JP2006504745A - エポｄ及び５−ｆｕ／ゲムシタビン - Google Patents
エポｄ及び５−ｆｕ／ゲムシタビン Download PDFInfo
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- JP2006504745A JP2006504745A JP2004543655A JP2004543655A JP2006504745A JP 2006504745 A JP2006504745 A JP 2006504745A JP 2004543655 A JP2004543655 A JP 2004543655A JP 2004543655 A JP2004543655 A JP 2004543655A JP 2006504745 A JP2006504745 A JP 2006504745A
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- epothilone
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- dehydroepothilone
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| KR101173510B1 (ko) | 2002-08-23 | 2012-08-21 | 슬로안-케테링인스티튜트퍼캔서리서치 | 에포틸론, 이의 중간물질과 유사체의 합성 및 이들의 용도 |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| JPWO2004080462A1 (ja) | 2003-03-10 | 2006-06-08 | エーザイ株式会社 | ｃ−Ｋｉｔキナーゼ阻害剤 |
| EP1683785B1 (en) | 2003-11-11 | 2013-10-16 | Eisai R&D Management Co., Ltd. | Urea derivative and process for producing the same |
| US20050215604A1 (en) * | 2004-03-26 | 2005-09-29 | Kosan Biosciences, Inc. | Combination therapies with epothilones and carboplatin |
| CA2579810C (en) | 2004-09-17 | 2012-01-24 | Eisai R&D Management Co., Ltd. | Stable pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide |
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| AU2007252506C1 (en) | 2006-05-18 | 2012-07-19 | Eisai R & D Management Co., Ltd. | Antitumor agent for thyroid cancer |
| JP5368096B2 (ja) | 2006-08-28 | 2013-12-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 未分化型胃癌に対する抗腫瘍剤 |
| CN101616671A (zh) | 2007-01-19 | 2009-12-30 | 卫材R&D管理有限公司 | 胰腺癌治疗用组合物 |
| EP2119707B1 (en) | 2007-01-29 | 2015-01-14 | Eisai R&D Management Co., Ltd. | Composition for treatment of undifferentiated-type of gastric cancer |
| CN101848895B (zh) | 2007-11-09 | 2013-10-23 | 卫材R&D管理有限公司 | 血管新生抑制物质和抗肿瘤性铂络合物的组合使用 |
| EP2571525A4 (en) | 2010-05-18 | 2016-04-27 | Cerulean Pharma Inc | Compositions and methods for treating autoimmune and other diseases |
| MX2012014776A (es) | 2010-06-25 | 2013-01-29 | Eisai R&D Man Co Ltd | Agente antitumoral que emplea compuestos con efecto inhibidor de cinasas combinados. |
| AU2012246490B2 (en) | 2011-04-18 | 2016-08-04 | Eisai R&D Management Co., Ltd. | Therapeutic agent for tumor |
| EP3444363B1 (en) | 2011-06-03 | 2020-11-25 | Eisai R&D Management Co., Ltd. | Biomarkers for prediciting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
| EP2937337A4 (en) | 2012-12-21 | 2016-06-22 | Eisai R&D Man Co Ltd | AMORPHIC FORM OF CHINOLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
| CA2912219C (en) | 2013-05-14 | 2021-11-16 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds |
| KR102329681B1 (ko) | 2014-08-28 | 2021-11-23 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 고순도의 퀴놀린 유도체 및 이를 제조하는 방법 |
| DK3263106T3 (da) | 2015-02-25 | 2024-01-08 | Eisai R&D Man Co Ltd | Fremgangsmåde til undertrykkelse af bitterhed af quinolinderivat |
| WO2016140717A1 (en) | 2015-03-04 | 2016-09-09 | Merck Sharp & Dohme Corp. | Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer |
| WO2016204193A1 (ja) | 2015-06-16 | 2016-12-22 | 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ | 抗がん剤 |
| EP3338779B1 (en) | 2015-08-20 | 2021-06-30 | Eisai R&D Management Co., Ltd. | Lenvatinib in combination with etoposide and ifosfamide for use in treating a tumor |
| US12303505B2 (en) | 2017-02-08 | 2025-05-20 | Eisai R&D Management Co., Ltd. | Tumor-treating pharmaceutical composition |
| CA3061888A1 (en) | 2017-05-16 | 2018-11-22 | Eisai R&D Management Co., Ltd. | Treatment of hepatocellular carcinoma |
