JP2006510632A5 - - Google Patents
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- Publication number
- JP2006510632A5 JP2006510632A5 JP2004557604A JP2004557604A JP2006510632A5 JP 2006510632 A5 JP2006510632 A5 JP 2006510632A5 JP 2004557604 A JP2004557604 A JP 2004557604A JP 2004557604 A JP2004557604 A JP 2004557604A JP 2006510632 A5 JP2006510632 A5 JP 2006510632A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- agent according
- motomeko
- hydrocarbyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/309,526 US6638928B1 (en) | 2002-12-03 | 2002-12-03 | Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines |
| PCT/US2003/038637 WO2004050616A2 (en) | 2002-12-03 | 2003-12-03 | Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006510632A JP2006510632A (ja) | 2006-03-30 |
| JP2006510632A5 true JP2006510632A5 (enExample) | 2007-01-25 |
Family
ID=29250402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004557604A Pending JP2006510632A (ja) | 2002-12-03 | 2003-12-03 | 置換２，３−ベンゾジアゼピン類による過敏性腸症候群及び非潰瘍性消化不良の治療 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6638928B1 (enExample) |
| EP (1) | EP1567162A4 (enExample) |
| JP (1) | JP2006510632A (enExample) |
| AU (1) | AU2003297663A1 (enExample) |
| CA (1) | CA2508546A1 (enExample) |
| WO (1) | WO2004050616A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006514084A (ja) * | 2002-12-03 | 2006-04-27 | ヴェラ ファーマスーティカルズ インコーポレイテッド | １−（３−ヒドロキシ−４−メトキシフェニル）−４−メチル−５−エチル−７，８−ジメトキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途 |
| CA2508542A1 (en) * | 2002-12-03 | 2004-06-17 | Vela Pharmaceuticals, Inc. | Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof |
| US6864251B2 (en) * | 2002-12-03 | 2005-03-08 | Vela Pharmaceuticals, Inc. | Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines |
| US20060128955A1 (en) * | 2003-05-09 | 2006-06-15 | Vela Pharmaceuticals, Inc. | Method of isolating (R)-tofisopam |
| US7265106B2 (en) * | 2003-05-09 | 2007-09-04 | Vela Aquisition Corporation | Method for isolating (R)-tofisopam |
| US20070021412A1 (en) * | 2003-05-16 | 2007-01-25 | Vela Pharmaceuticals, Inc. | Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine |
| US20040229867A1 (en) * | 2003-05-16 | 2004-11-18 | Kucharik Robert F. | Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (R) 2,3-benzodiazepine |
| EP1718148A2 (en) * | 2004-02-03 | 2006-11-08 | The Regents of the University of California | Methods of treating irritable bowel syndrome |
| FR2870539B1 (fr) * | 2004-05-19 | 2006-08-04 | Greenpharma Sa Sa | Nouvelles methodes et medicaments |
| US7541355B2 (en) * | 2005-05-23 | 2009-06-02 | Vela Acquisition Corporation | Conversion process for 2,3-benzodiazepine enantiomers |
| US7748376B2 (en) | 2007-10-31 | 2010-07-06 | Bender William H | Solar collector stabilized by cables and a compression element |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK118660B (da) | 1966-12-09 | 1970-09-21 | Egyt Gyogyszervegyeszeti Gyar | Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid. |
| HU179018B (en) * | 1978-10-19 | 1982-08-28 | Gyogyszerkutato Intezet | Process for producing new 5h-2,3-benzodiazepine derivatives |
| HU186760B (en) | 1981-03-12 | 1985-09-30 | Gyogyszerkutato Intezet | Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives |
| HU191698B (en) | 1984-07-27 | 1987-03-30 | Gyogyszerkutato Intezet | Process for producing new 1-aryl-5h-2beta-benzodiazepines |
| HU195788B (en) | 1986-05-21 | 1988-07-28 | Gyogyszerkutato Intezet | Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them |
| HU198494B (en) | 1986-08-15 | 1989-10-30 | Gyogyszerkutato Intezet | Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same |
| US5140023A (en) * | 1990-04-27 | 1992-08-18 | G. D. Searle & Co. | Azatetracycle compounds |
| HU207055B (en) | 1990-10-17 | 1993-03-01 | Gyogyszerkutato Intezet | Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same |
| HU206719B (en) | 1990-12-21 | 1992-12-28 | Gyogyszerkutato Intezet | Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them |
| HU219778B (hu) | 1990-12-21 | 2001-07-30 | Gyógyszerkutató Intézet Közös Vállalat | Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények |
| US5519019A (en) | 1990-12-21 | 1996-05-21 | Gyogyszerkutato Intezet | N-acyl-2,3-benzoidazepine derivatives, pharmaceutical compositions containing them and process for preparing same |
| US5521174A (en) | 1990-12-21 | 1996-05-28 | Gyogyszerkutato Intezet Kv. | N-acyl-2,3-benzodiazepine derivatives and a method of treating spasms of the skeletal musculature therewith |
| US5639751A (en) | 1990-12-21 | 1997-06-17 | Cyogyszerkutato Intezet Kft | N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders |
| HU208429B (en) | 1991-05-03 | 1993-10-28 | Gyogyszerkutato Intezet | Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity |
| HU224435B1 (hu) | 1995-02-09 | 2005-10-28 | EGIS Gyógyszergyár Rt. | Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények |
| US5891871A (en) | 1996-03-21 | 1999-04-06 | Cocensys, Inc. | Substituted 2,3-benzodiazepin-4-ones and the use thereof |
| HK1046500A1 (zh) * | 1998-10-27 | 2003-01-17 | Vela Pharmaceuticals Inc. | 旋光纯(r)tofisopam用於治疗和预防焦虑症的用途及其组合物 |
| US6080736A (en) | 1999-10-27 | 2000-06-27 | Janus Pharmaceuticals, Inc. | Methods and compositions for treating and preventing anxiety and anxiety disorders using optically pure (R) tofisopam |
| FR2824065A1 (fr) * | 2001-04-26 | 2002-10-31 | Neuro3D | Composes inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations |
| US6649607B2 (en) * | 2001-05-18 | 2003-11-18 | Vela Pharmaceuticals, Inc. | Compositions and methods for treating or preventing convulsions or seizures |
| JP2006514084A (ja) * | 2002-12-03 | 2006-04-27 | ヴェラ ファーマスーティカルズ インコーポレイテッド | １−（３−ヒドロキシ−４−メトキシフェニル）−４−メチル−５−エチル−７，８−ジメトキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途 |
| CA2508542A1 (en) * | 2002-12-03 | 2004-06-17 | Vela Pharmaceuticals, Inc. | Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof |
| US6864251B2 (en) * | 2002-12-03 | 2005-03-08 | Vela Pharmaceuticals, Inc. | Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines |
| JP2007513171A (ja) * | 2003-12-03 | 2007-05-24 | ヴェラ ファーマスーティカルズ インコーポレイテッド | ２，３−ベンゾジアゼピン低投与量による上皮の炎症性疾患の治療 |
-
2002
- 2002-12-03 US US10/309,526 patent/US6638928B1/en not_active Expired - Fee Related
-
2003
- 2003-12-03 JP JP2004557604A patent/JP2006510632A/ja active Pending
- 2003-12-03 CA CA002508546A patent/CA2508546A1/en not_active Abandoned
- 2003-12-03 AU AU2003297663A patent/AU2003297663A1/en not_active Abandoned
- 2003-12-03 EP EP03812516A patent/EP1567162A4/en not_active Withdrawn
- 2003-12-03 WO PCT/US2003/038637 patent/WO2004050616A2/en not_active Ceased
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