JP2006510632A - 置換２，３−ベンゾジアゼピン類による過敏性腸症候群及び非潰瘍性消化不良の治療 - Google Patents

置換２，３−ベンゾジアゼピン類による過敏性腸症候群及び非潰瘍性消化不良の治療 Download PDF

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JP2006510632A
JP2006510632A JP2004557604A JP2004557604A JP2006510632A JP 2006510632 A JP2006510632 A JP 2006510632A JP 2004557604 A JP2004557604 A JP 2004557604A JP 2004557604 A JP2004557604 A JP 2004557604A JP 2006510632 A JP2006510632 A JP 2006510632A
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compound
pharmaceutically acceptable
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ダブリュー．ハリス ハーバート
エフ．クチャリック ロバート
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ヴェラ ファーマスーティカルズ インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2004557604A 2002-12-03 2003-12-03 置換２，３−ベンゾジアゼピン類による過敏性腸症候群及び非潰瘍性消化不良の治療 Pending JP2006510632A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/309,526 US6638928B1 (en) 2002-12-03 2002-12-03 Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
PCT/US2003/038637 WO2004050616A2 (en) 2002-12-03 2003-12-03 Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines

Publications (2)

Publication Number Publication Date
JP2006510632A true JP2006510632A (ja) 2006-03-30
JP2006510632A5 JP2006510632A5 (https=) 2007-01-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004557604A Pending JP2006510632A (ja) 2002-12-03 2003-12-03 置換２，３−ベンゾジアゼピン類による過敏性腸症候群及び非潰瘍性消化不良の治療

Country Status (6)

Country Link
US (1) US6638928B1 (https=)
EP (1) EP1567162A4 (https=)
JP (1) JP2006510632A (https=)
AU (1) AU2003297663A1 (https=)
CA (1) CA2508546A1 (https=)
WO (1) WO2004050616A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006510635A (ja) * 2002-12-03 2006-03-30 ヴェラ ファーマスーティカルズ インコーポレイテッド ２，３−ベンゾジアゼピンによる炎症性疾患の治療
JP2006510634A (ja) * 2002-12-03 2006-03-30 ヴェラ ファーマスーティカルズ インコーポレイテッド １−（３，４−ジメトキシフェニル）−４−メチル−５−エチル−７−メトキシ−８−ヒドロキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途
JP2006528246A (ja) * 2003-05-16 2006-12-14 ヴェラ ファーマスーティカルズ インコーポレイテッド 鏡像的に純粋な（ｒ）２，３−ベンゾジアゼピンを使用する胃腸の機能不全及び関連するストレスの治療

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2510275A1 (en) * 2002-12-03 2004-08-19 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5h-2,3-benzodiazepine and uses therof
US7265106B2 (en) * 2003-05-09 2007-09-04 Vela Aquisition Corporation Method for isolating (R)-tofisopam
US20060128955A1 (en) * 2003-05-09 2006-06-15 Vela Pharmaceuticals, Inc. Method of isolating (R)-tofisopam
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
EP1718148A2 (en) * 2004-02-03 2006-11-08 The Regents of the University of California Methods of treating irritable bowel syndrome
FR2870539B1 (fr) * 2004-05-19 2006-08-04 Greenpharma Sa Sa Nouvelles methodes et medicaments
US7541355B2 (en) * 2005-05-23 2009-06-02 Vela Acquisition Corporation Conversion process for 2,3-benzodiazepine enantiomers
US7748376B2 (en) 2007-10-31 2010-07-06 Bender William H Solar collector stabilized by cables and a compression element