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| WO2000061142A1 (en) * | 1999-04-14 | 2000-10-19 | Dana-Farber Cancer Institute, Inc. | Method and composition for the treatment of cancer |
| JP2005513167A (ja) * | 2002-01-14 | 2005-05-12 | ノバルティス アクチエンゲゼルシャフト | エポシロン誘導体と代謝拮抗剤からなる組合せ |
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| US6242469B1 (en) * | 1996-12-03 | 2001-06-05 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6204388B1 (en) * | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6596875B2 (en) * | 2000-02-07 | 2003-07-22 | James David White | Method for synthesizing epothilones and epothilone analogs |
| HK1038923B (en) * | 1999-02-22 | 2004-03-19 | Helmholtz-Zentrum Fur Infektionsforschung Gmbh | C-21 modified EPOTHILONES |
| US6291684B1 (en) * | 1999-03-29 | 2001-09-18 | Bristol-Myers Squibb Company | Process for the preparation of aziridinyl epothilones from oxiranyl epothilones |
| US6489314B1 (en) * | 2001-04-03 | 2002-12-03 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
| SK11082003A3 (sk) * | 2001-03-14 | 2004-08-03 | Bristol-Myers Squibb Company | Kombinácia analógov epotilónu a chemoterapeutických činidiel na liečenie proliferatívnych ochorení |
| TWI287986B (en) * | 2001-12-13 | 2007-10-11 | Novartis Ag | Use of Epothilones for the treatment of the carcinoid syndrome |
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2003
- 2003-10-09 MX MXPA05003706A patent/MXPA05003706A/es not_active Application Discontinuation
- 2003-10-09 RU RU2005114018/14A patent/RU2005114018A/ru not_active Application Discontinuation
- 2003-10-09 WO PCT/US2003/032148 patent/WO2004032872A2/en not_active Ceased
- 2003-10-09 BR BR0315169-7A patent/BR0315169A/pt not_active IP Right Cessation
- 2003-10-09 CA CA002499682A patent/CA2499682A1/en not_active Abandoned
- 2003-10-09 CN CNB2003801009323A patent/CN1297258C/zh not_active Expired - Fee Related
- 2003-10-09 KR KR1020057006143A patent/KR20050051688A/ko not_active Withdrawn
- 2003-10-09 JP JP2004543655A patent/JP2006504745A/ja active Pending
- 2003-10-09 AU AU2003279923A patent/AU2003279923A1/en not_active Abandoned
- 2003-10-09 EP EP03773239A patent/EP1551378A4/en not_active Withdrawn
-
2004
- 2004-05-03 US US10/683,203 patent/US20040167097A1/en not_active Abandoned
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000061142A1 (en) * | 1999-04-14 | 2000-10-19 | Dana-Farber Cancer Institute, Inc. | Method and composition for the treatment of cancer |
| JP2005513167A (ja) * | 2002-01-14 | 2005-05-12 | ノバルティス アクチエンゲゼルシャフト | エポシロン誘導体と代謝拮抗剤からなる組合せ |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019504893A (ja) * | 2016-02-06 | 2019-02-21 | ベイジン バイオスター テクノロジーズ， リミテッド | 脱エポキシ化エポチロン誘導体の製剤、その調製及び腫瘍の治療におけるその使用 |
| US10980782B2 (en) | 2016-02-06 | 2021-04-20 | Beijing Biostar Technologies, Ltd. | De-epoxidized epothilone derivative preparation, preparation of same and use thereof in the treatment of tumor |
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA05003706A (es) | 2005-07-01 |
| CN1703208A (zh) | 2005-11-30 |
| CN1297258C (zh) | 2007-01-31 |
| BR0315169A (pt) | 2005-08-23 |
| AU2003279923A1 (en) | 2004-05-04 |
| WO2004032872A3 (en) | 2004-11-11 |
| CA2499682A1 (en) | 2004-04-22 |
| WO2004032872A2 (en) | 2004-04-22 |
| EP1551378A4 (en) | 2006-09-06 |
| KR20050051688A (ko) | 2005-06-01 |
| US20040167097A1 (en) | 2004-08-26 |
| EP1551378A2 (en) | 2005-07-13 |
| RU2005114018A (ru) | 2006-01-20 |
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