CN100436440C - 苯并吡喃酮化合物、其组合物以及其治疗方法 - Google Patents

苯并吡喃酮化合物、其组合物以及其治疗方法 Download PDF

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Publication number
CN100436440C
CN100436440C CNB038136961A CN03813696A CN100436440C CN 100436440 C CN100436440 C CN 100436440C CN B038136961 A CNB038136961 A CN B038136961A CN 03813696 A CN03813696 A CN 03813696A CN 100436440 C CN100436440 C CN 100436440C
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China
Prior art keywords
compound
acceptable salt
pharmaceutically acceptable
cancer
cells
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Expired - Fee Related
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CNB038136961A
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English (en)
Chinese (zh)
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CN1659159A (zh
Inventor
J·A·麦基
S·S·巴瓦特
J·雷诺
M·米斯巴赫
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Novartis AG
Signal Pharmaceuticals LLC
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Novartis AG
Signal Pharmaceuticals LLC
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Priority claimed from US10/125,965 external-priority patent/US6620838B1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • A—HUMAN NECESSITIES
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    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Public Health (AREA)
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  • Engineering & Computer Science (AREA)
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  • Endocrinology (AREA)
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  • Hematology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
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  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
CNB038136961A 2002-04-19 2003-04-18 苯并吡喃酮化合物、其组合物以及其治疗方法 Expired - Fee Related CN100436440C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/125,965 US6620838B1 (en) 2002-04-19 2002-04-19 Benzopyrazone compounds, compositions thereof, and methods of treatment therewith
US10/125,965 2002-04-19
US10/412,997 US20040092572A1 (en) 2002-04-19 2003-04-14 Benzopyranone compounds, compositions thereof, and methods of treatment therewith
US10/412,997 2003-04-14

Publications (2)

Publication Number Publication Date
CN1659159A CN1659159A (zh) 2005-08-24
CN100436440C true CN100436440C (zh) 2008-11-26

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CNB038136961A Expired - Fee Related CN100436440C (zh) 2002-04-19 2003-04-18 苯并吡喃酮化合物、其组合物以及其治疗方法

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Country Link
US (1) US20070015817A1 (enExample)
EP (1) EP1497277A1 (enExample)
JP (1) JP2006504629A (enExample)
CN (1) CN100436440C (enExample)
AU (1) AU2003239155B2 (enExample)
CA (1) CA2482986A1 (enExample)
IL (1) IL164662A0 (enExample)
MX (1) MXPA04010433A (enExample)
NZ (1) NZ536291A (enExample)
WO (1) WO2003089422A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091235B2 (en) * 2002-10-15 2006-08-15 Signal Pharmaceuticals, Llc Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer
WO2006125324A1 (en) * 2005-05-27 2006-11-30 Queen's University At Kingston Treatment of protein folding disorders
AU2006262190A1 (en) * 2005-06-24 2007-01-04 Signal Pharmaceuticals, Llc. Benzopyranone compounds for treating cancer
GB0607389D0 (en) * 2006-04-12 2006-05-24 Novartis Ag Organic compounds
CA2679629A1 (en) * 2007-02-27 2008-09-04 Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services Use of histone deacetylase inhibitors for the treatment of central nervous system metastases
CN101627989B (zh) * 2009-06-18 2011-12-07 中国人民解放军第二军医大学 一种小分子有机化合物jfd-03169在制备抗肿瘤药物中的用途
US9138309B2 (en) 2010-02-05 2015-09-22 Allergan, Inc. Porous materials, methods of making and uses
US9205577B2 (en) * 2010-02-05 2015-12-08 Allergan, Inc. Porogen compositions, methods of making and uses
US11202853B2 (en) * 2010-05-11 2021-12-21 Allergan, Inc. Porogen compositions, methods of making and uses
TWI702219B (zh) * 2018-07-12 2020-08-21 美商美國禮來大藥廠 選擇性雌激素受體降解劑
MX2021000377A (es) * 2018-07-12 2021-03-25 Lilly Co Eli Degradadores selectivos del receptor de estrogeno.
CA3127291A1 (en) * 2019-02-11 2020-08-20 Saganatura Ehf. Method for enhancing .beta.-adrenergic response
CN118005596A (zh) * 2023-05-24 2024-05-10 内蒙古大学 一种钯催化制备β-榄香烯色满醇类衍生物的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001049673A2 (en) * 1999-12-30 2001-07-12 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE248157T1 (de) * 1998-12-30 2003-09-15 Signal Pharm Inc Verbindungen und verfahren zur modulation von estrogen rezeptoren
US6331562B1 (en) * 1998-12-30 2001-12-18 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
US6291456B1 (en) * 1998-12-30 2001-09-18 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001049673A2 (en) * 1999-12-30 2001-07-12 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors

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Publication number Publication date
US20070015817A1 (en) 2007-01-18
EP1497277A1 (en) 2005-01-19
MXPA04010433A (es) 2005-08-19
NZ536291A (en) 2006-09-29
WO2003089422A1 (en) 2003-10-30
JP2006504629A (ja) 2006-02-09
CA2482986A1 (en) 2003-10-30
AU2003239155A1 (en) 2003-11-03
CN1659159A (zh) 2005-08-24
IL164662A0 (en) 2005-12-18
AU2003239155B2 (en) 2008-12-04

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