JP2006501273A - ヘテロ環置換インドリノン、その製法及び薬物としてのその使用 - Google Patents

ヘテロ環置換インドリノン、その製法及び薬物としてのその使用 Download PDF

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Publication number
JP2006501273A
JP2006501273A JP2004537020A JP2004537020A JP2006501273A JP 2006501273 A JP2006501273 A JP 2006501273A JP 2004537020 A JP2004537020 A JP 2004537020A JP 2004537020 A JP2004537020 A JP 2004537020A JP 2006501273 A JP2006501273 A JP 2006501273A
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Prior art keywords
group
alkyl
amino
methylene
indolinone
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JP2004537020A
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Japanese (ja)
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JP2006501273A5 (enExample
Inventor
イェルク クライ
アルミン ヘッケル
フランク ヒルベルク
ゲラルト ユールゲン ロス
リンツ トルシュテン レーマン
ラルフ エル ハー ロッツ
グリュント ウルリケ トンチュ
メール ヤコブス セー アー ファン
Original Assignee
ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト
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Priority claimed from DE2002142350 external-priority patent/DE10242350A1/de
Priority claimed from DE10252969A external-priority patent/DE10252969A1/de
Application filed by ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト filed Critical ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト
Publication of JP2006501273A publication Critical patent/JP2006501273A/ja
Publication of JP2006501273A5 publication Critical patent/JP2006501273A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2004537020A 2002-09-12 2003-09-09 ヘテロ環置換インドリノン、その製法及び薬物としてのその使用 Pending JP2006501273A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE2002142350 DE10242350A1 (de) 2002-09-12 2002-09-12 Heterocyclisch substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
DE10252969A DE10252969A1 (de) 2002-11-14 2002-11-14 Heterocyclisch substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
PCT/EP2003/009978 WO2004026829A2 (de) 2002-09-12 2003-09-09 Heterocyclisch substituierte indolinone und deren verwendung als rezeptor-tyrosinkinasen inhibitoren

Publications (2)

Publication Number Publication Date
JP2006501273A true JP2006501273A (ja) 2006-01-12
JP2006501273A5 JP2006501273A5 (enExample) 2006-02-23

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ID=32031471

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JP2004537020A Pending JP2006501273A (ja) 2002-09-12 2003-09-09 ヘテロ環置換インドリノン、その製法及び薬物としてのその使用

Country Status (12)

Country Link
US (1) US7148249B2 (enExample)
EP (1) EP1551830B1 (enExample)
JP (1) JP2006501273A (enExample)
AR (1) AR041194A1 (enExample)
AT (1) ATE427947T1 (enExample)
AU (1) AU2003273842A1 (enExample)
CA (1) CA2498781A1 (enExample)
DE (1) DE50311397D1 (enExample)
ES (1) ES2324710T3 (enExample)
PE (1) PE20041080A1 (enExample)
TW (1) TW200407125A (enExample)
WO (1) WO2004026829A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010502741A (ja) * 2006-09-11 2010-01-28 キュリス，インコーポレイテッド Ｐｔｋインヒビターとしての亜鉛結合部分を含む置換２−インドリノン
JP2010530401A (ja) * 2007-06-21 2010-09-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ インドリン−２−オンおよびアザ−インドリン−２−オン
JP2011504919A (ja) * 2007-12-03 2011-02-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング インドリノン誘導体の製造方法
JP2011505346A (ja) * 2007-12-03 2011-02-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング インドリノン誘導体及びその製造方法
JP2011529470A (ja) * 2008-07-29 2011-12-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規化合物