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5592377A (en) * 1978-10-19 1980-07-12 Egyt Gyogyszervegyeszeti Gyar Novel benzodiazepin derivative
JPH04225979A (ja) * 1990-04-27 1992-08-14 G D Searle & Co アザテトラサイクリック化合物
WO2000024400A1 (en) * 1998-10-27 2000-05-04 Vela Pharmaceuticals Inc. Use of optically pure (r)-tofisopam for treating and preventing anxiety disorders and composition thereof
WO2002088096A1 (fr) * 2001-04-26 2002-11-07 Neuro3D Composes inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations
JP2006510635A (ja) * 2002-12-03 2006-03-30 ヴェラ ファーマスーティカルズ インコーポレイテッド ２，３−ベンゾジアゼピンによる炎症性疾患の治療
JP2006510634A (ja) * 2002-12-03 2006-03-30 ヴェラ ファーマスーティカルズ インコーポレイテッド １−（３，４−ジメトキシフェニル）−４−メチル−５−エチル−７−メトキシ−８−ヒドロキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途
JP2006514084A (ja) * 2002-12-03 2006-04-27 ヴェラ ファーマスーティカルズ インコーポレイテッド １−（３−ヒドロキシ−４−メトキシフェニル）−４−メチル−５−エチル−７，８−ジメトキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK118660B (da) 1966-12-09 1970-09-21 Egyt Gyogyszervegyeszeti Gyar Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid.
HU186760B (en) 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
HU191698B (en) 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU195788B (en) 1986-05-21 1988-07-28 Gyogyszerkutato Intezet Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them
HU198494B (en) 1986-08-15 1989-10-30 Gyogyszerkutato Intezet Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
HU207055B (en) 1990-10-17 1993-03-01 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same
US5521174A (en) 1990-12-21 1996-05-28 Gyogyszerkutato Intezet Kv. N-acyl-2,3-benzodiazepine derivatives and a method of treating spasms of the skeletal musculature therewith
HU206719B (en) 1990-12-21 1992-12-28 Gyogyszerkutato Intezet Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
US5639751A (en) 1990-12-21 1997-06-17 Cyogyszerkutato Intezet Kft N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders
US5519019A (en) 1990-12-21 1996-05-21 Gyogyszerkutato Intezet N-acyl-2,3-benzoidazepine derivatives, pharmaceutical compositions containing them and process for preparing same
HU219778B (hu) 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
HU208429B (en) 1991-05-03 1993-10-28 Gyogyszerkutato Intezet Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity
HU224435B1 (hu) 1995-02-09 2005-10-28 EGIS Gyógyszergyár Rt. Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények
US5891871A (en) 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
US6080736A (en) 1999-10-27 2000-06-27 Janus Pharmaceuticals, Inc. Methods and compositions for treating and preventing anxiety and anxiety disorders using optically pure (R) tofisopam
US6649607B2 (en) * 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
EP1689408A4 (en) * 2003-12-03 2010-03-03 Vela Acquisition Corp TREATMENT OF INFLAMMATORY DISORDERS OF EPITHELIUM USING LOW DOSE 2,3-BENZODIAZEPINES

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5592377A (en) * 1978-10-19 1980-07-12 Egyt Gyogyszervegyeszeti Gyar Novel benzodiazepin derivative
JPH04225979A (ja) * 1990-04-27 1992-08-14 G D Searle & Co アザテトラサイクリック化合物
WO2000024400A1 (en) * 1998-10-27 2000-05-04 Vela Pharmaceuticals Inc. Use of optically pure (r)-tofisopam for treating and preventing anxiety disorders and composition thereof
WO2002088096A1 (fr) * 2001-04-26 2002-11-07 Neuro3D Composes inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations
JP2006510635A (ja) * 2002-12-03 2006-03-30 ヴェラ ファーマスーティカルズ インコーポレイテッド ２，３−ベンゾジアゼピンによる炎症性疾患の治療
JP2006510634A (ja) * 2002-12-03 2006-03-30 ヴェラ ファーマスーティカルズ インコーポレイテッド １−（３，４−ジメトキシフェニル）−４−メチル−５−エチル−７−メトキシ−８−ヒドロキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途
JP2006514084A (ja) * 2002-12-03 2006-04-27 ヴェラ ファーマスーティカルズ インコーポレイテッド １−（３−ヒドロキシ−４−メトキシフェニル）−４−メチル−５−エチル−７，８−ジメトキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006510635A (ja) * 2002-12-03 2006-03-30 ヴェラ ファーマスーティカルズ インコーポレイテッド ２，３−ベンゾジアゼピンによる炎症性疾患の治療
JP2006510634A (ja) * 2002-12-03 2006-03-30 ヴェラ ファーマスーティカルズ インコーポレイテッド １−（３，４−ジメトキシフェニル）−４−メチル−５−エチル−７−メトキシ−８−ヒドロキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途
JP2006528246A (ja) * 2003-05-16 2006-12-14 ヴェラ ファーマスーティカルズ インコーポレイテッド 鏡像的に純粋な（ｒ）２，３−ベンゾジアゼピンを使用する胃腸の機能不全及び関連するストレスの治療

Also Published As

Publication number Publication date
WO2004050616A2 (en) 2004-06-17
WO2004050616A3 (en) 2004-09-10
EP1567162A2 (en) 2005-08-31
AU2003297663A8 (en) 2004-06-23
EP1567162A4 (en) 2008-04-30
US6638928B1 (en) 2003-10-28
AU2003297663A1 (en) 2004-06-23
CA2508546A1 (en) 2004-06-17

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