DE60306918D1 - Substituierte, ringkondensierte imidazolderivate: gabaa-rezeptorliganden - Google Patents
Substituierte, ringkondensierte imidazolderivate: gabaa-rezeptorligandenInfo
- Publication number
- DE60306918D1 DE60306918D1 DE60306918T DE60306918T DE60306918D1 DE 60306918 D1 DE60306918 D1 DE 60306918D1 DE 60306918 T DE60306918 T DE 60306918T DE 60306918 T DE60306918 T DE 60306918T DE 60306918 D1 DE60306918 D1 DE 60306918D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- receptors
- gaba
- imidazole derivatives
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003446 ligand Substances 0.000 title abstract 3
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- 102000027484 GABAA receptors Human genes 0.000 title 1
- 108091008681 GABAA receptors Proteins 0.000 title 1
- 210000003169 central nervous system Anatomy 0.000 abstract 4
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 3
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 3
- 241001465754 Metazoa Species 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 244000144972 livestock Species 0.000 abstract 1
- 230000004807 localization Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38130202P | 2002-05-17 | 2002-05-17 | |
| US381302P | 2002-05-17 | ||
| PCT/US2003/015578 WO2003097643A1 (en) | 2002-05-17 | 2003-05-15 | Substituted ring-fused imidazole derivates: gabaa receptor ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60306918D1 true DE60306918D1 (de) | 2006-08-31 |
| DE60306918T2 DE60306918T2 (de) | 2007-03-01 |
Family
ID=29550099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60306918T Expired - Fee Related DE60306918T2 (de) | 2002-05-17 | 2003-05-15 | Substituierte, ringkondensierte imidazolderivate: gabaa-rezeptorliganden |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6916827B2 (de) |
| EP (1) | EP1506194B1 (de) |
| JP (1) | JP2006502974A (de) |
| AT (1) | ATE333455T1 (de) |
| AU (1) | AU2003237881A1 (de) |
| CA (1) | CA2486339A1 (de) |
| DE (1) | DE60306918T2 (de) |
| ES (1) | ES2273008T3 (de) |
| WO (1) | WO2003097643A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004004143T2 (de) * | 2003-07-25 | 2007-10-11 | Neurogen Corp., Branford | Imidazopyrimidine und triazolopyrimidine: benzodiazepinrezeptorliganden |
| JP4836280B2 (ja) | 2004-06-18 | 2011-12-14 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 癌を治療するためのキネシンスピンドルタンパク質（ｋｓｐ）阻害剤としてのｎ−（１−（１−ベンジル−４−フェニル−１ｈ−イミダゾール−２−イル）−２，２−ジメチルプロピル）ベンズアミド誘導体および関連化合物 |
| KR20090097210A (ko) | 2007-01-05 | 2009-09-15 | 노파르티스 아게 | 키네신 방추체 단백질 (ｅｇ－５) 억제제로서의 이미다졸 유도체 |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4812462A (en) * | 1986-04-01 | 1989-03-14 | Warner-Lambert Company | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity |
| CA2004911A1 (en) | 1988-12-22 | 1990-06-22 | Mitsuaki Ohta | 4,5,6,7-tetrahydrobenzimidazole derivatives |
| US5130302A (en) | 1989-12-20 | 1992-07-14 | Boron Bilogicals, Inc. | Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same |
| US5362732A (en) | 1989-12-20 | 1994-11-08 | University Of North Carolina At Chapel Hill | Boronated compounds |
| US5262537A (en) * | 1993-03-19 | 1993-11-16 | Anaquest, Inc. | Derivatives of 4,5,6,7-tetrahydroimidazo-[4,5-c]pyridinyl-6-carboxylic acid |
| EP0830359A1 (de) | 1995-06-05 | 1998-03-25 | Neurogen Corporation | Substituierte aryl und cycloalkyl imidazolone, eine klasse von liganden für gaba-rezeptoren in gehirn |
| US5637725A (en) * | 1995-06-05 | 1997-06-10 | Neurogen Corporation | Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands |
| US5804686A (en) | 1996-01-19 | 1998-09-08 | Neurogen Corporation | fused pyrrolecarboxamides; a new class of GABA brain receptor ligands |
| US6211365B1 (en) * | 1996-01-19 | 2001-04-03 | Neurogen Corporation | Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands |
| US5789416B1 (en) | 1996-08-27 | 1999-10-05 | Cv Therapeutics Inc | N6 mono heterocyclic substituted adenosine derivatives |
| JP3619017B2 (ja) | 1998-06-24 | 2005-02-09 | 日本臓器製薬株式会社 | 新規アラビノシルアデニン誘導体 |
| WO2002002557A2 (en) | 2000-06-30 | 2002-01-10 | Neurogen Corporation | 2-phenylimidazo[1,2-a]pyridine derivatives: a new class of gaba brain receptor ligands |
| PA8535601A1 (es) | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
-
2003
- 2003-05-15 ES ES03736638T patent/ES2273008T3/es not_active Expired - Lifetime
- 2003-05-15 WO PCT/US2003/015578 patent/WO2003097643A1/en active IP Right Grant
- 2003-05-15 EP EP03736638A patent/EP1506194B1/de not_active Expired - Lifetime
- 2003-05-15 US US10/438,496 patent/US6916827B2/en not_active Expired - Fee Related
- 2003-05-15 CA CA002486339A patent/CA2486339A1/en not_active Abandoned
- 2003-05-15 AU AU2003237881A patent/AU2003237881A1/en not_active Abandoned
- 2003-05-15 DE DE60306918T patent/DE60306918T2/de not_active Expired - Fee Related
- 2003-05-15 AT AT03736638T patent/ATE333455T1/de not_active IP Right Cessation
- 2003-05-15 JP JP2004505375A patent/JP2006502974A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2486339A1 (en) | 2003-11-27 |
| JP2006502974A (ja) | 2006-01-26 |
| EP1506194B1 (de) | 2006-07-19 |
| ATE333455T1 (de) | 2006-08-15 |
| AU2003237881A1 (en) | 2003-12-02 |
| WO2003097643A1 (en) | 2003-11-27 |
| EP1506194A1 (de) | 2005-02-16 |
| ES2273008T3 (es) | 2007-05-01 |
| US6916827B2 (en) | 2005-07-12 |
| DE60306918T2 (de) | 2007-03-01 |
| US20040014780A1 (en) | 2004-01-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |