JP2006504629A5 - - Google Patents
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- JP2006504629A5 JP2006504629A5 JP2003586143A JP2003586143A JP2006504629A5 JP 2006504629 A5 JP2006504629 A5 JP 2006504629A5 JP 2003586143 A JP2003586143 A JP 2003586143A JP 2003586143 A JP2003586143 A JP 2003586143A JP 2006504629 A5 JP2006504629 A5 JP 2006504629A5
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- JP
- Japan
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- pharmaceutical composition
- compound according
- pharmaceutically acceptable
- acceptable salt
- compound
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- 150000001875 compounds Chemical class 0.000 claims 40
- 239000008194 pharmaceutical composition Substances 0.000 claims 29
- 150000003839 salts Chemical class 0.000 claims 25
- 239000004480 active ingredient Substances 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 238000010276 construction Methods 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 9
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 108010041356 Estrogen Receptor beta Proteins 0.000 claims 4
- 102100038595 Estrogen receptor Human genes 0.000 claims 4
- 101710196141 Estrogen receptor Proteins 0.000 claims 4
- 102100029951 Estrogen receptor beta Human genes 0.000 claims 4
- 206010060862 Prostate cancer Diseases 0.000 claims 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 4
- 229910052794 bromium Inorganic materials 0.000 claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 229910052740 iodine Inorganic materials 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 108090000695 Cytokines Proteins 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 3
- 102000004889 Interleukin-6 Human genes 0.000 claims 3
- 108090001005 Interleukin-6 Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 108020005497 Nuclear hormone receptor Proteins 0.000 claims 3
- 102000007399 Nuclear hormone receptor Human genes 0.000 claims 3
- 206010003246 arthritis Diseases 0.000 claims 3
- 210000002449 bone cell Anatomy 0.000 claims 3
- 208000019664 bone resorption disease Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
- 201000009273 Endometriosis Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 206010062767 Hypophysitis Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 210000004204 blood vessel Anatomy 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 210000000481 breast Anatomy 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 210000000918 epididymis Anatomy 0.000 claims 2
- 201000010063 epididymitis Diseases 0.000 claims 2
- 229940011871 estrogen Drugs 0.000 claims 2
- 239000000262 estrogen Substances 0.000 claims 2
- 210000001508 eye Anatomy 0.000 claims 2
- 230000006870 function Effects 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 230000014509 gene expression Effects 0.000 claims 2
- 210000002216 heart Anatomy 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 210000001320 hippocampus Anatomy 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 210000003016 hypothalamus Anatomy 0.000 claims 2
- 210000000987 immune system Anatomy 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 210000003635 pituitary gland Anatomy 0.000 claims 2
- 210000002307 prostate Anatomy 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 210000001550 testis Anatomy 0.000 claims 2
- 210000003932 urinary bladder Anatomy 0.000 claims 2
- 210000004291 uterus Anatomy 0.000 claims 2
- 125000004768 (C1-C4) alkylsulfinyl group Chemical group 0.000 claims 1
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000000044 Amnesia Diseases 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 206010065687 Bone loss Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000002177 Cataract Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 229940126062 Compound A Drugs 0.000 claims 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- 206010020112 Hirsutism Diseases 0.000 claims 1
- 208000033830 Hot Flashes Diseases 0.000 claims 1
- 206010060800 Hot flush Diseases 0.000 claims 1
- 208000037147 Hypercalcaemia Diseases 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 201000002980 Hyperparathyroidism Diseases 0.000 claims 1
- 208000006001 Hypothalamic Neoplasms Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 206010027304 Menopausal symptoms Diseases 0.000 claims 1
- 206010027951 Mood swings Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000010191 Osteitis Deformans Diseases 0.000 claims 1
- 208000003076 Osteolysis Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 208000027868 Paget disease Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 230000005907 cancer growth Effects 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 230000001335 demethylating effect Effects 0.000 claims 1
- 230000001627 detrimental effect Effects 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 230000002500 effect on skin Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000003256 environmental substance Substances 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 230000003054 hormonal effect Effects 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000000148 hypercalcaemia Effects 0.000 claims 1
