JP2006506101A - インフルエンザウイルス非構造タンパク質１の阻害剤を設計する方法 - Google Patents

インフルエンザウイルス非構造タンパク質１の阻害剤を設計する方法 Download PDF

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JP2006506101A
JP2006506101A JP2005507162A JP2005507162A JP2006506101A JP 2006506101 A JP2006506101 A JP 2006506101A JP 2005507162 A JP2005507162 A JP 2005507162A JP 2005507162 A JP2005507162 A JP 2005507162A JP 2006506101 A JP2006506101 A JP 2006506101A
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Japan
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dsrna
protein
ns1a
influenza virus
compound
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JP2005507162A
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Japanese (ja)
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JP2006506101A5 (https=
Inventor
モンテリオーネ，ガエターノ・ティー
クルーグ，ロバート・エム
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Rutgers State University of New Jersey
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Rutgers State University of New Jersey
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Publication of JP2006506101A publication Critical patent/JP2006506101A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2005507162A 2002-11-13 2003-11-13 インフルエンザウイルス非構造タンパク質１の阻害剤を設計する方法 Pending JP2006506101A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42566102P 2002-11-13 2002-11-13
US47745303P 2003-06-10 2003-06-10
PCT/US2003/036292 WO2004043404A2 (en) 2002-11-13 2003-11-13 Process for designing inhibitors of influenza virus non-structural protein 1

Publications (2)

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JP2006506101A true JP2006506101A (ja) 2006-02-23
JP2006506101A5 JP2006506101A5 (https=) 2007-02-01

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ID=32314599

Family Applications (1)

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JP2005507162A Pending JP2006506101A (ja) 2002-11-13 2003-11-13 インフルエンザウイルス非構造タンパク質１の阻害剤を設計する方法

Country Status (5)

Country Link
US (2) US20080234175A1 (https=)
JP (1) JP2006506101A (https=)
AU (1) AU2003290842A1 (https=)
CA (1) CA2505949A1 (https=)
WO (1) WO2004043404A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101471245B1 (ko) * 2012-05-31 2014-12-10 충북대학교 산학협력단 Ａ형 인플루엔자 바이러스 감염 질환의 예방 및 치료용 조성물

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4837827B2 (ja) 1998-06-12 2011-12-14 マウント シナイ スクール オブ メディシン 新規なウイルス増殖方法およびそのためのインターフェロン欠損培養基
WO2001077394A1 (en) 2000-04-10 2001-10-18 Mount Sinai School Of Medicine Of New York University Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents
DK2497492T3 (en) 2004-06-01 2018-11-26 Icahn School Med Mount Sinai Genetically modified swine influenza virus and its applications
WO2006088481A2 (en) * 2005-02-15 2006-08-24 Mount Sinai School Of Medicine Of New York University Genetically engineered equine influenza virus and uses thereof
EP1948796A1 (en) * 2005-11-07 2008-07-30 Dow Gloval Technologies Inc. Process for the preparation of nucleic acid duplexes
US9119810B2 (en) 2005-11-18 2015-09-01 Rutgers, The State University Of New Jersey Compositions and vaccines against influenza A and influenza B infections
US7709190B2 (en) 2005-12-02 2010-05-04 Board Of Regents, The University Of Texas System Influenza A virus vaccines and inhibitors
US7601490B2 (en) 2005-12-02 2009-10-13 Board Of Regents, The University Of Texas System Development of influenza A antivirals
CN102002489B (zh) * 2009-09-02 2013-06-12 中国科学院微生物研究所 抑制H1N1型流感病毒增殖的microRNA及其应用
WO2011147199A1 (en) * 2010-05-28 2011-12-01 Versitech Limited Compounds and methods for treating viral infections
KR20170122786A (ko) 2015-02-26 2017-11-06 베링거잉겔하임베트메디카게엠베하 2가 돼지 인플루엔자 바이러스 백신
JP2024536360A (ja) * 2021-10-06 2024-10-04 セキラス インコーポレイテッド 核酸結合タンパク質を含む脂質ナノ粒子

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750394A (en) * 1994-05-20 1998-05-12 The Mount Sinai Medical Center Identification and use of antiviral compounds that inhibit interaction of host cell proteins and viral proteins required for viral replication
US5843724A (en) * 1995-04-27 1998-12-01 Rutgers University Chimeric nucleic acids and proteins for inhibiting HIV-1 expression
CN1278921A (zh) * 1997-09-12 2001-01-03 基因实验室公司 dsRNA/dsRNA结合蛋白方法及组合物

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
JPN6009051271, Ｎａｔ． Ｓｔｒｕｃｔ． Ｂｉｏｌ．, 1997, ｖｏｌ．４， ｎｏ．１１, ｐ．８９６−８９９ *
JPN6009051274, Ｎａｔ． Ｓｔｒｕｃｔ． Ｂｉｏｌ．, 1997, ｖｏｌ．４， ｎｏ．１１, ｐ．８９１−８９５ *
JPN6009051276, Ｖｉｒｏｌｏｇｙ, 1996, ｖｏｌ．２２３， ｎｏ．１, ｐ．４１−５０ *
JPN6009051278, Ｖｉｒｏｌｏｇｙ, 1995, ｖｏｌ．２１４， ｎｏ．１, ｐ．２２２−２２８ *
JPN6009051280, ＲＮＡ, 1995, ｖｏｌ．１， ｎｏ．５, ｐ．９４８−９５６ *
JPN6009051281, Ｊ． Ｖｉｒｏｌ．, 1994, ｖｏｌ．６８， ｎｏ．４, ｐ．２４３３−２４４１ *
JPN6009051283, Ｊ． Ｇｅｎ． Ｖｉｒｏｌ．, 1992, ｖｏｌ．７３， ｎｏ．１２, ｐ．３３２５−３３２９ *
JPN6009051285, ＲＮＡ, 1999, ｖｏｌ．５， ｎｏ．２, ｐ．１９５−２０５ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101471245B1 (ko) * 2012-05-31 2014-12-10 충북대학교 산학협력단 Ａ형 인플루엔자 바이러스 감염 질환의 예방 및 치료용 조성물

Also Published As

Publication number Publication date
AU2003290842A1 (en) 2004-06-03
US20080234175A1 (en) 2008-09-25
US20100081126A1 (en) 2010-04-01
AU2003290842A8 (en) 2004-06-03
CA2505949A1 (en) 2004-05-27
WO2004043404A3 (en) 2004-09-23
WO2004043404A2 (en) 2004-05-27

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