JP2006507484A5 - - Google Patents

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Publication number
JP2006507484A5
JP2006507484A5 JP2004539916A JP2004539916A JP2006507484A5 JP 2006507484 A5 JP2006507484 A5 JP 2006507484A5 JP 2004539916 A JP2004539916 A JP 2004539916A JP 2004539916 A JP2004539916 A JP 2004539916A JP 2006507484 A5 JP2006507484 A5 JP 2006507484A5
Authority
JP
Japan
Prior art keywords
yyx
ysa
motif
peptide
tandem repeat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2004539916A
Other languages
English (en)
Japanese (ja)
Other versions
JP4533750B2 (ja
JP2006507484A (ja
Filing date
Publication date
Priority claimed from US10/256,538 external-priority patent/US20040072236A1/en
Application filed filed Critical
Publication of JP2006507484A publication Critical patent/JP2006507484A/ja
Publication of JP2006507484A5 publication Critical patent/JP2006507484A5/ja
Application granted granted Critical
Publication of JP4533750B2 publication Critical patent/JP4533750B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2004539916A 2002-09-27 2003-09-26 ＰｒＰＳｃ相互作用分子とその用途 Expired - Fee Related JP4533750B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/256,538 US20040072236A1 (en) 2002-09-27 2002-09-27 PrPSc -interacting molecules and uses thereof
PCT/US2003/030273 WO2004029072A2 (en) 2002-09-27 2003-09-25 PrPsc -INTERACTING MOLECULES AND USES THEREOF

Publications (3)

Publication Number Publication Date
JP2006507484A JP2006507484A (ja) 2006-03-02
JP2006507484A5 true JP2006507484A5 (enExample) 2006-11-02
JP4533750B2 JP4533750B2 (ja) 2010-09-01

Family

ID=32041771

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004539916A Expired - Fee Related JP4533750B2 (ja) 2002-09-27 2003-09-26 ＰｒＰＳｃ相互作用分子とその用途

Country Status (7)

Country Link
US (2) US20040072236A1 (enExample)
EP (1) EP1575989B1 (enExample)
JP (1) JP4533750B2 (enExample)
AT (1) ATE467124T1 (enExample)
CA (1) CA2500120A1 (enExample)
DE (1) DE60332488D1 (enExample)
WO (1) WO2004029072A2 (enExample)

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US7041807B1 (en) 1999-06-23 2006-05-09 Caprion Pharmaceuticals, Inc. Antibodies to a YYX epitope of a mammalian prion protein
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
EP1395833B1 (en) 2001-05-31 2013-02-27 Adlyfe, Inc. Misfolded protein sensor method
US20040072236A1 (en) 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
AU2004229535A1 (en) * 2003-04-14 2004-10-28 Pathogen Removal And Diagnostic Technologies, Inc. Method for identifying ligands specific for structural isoforms of proteins
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
NZ580256A (en) 2003-08-13 2011-07-29 Novartis Vaccines & Diagnostic Prion-specific peptide reagents comprising the sequence KKRPKPGG
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
US7328063B2 (en) * 2004-11-30 2008-02-05 Cardiac Pacemakers, Inc. Method and apparatus for arrhythmia classification using atrial signal mapping
JP5162250B2 (ja) * 2005-01-13 2013-03-13 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド プリオン特異的ペプチド試薬を使用するｅｌｉｓａアッセイ
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
AU2006214463B2 (en) * 2005-02-15 2012-08-30 Presympto, Inc. Method for detecting misfolded proteins and prions
EP1931695B1 (en) * 2005-09-09 2013-04-10 Novartis AG Prion-specific peptoid reagents
JP4769925B2 (ja) * 2006-03-15 2011-09-07 国立大学法人東北大学 異常型プリオン蛋白質の濃縮方法、および除去方法
EP2156181B1 (en) * 2006-07-28 2015-11-04 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
US7601506B2 (en) * 2006-07-28 2009-10-13 Idexx Laboratories, Inc. Identification of leucocytes bearing diagnostic markers for transmissible spongiform encephalopathies
CA2675039A1 (en) * 2007-01-12 2008-07-17 Alicon Ag Method for removing prion protein
BRPI0910456A2 (pt) * 2008-04-25 2016-07-19 Univ Saskatchewan petídeos imunogênicos priônicos e suas repetições
BRPI0910550A2 (pt) * 2008-04-30 2015-09-29 Novartis Ag ensaio para confôrmeros patogênicos
US20120009209A1 (en) * 2010-06-10 2012-01-12 The Regents Of The University Of California Enrichment and purification of infectious prion proteins
CN103221823A (zh) * 2010-09-13 2013-07-24 Abbvie公司 高度灵敏的单克隆抗体残留物检测测定法

