JP2006507484A5 - - Google Patents

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Publication number
JP2006507484A5
JP2006507484A5 JP2004539916A JP2004539916A JP2006507484A5 JP 2006507484 A5 JP2006507484 A5 JP 2006507484A5 JP 2004539916 A JP2004539916 A JP 2004539916A JP 2004539916 A JP2004539916 A JP 2004539916A JP 2006507484 A5 JP2006507484 A5 JP 2006507484A5
Authority
JP
Japan
Prior art keywords
yyx
ysa
motif
peptide
tandem repeat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2004539916A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006507484A (ja
JP4533750B2 (ja
Filing date
Publication date
Priority claimed from US10/256,538 external-priority patent/US20040072236A1/en
Application filed filed Critical
Publication of JP2006507484A publication Critical patent/JP2006507484A/ja
Publication of JP2006507484A5 publication Critical patent/JP2006507484A5/ja
Application granted granted Critical
Publication of JP4533750B2 publication Critical patent/JP4533750B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2004539916A 2002-09-27 2003-09-26 ＰｒＰＳｃ相互作用分子とその用途 Expired - Fee Related JP4533750B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/256,538 US20040072236A1 (en) 2002-09-27 2002-09-27 PrPSc -interacting molecules and uses thereof
PCT/US2003/030273 WO2004029072A2 (en) 2002-09-27 2003-09-25 PrPsc -INTERACTING MOLECULES AND USES THEREOF

Publications (3)

Publication Number Publication Date
JP2006507484A JP2006507484A (ja) 2006-03-02
JP2006507484A5 true JP2006507484A5 (enExample) 2006-11-02
JP4533750B2 JP4533750B2 (ja) 2010-09-01

Family

ID=32041771

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004539916A Expired - Fee Related JP4533750B2 (ja) 2002-09-27 2003-09-26 ＰｒＰＳｃ相互作用分子とその用途

Country Status (7)

Country Link
US (2) US20040072236A1 (enExample)
EP (1) EP1575989B1 (enExample)
JP (1) JP4533750B2 (enExample)
AT (1) ATE467124T1 (enExample)
CA (1) CA2500120A1 (enExample)
DE (1) DE60332488D1 (enExample)
WO (1) WO2004029072A2 (enExample)

Families Citing this family (21)

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Publication number Priority date Publication date Assignee Title
US7041807B1 (en) 1999-06-23 2006-05-09 Caprion Pharmaceuticals, Inc. Antibodies to a YYX epitope of a mammalian prion protein
AU2002320045B2 (en) 2001-05-31 2008-05-08 Adlyfe, Inc. Misfolded protein sensor method
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
US20040072236A1 (en) 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
JP2006524340A (ja) * 2003-04-14 2006-10-26 アメリカン ナショナル レッド クロス タンパク質の構造アイソフォームに特異的なリガンドを特定するための方法
ES2398394T3 (es) 2003-08-13 2013-03-15 Novartis Vaccines And Diagnostics, Inc. Reactivos peptídicos específicos de prión
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
US7328063B2 (en) * 2004-11-30 2008-02-05 Cardiac Pacemakers, Inc. Method and apparatus for arrhythmia classification using atrial signal mapping
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
US20090130774A1 (en) * 2005-01-13 2009-05-21 David Peretz Elisa assays using prion-specific peptide reagents
EP1853915B1 (en) * 2005-02-15 2011-10-12 Adlyfe, Inc. Method for detecting misfolded proteins and prions
WO2007030804A1 (en) * 2005-09-09 2007-03-15 Novartis Ag Prion-specific peptoid reagents
JP4769925B2 (ja) * 2006-03-15 2011-09-07 国立大学法人東北大学 異常型プリオン蛋白質の濃縮方法、および除去方法
JP5097206B2 (ja) * 2006-07-28 2012-12-12 エイディーライフ インコーポレイティッド 診断および治療のためのペプチドプローブ
US7601506B2 (en) * 2006-07-28 2009-10-13 Idexx Laboratories, Inc. Identification of leucocytes bearing diagnostic markers for transmissible spongiform encephalopathies
WO2008083972A2 (en) * 2007-01-12 2008-07-17 Alicon Ag Method for removing prion protein
US9056918B2 (en) * 2008-04-25 2015-06-16 University Of Saskatchewan Prion epitopes and methods of use thereof
JP2011520108A (ja) * 2008-04-30 2011-07-14 ノバルティス アーゲー 病原性配座異性体についてのアッセイ
US20120009209A1 (en) * 2010-06-10 2012-01-12 The Regents Of The University Of California Enrichment and purification of infectious prion proteins
EP2616807A1 (en) 2010-09-13 2013-07-24 Abbvie Inc. A highly sensitive monoclonal antibody residual detection assay

