JP2006504629A - ベンゾピラノン化合物、その組成物およびそれを使用する治療方法 - Google Patents

ベンゾピラノン化合物、その組成物およびそれを使用する治療方法 Download PDF

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JP2006504629A
JP2006504629A JP2003586143A JP2003586143A JP2006504629A JP 2006504629 A JP2006504629 A JP 2006504629A JP 2003586143 A JP2003586143 A JP 2003586143A JP 2003586143 A JP2003586143 A JP 2003586143A JP 2006504629 A JP2006504629 A JP 2006504629A
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compound
pharmaceutically acceptable
acceptable salt
cancer
cell
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JP2006504629A5 (enExample
Inventor
マッキー，ジェフリー，エー．
ブハグワット，シュリパッド，エス．
レナウド，ヨハンヌ
ミスバッハ，マーティン
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シグナル ファーマシューティカルズ，エルエルシー
ノバルティス アーゲー
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Priority claimed from US10/125,965 external-priority patent/US6620838B1/en
Application filed by シグナル ファーマシューティカルズ，エルエルシー, ノバルティス アーゲー filed Critical シグナル ファーマシューティカルズ，エルエルシー
Publication of JP2006504629A publication Critical patent/JP2006504629A/ja
Publication of JP2006504629A5 publication Critical patent/JP2006504629A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
JP2003586143A 2002-04-19 2003-04-18 ベンゾピラノン化合物、その組成物およびそれを使用する治療方法 Pending JP2006504629A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/125,965 US6620838B1 (en) 2002-04-19 2002-04-19 Benzopyrazone compounds, compositions thereof, and methods of treatment therewith
US10/412,997 US20040092572A1 (en) 2002-04-19 2003-04-14 Benzopyranone compounds, compositions thereof, and methods of treatment therewith
PCT/US2003/012283 WO2003089422A1 (en) 2002-04-19 2003-04-18 Benzopyranone compounds, compositions thereof, and methods of treatment therewith

Publications (2)

Publication Number Publication Date
JP2006504629A true JP2006504629A (ja) 2006-02-09
JP2006504629A5 JP2006504629A5 (enExample) 2006-06-08

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JP2003586143A Pending JP2006504629A (ja) 2002-04-19 2003-04-18 ベンゾピラノン化合物、その組成物およびそれを使用する治療方法

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Country Link
US (1) US20070015817A1 (enExample)
EP (1) EP1497277A1 (enExample)
JP (1) JP2006504629A (enExample)
CN (1) CN100436440C (enExample)
AU (1) AU2003239155B2 (enExample)
CA (1) CA2482986A1 (enExample)
IL (1) IL164662A0 (enExample)
MX (1) MXPA04010433A (enExample)
NZ (1) NZ536291A (enExample)
WO (1) WO2003089422A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021530486A (ja) * 2018-07-12 2021-11-11 イーライ リリー アンド カンパニー 選択的エストロゲン受容体分解剤

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091235B2 (en) * 2002-10-15 2006-08-15 Signal Pharmaceuticals, Llc Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer
WO2006125324A1 (en) * 2005-05-27 2006-11-30 Queen's University At Kingston Treatment of protein folding disorders
AU2006262190A1 (en) * 2005-06-24 2007-01-04 Signal Pharmaceuticals, Llc. Benzopyranone compounds for treating cancer
GB0607389D0 (en) * 2006-04-12 2006-05-24 Novartis Ag Organic compounds
CA2679629A1 (en) * 2007-02-27 2008-09-04 Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services Use of histone deacetylase inhibitors for the treatment of central nervous system metastases
CN101627989B (zh) * 2009-06-18 2011-12-07 中国人民解放军第二军医大学 一种小分子有机化合物jfd-03169在制备抗肿瘤药物中的用途
US9138309B2 (en) 2010-02-05 2015-09-22 Allergan, Inc. Porous materials, methods of making and uses
US9205577B2 (en) * 2010-02-05 2015-12-08 Allergan, Inc. Porogen compositions, methods of making and uses
US11202853B2 (en) * 2010-05-11 2021-12-21 Allergan, Inc. Porogen compositions, methods of making and uses
TWI702219B (zh) * 2018-07-12 2020-08-21 美商美國禮來大藥廠 選擇性雌激素受體降解劑
CA3127291A1 (en) * 2019-02-11 2020-08-20 Saganatura Ehf. Method for enhancing .beta.-adrenergic response
CN118005596A (zh) * 2023-05-24 2024-05-10 内蒙古大学 一种钯催化制备β-榄香烯色满醇类衍生物的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001049673A2 (en) * 1999-12-30 2001-07-12 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE248157T1 (de) * 1998-12-30 2003-09-15 Signal Pharm Inc Verbindungen und verfahren zur modulation von estrogen rezeptoren
US6331562B1 (en) * 1998-12-30 2001-12-18 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
US6291456B1 (en) * 1998-12-30 2001-09-18 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001049673A2 (en) * 1999-12-30 2001-07-12 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021530486A (ja) * 2018-07-12 2021-11-11 イーライ リリー アンド カンパニー 選択的エストロゲン受容体分解剤
JP7085056B2 (ja) 2018-07-12 2022-06-15 イーライ リリー アンド カンパニー 選択的エストロゲン受容体分解剤

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US20070015817A1 (en) 2007-01-18
EP1497277A1 (en) 2005-01-19
MXPA04010433A (es) 2005-08-19
NZ536291A (en) 2006-09-29
CN100436440C (zh) 2008-11-26
WO2003089422A1 (en) 2003-10-30
CA2482986A1 (en) 2003-10-30
AU2003239155A1 (en) 2003-11-03
CN1659159A (zh) 2005-08-24
IL164662A0 (en) 2005-12-18
AU2003239155B2 (en) 2008-12-04

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