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FI90990C (fi) * 1984-12-18 1994-04-25 Boehringer Ingelheim Int Rekombinantti-DNA-molekyyli, transformoitu isäntäorganismi ja menetelmä interferonin valmistamiseksi
CA1339465C (en) 1986-04-30 1997-09-16 Richard J. Massey Electrochemiluminescent assays
SU1529119A1 (ru) 1987-04-20 1989-12-15 Белорусский научно-исследовательский институт эпидемиологии и микробиологии Способ определени нейровирусов в спинномозговой жидкости
US4806627A (en) * 1987-05-29 1989-02-21 Research Foundation Of Mental Hygiene Inc. Hybrid cell lines producing monoclonal antibodies dircted against scrapie-associated fibril proteins
AU9028791A (en) 1990-10-05 1992-04-28 President And Fellows Of Harvard College Detection and isolation of ligands
EP0619841B1 (en) 1990-10-30 1998-07-08 La Jolla Cancer Research Foundation T-cadherin adhesion molecule
NZ246059A (en) * 1991-12-03 1995-08-28 Proteus Molecular Design Synthetic polypeptides with at least one antigenic site of a prion protein, methods of their use and manufacture, antibodies thereto, compositions and kits
US5597725A (en) * 1992-04-17 1997-01-28 Doheny Eye Institute Cadherin-specific antibodies and hybridoma cell lines
US5646250A (en) * 1992-04-17 1997-07-08 Doheny Eye Institute Cadherin polypeptides
JPH07500019A (ja) * 1992-04-17 1995-01-05 ドーニー　アイ　インスティテュート カドヘリン物質および方法
AU4376093A (en) 1992-05-15 1993-12-13 Instituto Nazionale Neurologico C. Besta Soluble prion polypeptides, and methods for detecting and purifying thereof
US5276059A (en) 1992-07-10 1994-01-04 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of diseases associated with amyloid formation
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US5679530A (en) 1995-04-12 1997-10-21 Ludwig Institute For Cancer Research Isolated protein having molecular weight of from about 55 kilodaltons to about 65 kilodaltons (SDS-page) which binds to prion protein
US5948763A (en) 1995-06-07 1999-09-07 New York University Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits
EP1416280A3 (en) 1995-09-14 2005-08-10 The Regents of the University of California Antibodies specific for native PrPsc
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
ATE249046T1 (de) 1996-05-14 2003-09-15 Winnacker Ernst Ludwig Prof Chaperone, die prionproteine binden und zwischen den isoformen prpc und prpsc unterscheiden können
DE69714451T2 (de) * 1996-05-29 2003-01-30 Mcgill University, Montreal Prionbindende proteine und deren verwendungen
US5891641A (en) * 1997-02-21 1999-04-06 The Regents Of The University Of California Assay for disease related conformation of a protein
EP0861900A1 (en) 1997-02-21 1998-09-02 Erziehungsdirektion Of The Canton Zurich Immunological detection of prions
DE19741607A1 (de) 1997-09-20 1999-03-25 Prionics Ag Synthetische Polypeptide zur Diagnose und Therapie von Prionerkrankungen
US6165784A (en) 1997-10-14 2000-12-26 The United States Of America As Represented By The Secretary Of Agriculture Antibodies for the detection of prion protein as an indication of transmissible spongiform encephalopathies
BR9908059A (pt) 1998-02-20 2002-01-08 Univ California Método de análise para espécies especìficas de conformações de uma proteìna relacionadas a várias doenças
US6211149B1 (en) * 1998-08-03 2001-04-03 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors of formation of protease resistant prion protein
GB2348203B (en) * 1998-11-04 2002-06-19 Imp College Innovations Ltd Solube beta-forms of prion proteins, methods of preparation and use
MXPA01013186A (es) * 1999-06-23 2002-08-12 Caprion Pharmaceuticals Inc Peptidos de la proteina prion y sus usos.
AU5778400A (en) * 1999-06-29 2001-01-31 Caprion Pharmaceuticals, Inc. Prion protein binding proteins and uses thereof
AU2001251358A1 (en) * 2000-04-05 2001-10-23 V.I. Technologies, Inc. Prion-binding ligands and methods of using same
DE10230141B4 (de) * 2002-07-04 2004-07-15 Priontype Gmbh Verfahren und Kit zur Anreicherung und zum Nachweis von veränderten Prion-Proteinen (PrPSc)
US20040072236A1 (en) 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof

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