JP2006510618A5 - - Google Patents
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- Publication number
- JP2006510618A5 JP2006510618A5 JP2004553852A JP2004553852A JP2006510618A5 JP 2006510618 A5 JP2006510618 A5 JP 2006510618A5 JP 2004553852 A JP2004553852 A JP 2004553852A JP 2004553852 A JP2004553852 A JP 2004553852A JP 2006510618 A5 JP2006510618 A5 JP 2006510618A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- phenyl
- pain
- oxo
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims 52
- 208000002193 Pain Diseases 0.000 claims 33
- 230000036407 pain Effects 0.000 claims 29
- 239000000651 prodrug Substances 0.000 claims 28
- 229940002612 prodrug Drugs 0.000 claims 28
- 150000003839 salts Chemical class 0.000 claims 15
- 239000012453 solvate Substances 0.000 claims 15
- 206010002091 Anaesthesia Diseases 0.000 claims 12
- 230000037005 anaesthesia Effects 0.000 claims 12
- 230000037396 body weight Effects 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- BEQZHFIKTBVCAU-LBPRGKRZSA-N (2s)-2-amino-2-(2-chlorophenyl)cyclohexan-1-one Chemical compound C=1C=CC=C(Cl)C=1[C@@]1(N)CCCCC1=O BEQZHFIKTBVCAU-LBPRGKRZSA-N 0.000 claims 8
- BEQZHFIKTBVCAU-UHFFFAOYSA-N 2-amino-2-(2-chlorophenyl)-1-cyclohexanone Chemical compound C=1C=CC=C(Cl)C=1C1(N)CCCCC1=O BEQZHFIKTBVCAU-UHFFFAOYSA-N 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 230000003444 anaesthetic effect Effects 0.000 claims 8
- 230000000202 analgesic effect Effects 0.000 claims 8
- 229960003299 ketamine Drugs 0.000 claims 8
- 238000009472 formulation Methods 0.000 claims 7
- LNJROULPSUMIKM-UHFFFAOYSA-N benzyl n-[1-(2-chlorophenyl)-2-oxocyclohexyl]carbamate Chemical compound ClC1=CC=CC=C1C1(NC(=O)OCC=2C=CC=CC=2)C(=O)CCCC1 LNJROULPSUMIKM-UHFFFAOYSA-N 0.000 claims 5
- HCZIRBMTVSUBQG-UHFFFAOYSA-N butyl n-[1-(2-chlorophenyl)-2-oxocyclohexyl]carbamate Chemical compound C=1C=CC=C(Cl)C=1C1(NC(=O)OCCCC)CCCCC1=O HCZIRBMTVSUBQG-UHFFFAOYSA-N 0.000 claims 5
- JSMLYOVUWZPMRT-UHFFFAOYSA-N ethyl 2-[[1-(2-chlorophenyl)-2-oxocyclohexyl]amino]acetate Chemical compound C=1C=CC=C(Cl)C=1C1(NCC(=O)OCC)CCCCC1=O JSMLYOVUWZPMRT-UHFFFAOYSA-N 0.000 claims 5
- NFEDRUZLYVEQFI-UHFFFAOYSA-N ethyl n-[1-(2-chlorophenyl)-2-oxocyclohexyl]carbamate Chemical compound C=1C=CC=C(Cl)C=1C1(NC(=O)OCC)CCCCC1=O NFEDRUZLYVEQFI-UHFFFAOYSA-N 0.000 claims 5
- VRURQRAMHBAFOK-UHFFFAOYSA-N phenyl n-[1-(2-chlorophenyl)-2-oxocyclohexyl]carbamate Chemical compound ClC1=CC=CC=C1C1(NC(=O)OC=2C=CC=CC=2)C(=O)CCCC1 VRURQRAMHBAFOK-UHFFFAOYSA-N 0.000 claims 5
- BJHGQFPMVBHYLW-UHFFFAOYSA-N propan-2-yl n-[1-(2-chlorophenyl)-2-oxocyclohexyl]carbamate Chemical compound C=1C=CC=C(Cl)C=1C1(NC(=O)OC(C)C)CCCCC1=O BJHGQFPMVBHYLW-UHFFFAOYSA-N 0.000 claims 5
- YQEZLKZALYSWHR-ZDUSSCGKSA-N (S)-ketamine Chemical compound C=1C=CC=C(Cl)C=1[C@@]1(NC)CCCCC1=O YQEZLKZALYSWHR-ZDUSSCGKSA-N 0.000 claims 4
- 208000000003 Breakthrough pain Diseases 0.000 claims 4
- 208000000094 Chronic Pain Diseases 0.000 claims 4
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 claims 4
- 230000035606 childbirth Effects 0.000 claims 4
- 208000004296 neuralgia Diseases 0.000 claims 4
- 208000021722 neuropathic pain Diseases 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- -1 azaaryl Chemical group 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000002270 dispersing agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000000945 filler Substances 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 208000007914 Labor Pain Diseases 0.000 claims 1
- 208000035945 Labour pain Diseases 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 239000007975 buffered saline Substances 0.000 claims 1