- 208000030915 hypercalcemia disease Diseases 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 208000029791 lytic metastatic bone lesion Diseases 0.000 claims 1
- 208000027202 mammary Paget disease Diseases 0.000 claims 1
- 230000006984 memory degeneration Effects 0.000 claims 1
- 208000023060 memory loss Diseases 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 230000000399 orthopedic effect Effects 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000021595 spermatogenesis Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 230000009441 vascular protection Effects 0.000 claims 1
- 0 *c(cc(C(F)(F)F)cc1)c1C(C(Oc1c2)=O)=C(Cc(cc3)ccc3OCCN3CCCC3)c1ccc2O Chemical compound *c(cc(C(F)(F)F)cc1)c1C(C(Oc1c2)=O)=C(Cc(cc3)ccc3OCCN3CCCC3)c1ccc2O 0.000 description 2
- VPQPTNUJICRRJP-UHFFFAOYSA-N Oc1ccc(C(Cc(cc2)ccc2OCCN2CCCC2)=C(c(cc2)ccc2Cl)C(O2)=O)c2c1 Chemical compound Oc1ccc(C(Cc(cc2)ccc2OCCN2CCCC2)=C(c(cc2)ccc2Cl)C(O2)=O)c2c1 VPQPTNUJICRRJP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/125,965 US6620838B1 (en) | 2002-04-19 | 2002-04-19 | Benzopyrazone compounds, compositions thereof, and methods of treatment therewith |
| US10/412,997 US20040092572A1 (en) | 2002-04-19 | 2003-04-14 | Benzopyranone compounds, compositions thereof, and methods of treatment therewith |
| PCT/US2003/012283 WO2003089422A1 (en) | 2002-04-19 | 2003-04-18 | Benzopyranone compounds, compositions thereof, and methods of treatment therewith |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006504629A JP2006504629A (ja) | 2006-02-09 |
| JP2006504629A5 true JP2006504629A5 (enExample) | 2006-06-08 |
Family
ID=29254002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003586143A Pending JP2006504629A (ja) | 2002-04-19 | 2003-04-18 | ベンゾピラノン化合物、その組成物およびそれを使用する治療方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20070015817A1 (enExample) |
| EP (1) | EP1497277A1 (enExample) |
| JP (1) | JP2006504629A (enExample) |
| CN (1) | CN100436440C (enExample) |
| AU (1) | AU2003239155B2 (enExample) |
| CA (1) | CA2482986A1 (enExample) |
| IL (1) | IL164662A0 (enExample) |
| MX (1) | MXPA04010433A (enExample) |
| NZ (1) | NZ536291A (enExample) |
| WO (1) | WO2003089422A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7091235B2 (en) * | 2002-10-15 | 2006-08-15 | Signal Pharmaceuticals, Llc | Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer |
| WO2006125324A1 (en) * | 2005-05-27 | 2006-11-30 | Queen's University At Kingston | Treatment of protein folding disorders |
| AU2006262190A1 (en) * | 2005-06-24 | 2007-01-04 | Signal Pharmaceuticals, Llc. | Benzopyranone compounds for treating cancer |
| GB0607389D0 (en) * | 2006-04-12 | 2006-05-24 | Novartis Ag | Organic compounds |
| CA2679629A1 (en) * | 2007-02-27 | 2008-09-04 | Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services | Use of histone deacetylase inhibitors for the treatment of central nervous system metastases |
| CN101627989B (zh) * | 2009-06-18 | 2011-12-07 | 中国人民解放军第二军医大学 | 一种小分子有机化合物jfd-03169在制备抗肿瘤药物中的用途 |
| US9138309B2 (en) | 2010-02-05 | 2015-09-22 | Allergan, Inc. | Porous materials, methods of making and uses |
| US9205577B2 (en) * | 2010-02-05 | 2015-12-08 | Allergan, Inc. | Porogen compositions, methods of making and uses |
| US11202853B2 (en) * | 2010-05-11 | 2021-12-21 | Allergan, Inc. | Porogen compositions, methods of making and uses |
| TWI702219B (zh) * | 2018-07-12 | 2020-08-21 | 美商美國禮來大藥廠 | 選擇性雌激素受體降解劑 |
| MX2021000377A (es) * | 2018-07-12 | 2021-03-25 | Lilly Co Eli | Degradadores selectivos del receptor de estrogeno. |
| CA3127291A1 (en) * | 2019-02-11 | 2020-08-20 | Saganatura Ehf. | Method for enhancing .beta.-adrenergic response |
| CN118005596A (zh) * | 2023-05-24 | 2024-05-10 | 内蒙古大学 | 一种钯催化制备β-榄香烯色满醇类衍生物的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE248157T1 (de) * | 1998-12-30 | 2003-09-15 | Signal Pharm Inc | Verbindungen und verfahren zur modulation von estrogen rezeptoren |
| US6331562B1 (en) * | 1998-12-30 | 2001-12-18 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
| US6291456B1 (en) * | 1998-12-30 | 2001-09-18 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
| AU781282B2 (en) * | 1999-12-30 | 2005-05-12 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
-
2003
- 2003-04-18 AU AU2003239155A patent/AU2003239155B2/en not_active Expired - Fee Related
- 2003-04-18 WO PCT/US2003/012283 patent/WO2003089422A1/en not_active Ceased
- 2003-04-18 NZ NZ536291A patent/NZ536291A/en unknown
- 2003-04-18 CA CA002482986A patent/CA2482986A1/en not_active Abandoned
- 2003-04-18 JP JP2003586143A patent/JP2006504629A/ja active Pending
- 2003-04-18 EP EP03733871A patent/EP1497277A1/en not_active Withdrawn
- 2003-04-18 CN CNB038136961A patent/CN100436440C/zh not_active Expired - Fee Related
- 2003-04-18 MX MXPA04010433A patent/MXPA04010433A/es active IP Right Grant
-
2004
- 2004-10-18 IL IL16466204A patent/IL164662A0/xx unknown
-
2006
- 2006-09-18 US US11/523,373 patent/US20070015817A1/en not_active Abandoned
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