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FI90990C (fi) * 1984-12-18 1994-04-25 Boehringer Ingelheim Int Rekombinantti-DNA-molekyyli, transformoitu isäntäorganismi ja menetelmä interferonin valmistamiseksi
WO1987006706A1 (en) 1986-04-30 1987-11-05 Igen, Inc. Electrochemiluminescent assays
SU1529119A1 (ru) 1987-04-20 1989-12-15 Белорусский научно-исследовательский институт эпидемиологии и микробиологии Способ определени нейровирусов в спинномозговой жидкости
US4806627A (en) * 1987-05-29 1989-02-21 Research Foundation Of Mental Hygiene Inc. Hybrid cell lines producing monoclonal antibodies dircted against scrapie-associated fibril proteins
WO1992006220A1 (en) 1990-10-05 1992-04-16 President And Fellows Of Harvard College Detection and isolation of ligands
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WO1993011155A1 (en) * 1991-12-03 1993-06-10 Proteus Molecular Design Limited Fragments of prion proteins
US5597725A (en) * 1992-04-17 1997-01-28 Doheny Eye Institute Cadherin-specific antibodies and hybridoma cell lines
WO1993021302A1 (en) * 1992-04-17 1993-10-28 Doheny Eye Institute Cadherin materials and methods
US5646250A (en) * 1992-04-17 1997-07-08 Doheny Eye Institute Cadherin polypeptides
WO1993023432A1 (en) 1992-05-15 1993-11-25 New York University Soluble prion polypeptides, and methods for detecting and purifying thereof
US5276059A (en) 1992-07-10 1994-01-04 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of diseases associated with amyloid formation
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US5679530A (en) 1995-04-12 1997-10-21 Ludwig Institute For Cancer Research Isolated protein having molecular weight of from about 55 kilodaltons to about 65 kilodaltons (SDS-page) which binds to prion protein
US5948763A (en) 1995-06-07 1999-09-07 New York University Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits
EP1416280A3 (en) 1995-09-14 2005-08-10 The Regents of the University of California Antibodies specific for native PrPsc
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
ATE249046T1 (de) 1996-05-14 2003-09-15 Winnacker Ernst Ludwig Prof Chaperone, die prionproteine binden und zwischen den isoformen prpc und prpsc unterscheiden können
JP2000512131A (ja) * 1996-05-29 2000-09-19 マクギル ユニバーシティー プリオン蛋白結合蛋白およびその使用法
US5891641A (en) * 1997-02-21 1999-04-06 The Regents Of The University Of California Assay for disease related conformation of a protein
EP0861900A1 (en) 1997-02-21 1998-09-02 Erziehungsdirektion Of The Canton Zurich Immunological detection of prions
DE19741607A1 (de) 1997-09-20 1999-03-25 Prionics Ag Synthetische Polypeptide zur Diagnose und Therapie von Prionerkrankungen
US6165784A (en) 1997-10-14 2000-12-26 The United States Of America As Represented By The Secretary Of Agriculture Antibodies for the detection of prion protein as an indication of transmissible spongiform encephalopathies
DE69909442T2 (de) 1998-02-20 2004-04-22 The Regents Of The University Of California, Oakland Assay für spezifische stämme von mit mehreren krankheiten zusammenhängenden proteinkonformationen
US6211149B1 (en) * 1998-08-03 2001-04-03 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors of formation of protease resistant prion protein
GB2348203B (en) * 1998-11-04 2002-06-19 Imp College Innovations Ltd Solube beta-forms of prion proteins, methods of preparation and use
ES2278617T3 (es) * 1999-06-23 2007-08-16 Idexx Laboratories Inc Peptidos de proteinas de prion y sus usos.
WO2001000235A1 (en) * 1999-06-29 2001-01-04 Mcgill University Prion protein binding proteins and uses thereof
CA2405568A1 (en) * 2000-04-05 2001-10-18 North Carolina State University Prion-binding peptidic ligands and methods of using same
DE10230141B4 (de) * 2002-07-04 2004-07-15 Priontype Gmbh Verfahren und Kit zur Anreicherung und zum Nachweis von veränderten Prion-Proteinen (PrPSc)
US20040072236A1 (en) 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof

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