- 230000002996 emotional effect Effects 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000012669 liquid formulation Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 239000008223 sterile water Substances 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42679302P | 2002-11-18 | 2002-11-18 | |
| PCT/US2003/036789 WO2004045601A1 (en) | 2002-11-18 | 2003-11-18 | Analgesic uses of norketamine and ketamine/norketamine prodrugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006510618A JP2006510618A (ja) | 2006-03-30 |
| JP2006510618A5 true JP2006510618A5 (https=) | 2007-01-25 |
Family
ID=32326427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004553852A Withdrawn JP2006510618A (ja) | 2002-11-18 | 2003-11-18 | ノルケタミンおよびケタミン／ノルケタミンプロドラッグの鎮痛的使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20040248964A1 (https=) |
| EP (2) | EP1567145B1 (https=) |
| JP (1) | JP2006510618A (https=) |
| AT (1) | ATE432697T1 (https=) |
| AU (1) | AU2003291037A1 (https=) |
| CA (1) | CA2506615A1 (https=) |
| DE (1) | DE60327883D1 (https=) |
| NZ (1) | NZ540282A (https=) |
| WO (1) | WO2004045601A1 (https=) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0523031D0 (en) * | 2005-11-11 | 2005-12-21 | Yaupon Therapeutics | Enhancement of morphine analgesia by s(-)-norketamine |
| US8865743B2 (en) | 2006-01-06 | 2014-10-21 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
| US8753308B2 (en) | 2006-01-06 | 2014-06-17 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
| US9066847B2 (en) | 2007-01-05 | 2015-06-30 | Aceirx Pharmaceuticals, Inc. | Storage and dispensing devices for administration of oral transmucosal dosage forms |
| US8252328B2 (en) | 2006-01-06 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
| US8252329B2 (en) | 2007-01-05 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
| US8357114B2 (en) | 2006-01-06 | 2013-01-22 | Acelrx Pharmaceuticals, Inc. | Drug dispensing device with flexible push rod |
| US8202535B2 (en) | 2006-01-06 | 2012-06-19 | Acelrx Pharmaceuticals, Inc. | Small-volume oral transmucosal dosage forms |
| US9289583B2 (en) | 2006-01-06 | 2016-03-22 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
| US8535714B2 (en) | 2006-01-06 | 2013-09-17 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
| US20070260491A1 (en) * | 2006-05-08 | 2007-11-08 | Pamela Palmer | System for delivery and monitoring of administration of controlled substances |
| WO2009131794A1 (en) * | 2008-03-27 | 2009-10-29 | University Of Kentucky Research Foundation | Opioid-ketamine and norketamine codrug combinations for pain management |
| WO2010036937A1 (en) | 2008-09-27 | 2010-04-01 | Taraxos Inc. | Topical formulations for treatment of neuropathy |
| US8945592B2 (en) | 2008-11-21 | 2015-02-03 | Acelrx Pharmaceuticals, Inc. | Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same |
| CN102471222B (zh) * | 2009-07-16 | 2015-09-02 | 苏威氟有限公司 | 制备碳酸氟烷基(氟)烷基酯和氨基甲酸酯的方法 |
| WO2013056229A1 (en) * | 2011-10-14 | 2013-04-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | The use of (2r, 6r)-hydroxynorketamine, (s)-dehydronorketamine and other stereoisomeric dehydro and hydroxylated metabolites of (r,s)- ketamine in the treatment of depression and neuropathic pain |
| US20120323214A1 (en) * | 2012-05-16 | 2012-12-20 | Totada R Shantha | Alzheimer's disease treatment with multiple therapeutic agents delivered to the olfactory region through a special delivery catheter and iontophoresis |
| US20140079740A1 (en) * | 2012-08-02 | 2014-03-20 | ClinPharm Support GmbH | Oral transmucosal adminstration forms of s-ketamine |
| HK1212673A1 (zh) | 2012-10-08 | 2016-06-17 | 奥克兰服务有限公司 | 氯胺酮衍生物 |
| US20140274981A1 (en) | 2013-03-15 | 2014-09-18 | Janssen Pharmaceutica Nv | Pharmaceutical composition of s-ketamine hydrochloride |