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US6982260B1 (en) 1999-11-22 2006-01-03 Warner-Lambert Company Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes
EP1330444B1 (en) 2000-11-01 2011-03-23 Millennium Pharmaceuticals, Inc. Nitrogenous heterocyclic compounds and process for making them
US20040204458A1 (en) * 2002-08-16 2004-10-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of Lck inhibitors for treatment of immunologic diseases
ES2305887T3 (es) 2003-12-18 2008-11-01 Janssen Pharmaceutica Nv Derivados de pirido y pirimidopirimidinas como agentes antiproliferativos.
KR100629713B1 (ko) * 2004-04-10 2006-09-29 (주)아모레퍼시픽 펜타에리스리톨 유도체와 이의 제조방법, 및 이를포함하는 액정베이스
NI200700147A (es) 2004-12-08 2019-05-10 Janssen Pharmaceutica Nv Derivados de quinazolina inhibidores de cinasas dirigidos a multip
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
EP2044084B1 (en) 2006-07-13 2016-02-17 Janssen Pharmaceutica NV Mtki quinazoline derivatives
DK2185562T3 (en) 2007-07-27 2016-02-22 Janssen Pharmaceutica Nv PYRROLOPYRIMIDINES SUITABLE FOR TREATING PROLIFERATIVE DISEASES
US8765748B2 (en) 2007-12-21 2014-07-01 University Health Network Indazolyl, benzimidazolyl, benzotriazolyl substituted indolinone derivatives as kinase inhibitors useful in the treatment of cancer
EA020046B1 (ru) * 2008-06-06 2014-08-29 Бёрингер Ингельхайм Интернациональ Гмбх Фармацевтическая комбинация
WO2010115279A1 (en) 2009-04-06 2010-10-14 University Health Network Kinase inhibitors and method of treating cancer with same
JP5442906B2 (ja) 2010-04-06 2014-03-19 ユニバーシティ・ヘルス・ネットワーク キナーゼインヒビターおよびこれを用いた癌の治療方法
WO2012048411A1 (en) * 2010-10-13 2012-04-19 University Health Network Plk-4 inhibitors and method of treating cancer with same
CN103848814B (zh) * 2012-12-06 2016-08-17 山东亨利医药科技有限责任公司 作为酪氨酸激酶抑制剂的取代吲哚满酮衍生物
EP2930167B1 (en) * 2012-12-06 2018-11-21 KBP Biosciences Co., Ltd. An indolinone derivative as tyrosine kinase inhibitor
EP3012248B1 (en) * 2013-06-20 2019-09-11 Institute of Radiation Medicine, Academy of Military Medical Sciences, People's Liberation Army of China Substance having tyrosine kinase inhibitory activity and preparation method and use thereof
CA2927612C (en) 2013-10-18 2022-08-30 University Health Network Treatment for pancreatic cancer
CA3048376A1 (en) 2016-12-27 2018-07-05 Riken Bmp-signal-inhibiting compound
CN112174943A (zh) * 2019-07-03 2021-01-05 四川大学 一种吲哚-2-酮类化合物在制备防治口腔细菌产品中的用途
CN114213396B (zh) * 2022-01-27 2023-03-24 深圳市乐土生物医药有限公司 一种吲哚-2-酮类化合物及其制备方法与用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001016130A1 (de) * 1999-08-27 2001-03-08 Boehringer Ingelheim Pharma Kg Substituierte indolinone als tyrosinkinase inhibitoren
WO2001027081A1 (de) * 1999-10-13 2001-04-19 Boehringer Ingelheim Pharma Kg In 6-stellung substituierte indolinone, ihre herstellung und ihre verwendung als arzneimittel
JP2002525356A (ja) * 1998-09-25 2002-08-13 ベーリンガー インゲルハイム ファルマ コマンディトゲゼルシャフト 新規置換インドリノン、それらの調製及び薬物としてのそれらの使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6762180B1 (en) * 1999-10-13 2004-07-13 Boehringer Ingelheim Pharma Kg Substituted indolines which inhibit receptor tyrosine kinases
DE19949209A1 (de) 1999-10-13 2001-04-19 Boehringer Ingelheim Pharma In 5-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
DE10117204A1 (de) * 2001-04-06 2002-10-10 Boehringer Ingelheim Pharma In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002525356A (ja) * 1998-09-25 2002-08-13 ベーリンガー インゲルハイム ファルマ コマンディトゲゼルシャフト 新規置換インドリノン、それらの調製及び薬物としてのそれらの使用
WO2001016130A1 (de) * 1999-08-27 2001-03-08 Boehringer Ingelheim Pharma Kg Substituierte indolinone als tyrosinkinase inhibitoren
WO2001027081A1 (de) * 1999-10-13 2001-04-19 Boehringer Ingelheim Pharma Kg In 6-stellung substituierte indolinone, ihre herstellung und ihre verwendung als arzneimittel

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010502741A (ja) * 2006-09-11 2010-01-28 キュリス，インコーポレイテッド Ｐｔｋインヒビターとしての亜鉛結合部分を含む置換２−インドリノン
JP2010530401A (ja) * 2007-06-21 2010-09-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ インドリン−２−オンおよびアザ−インドリン−２−オン
JP2011504919A (ja) * 2007-12-03 2011-02-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング インドリノン誘導体の製造方法
JP2011505346A (ja) * 2007-12-03 2011-02-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング インドリノン誘導体及びその製造方法
JP2015071602A (ja) * 2007-12-03 2015-04-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング インドリノン誘導体及びその製造方法
JP2011529470A (ja) * 2008-07-29 2011-12-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規化合物

Also Published As

Publication number Publication date
ATE427947T1 (de) 2009-04-15
PE20041080A1 (es) 2005-02-17
WO2004026829A3 (de) 2004-10-07
ES2324710T3 (es) 2009-08-13
EP1551830B1 (de) 2009-04-08
AU2003273842A1 (en) 2004-04-08
EP1551830A2 (de) 2005-07-13
AR041194A1 (es) 2005-05-04
WO2004026829A2 (de) 2004-04-01
US7148249B2 (en) 2006-12-12
AU2003273842A8 (en) 2004-04-08
TW200407125A (en) 2004-05-16
US20050054710A1 (en) 2005-03-10
DE50311397D1 (de) 2009-05-20
CA2498781A1 (en) 2004-04-01

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