2007-07-25 | 2010-10-06 | 中山大学 | 雷公藤内酯醇在制备治疗与c-KIT酪氨酸激酶相关肿瘤的药物的用途 |
| CN104387406A (zh) * | 2009-02-05 | 2015-03-04 | 药物起源公司 | 作为抗癌药和免疫调制剂的雷公藤内酯 c-环衍生物 |
| US9150600B2 (en) | 2009-05-07 | 2015-10-06 | Regents Of The University Of Minnesota | Triptolide prodrugs |
| EP2427467B1 (en) | 2009-05-07 | 2015-08-05 | Regents of the University of Minnesota | Triptolide prodrugs |
| CN102258525A (zh) * | 2010-05-28 | 2011-11-30 | 上海汇伦生命科技有限公司 | Hq-091212的药物应用 |
| CN103709227B (zh) * | 2012-10-09 | 2017-07-04 | 上海汇伦生命科技有限公司 | 双键取代雷公藤内酯衍生物及其制备方法和应用 |
| CN105263475A (zh) * | 2013-03-15 | 2016-01-20 | 制药创源有限公司 | 雷公藤甲素静脉注射乳剂用作免疫调制剂和抗癌药 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1027371C (zh) * | 1989-09-08 | 1995-01-11 | 中国医学科学院皮肤病研究所 | 二萜内酯化合物的合成方法 |
| US5430054A (en) * | 1989-12-22 | 1995-07-04 | Jiangsu Family Planning Institute | Preparation methods of diterpene lactone compounds and application of the same to antifertility |
| US5663335A (en) * | 1996-03-01 | 1997-09-02 | Pharmagenesis, Inc. | Immunosuppressive compounds and methods |
| CN1257507A (zh) * | 1997-05-23 | 2000-06-21 | 赫斯特·马里昂·罗素公司 | 适合用于自身免疫性疾病治疗的新的雷公藤内酯衍生物 |
| US6004999A (en) * | 1997-05-23 | 1999-12-21 | Hoechst Marion Roussel, Inc. | Triptolide derivatives useful in the treatment of autoimmune diseases |
| DE69932649T2 (de) * | 1998-09-02 | 2007-08-09 | Pharmagenesis, Inc., Palo Alto | Triptolid-Prodrugs mit hoher Wasserlöslichkeit |
| JP2001081030A (ja) * | 1999-07-13 | 2001-03-27 | Mitsuhiro Hatta | 免疫抑制剤の副作用防御剤 |
| US6620843B2 (en) * | 2001-01-19 | 2003-09-16 | Pharmagenesis | Anticancer treatment using triptolide prodrugs |
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2003
- 2003-12-16 WO PCT/US2003/040104 patent/WO2004058246A1/en not_active Ceased
- 2003-12-16 AU AU2003297211A patent/AU2003297211A1/en not_active Abandoned
- 2003-12-16 EP EP03814060A patent/EP1581208A1/en not_active Withdrawn
- 2003-12-16 CN CNA2003801061290A patent/CN1726025A/zh active Pending
- 2003-12-16 CA CA002508217A patent/CA2508217A1/en not_active Abandoned
- 2003-12-16 US US10/738,753 patent/US7019151B2/en not_active Expired - Fee Related
- 2003-12-16 JP JP2004563632A patent/JP2006513209A/ja active Pending
-
2006
- 2006-01-27 US US11/340,928 patent/US7098348B2/en not_active Expired - Fee Related