| DK2983787T3 (da) * | 2013-04-12 | 2020-01-06 | Icahn School Med Mount Sinai | Fremgangsmåde til behandling af posttraumatisk stresssygdom |
| HUE056378T2 (hu) | 2013-09-13 | 2022-02-28 | Univ Chiba Nat Univ Corp | R-Ketamin és sójának alkalmazása gyógyszerekként |
| WO2015101693A1 (es) * | 2013-12-31 | 2015-07-09 | Servicio Andaluz De Salud | Composiciones y preparaciones combinadas para el tratamiento de las algias orofaríngeas |
| EP3094312B1 (en) | 2014-01-14 | 2019-03-13 | Children's Hospital Medical Center | Compositions comprising ketamine for treating an autism spectrum disorder |
| AU2015318123A1 (en) | 2014-09-15 | 2017-03-30 | Janssen Pharmaceutica Nv | Val66Met (SNP rs6265) genotype specific dosing regimens and methods for the treatment of depression |
| DK3215147T3 (da) | 2014-11-04 | 2024-04-02 | Acadia Pharm Inc | Neurodæmpende norketamin-forbindelser og fremgangsmåder |
| NZ732808A (en) | 2014-12-23 | 2021-12-24 | Acelrx Pharmaceuticals Inc | Systems, devices and methods for dispensing oral transmucosal dosage forms |
| US9844551B2 (en) | 2015-01-14 | 2017-12-19 | Children's Hospital Medical Center | Compositions and methods for treatment of fragile X syndrome |
| US11426366B2 (en) | 2015-05-15 | 2022-08-30 | Arizona Board Of Regents On Behalf Of The Universsity Of Arizona | Compositions and methods for treating motor disorders |
| US9918993B2 (en) * | 2015-06-19 | 2018-03-20 | Imprimis Pharmaceuticals, Inc. | Pharmaceutical compositions for anesthesiological applications |
| CN107847469A (zh) | 2015-06-27 | 2018-03-27 | 美国神农制药责任有限公司 | 氯胺酮透皮递送系统 |
| US11111210B2 (en) | 2015-11-18 | 2021-09-07 | Spirify Pharma Inc. | Phenyl cyclohexanone derivatives and methods of making and using them |
| US11827606B2 (en) | 2015-11-18 | 2023-11-28 | Spirify Pharma Inc. | Phenyl cyclohexanone derivatives and methods of making and using them |
| US20180318268A1 (en) | 2015-11-19 | 2018-11-08 | Biohaven Pharmaceutical Holding Company Ltd. | Amine prodrugs of pharmaceutical compounds |
| US11006661B2 (en) * | 2016-08-15 | 2021-05-18 | Mamood Valadi | Cigarette-like device for administration of substances |
| US9963435B2 (en) | 2016-08-31 | 2018-05-08 | Dart Neuroscience, Llc | Compounds for therapeutic use |
| CA3034885A1 (en) * | 2016-08-31 | 2018-03-08 | Dart Neuroscience, Llc | Hydroxynorketamine derivatives for the treatment of disorders |
| AU2017351437B2 (en) * | 2016-10-27 | 2022-01-27 | National University Corporation Chiba University | Application of (S)-norketamine and salt thereof as pharmaceutical |
| WO2019033330A1 (en) | 2017-08-17 | 2019-02-21 | Xw Laboratories, Inc. | PREPARATION AND USES OF DERIVATIVES TRACERS OF OXYGEN REACTIVE SPECIES |
| EP3679051B1 (en) | 2017-09-04 | 2021-12-29 | XWPharma Ltd. | Preparation and use of reactive oxygen species scavenger |
| US20200009081A1 (en) | 2017-09-13 | 2020-01-09 | Janssen Pharmaceutica N.V. | Delivery Of Esketamine For The Treatment Of Depression |
| US20200405663A1 (en) * | 2017-09-27 | 2020-12-31 | National University Corporation Chiba University | R-ketamine and derivative thereof as prophylactic or therapeutic agent for neurodegeneration disease or recognition functional disorder |
| KR20240011237A (ko) | 2017-12-22 | 2024-01-25 | 얀센 파마슈티카 엔브이 | 우울증 치료를 위한 에스케타민 |
| ES2907692T3 (es) | 2017-12-29 | 2022-04-26 | Celon Pharma Sa | Composición de ketamina de polvo seco para su administración por vía pulmonar en la depresión resistente al tratamiento |
| PL3737665T3 (pl) * | 2018-01-10 | 2026-04-20 | XWPharma Ltd. | Proleki ketaminy, ich kompozycje i zastosowania |
| US11980595B2 (en) | 2018-02-15 | 2024-05-14 | National University Corporation Chiba University | Preventive or therapeutic agent and pharmaceutical composition for inflammatory diseases or bone diseases |
