JP2006504741A5 - - Google Patents
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- Publication number
- JP2006504741A5 JP2006504741A5 JP2004543508A JP2004543508A JP2006504741A5 JP 2006504741 A5 JP2006504741 A5 JP 2006504741A5 JP 2004543508 A JP2004543508 A JP 2004543508A JP 2004543508 A JP2004543508 A JP 2004543508A JP 2006504741 A5 JP2006504741 A5 JP 2006504741A5
- Authority
- JP
- Japan
- Prior art keywords
- brimonidine
- administration
- compound
- suspension test
- tail suspension
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- PLRACCBDVIHHLZ-UHFFFAOYSA-N 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Chemical compound C1N(C)CCC(C=2C=CC=CC=2)=C1 PLRACCBDVIHHLZ-UHFFFAOYSA-N 0.000 description 2
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 description 2
- 101001135571 Mus musculus Tyrosine-protein phosphatase non-receptor type 2 Proteins 0.000 description 2
- 229960003679 brimonidine Drugs 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000003194 forelimb Anatomy 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41703102P | 2002-10-08 | 2002-10-08 | |
| PCT/US2003/031842 WO2004032934A1 (en) | 2002-10-08 | 2003-10-07 | Method of using (2-imidazolin-2-ylamino) qinoxalines in the treatment of dementia and parkinsons |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006504741A JP2006504741A (ja) | 2006-02-09 |
| JP2006504741A5 true JP2006504741A5 (enExample) | 2006-11-24 |
Family
ID=32093952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004543508A Pending JP2006504741A (ja) | 2002-10-08 | 2003-10-07 | 痴呆およびパーキンソン病の処置における（２−イミダゾリン−２−イルアミノ）キノキサリンの使用方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20040116436A1 (enExample) |
| EP (1) | EP1549314B1 (enExample) |
| JP (1) | JP2006504741A (enExample) |
| KR (1) | KR20050056235A (enExample) |
| CN (1) | CN100370988C (enExample) |
| AT (1) | ATE380551T1 (enExample) |
| AU (2) | AU2003279874A1 (enExample) |
| BR (1) | BR0314541A (enExample) |
| CA (1) | CA2501348A1 (enExample) |
| DE (1) | DE60318081T2 (enExample) |
| ES (1) | ES2297233T3 (enExample) |
| HK (1) | HK1080408B (enExample) |
| IL (1) | IL167848A (enExample) |
| MX (1) | MXPA05003665A (enExample) |
| NO (1) | NO20051664L (enExample) |
| NZ (1) | NZ539329A (enExample) |
| PL (1) | PL376347A1 (enExample) |
| RU (1) | RU2332218C2 (enExample) |
| WO (1) | WO2004032934A1 (enExample) |
| ZA (1) | ZA200502745B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7512436B2 (en) * | 2004-02-12 | 2009-03-31 | The Regents Of The University Of Michigan | Method of evaluating metabolism of the eye |
| US9095506B2 (en) | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| US20100298305A1 (en) * | 2008-11-26 | 2010-11-25 | The United States Government, As Represented By The Department Of Veterans Affairs | Tizanidine for the treatment of post-traumatic stress disorder and nightmares |
| DE102009043750A1 (de) * | 2009-09-30 | 2011-08-04 | Carl Zeiss Meditec AG, 07745 | Verfahren und Vorrichtung zur Detektion von Ablagerungen im Auge |
| WO2016089997A1 (en) * | 2014-12-02 | 2016-06-09 | Yale University | Methods of preventing neurodegeneration of association cortex in a mammal |
| RU2680526C1 (ru) * | 2016-07-05 | 2019-02-22 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) | Нейропротекторное средство, обладающее свойствами антиоксиданта и донатора оксида азота |
| CA3031528A1 (en) * | 2016-08-01 | 2018-02-08 | Cognoptix, Inc. | System and method for detecting tau protein in ocular tissue |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE795970A (fr) * | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
| US4029792A (en) * | 1972-02-29 | 1977-06-14 | Pfizer Inc. | (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents |
| US5210076A (en) * | 1988-09-13 | 1993-05-11 | Berliner David L | Methods of treating Parkinson's disease using melanin |
| WO1996037226A2 (en) * | 1995-05-26 | 1996-11-28 | Pfizer Inc. | Combinations for the treatment of parkinsonism containing selective nmda antagonists |
| US6194415B1 (en) * | 1995-06-28 | 2001-02-27 | Allergan Sales, Inc. | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
| US6841684B2 (en) * | 1997-12-04 | 2005-01-11 | Allergan, Inc. | Imidiazoles having reduced side effects |
| DE69823868T2 (de) * | 1997-12-04 | 2005-04-21 | Allergan Inc | Substituierte imidazole derivate mit agonistischähnlicher wirkung auf die alpha 2b oder 2b/2c adrenergischen rezeptoren |
| US6329369B1 (en) * | 1997-12-04 | 2001-12-11 | Allergan Sales, Inc. | Methods of treating pain and other conditions |
| US6313172B1 (en) * | 2000-04-13 | 2001-11-06 | Allergan Sales, Inc. | Methods and compositions for modulating alpha adrenergic receptor activity |
| CA2402405C (en) * | 2000-07-14 | 2008-02-12 | Allergan Sales, Inc. | Compositions containing alpha-2-adrenergic agonist components |
-
2003
- 2003-10-07 PL PL03376347A patent/PL376347A1/xx not_active Application Discontinuation
- 2003-10-07 US US10/680,996 patent/US20040116436A1/en not_active Abandoned
- 2003-10-07 CN CNB2003801011164A patent/CN100370988C/zh not_active Expired - Fee Related
- 2003-10-07 RU RU2005114505/14A patent/RU2332218C2/ru not_active IP Right Cessation
- 2003-10-07 WO PCT/US2003/031842 patent/WO2004032934A1/en not_active Ceased
- 2003-10-07 MX MXPA05003665A patent/MXPA05003665A/es active IP Right Grant
- 2003-10-07 ES ES03773199T patent/ES2297233T3/es not_active Expired - Lifetime
- 2003-10-07 NZ NZ539329A patent/NZ539329A/en not_active IP Right Cessation
- 2003-10-07 DE DE60318081T patent/DE60318081T2/de not_active Expired - Lifetime
- 2003-10-07 BR BR0314541-7A patent/BR0314541A/pt not_active IP Right Cessation
- 2003-10-07 KR KR1020057006115A patent/KR20050056235A/ko not_active Ceased
- 2003-10-07 CA CA002501348A patent/CA2501348A1/en not_active Abandoned
- 2003-10-07 AT AT03773199T patent/ATE380551T1/de not_active IP Right Cessation
- 2003-10-07 JP JP2004543508A patent/JP2006504741A/ja active Pending
- 2003-10-07 HK HK06100172.4A patent/HK1080408B/en not_active IP Right Cessation
- 2003-10-07 AU AU2003279874A patent/AU2003279874A1/en not_active Abandoned
- 2003-10-07 EP EP03773199A patent/EP1549314B1/en not_active Expired - Lifetime
-
2005
- 2005-04-04 IL IL167848A patent/IL167848A/en not_active IP Right Cessation
- 2005-04-04 NO NO20051664A patent/NO20051664L/no not_active Application Discontinuation
- 2005-04-05 ZA ZA200502745A patent/ZA200502745B/en unknown
-
2010
- 2010-02-26 AU AU2010200730A patent/AU2010200730A1/en not_active Abandoned
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