JP2006502974A - 置換環縮合イミダゾール誘導体：ｇａｂａａ受容体リガンド - Google Patents
置換環縮合イミダゾール誘導体：ｇａｂａａ受容体リガンド Download PDFInfo
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- JP2006502974A JP2006502974A JP2004505375A JP2004505375A JP2006502974A JP 2006502974 A JP2006502974 A JP 2006502974A JP 2004505375 A JP2004505375 A JP 2004505375A JP 2004505375 A JP2004505375 A JP 2004505375A JP 2006502974 A JP2006502974 A JP 2006502974A
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38130202P | 2002-05-17 | 2002-05-17 | |
| PCT/US2003/015578 WO2003097643A1 (fr) | 2002-05-17 | 2003-05-15 | Derives d'imidazole a cycles fusionnes se fixant aux recepteurs gabaa, ligands des recepteurs gabaa |
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| JP2006502974A true JP2006502974A (ja) | 2006-01-26 |
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Family Applications (1)
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|---|---|---|---|
| JP2004505375A Pending JP2006502974A (ja) | 2002-05-17 | 2003-05-15 | 置換環縮合イミダゾール誘導体：ｇａｂａａ受容体リガンド |
Country Status (9)
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| US (1) | US6916827B2 (fr) |
| EP (1) | EP1506194B1 (fr) |
| JP (1) | JP2006502974A (fr) |
| AT (1) | ATE333455T1 (fr) |
| AU (1) | AU2003237881A1 (fr) |
| CA (1) | CA2486339A1 (fr) |
| DE (1) | DE60306918T2 (fr) |
| ES (1) | ES2273008T3 (fr) |
| WO (1) | WO2003097643A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2537331A1 (fr) * | 2003-07-25 | 2005-02-10 | Neurogen Corporation | Imidazo-pyrimidines et triazolo-pyrimidines: ligands de recepteur de benzodiazepine |
| BRPI0510929A (pt) | 2004-06-18 | 2007-07-17 | Chiron Corp | derivados de n-(1-(1-benzil-4-fenil-1h-imidazol-2-il)-2,2-dimetilpropil) benzamida e compostos relacionados como inibidores de proteìna de eixo de kinesin (ksp) para o tratamento de cáncer |
| US7820646B2 (en) | 2007-01-05 | 2010-10-26 | Novartis Vaccines And Diagnostics, Inc. | Cyclized derivatives as Eg-5 inhibitors |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4812462A (en) * | 1986-04-01 | 1989-03-14 | Warner-Lambert Company | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity |
| CA2004911A1 (fr) | 1988-12-22 | 1990-06-22 | Mitsuaki Ohta | Derives de 4,5,6,7-tetrahydrobenzimidazole |
| US5130302A (en) | 1989-12-20 | 1992-07-14 | Boron Bilogicals, Inc. | Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same |
| US5362732A (en) | 1989-12-20 | 1994-11-08 | University Of North Carolina At Chapel Hill | Boronated compounds |
| US5262537A (en) * | 1993-03-19 | 1993-11-16 | Anaquest, Inc. | Derivatives of 4,5,6,7-tetrahydroimidazo-[4,5-c]pyridinyl-6-carboxylic acid |
| AU717630B2 (en) | 1995-06-05 | 2000-03-30 | Neurogen Corporation | Novel substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands |
| US5637725A (en) * | 1995-06-05 | 1997-06-10 | Neurogen Corporation | Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands |
| US6211365B1 (en) * | 1996-01-19 | 2001-04-03 | Neurogen Corporation | Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands |
| US5804686A (en) * | 1996-01-19 | 1998-09-08 | Neurogen Corporation | fused pyrrolecarboxamides; a new class of GABA brain receptor ligands |
| US5789416B1 (en) | 1996-08-27 | 1999-10-05 | Cv Therapeutics Inc | N6 mono heterocyclic substituted adenosine derivatives |
| JP3619017B2 (ja) | 1998-06-24 | 2005-02-09 | 日本臓器製薬株式会社 | 新規アラビノシルアデニン誘導体 |
| US6552037B2 (en) | 2000-06-30 | 2003-04-22 | Neurogen Corporation | 2-Substituted imidazo[1,2-A]pyridine derivatives |
| PA8535601A1 (es) * | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
-
2003
- 2003-05-15 CA CA002486339A patent/CA2486339A1/fr not_active Abandoned
- 2003-05-15 AU AU2003237881A patent/AU2003237881A1/en not_active Abandoned
- 2003-05-15 JP JP2004505375A patent/JP2006502974A/ja active Pending
- 2003-05-15 WO PCT/US2003/015578 patent/WO2003097643A1/fr active IP Right Grant
- 2003-05-15 DE DE60306918T patent/DE60306918T2/de not_active Expired - Fee Related
- 2003-05-15 EP EP03736638A patent/EP1506194B1/fr not_active Expired - Lifetime
- 2003-05-15 AT AT03736638T patent/ATE333455T1/de not_active IP Right Cessation
- 2003-05-15 ES ES03736638T patent/ES2273008T3/es not_active Expired - Lifetime
- 2003-05-15 US US10/438,496 patent/US6916827B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6916827B2 (en) | 2005-07-12 |
| DE60306918D1 (de) | 2006-08-31 |
| AU2003237881A1 (en) | 2003-12-02 |
| WO2003097643A1 (fr) | 2003-11-27 |
| ATE333455T1 (de) | 2006-08-15 |
| US20040014780A1 (en) | 2004-01-22 |
| ES2273008T3 (es) | 2007-05-01 |
| CA2486339A1 (fr) | 2003-11-27 |
| DE60306918T2 (de) | 2007-03-01 |
| EP1506194A1 (fr) | 2005-02-16 |
| EP1506194B1 (fr) | 2006-07-19 |
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