| WO2019213551A1 (en) | 2018-05-04 | 2019-11-07 | Perception Neuroscience, Inc. | Methods of treating substance abuse |
| JP2022524008A (ja) | 2019-03-05 | 2022-04-27 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | うつ病の治療のためのエスケタミン |
| WO2020237747A1 (zh) * | 2019-05-24 | 2020-12-03 | 北京大学深圳研究生院 | 一种长效化合物在制备药物中的应用 |
| US11753378B2 (en) * | 2021-04-19 | 2023-09-12 | Zevra Therapeutics, Inc. | Ketamine compounds and processes for making and using them |
| EP4559522A3 (en) | 2021-08-13 | 2025-07-16 | XWPharma Ltd. | Pharmaceutical compositions and oral dosage forms of ketamine derivatives |
| EP4289815A1 (en) | 2022-06-10 | 2023-12-13 | Pcas | Crystalline forms of norketamine |
| EP4577305A2 (en) * | 2022-08-25 | 2025-07-02 | 1/1The Trustees Of Columbia University In The City Of New York | Compositions and methods for the treatment of alzheimer's disease and other neurogenerative disease |
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| US713A (en) | 1838-04-25 | Improvement in many-chambered-cylinder fire-arms | ||
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| US5352456A (en) | 1991-10-10 | 1994-10-04 | Cygnus Therapeutic Systems | Device for administering drug transdermally which provides an initial pulse of drug |
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| SE9203743D0 (sv) | 1992-12-11 | 1992-12-11 | Astra Ab | Efficient use |
| US5543434A (en) * | 1994-02-25 | 1996-08-06 | Weg; Stuart L. | Nasal administration of ketamine to manage pain |
| ATE287703T1 (de) | 1995-04-14 | 2005-02-15 | Nektar Therapeutics | Pulverförmige pharmazeutische formulierungen mit verbesserter dispergierbarkeit |
| CA2230690C (en) * | 1995-08-30 | 2008-12-23 | Stuart L. Weg | Administration of ketamine to manage pain and to reduce drug dependency |
| AUPN605795A0 (en) | 1995-10-19 | 1995-11-09 | F.H. Faulding & Co. Limited | Analgesic pharmaceutical composition |
| US6248789B1 (en) | 1996-08-29 | 2001-06-19 | Stuart L. Weg | Administration of ketamine to manage pain and to reduce drug dependency |
| EP1829539A3 (en) * | 1996-11-05 | 2008-02-20 | HEADEXPLORER ApS | A method for treating tension-type headache |
| AU756136B2 (en) | 1997-06-23 | 2003-01-02 | Queen's University At Kingston | Microdose therapy |
| US6630169B1 (en) | 1999-03-31 | 2003-10-07 | Nektar Therapeutics | Particulate delivery systems and methods of use |
| US6406745B1 (en) | 1999-06-07 | 2002-06-18 | Nanosphere, Inc. | Methods for coating particles and particles produced thereby |
| US6565888B1 (en) | 2000-08-23 | 2003-05-20 | Alkermes Controlled Therapeutics, Inc. | Methods and compositions for the targeted delivery of biologically active agents |
| US20050148673A1 (en) * | 2002-07-11 | 2005-07-07 | Harbut Ronald E. | Prolonged administration of NMDA antagonist and safener drug to alter neuropathic pain condition |
-
2003
- 2003-11-18 JP JP2004553852A patent/JP2006510618A/ja not_active Withdrawn
- 2003-11-18 WO PCT/US2003/036789 patent/WO2004045601A1/en not_active Ceased
- 2003-11-18 DE DE60327883T patent/DE60327883D1/de not_active Expired - Fee Related
- 2003-11-18 AU AU2003291037A patent/AU2003291037A1/en not_active Abandoned
- 2003-11-18 EP EP03783623A patent/EP1567145B1/en not_active Expired - Lifetime
- 2003-11-18 NZ NZ540282A patent/NZ540282A/en unknown
- 2003-11-18 CA CA002506615A patent/CA2506615A1/en not_active Abandoned
- 2003-11-18 AT AT03783623T patent/ATE432697T1/de not_active IP Right Cessation
- 2003-11-18 US US10/714,643 patent/US20040248964A1/en not_active Abandoned
- 2003-11-18 EP EP08168894A patent/EP2027854A1/en not_active Withdrawn
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