JP2006504452A - コラーゲンを主成分とした椎間板増強材料及び増強方法 - Google Patents
コラーゲンを主成分とした椎間板増強材料及び増強方法 Download PDFInfo
- Publication number
- JP2006504452A JP2006504452A JP2004537942A JP2004537942A JP2006504452A JP 2006504452 A JP2006504452 A JP 2006504452A JP 2004537942 A JP2004537942 A JP 2004537942A JP 2004537942 A JP2004537942 A JP 2004537942A JP 2006504452 A JP2006504452 A JP 2006504452A
- Authority
- JP
- Japan
- Prior art keywords
- collagen
- based material
- intervertebral disc
- disc
- injected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 102000008186 Collagen Human genes 0.000 title claims abstract description 89
- 108010035532 Collagen Proteins 0.000 title claims abstract description 89
- 229920001436 collagen Polymers 0.000 title claims abstract description 89
- 238000000034 method Methods 0.000 title claims abstract description 40
- 239000002245 particle Substances 0.000 claims abstract description 29
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- 229940088710 antibiotic agent Drugs 0.000 claims abstract description 4
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- 239000000203 mixture Substances 0.000 claims description 15
- 239000000725 suspension Substances 0.000 claims description 13
- 230000003190 augmentative effect Effects 0.000 claims description 12
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- 238000009472 formulation Methods 0.000 claims description 10
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- 238000002347 injection Methods 0.000 abstract description 44
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- 238000002513 implantation Methods 0.000 abstract description 3
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- 239000000730 antalgic agent Substances 0.000 abstract description 2
- 210000003195 fascia Anatomy 0.000 description 21
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 15
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- 239000002609 medium Substances 0.000 description 10
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- 210000002805 bone matrix Anatomy 0.000 description 8
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- MIKKOBKEXMRYFQ-WZTVWXICSA-N meglumine amidotrizoate Chemical compound C[NH2+]C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C([O-])=O)=C1I MIKKOBKEXMRYFQ-WZTVWXICSA-N 0.000 description 2
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- OCKGFTQIICXDQW-ZEQRLZLVSA-N 5-[(1r)-1-hydroxy-2-[4-[(2r)-2-hydroxy-2-(4-methyl-1-oxo-3h-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methyl-3h-2-benzofuran-1-one Chemical compound C1=C2C(=O)OCC2=C(C)C([C@@H](O)CN2CCN(CC2)C[C@H](O)C2=CC=C3C(=O)OCC3=C2C)=C1 OCKGFTQIICXDQW-ZEQRLZLVSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010061246 Intervertebral disc degeneration Diseases 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 210000001361 achilles tendon Anatomy 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- 210000001264 anterior cruciate ligament Anatomy 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
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- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000012669 compression test Methods 0.000 description 1
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- 239000003193 general anesthetic agent Substances 0.000 description 1
- 230000000887 hydrating effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 208000021600 intervertebral disc degenerative disease Diseases 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 210000000426 patellar ligament Anatomy 0.000 description 1
- 210000002967 posterior cruciate ligament Anatomy 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000012846 protein folding Effects 0.000 description 1
- 230000004850 protein–protein interaction Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
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- 238000007789 sealing Methods 0.000 description 1
- 210000001032 spinal nerve Anatomy 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 238000010947 wet-dispersion method Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Surgical Instruments (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/245,955 US20040054414A1 (en) | 2002-09-18 | 2002-09-18 | Collagen-based materials and methods for augmenting intervertebral discs |
| PCT/US2003/029278 WO2004026189A2 (en) | 2002-09-18 | 2003-09-16 | Collagen-based materials and methods for augmenting intervertebral discs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006504452A true JP2006504452A (ja) | 2006-02-09 |
| JP2006504452A5 JP2006504452A5 (https=) | 2006-11-02 |
Family
ID=35529845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004537942A Pending JP2006504452A (ja) | 2002-09-18 | 2003-09-16 | コラーゲンを主成分とした椎間板増強材料及び増強方法 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1620045A2 (https=) |
| JP (1) | JP2006504452A (https=) |
| KR (1) | KR20050057442A (https=) |
| CN (1) | CN101198297A (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007502653A (ja) * | 2003-08-21 | 2007-02-15 | ウォーソー・オーソペディック・インコーポレーテッド | 椎間円板移植片 |
| JP2013508116A (ja) * | 2009-10-27 | 2013-03-07 | スパイン ウェイブ，インコーポレーテッド | 放射線不透過性の注入可能核ヒドロゲル組成物 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019151444A1 (ja) * | 2018-01-31 | 2019-08-08 | 国立大学法人神戸大学 | 椎間板変性の治療剤および椎間板細胞培養材 |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63119772A (ja) * | 1986-06-25 | 1988-05-24 | コラ−ゲン コ−ポレ−シヨン | 改善された侵入可能性を有する注射可能な注入組成物 |
| JPH05508795A (ja) * | 1990-12-21 | 1993-12-09 | ハウメディカ・インコーポレーテッド | ヒドロゲル製椎間板髄核 |
| JPH06319760A (ja) * | 1993-04-21 | 1994-11-22 | Sulzer Medizinaltechnik Ag | 椎間人工器官及びその移植方法 |
| JPH0898851A (ja) * | 1994-09-08 | 1996-04-16 | Howmedica Inc | ヒドロゲル椎間円板核 |
| JPH08336583A (ja) * | 1995-06-07 | 1996-12-24 | Collagn Corp | 硬組織の修復および増強用の成形可能なコラーゲン組成物 |
| JPH10507386A (ja) * | 1994-10-17 | 1998-07-21 | レイメディカ， インコーポレイテッド | 人工脊椎円板核 |
| WO2002017825A2 (en) * | 2000-08-28 | 2002-03-07 | Disc Dynamics, Inc. | Intervertebral disc prosthesis |
| JP2002516156A (ja) * | 1998-05-29 | 2002-06-04 | アドバンスト バイオ サーフェイシズ，インコーポレイティド | 移植可能な組織修復装置 |
| JP2002516712A (ja) * | 1998-06-04 | 2002-06-11 | レイメディカ・インコーポレイテッド | テーパー状のプロテーゼ脊髄椎間板核 |
| JP2005511207A (ja) * | 2001-12-10 | 2005-04-28 | コルバー・ライフサイエンス・リミテッド | 椎間板治療の方法、デバイス、及び調製物 |
-
2003
- 2003-09-16 KR KR1020057004664A patent/KR20050057442A/ko not_active Ceased
- 2003-09-16 JP JP2004537942A patent/JP2006504452A/ja active Pending
- 2003-09-16 CN CNA038251973A patent/CN101198297A/zh active Pending
- 2003-09-16 EP EP03749741A patent/EP1620045A2/en not_active Withdrawn
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63119772A (ja) * | 1986-06-25 | 1988-05-24 | コラ−ゲン コ−ポレ−シヨン | 改善された侵入可能性を有する注射可能な注入組成物 |
| JPH05508795A (ja) * | 1990-12-21 | 1993-12-09 | ハウメディカ・インコーポレーテッド | ヒドロゲル製椎間板髄核 |
| JPH06319760A (ja) * | 1993-04-21 | 1994-11-22 | Sulzer Medizinaltechnik Ag | 椎間人工器官及びその移植方法 |
| JPH0898851A (ja) * | 1994-09-08 | 1996-04-16 | Howmedica Inc | ヒドロゲル椎間円板核 |
| JPH10507386A (ja) * | 1994-10-17 | 1998-07-21 | レイメディカ， インコーポレイテッド | 人工脊椎円板核 |
| JPH08336583A (ja) * | 1995-06-07 | 1996-12-24 | Collagn Corp | 硬組織の修復および増強用の成形可能なコラーゲン組成物 |
| JP2002516156A (ja) * | 1998-05-29 | 2002-06-04 | アドバンスト バイオ サーフェイシズ，インコーポレイティド | 移植可能な組織修復装置 |
| JP2002516712A (ja) * | 1998-06-04 | 2002-06-11 | レイメディカ・インコーポレイテッド | テーパー状のプロテーゼ脊髄椎間板核 |
| WO2002017825A2 (en) * | 2000-08-28 | 2002-03-07 | Disc Dynamics, Inc. | Intervertebral disc prosthesis |
| JP2005511207A (ja) * | 2001-12-10 | 2005-04-28 | コルバー・ライフサイエンス・リミテッド | 椎間板治療の方法、デバイス、及び調製物 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007502653A (ja) * | 2003-08-21 | 2007-02-15 | ウォーソー・オーソペディック・インコーポレーテッド | 椎間円板移植片 |
| JP2013508116A (ja) * | 2009-10-27 | 2013-03-07 | スパイン ウェイブ，インコーポレーテッド | 放射線不透過性の注入可能核ヒドロゲル組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101198297A (zh) | 2008-06-11 |
| KR20050057442A (ko) | 2005-06-16 |
| EP1620045A2 (en) | 2006-02-01 |
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| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20100405 |
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| A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20100611 |